Identification Of Number Research Articles

Analisis Kepatuhan Wajib Pajak Usaha Mikro Kecil dan Menengah (UMKM)

Analysis of MSME taxpayer compliance in Habi Village. The purpose of this research was to determine and analyze the compliance of MSME taxpayer in Habi Village in paying taxes. This research employed a descriptive qualitative study, and the data collection teachnque for writing this thesis used the interview method. The number of informants in this study were five MSMEs in Habi Village. The research revealed thas two MSME owner in Habi Village had registered their businesses as taxpayers, while there others had not obtained an NPWP (taxpayer identification number). Additionally, some MSMEs in Habi Village lacked knowladge and understanding about income tax, including how to properly register as taxpayers, resubmit notification letters, pay tax arrears before the due date, and calculate and pay taxes owed on their income.

Stability and Robustness Analysis and Optimization for Gain-Scheduled Control of Aero-Engines

Abstract Gainscheduled control is widely applied in the aerospace domain, yet the selection of design points for gainscheduling controllers to ensure stability and robustness throughout the range of scheduling variables remains theoretically unguided. Therefore, this paper introduces an analysis and optimization method for the stability and robustness of gain-scheduled control, aimed at providing a theoretical framework for design points selection. Initially, the method characterizes the gainscheduled control system as a polytopic Linear Parameter Varying (LPV) system, wherein the design points of the gainscheduled control system correspond to the vertices of the polytopic LPV system. Subsequently, the method utilizes Linear Matrix Inequality techniques to demonstrate the stability of a polytopic LPV system with a corresponding number of vertices, and by assessing the approximation degree between the polytopic LPV system and the gainscheduled control system with an identical number of design points, it evaluates and ensures the stability of the latter, thereby establishing the minimal requirements for the number of design points. After ensuring stability, the method further refines the number of design points within the gainscheduled control system to meet additional robustness and performance considerations. A case study on turbofan engine controls validates the proposed method. New design points, selected via stability and robustness analysis, enhance the system's steadystate phase margin and robustness against model uncertainties. Moreover, compared to a vgap metric-based method, the two methods exhibit similar performance in terms of stability, robustness, and tracking control. However, the proposed method requires fewer design points, resulting in less conservatism.

Pengaruh Pengetahuan Wajib Pajak, Sanksi Pajak Dan Kualitas Pelayanan Perpajakan Kepatuhan Wajib Pajak UMKM Di Kota Padang

Revenue from the tax sector is the largest revenue compared to revenue from other sectors in Indonesia. The contribution of taxes to total state revenue averages more than 70 percent each year. The importance of tax contributions to national income greatly impacts the smooth running of government administration and the country's economy. The importance of tax revenue for the Indonesian state encourages the government to issue various policies to improve taxpayer compliance. Taxpayer compliance is an obligation that must be owned by taxpayers because taxes are a source of state revenue (Serliati & Febrianti, 2020). Increasing taxpayer compliance will increase state revenue. The purpose of this study is to see the factors that influence taxpayer compliance, especially MSME taxpayers, including: taxpayer knowledge, tax sanctions, and the quality of tax services. This study uses a quantitative approach with a population of individual taxpayers conducting Small, Micro and Medium Enterprises (MSMEs) in Padang City who have a Taxpayer Identification Number (NPWP). The results of hypothesis testing in the study prove that mandatory knowledge, tax sanctions and the quality of tax services affect the compliance of MSME taxpayers in Padang City.

A comparative study of the effects of advanced platelet-rich fibrin and resorbable collagen membrane in the treatment of gingival recession: a split-mouth, randomized clinical trial

AimThis study aimed to assess the effectiveness of advanced platelet-rich fibrin (A-PRF) combined with the pinhole surgical technique (PST) for enhancing root coverage (RC) in individuals with Miller class I or II gingival recessions (GR). Additionally, it compared the clinical effect of A-PRF and resorbable collagen membrane (RCM).Materials and methodsA total of 18 patients, encompassing 36 treatment sides of 18 Miller class I or II, were randomly assigned to the PST + A-PRF side (18 sides) and the PST + RCM side (18 sides). Clinical assessments of various parameters, including plaque index (PI), clinical attachment level (CAL), keratinized tissue width (KTW), recession depth (RD), recession width (RW), and gingival thickness (GT) were conducted at baseline and three months after the surgical procedure. A numeric rating scale (NRS) was also evaluated during the 1st, 2nd, 3rd and 4th days. This study was formally recorded under the TCTR identification number TCTR20230613005 in the Thai Clinical Trials Register-Medical Research Foundation of Thailand (MRF) on 13/06/2023. Furthermore, it was ethically approved by Sana’a University’s Ethical Committee for Medical Research.ResultsWhen comparing the values of 3 months follow-up with the baseline values, intra-side comparison of the PST + A-PRF group showed significant improvements in PI (P = 0.02), CAL (P = 0.01), and RD (P = 0.04), and GT values (P < 0.01). The improvements in the PST + A-PRF group were through the reduction of baseline values of PI, CAL, and RD; the mean reductions in PI, CAL, and RD were 0.44 ± 0.71, 0.33 ± 0.45, and 0.22 ± 0.43 respectively, and a significant increase in GT value (0.44 ± 0.24). While there was an insignificant increase in KTW value with no change in RW values (4.50 ± 0.71, P = 1). In contrast, intra- side comparison of PST + RCM side showed only a significant reduction in PI value (0.44 ± 0.71, P = 0.02) and a significant increase in GT value (0.42 ± 0.26, P = < 0.01). Meanwhile, there were insignificant improvements in CAL (2.89 ± 0.95), KTW (3.97 ± 0.74), and RD (1.94 ± 0.87) values. Regarding inter-side comparison, there were no statistically significant among all variables (p > 0.05). The pain scores of the numeric rating scale were significantly lower on the PST + A-PRF sides compared with the PST + RCM sides, especially on the 1st, 2nd, and 3rd days (P < 0.001).ConclusionBoth A-PRF and RCM showed not wholly satisfactory outcomes in gingival recession treatment. Interestingly, the combination of PST with A-PRF has proven more effective than combining PST with RCM. Additionally, the localized application of A-PRF has been shown to reduce post-operative pain following the pinhole surgical technique.

Analysis of the Implementation of the Online Single Submission System in NIB Services on the Growth of MSMEs Businesses in Padang Siempuan City

The Government Regulation issued by President Joko Widodo on June 21, 2018, which regulates the Online Single Submission (OSS), faces various obstacles in its implementation. These obstacles involve business actors and agencies responsible for permits within the OSS. One of the main obstacles is the lack of understanding regarding the use of the OSS system. Meanwhile, in Padang Sidempuan City, there are 10,641 MSMEs in Padang Sidempuan based on data from December 2022, and from the initial research data, it turns out that many are still unaware of the OSS and do not have an NIB. This research is a qualitative study using a descriptive approach, in the form of field research. The results of this study indicate the absence of the Impact of OSS Implementation and Business Identification Number on the Growth of Sharia Businesses in Padang Sidempuan City. The reasons for this are that Sharia business actors do not know how to use the OSS System and are also unaware of the benefits of having a Business Identification Number.

Parents' perceptions of patient safety in paediatric hospital care-A mixed-methods systematic review.

To identify and summarize evidence on paediatric patient safety in a hospital setting from parents' point of view. A mixed-methods systematic review. ID number CRD42023453626. PubMed, Scopus, ScienceDirect, the Cochrane Library and the Wiley database were searched in July 2023. Two researchers independently applied eligibility criteria, selected studies and conducted a quality appraisal. Data-based convergent synthesis and thematic content analysis were employed. Twelve studies were included: eight qualitative research studies, two cross-sectional studies, one non-randomized experimental study and one mixed-methods study. The results were grouped into two themes-parental perceptions of inclusion in paediatric patient safety and parental perceptions of exclusion from paediatric patient safety-and comprised seven main subthemes: comfort in communication, parental engagement, communication difficulties, withdrawal from activity, uncertainty about available information and threats to patient safety. Parents are willing to be engaged in care but require support from healthcare professionals, as they are often anxious about the condition of their children and actions they believe might be helpful. They need to be treated as valuable partners and be engaged in communication and decision processes. The development and implementation of interventions involving parents in ensuring the safety of hospitalized paediatric patients should be of the utmost priority to healthcare organizations, as the common theme throughout the included studies was the need for improved communication with and recognition of parents as allies. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist was followed. No Patient or Public Contribution.

Proteomic stable isotope probing with an upgraded Sipros algorithm for improved identification and quantification of isotopically labeled proteins

BackgroundProteomic stable isotope probing (SIP) is used in microbial ecology to trace a non-radioactive isotope from a labeled substrate into de novo synthesized proteins in specific populations that are actively assimilating and metabolizing the substrate in a complex microbial community. The Sipros algorithm is used in proteomic SIP to identify variably labeled proteins and quantify their isotopic enrichment levels (atom%) by performing enrichment-resolved database searching.ResultsIn this study, Sipros was upgraded to improve the labeled protein identification, isotopic enrichment quantification, and database searching speed. The new Sipros 4 was compared with the existing Sipros 3, Calisp, and MetaProSIP in terms of the number of identifications and the accuracy and precision of atom% quantification on both the peptide and protein levels using standard E. coli cultures with 1.07 atom%, 2 atom%, 5 atom%, 25 atom%, 50 atom%, and 99 atom% 13C enrichment. Sipros 4 outperformed Calisp and MetaProSIP across all samples, especially in samples with ≥ 5 atom% 13C labeling. The computational speed on Sipros 4 was > 20 times higher than Sipros 3 and was on par with the overall speed of Calisp- and MetaProSIP-based pipelines. Sipros 4 also demonstrated higher sensitivity for the detection of labeled proteins in two 13C-SIP experiments on a real-world soil community. The labeled proteins were used to trace 13C from 13C-methanol and 13C-labeled plant exudates to the consuming soil microorganisms and their newly synthesized proteins.ConclusionOverall, Sipros 4 improved the quality of the proteomic SIP results and reduced the computational cost of SIP database searching, which will make proteomic SIP more useful and accessible to the border community.-J6PT921fQgCkWKyfrRUdgVideo

Antral membrane balloon technique versus Densah bur in crestal sinus lift with simultaneous implant placement: a randomized clinical trial

BackgroundThe posterior maxilla presents challenges for implant insertion because of the poor bone quality as well as the loss of vertical bone height. Indirect transcrestal sinus lift techniques are advised when a few millimeters of additional height are needed. This study aimed to evaluate the clinical and radiographic outcomes of antral membrane balloon technique versus Densah burs for transcrestal maxillary sinus lifting with simultaneous implant placement.Materials and methodsThis randomized clinical trial was conducted on 22 patients received 32 dental implants for replacement of missed maxillary posterior teeth after crestal maxillary sinus lifting. The patients were randomly divided into two groups. Group 1, patients underwent crestal sinus floor elevation with simultaneous implant placement using antral membrane balloon technique. Group 2, patients underwent crestal sinus floor elevation with simultaneous implant placement using Densah burs. Patients were evaluated clinically and radiographically using cone beam computed tomography (CBCT) at regular time intervals immediately, 6 months and 12 months after surgery. All clinical and radiographic parameters were statistically analyzed.ResultsAll dental implants were successful for 12 months of follow up. Regarding implant primary stability, there was a statistical significant difference between the study groups in favor of Densah group (P = 0.004), while there was no significant difference after 6 months (P = 0.07). Radiographically, balloon group showed a statistically significant immediate postoperative vertical bone height (P < 0.0001), and significant reduction in vertical bone height after 6 months (P < 0.0001). Densah group showed significant increase in bone density (P ≤ 0.05).ConclusionBoth techniques demonstrated successful clinical and radiographic outcomes for crestal sinus lift. The antral membrane balloon group demonstrated better immediate postoperative vertical bone gain, while Densah burs had higher implant primary stability and bone density.Trial registrationThis study was registered in Clinical-Trials.gov PRS (https://register.clinicaltrials.gov) under identification number NCT05922592 on 28/06/2023.

A randomised, two-arm (1:1 ratio), double blind, placebo controlled phase III trial to assess the efficacy, safety, cost and cost-effectiveness of Rituximab in treating de novo or relapsing NS in patients with MCD/FSGS (TURING)

BackgroundMinimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS) are a spectrum of disease causing the nephrotic syndrome (NS), characterised by proteinuria with debilitating oedema, as well as a high risk of venous thromboembolic disease and infection. Untreated, 50–60% patients with FSGS progress to end stage kidney disease after 5 years. These diseases respond to immunosuppression with high dose glucocorticoids, but 75% will relapse as the glucocorticoids are withdrawn, leading to significant morbidity associated with prolonged use. In children, the B cell depleting monoclonal antibody rituximab reduces relapse risk, but this drug has not been tested in randomised controlled trial in adults.Methods130–150 adults with new or relapsing MCD/FSGS, from UK Renal Units, are being randomised to receive either rituximab (two 1 g infusions two weeks apart) or placebo. Partipicipants are recruited when they present with nephrosis, and all are treated with glucocorticoids as per KDIGO guidelines. Once in remission, prednisolone is withdrawn according to a pre-specified regimen. If in remission at 6 months, participants receive a further dose of trial drug. If they relapse, they are unblinded, and if they have received placebo, they are offered open label rituximab with protocolised prednisolone as in the main phase of the trial. The primary end point is time from remission to relapse. A number of secondary endpoints will be assessed including the effect of rituximab on: (1) NHS and societal resource use and hence cost: (2) safety: (3) other measures of efficacy, such as achievement of partial and complete remission of NS and the preservation of renal function: (4) health status of participant.Trial RegistrationTURING received ethical approval on 14 Jun 2019 - REC reference: 19/LO/0738. It is registered on EudraCT, with ID number: 2018-004611-50, with a start date of 2019-06-14.

STANDARD AND BIOPSYCHOSOCIAL OSTEOPATHIC MANAGEMENT FOR PATIENTS WITH NON-SPECIFIC LOW BACK PAIN (THE OSCAR STUDY): A SINGLE-CASE EXPERIMENTAL DESIGN

Purpose and BackgroundGuidelines recommend biopsychosocial care for chronic, complex musculoskeletal conditions, including non-specific low back pain. The aims were: 1/ to assess how patients with low back pain respond to osteopathic treatment, both before and after an osteopath has completed a Biopsychosocial Pain Management (BPM) course; and 2/ to assess if it is feasible and acceptable for osteopath participants to receive weekly SCED data and use it to guide patient management.Methods and ResultsA multiple baseline single case experimental design trial (clinicaltrials.gov, on 18/10/2021, ID number NCT05120921) with 11 UK osteopaths was conducted. Patients were randomised to early, middle or late treatment start dates. Statistical analysis assessed the change between baseline, intervention and follow-up periods. Primary outcomes were the Numeric Pain Rating (NPR) and Patient Specific Function Scales (PSFS), measured during the baseline, the 6-week intervention, and during a 12-week follow-up period.At baseline, the osteopaths reported stronger biopsychosocial attitudes to pain, compared to biomedical beliefs (PABS: 34 behavioural scale; 29 biomedical scale). Overall, patient participants showed daily increases in symptoms during the pre-treatment phase (+0.24/day, p&lt;0.001), and daily decreases during treatment (−2.94 over the treatment phase, p&lt;0.001), which continued post-treatment (−3.36 over 12 weeks, p=0.04). Similar improvements were observed for function.ConclusionOsteopathic care was shown to help patients with persistent low back pain. Patient recruitment was challenging because of the randomisation. With further development, the method shows feasibility as a means of enhancing research activity among practising clinicians.Previous presentations or publications of the workThe protocol was published (https://doi.org/10.1016/j.ijosm.2023.100660) and presented at SBPR in 2022. The results were presented to an osteopathic conference in October 2023.Ethics approval was received from the University College of Osteopathy Research Ethics Committee.Conflicts of interestsJerry Draper-Rodi receives fees from the sales of the e-learning course on the biopsychosocial management on the UCO CPD platform.Sources of fundingThe research was funded by the Osteopathic Foundation.

Subjective risk factors of severe pain at discharge from the emergency department.

To examine the risk factors for severe pain upon discharge from the emergency department, assuming appropriate pharmacological treatment of pain, in order to improve pain relief in emergency departments and reduce the risk of potential chronic pain. An analytic study was conducted utilizing data from a multicenter randomized controlled trial to evaluate patients' experiences upon admission and discharge from the emergency department (ED). Severe pain was defined by a score of six on a numerical rating scale of zero to ten. Stress and negative emotions (including anger, fear, sadness, and regret) were evaluated using numerical rating scales, respectively ranging from 0 to 10 and 1 to 5. The risk factors of severe pain at discharge (SPD) from ED were calculated using logistic regression considering patient characteristics evaluated at their admission to the ED. From the 1240 patients analyzed, 22.2% had SPD from the ED. Each increase of one point in the intensity of acute pain and anger was significantly associated with a higher risk of SPD from ED. In addition, woman, negative self-perceived health, and age under 65years, are other significant factors associated with SPD from the ED. In addition to acute pain on admission, this study highlights new factors to consider when managing pain in emergency care, such as anger, and self-perceived health. Addressing these aspects can help reduce the likelihood of developing SPD from the ED, which in turn could potentially lead to the onset of chronic pain in future. SOFTER IV Project clinical identification number: NCT04916678.

Quantitative Comparison of Deparaffinization, Rehydration, and Extraction Methods for FFPE Tissue Proteomics and Phosphoproteomics.

Formalin-fixed paraffin-embedded (FFPE) tissues are suitable for proteomic and phosphoproteomic biomarker studies by data-independent acquisition mass spectrometry. The choice of the sample preparation method influences the number, intensity, and reproducibility of identifications. By comparing four deparaffinization and rehydration methods, including heptane, histolene, SubX, and xylene, we found that heptane and methanol produced the lowest coefficients of variation (CVs). Using this, five extraction methods from the literature were modified and evaluated for their performance using kidney, leg muscle, lung, and testicular rat organs. All methods performed well, except for SP3 due to insufficient tissue lysis. Heat n' Beat was the fastest and most reproducible method with the highest digestion efficiency and lowest CVs. S-Trap produced the highest peptide yield, while TFE produced the best phosphopeptide enrichment efficiency. The quantitation of FFPE-derived peptides remains an ongoing challenge with bias in UV and fluorescence assays across methods, most notably in SPEED. Functional enrichment analysis demonstrated that each method favored extracting some gene ontology cellular components over others including chromosome, cytoplasmic, cytoskeleton, endoplasmic reticulum, membrane, mitochondrion, and nucleoplasm protein groups. The outcome is a set of recommendations for choosing the most appropriate method for different settings.

Suture reinforcement using a modified cyanoacrylate glue to prevent anastomotic leak in colorectal surgery: a prospective multicentre randomized trial

BackgroundAnastomotic leakage (AL) is the most frequent life-threating complication following colorectal surgery. Several attempts have been made to prevent AL. This prospective, randomized, multicentre trial aimed to evaluate the safety and efficacy of nebulised modified cyanoacrylate in preventing AL after rectal surgery.MethodsPatients submitted to colorectal surgery for carcinoma of the high-medium rectum across five high-volume centres between June 2021 and January 2023 entered the study and were randomized into group A (anastomotic reinforcement with cyanoacrylate) and group B (no reinforcement) and followed up for 30 days. Anastomotic reinforcement was performed via nebulisation of 1 mL of a modified cyanoacrylate glue. Preoperative features and intraoperative and postoperative results were recorded and compared. The study was registered at ClinicalTrials.gov (ID number NCT03941938).ResultsOut of 152 patients, 133 (control group, n = 72; cyanoacrylate group, n = 61) completed the follow-up. ALs were detected in nine patients (12.5%) in the control group (four grade B and five grade C) and in four patients (6.6%), in the cyanoacrylate group (three grade B and one grade C); however, despite this trend, the differences were not statistically significant (p = 0.36). However, Clavien–Dindo complications grade > 2 were significantly higher in the control group (12.5% vs. 3.3%, p = 0.04). No adverse effects related to the glue application were reported.ConclusionThe role of modified cyanoacrylate application in AL prevention remains unclear. However its use to seal colorectal anastomoses is safe and could help to reduce severe postoperative complications.

68 Use of artificial intelligence to derive International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) elements from unstructured medical records

Abstract Background Artificial intelligence technologies invoking large language models (LLMs) may be able to automate data collection for the IMDC registry, an otherwise labor-intensive process. We evaluate a proprietary tool (HopeLLM) in expediting data abstraction. Methods We utilized a City of Hope-managed IMDC data set that includes patients with metastatic renal cell carcinoma. From this data set, we randomly selected patients who initiated care after 2018 and had sufficient treatment-related information within the Epic electronic health record system to determine HopeLLM performance. Patient identification numbers were manually extracted to prompt HopeLLM for data abstraction. We compared treatment start and end dates between manually registered information and HopeLLM estimations. The difference ratio in months was compared between the two sources. Lin’s concordance correlation coefficient was performed to quantify the rate of agreement between both sources. Results Among 513 records, 91 patients were randomly selected. A total of 164 lines of treatment were recorded manually in the registry, and 146 were recorded by HopeLLM. A total of 75 lines of treatment were unique to the registry, while 42 were unique to HopeLLM. There were 117 unmatched lines of treatment between the registry and HopeLLM, which were not considered for concordance analysis. We recorded a difference (median (IQR)) of 0 mos (0-0.09 mos) for start dates between the registry and HopeLLM, with a concordance correlation coefficient of 0.99 (95%CI 0.99-0.99). We recorded a difference of 2.15 mos (0.46-5.54 mos) for end dates between the registry and HopeLLM, with a concordance correlation coefficient of 0.92 (95%CI 0.88-0.95). Conclusions HopeLLM can streamline data abstraction from unstructured medical records onto the IMDC database, as it accurately predicts treatment start and end dates for patients with metastatic renal cell carcinoma.

Three-dimensional replica of the temporal bone in the teaching of human anatomy.

The current study proposes the comparison of the visualization and identification of anatomical details between natural human temporal bone, its respective copy from three-dimensional printing, and the virtual model obtained from CBCT. The sample consisted of undergraduate students in Dentistry (Group UE, n = 22), Postgraduate students in Radiology and Imaging (Group P-RI, n = 20), and Postgraduate students in Forensic Odontology (Group P-FO, n = 24). All participants attended a theoretical class on specialized anatomy of the temporal bone and subsequently performed the markings of 10 determined structures. The number of correct identifications was similar in natural bone and printed three-dimensional models in all groups (p > 0.05). The virtual model showed a significantly lower number of correct structures (p < 0.05) in the 3 groups. In general, there were significantly higher percentages of accurate answers among postgraduate students compared to undergraduate students. Most graduate students believed that the printed three-dimensional model could be used to teach anatomy in place of natural bone, while undergraduate students disagreed or were unsure (p < 0.05). Regarding the virtual tomographic image, in all groups, students disagreed or were not sure that its use would be beneficial in replacing natural bone. Three-dimensional and virtual models can be used as auxiliary tools in teaching anatomy, complementing practical learning with natural bones.

Effectiveness of different doses of dexmedetomidine on intraoperative haemodynamic profiles and postoperative pain in patients undergoing abdominal surgery at Dilla University Referral Hospital, Ethiopia, 2024: a double-blind randomized controlled trial.

Abdominal surgery stands as one of the most frequently conducted procedures across surgical specialties, accounting for up to half of surgery-related expenses. Hemodynamic instability emerges as a significant concern during anaesthesia and surgery, provoked by the stress of intubation, surgical incision, and anaesthetic agents. Following abdominal surgery, pain is an inevitable consequence, typically managed with opioid-based analgesia. However, the adverse effects associated with opioids often overshadow their analgesic benefits, particularly in the context of abdominal surgery. Consequently, there exists a necessity to explore and assess alternative non-opioid pain management options post-abdominal surgery as part of a broader strategy to reduce opioid usage. The primary aim of this investigation is to assess the effectiveness of varying doses of dexmedetomidine in regulating intraoperative hemodynamics and alleviating postoperative pain in patients undergoing abdominal surgery. Ethical clearance and institutional review board were obtained from the ethical clearance committee of Dilla University College of Medicine and Health Sciences with protocol unique number of duirb/008/22-01. Our trial has been prospectively registered on the Pan African Clinical Trial Registry with a unique identification number for the registry PACTR202208813896934. Statistical package and analysis were performed by using SPSS version 25. The distribution of data was checked by using Shapiro-Wilk test and the homogeneity of variance was checked by Levene's test. Analysis of variance (ANOVA) and Kruskal-Wallis H test were used for normally distributed continuous data and non-normally distributed or non-parametric data, respectively. P value less than 0.05 with a power of 90% was considered statistically significant. There was a statistically significant increase in mean SBP in the control group at the different critical time points (P<0.05), as compared to the baseline value, while there was no significant difference in mean systolic blood pressure (SBP) between the baseline and all other levels for group 2 and group 3. A statistically significant increase in mean arterial pressure (MAP) was detected in the control group at immediately after intubation (P=0.009) as compared to the baseline value, while a statistically significant reduction in mean heart rate (HR) was observed in group 3 at 15th min after infusion and at 30th 30 min after induction compared to baseline with a P value of 0.002 and 0.008, respectively.Conclusion:Perioperative low-dose infusion of dexmedetomidine at the rate of 0.4mcg/kg/h is a useful anaesthesia adjuvant to control hemodynamic stress response to critical periods. It is wise to use this infusion dose as part of general anaesthesia to achieve better hemodynamic stability.

Microbe surveillance in the amphibian pet trade: Results from a pilot study

AbstractRegional and global trade of live animals can contribute to the spread and emergence of novel pathogens, including several important pathogens of amphibians. However, understanding the spread or even frequency of infections in large, complex amphibian trade networks has been difficult, in part because businesses tend to be reluctant to participate in surveillance programs. Thus, we developed a novel approach to surveillance in which anonymous participating businesses were sent surveillance kits through a trusted trade advocacy partner, samples were returned to researchers via anonymous prepaid envelopes, and results were provided via a secure website with access regulated by a unique personal identification number (PIN) created by the business. We tested samples for the amphibian pathogens, Batrachochytrium salamandrivorans (Bsal), Batrachochytrium dendrobatidis (Bd), and Ranavirus spp. (Rv), as well as the beneficial microbe, Janthinobacterium lividum (Jliv), using quantitative real‐time polymerase chain reaction (qPCR). Out of 120 businesses invited to complete an anonymous socioeconomic survey, 24 volunteered to participate in pathogen surveillance, of which 14 were sent surveillance kits. Eight of these businesses returned samples consisting of swabs collected from amphibians in 78 terrestrial habitats and water filters from 49 aquatic habitats. Copies of a highly conserved vertebrate gene (EBF3N), quantified using qPCR, were consistently low (&lt;100 copies) in returned samples, but similar to those collected by researchers, indicating comparable sample quality. Three samples (from two facilities) had detectable levels of Bd DNA; Bsal, Rv, and Jliv were not detected. This pilot study provides evidence that information about pathogens in pet trade networks can be acquired by developing partnerships with industry, and business participation might be enhanced by ensuring anonymity and inclusion of a trade advocacy partner.

Development of the Pneumococcal Genome Library, a core genome multilocus sequence typing scheme, and a taxonomic life identification number barcoding system to investigate and define pneumococcal population structure.

Investigating the genomic epidemiology of major bacterial pathogens is integral to understanding transmission, evolution, colonization, disease, antimicrobial resistance and vaccine impact. Furthermore, the recent accumulation of large numbers of whole genome sequences for many bacterial species enhances the development of robust genome-wide typing schemes to define the overall bacterial population structure and lineages within it. Using the previously published data, we developed the Pneumococcal Genome Library (PGL), a curated dataset of 30 976 genomes and contextual data for carriage and disease pneumococci recovered between 1916 and 2018 in 82 countries. We leveraged the size and diversity of the PGL to develop a core genome multilocus sequence typing (cgMLST) scheme comprised of 1222 loci. Finally, using multilevel single-linkage clustering, we stratified pneumococci into hierarchical clusters based on allelic similarity thresholds and defined these with a taxonomic life identification number (LIN) barcoding system. The PGL, cgMLST scheme and LIN barcodes represent a high-quality genomic resource and fine-scale clustering approaches for the analysis of pneumococcal populations, which support the genomic epidemiology and surveillance of this leading global pathogen.

Factors Influencing SIMRS Quality at Al-Islam H.M Mawardi General Hospital

This quantitative study investigates the impact of organizational factors on Hospital Management Information Systems (HMIS), employing the PRISM framework. The absence of a search menu linked to the primary key of national identity number in the HMIS was scrutinized for its effects. Results reveal significant influences of organizational factors on technical and behavioral aspects of HMIS. Notably, periodic evaluations by the IT team significantly enhance technological advancements within hospitals, while frequent training sessions for HMIS users markedly improve their comprehension of system functionalities. These findings underscore the pivotal role of organizational strategies in shaping the effectiveness and efficiency of HMIS, offering valuable insights for optimizing healthcare information management practices. Highlights : Organizational factors significantly influence technical enhancements in Hospital Management Information Systems. Frequent evaluations by the IT team contribute to technological advancements within hospital systems. Regular user training sessions enhance comprehension and utilization of HMIS functionalities Keywords: Hospital Management Information Systems, Organizational Factors, PRISM Analysis, Technology Improvement, User Training

Analisis Hubungan Literasi Keuangan Investor, Pengetahuan Investor, Risk Tolerance Investor Dan Regret Aversion Bias Investor Dengan Keputusan Investasi

Data of Otoritas Jasa Keuangan (OJK) result that the number of Single Investor Identification (SID) in Indonesia has increased from 2019 to May 2022. Most of these SID investors come from millennials who were born from 1980 to 2000. Investors in Bali SID also experienced an increase, especially in Denpasar City and Badung Regency. The aim of the research is to analyze the relationship between investor of financial literacy, investor knowledge, risk tolerance and regret aversion bias with stock investment decisions in Bali. The sampling technique uses the Slovin formula to obtain a minimum sample size. The data source was obtained from primary data by distributing a 5 Likert scale questionnaire to respondents via Google Form to BNI Securities and Mandiri Securities. Based on the research sample criteria, 129 research samples were obtained. Partial Least Square (PLS) - Structural Equation Modeling (SEM) is used for data analysis. The results are 1) investor financial literacy is significantly positively related to investment decisions, which means hypothesis 1 is accepted, 2) investor knowledge is significantly positively related to investment decisions, which means hypothesis 2 is accepted, 3) investor risk tolerance is significantly positively related to investment decisions so that Hypothesis 3 is accepted, 4) investor regret aversion bias is significantly positively related to investment decisions, which means hypothesis 4 is accepted.