Relative Novelty Research Articles

Exploring determining factors of MaaS app use and its potential effects on mobility behavior: Keys to gender-sensitive planning and management

Mobility as a Service (MaaS) has become an emerging trend in transportation planning and management due to its potential to overcome the challenges of urban mobility toward the achievement of sustainable mobility goals. This requires people to be willing to use MaaS apps. However, given their relative novelty, there is still a lack of research on the factors that influence the use of these apps, as well as the possible role of gender in such use. In this context, this study aims to explore the complex relationships between a set of relevant factors and their influence on the intention to adopt MaaS apps, with special attention to the role of gender as a moderating variable. For this purpose, a survey was conducted in the Madrid Metropolitan Area (Spain), comprising 8358 respondents (3627 men and 4731 women), and a four-step methodological procedure was adopted: (i) Exploratory Factor Analysis (EFA), (ii) Confirmatory Factor Analysis (CFA), (iii) Structural Equation Model (SEM) on the total sample (iv) Gender-sensitive analysis, including a Multi-group analysis – SEM. The results demonstrate that technophilia, perceived usefulness and perceived ease of use are determining factors. Green values and attitudes toward shared modes have a notable total positive effect. However, contrary to expected, attitudes toward public transport, car and bicycle hardly explain the intention to adopt MaaS apps. Our analysis also reveals significant gender differences in the causal relationships hypothesized in the model. These findings allow us to outline the policy initiatives that could favor the use of MaaS apps, with a gender-sensitive approach.

Cyberbullying and Internet Gaming Disorders in Pakistan: Strategies for Mitigation

Dear Editor,Cyberbullying and internet gaming disorders (IGDs) have emerged as significant concerns in Pakistan, particularly among adolescents. This editorial explores the prevalence, impacts, and potential interventions for these issues, drawing on recentresearch and literature. The need for a multifaceted approach involving parents, educators, communities, and government is emphasized to protect vulnerable populations and promote a healthier digital environment. The advent of widespread internet access in Pakistan has brought numerous benefits, yet it has also introduced challenges such as cyberbullying andinternet gaming disorders (IGDs). These phenomena have serious implications for the mental health and well-being of adolescents. Given the relative novelty of these issues in the local context and the paucity of research, it is crucial to develop a comprehensive understanding and effective strategies for mitigation. According to a met analysis of earlier research, Asianyouth have a high IGD prevalence 1 Defining Cyberbullying and IGDs Cyberbullying lacks a universally accepted definitiondue to its complexity. Alipan and Skues provide a useful framework, describing it as behavior that intentionally harms victims using information and communication technology, perceived as harmful by victims, and witnessed by bystanders as negative2 . IGDs are recognized in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as a condition warranting further study. Vulnerability of Adolescents Adolescents are particularly susceptible to cyberbullying and IGDs due to the developmental changes they experience. The American Academy of Pediatrics recommends against providing personal mobile phones to children under 13 years old, highlighting their vulnerability to risky behaviors3. The prefrontal cortex, responsible for decision making and impulse control, is not fully developed in adolescents, making them prone to impulsive and risky behaviors, including cyberbullying and excessive gaming.

Clinical Perspective of Myocardial Recovery and Improvement: Definitions, Prevalence, and Relevance.

Partial or complete imaging resolution of left ventricular (LV) systolic dysfunction in patients with heart failure with reduced ejection fraction (HFrEF) has gone by many names in the past few decades, including LV recovery, remission, reverse remodeling, and, most recently, improvement. This phenomenon has been described in a variety of clinical scenarios, including removal of an acute myocardial insult, unloading with durable LV assist devices, and treatment with various devices as well as pharmacotherapies, termed guideline-directed medical therapy (GDMT). Irrespective of definition, systolic improvement is associated with improved clinical outcomes compared to persistent systolic dysfunction. In the past few years, systolic improvement has been distinguished from HFrEF as a new clinical entity referred to as HF with improved EF (HFimpEF). Given the relative novelty of this condition, there is a paucity of data with regard to the clinical trajectory and management of this population. In this review, we describe the history of myocardial improvement terminology and explore notable findings that have led to the delineation of HFimpEF. Additionally, we highlight the importance of understanding LV trajectory and the potential opportunity for new GDMT management for clinicians when treating patients with HFimpEF.

Impact of perceived privacy and security in the TAM model: The perceived trust as the mediated factors

PurposeScholarly literature and industrial evidence imply how to improve face recognition technology. However, given the relative novelty of the influence on consumers' (users) emotions and behavior, little research has been undertaken on this issue. Hence, this paper aims to check the perceived role of privacy and security in behavioral intention in face recognition. As the mediated factor, we consider the impact of perceived privacy and perceived security on behavioral intention by trust, perceived ease of use, and perceived usefulness. FindingsThe results indicated that all the hypotheses are supported except for the effect of perceived privacy on trust Originality/valueThis paper analyzes the effect of perceived privacy and perceived security on behavioral intention in face recognition based on the Technology Acceptance Model (TAM), which has not been investigated thoroughly in the context of face recognition. Future research suggests using different samples or methods to test the stability of the results on these variables.

β-glycerophosphate, not low magnitude fluid shear stress, increases osteocytogenesis in the osteoblast-to-osteocyte cell line IDG-SW3

ABSTRACT Aim As osteoblasts deposit a mineralized collagen network, a subpopulation of these cells differentiates into osteocytes. Biochemical and mechanical stimuli, particularly fluid shear stress (FSS), are thought to regulate this, but their relative influence remains unclear. Here, we assess both biochemical and mechanical stimuli on long-term bone formation and osteocytogenesis using the osteoblast-osteocyte cell line IDG-SW3. Methods Due to the relative novelty and uncommon culture conditions of IDG-SW3 versus other osteoblast-lineage cell lines, effects of temperature and media formulation on matrix deposition and osteocytogenesis were initially characterized. Subsequently, the relative influence of biochemical (β-glycerophosphate (βGP) and ascorbic acid 2-phosphate (AA2P)) and mechanical stimulation on osteocytogenesis was compared, with intermittent application of low magnitude FSS generated by see-saw rocker. Results βGP and AA2P supplementation were required for mineralization and osteocytogenesis, with 33°C cultures retaining a more osteoblastic phenotype and 37°C cultures undergoing significantly higher osteocytogenesis. βGP concentration positively correlated with calcium deposition, whilst AA2P stimulated alkaline phosphatase (ALP) activity and collagen deposition. We demonstrate that increasing βGP concentration also significantly enhances osteocytogenesis as quantified by the expression of green fluorescent protein linked to Dmp1. Intermittent FSS (~0.06 Pa) rocker had no effect on osteocytogenesis and matrix deposition. Conclusions This work demonstrates the suitability and ease with which IDG-SW3 can be utilized in osteocytogenesis studies. IDG-SW3 mineralization was only mediated through biochemical stimuli with no detectable effect of low magnitude FSS. Osteocytogenesis of IDG-SW3 primarily occurred in mineralized areas, further demonstrating the role mineralization of the bone extracellular matrix has in osteocyte differentiation.

The Factors Inducing Undergraduate Entrepreneur Satisfaction Towards Blended Learning for Entrepreneurship Development in Sri Lanka: A Case Study at University of Colombo Institute for Agro-Technology and Rural Sciences

Blended learning has become increasingly important in higher education, especially in the context of entrepreneurship education in Sri Lanka. Despite its relative novelty in the country's higher education context, this study explores into its impact on undergraduate entrepreneurs' satisfaction with blended learning at the University of Colombo Institute for Agro-Technology and Rural Sciences. This research seeks to identify the key determinants of satisfaction and improve the quality of blended learning experiences for undergraduate entrepreneurs at the institute, contributing to the ongoing advancement of entrepreneurship education in Sri Lanka. The study covers the entire population (204) of undergraduate entrepreneurs pursuing bachelor’s degrees in Agro-Technology, ensuring a comprehensive perspective. To gather insights, a pre-tested questionnaire incorporating socio-economic information along with dimensions such as the learner, instructor, course, technology, design, environmental, and opportunity were used, and respondents were instructed to select the most an appropriate answer on the Likert scale, which ranges from strongly agree to strongly disagree, to express their views. The study's results showed that in the blended learning context, dimensions such as the instructor, course, design, environmental, and opportunity were positively and significantly correlated with the satisfaction levels of undergraduate entrepreneurs. In contrast, the learner and technology dimensions did not demonstrate a significant correlation with satisfaction. Policymakers should be aware of these features and prioritise the improvement of Sri Lanka's higher education system, with a particular emphasis on entrepreneurial development.

Solid Oxide Cell Reactor Model for Transient and Stationary Electrochemical H2O and CO2 Conversion Process Studies

The ability of high-temperature solid oxide cell (SOC) electrochemical reactors to efficiently convert atmospheric carbon to high value chemicals for industrial and energy storage applications via CO2 and co-electrolysis makes them a key technology for active carbon utilisation. However, due to additional operational risks from thermochemical reactions on thermal management, limited experimental capacity, and relative novelty, CO2 and co-electrolysis lag behind steam electrolysis in large-scale adoption. Here, a 1D+1D SOC model based on fundamental first principles considering three-dimensional heat transfer was improved via a unique method for representing co-electrolysis electrochemistry, solving with low computational effort. Validation against experimental data for two compositions and pressures, showed high levels of accuracy with respect to characteristic cell voltages, temperatures, and outlet compositions. The model also showed CO2 reduction during co-electrolysis mainly occurred via reverse water gas shift, while CO2 electrolysis still accounted for up to 35% of the total share. Pressurised co-electrolysis operation promotes exothermic methanation, causing pronounced heating of the reactor, consequently reducing the isothermal current density. Therefore, low to moderate pressurisation is likely most suited for coupling with downstream synthesis processes to avoid the installation of unnecessarily large systems and associated high costs.

Vote Buying, Norms, Context, and Trust in Elections

Conventional wisdom says vote buying undermines trust in elections, but few have examined this systematically. We identify why this relationship ought to hold, on average. We also derive two conditioning hypotheses: vote buying will be less consequential among citizens who view these exchanges as positive and in contexts marred by electoral irregularities. We test these three expectations with analyses of cross-national survey data and an original survey experiment. We find only a small and inconsistent relationship between vote buying and electoral trust. We find weak evidence on the role of norms and more support for the notion that context matters. We conclude that a modest connection between vote buying and electoral trust is driven less by approval of vote buying practices and more by variation in how elections are actually conducted and, related, the relative novelty of being exposed to vote buying.

An Evaluation of Autologous Fat Injection as a Treatment for Velopharyngeal Insufficiency: A Review and Integrated Data Analysis.

Velopharyngeal insufficiency (VPI) is a condition characterized by incomplete separation of the oral and nasal cavities during speech production, thereby leading to speech abnormalities and audible nasal emissions. Subsequently, this adversely impacts communication and potentially interpersonal social interactions. Autologous fat grafting (AFG) to the velopharynx, a minimally invasive technique, aims to improve oronasal separation by providing bulk and advancing the posterior pharyngeal wall toward the soft palate. Despite its potential, the relative novelty of AFG in treating VPI has resulted in reporting of inconsistent indications, varied surgical techniques, and mixed outcomes across existing literature. This systemic review examined the evidence of AFG for VPI treatment over the past decade (2013-2023). A thorough search across five electronic databases yielded 233 studies, with 20 meeting the inclusion criteria (e.g., utilized fat injection as their selected VPI treatment, conducted study in human subjects, did not perform additional surgical procedure at time of fat injection). Selected studies encompassed patient and surgical intervention characteristics, perceptual speech assessment (PSA) scores, gap sizes, nasalance measurements, and complications. The majority of patients had a prior cleft palate diagnosis (78.2%), in which nasoendoscopy was the prevalent method for visualizing the velopharyngeal port defect. Fat harvesting predominantly occurred from the abdomen (64.3%), with an average injection volume of 6.3 mL across studies. PSA and subjective gap size scores were consistently higher preoperatively than postoperatively. PSA score analysis from seven studies revealed significant and sustained improvements postoperatively. Gap size score analysis from four studies demonstrated similar preoperative and postoperative differences. Complications were reported in 17 studies, yielding a 2.7% summative complication rate among 594 cases. Autologous fat grafting has emerged as a minimally invasive, safe, and effective treatment for mild to moderate VPI. However, challenges remain because of variability in patient selection criteria, diagnostic modalities, and outcome measurements. This review underscores the need for randomized control trials to directly compare AFG with standard-of-care surgical interventions, providing more conclusive evidence of its clinical efficacy.

Global Experience in the Use of Unmanned Aviation Technologies in Public Administration: a Review

TUnmanned Aerial Systems (UAS), despite their relative novelty, are already an integral component of the general aviation structure, and, based on a number of complex and sophisticated solutions, including those related to artificial intelligence, are part of the spectrum of high technologies. UAS find application not only in the sphere of commerce, but also in the realisation of specific tasks of public administration, such as territory management, healthcare, emergency prevention and elimination, ensuring environmental safety and law and order, nature management. The purpose of the study, the results of which are presented in this publication, is to assess the current state and potential of the use of UAS in these areas based on a review of literature sources on the practice of their application in order to solve the tasks of public administration in different countries of the world. The main conclusion drawn from the analysis and characterising the general scientific novelty of the study is that, despite a significant number of specific examples, the breadth of UAS use range can be characterised as imaginary. The main and the only really significant application is various types of aerial survey in the interests of state control and supervision bodies. In the course of the work, a number of promising directions for the use of UAS have been identified. It is also noted that their wider implementation in the practice of public administration is hindered by the lack and/or imperfection of the relevant legal framework, typical for most legislative systems of the world, and postulates the need to actively address these issues in relation to the classification and certification of UAS, requirements for their operators and software, the procedure and rules of operation, the integration of unmanned aircraft (UAS) into the existing air traffic management system.

АКТУАЛЬНОСТЬ И ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ СПЛИНТ-ТЕРАПИИ ПРИ ДИСФУНКЦИИ ВИСОЧНО-НИЖНЕЧЕЛЮСТНОГО КОМПЛЕКСА И СОПУТСТВУЮЩЕЙ ГОЛОВНОЙ БОЛИ (ОБЗОР ЛИТЕРАТУРЫ)

Introduction. Currently, there is an increased incidence of episodic headache, which patients often attribute to emotional overstrain and stress. However, headaches can be a complication of a more complex condition such as temporomandibular disorder (TMD), which patients may not even be aware of. The use of splint therapy can relieve the patient of pain and discomfort, thereby improving quality of life. The aim of study was to identify the effectiveness of splint therapy in the treatment of dysfunction of the temporomandibular complex, complicated by headache, followed by its relief. Materials and methods. When writing this review, articles published in foreign and domestic scientific publications over the past 19 years have been studied. The articles had certain requirements: compliance with the topic, relevance, the number of participants in the study is greater than or equal to 20, the article does not violate anyone's rights and does not pursue commercial interests. Analysis of the structure and content of the articles allowed selecting 22 articles, which best reveal the topic. Of the selected articles, 7 met the requirements. Results and Discussion. The use of splint therapy as the main method of rehabilitation of patients with dysfunction of the temporomandibular complex raises many questions and doubts, however, this attitude is caused more by the relative novelty of the presented method than by its objective results. There are a large number of studies that describe the high effectiveness of this type of rehabilitation. Splint therapy can be used as an additional method in the complex treatment of headaches, as well as as a main tool in the treatment of joint and muscle pathologies and bruxism. Conclusions. Treatment of patients with TMD and concomitant headache requires a comprehensive approach. Splint therapy appears to be an effective method for eliminating myalgia and headache, as well as pain in the TMJ.

Development and testing of immersive virtual reality environment for safe unmanned aerial vehicle usage in construction scenarios

Robotics and autonomous systems are increasingly being used on construction sites to complete tasks and complement human effort. One such autonomous system is unmanned aerial vehicles (UAV), although their wrong use could be potentially hazardous to humans and the environment. Given its relative novelty in construction, there remains a dearth of knowledge about safety risks associated with their use as well as knowledge on skills and protocols for their safe operation. With construction being one of the most dangerous and accident-prone sectors, there is even more impetus to develop UAV safety competence. In this study, we explore the application of immersive virtual reality (VR) use for purposes of safety training pertaining to the use of UAVs in construction scenarios. Whereas, previous studies, focussed on effectiveness of VR as a tool for training individuals on UAV operations and safety risks in general, this study evaluates its effectiveness across distinctive themes of safety in order to compare its effectiveness in different domains of UAV safety. The study adopts design science for development of bespoke UAV safety training tool in VR using Building Information Modelling (BIM) and game engine-driven virtual prototyping. The immersive training tool was then applied in an experiment of participants (n = 100) with (n = 50) constituting a control group using more traditional training methods and a series of pre/post-test assessments. The findings confirmed the relative superiority of VR training over traditional methods, improving performance and retention by up to 22 % on average. The immersive VR was found to be most effective on participants retention of knowledge in general flight preparation, air traffic documentation, visibility management and warning signals. Further usability tests were performed on all participants (n = 100) revealing general presence and positive attitudes towards VR based UAV safety training when compared to traditional training. From a practice perspective this research proofs the effectiveness of a VR approach as more cost effective and safe approach to UAV training for both academia and practice with added advantage of being more realistic simulation of the UAV risk scenarios.

Things change, things stay the same: MrBeast and novel philanthropy

AbstractThere is a tendency in the study of philanthropy to see each new innovation or movement as transformative and distinct from what has come before. Before MrBeast there was philanthrocapitalism and before long there will be another shiny new toy for those of us who research or practice philanthropy to study. Happily, Rhodri Davies' analysis of MrBeast's philanthropy avoids falling into the trap of seeing novelty at every turn. Instead, he presents a nuanced and measured analysis of the criticisms of MrBeast and of his philanthropic endeavours, weighing up where the mud sticks and where it does not. This response explores the relative novelty of MrBeast's approach to philanthropy and of the criticisms that have been levied at it.

ANALYSIS OF EVALUATION CRITERIA INDICATING THE IMPORTANCE OF CREATIVE INDUSTRIES IN THE WORLD ECONOMY

The issues of studying the influence of creative industries at the national level and the global economy as a whole are gaining more and more popularity due to their active positive impact on the economic development of countries. Based on the relative novelty of the appearance of this term in the scientific field, this topic is insufficiently developed and requires a comprehensive study. The purpose of the study is to analyze a sample set of evaluation criteria involved in the evaluation of national creative sectors of countries. The research methodology includes the application of universal general scientific research methods. A multidisciplinary approach prevails in the study. The scientific significance of the work consists in the identification, systematization and presentation of evaluation criteria used to identify the importance of creative industries in the economy of countries, practical - in the possibility of applying the conclusions obtained from the results of the study for a deeper subsequent study of creative industries and their impact on the economy of the world. In this study, an analysis of the current state of creative industries and management of their development was used, as well as various approaches to assessing the effectiveness of the creative sector within the city and country format. This study is the initial stage of developing the concept of managing the entrepreneurial potential of creative industry entities in order to form a decent competitive environment in the creative industries market in the future and to fulfill the requests of authors and owners of intellectual property created within the framework of a specific industry affiliation of the creative sector.

Young children and adults use reasoning by exclusion rather than attraction to novelty to disambiguate novel word meanings.

Upon hearing a novel label, listeners tend to assume that it refers to a novel, rather than a familiar object. While this disambiguation or mutual exclusivity (ME) effect has been robustly shown across development, it is unclear what it involves. Do listeners use their pragmatic and lexical knowledge to exclude the familiar object and thus select the novel one? Or is the effect, at least in early childhood, simply based on an attraction to novelty and a direct mapping of the novel label to a novel object? In a preregistered online study with 2- to 3-year-olds (n = 75) and adults (n = 112), we examined (a) whether relative object novelty alone (without pragmatic or lexical information) could account for participants' disambiguation and (b) whether participants' decision processes involved reasoning by exclusion. Participants encountered either a known and an unknown object (classic ME condition) or two unknown objects, one completely novel and one preexposed (novelty condition) as potential referents of a novel label. Reasoning by exclusion was assessed by children's looking patterns and adults' explanations. In the classic ME condition, children and adults significantly chose the novel object and both used reasoning by exclusion. In contrast, in the novelty condition, children and adults chose randomly. Across conditions, a retention test revealed that adults remembered their prior selections, while children's performance was fragile. These results suggest that referent disambiguation is not based on relative object novelty alone. Instead, to resolve referential ambiguity, both young children and adults seem to make use of pragmatic and/or lexical sources of information and to engage in reasoning by exclusion strategies. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Abstract 64: Risk Factors for Carotid Artery Lipid Deposition Measured by Gray Scale Median of the Intima-Media in Children and Young Adults Over the Life Course

Introduction: Echogenicity of the carotid arterial wall, measured by gray scale median of the intima-media (GSM-IM), is a unitless measure that reflects lipid deposition in the arterial wall, with lower values indicating greater lipid deposition and atherosclerosis. Due to the relative novelty of GSM-IM, its progression and associated risk factors are incompletely understood. This study investigated the GSM profile in childhood and young adulthood using a longitudinal cohort of individuals followed over time, and conducted a priori analysis on the behavioral, psychosocial, and health risk factors for GSM. Methods: Data were collected as part of the Meta-Air2 follow-up study of participants enrolled in the Southern California Children’s Health Study. A total of 240 study participants underwent a carotid artery ultrasound examination in 2008 (mean age±standard deviation [ SD] : 11.2±0.6 years), and again between 2018 and 2023 (24.2±1.6 years) to assess changes in carotid artery health, including GSM-IM, carotid artery intima-media thickness (CIMT), and carotid artery distensibility. Participants self-reported lifestyle behaviors, psychosocial health, and underwent anthropometric and blood pressure measures at both time points. Mixed effects models were used to predict GSM-IM changes with repeated measurements of lifestyle behaviors, perceived stress, BMI, and blood pressure. Results: Means and SDs of GSM-IM were 110.0±27.4 in childhood, and 75.6±15.8 in adulthood, with an annual change rate of -2.6 per year. Individuals of Hispanic ethnicity, and those with lower parental education levels had significantly lower GSM-IM in both childhood and adulthood. GSM-IM was significantly correlated with other measures of carotid artery atherosclerosis, including CIMT (r=0.28; p <0.001) and carotid artery distensibility (r=0.36; p <0.001). Results of mixed effects models adjusting for covariates, indicated that higher BMI (β=-1.35; 95% confidence interval [CI], -1.70, -0.99; p <0.001) and systolic blood pressure (β=-0.32, 95% CI, -0.55, -0.09; p=0.007) were significantly associated with lower GSM-IM. A significant interaction between BMI and age (β difference=0.14; 95% CI, 0.09, 0.20; p <0.001) suggested that a per-unit change in BMI has a greater effect on GSM-IM among adolescents compared to young adults. Health compromising behaviors, including less sleeping time, smoking, drug use, and higher perceived stress were significantly associated with lower GSM-IM in unadjusted models. However, these associations were attenuated after adjustment for covariates. Conclusion: Our study highlights the influence of BMI, particularly during childhood, blood pressure and lifestyle behaviors on adverse changes in GSM-IM, indicative of greater lipid deposition. These risk factors may be key targets for early prevention for atherosclerosis.

The origins of digital service innovation (DSI): systematic review of ontology and future research agenda

PurposeThe purpose of this study is to disclose ontology of DSI as a novel concept in servitization community, explore the research context and themes (i.e. technological and industrial sectors) where DSI emerges, unveil methodological complexities of the research on digital servitization and DSI and provide guidelines for future research avenues regarding DSI.Design/methodology/approachBearing in mind the relative novelty of DSI as a concept in servitization literature, the authors adopted a systematic literature review approach to identify 111 peer-reviewed articles published in English language and available in business and management disciplines via scholar databases (Scopus). The analysis of literature discloses descriptive and thematic insights regarding digital servitization and DSI.FindingsThe study provides valuable insights from the descriptive and thematic analyses where classification of articles per publication year, citations, methodology/type of the paper, geographical location of data collection, as well as industrial sector and technological contexts are discussed. Moreover, the unique value of this study is observed through its specific focus on the characteristics of DSI-related literature.Originality/valueThe study is among the first of its kind to provide extensive descriptive and thematic insights on the available literature dealing with digital servitization and DSI, mapping out prior research across a wide spectrum of publication outlets and illustrating the chronological evolution of research on digital servitization and DSI.

Value Dynamics: The Pathways of Realisation

This article explores the role of intention-centred value preference in shaping pathways of realisation for individuals and organisations. The author argues that a focus on instrumentality, success and happiness is often at odds with more selfless forms of value realisation, and that this tension can derail value actors from their intended paths. The author defines value as the worthiness of a matter characterised by the hopefulness of the concerned actor(s) and emphasises the importance of understanding the phenomena of novelty, continuity and discontinuity in relation to value dynamics. Value dynamics encompass the processes of value creation, protection and destruction, and require careful assessment through qualitative and quantitative means to determine the state of optimism realisation and value congruence. Value congruence refers to the alignment of assumptions, actions and achievements concerning the value. To address the dynamic nature of value, the author presents a comprehensive conceptual framework consisting of nine principal pathways built on the principle of reciprocity across value actors, functions and realisations. This framework works under the premise that value does not remain static but keeps changing. It offers a practical framework for promoting value congruence in individuals and organisations.

Examining factors influencing public knowledge and practice of proper face mask usage during the COVID-19 pandemic: a cross-sectional study.

The COVID-19 pandemic had an enormous impact on people's quality of life worldwide. Appropriate use of facemasks is an important checkpoint in containing the spread of infection, which was believed to provide the desired level of protection and preserve the community. Given the relative novelty of facemask use in the general population, it is imperative to prioritize the promotion of appropriate facemask utilization and identify factors that may contribute to poor adherence. This study assessed the factors that determined facemask use among the public. A cross-sectional questionnaire-based study was conducted among the residents of the Kingdom of Saudi Arabia between November 2020 and January 2021. The current study explored the factors such as demographic characteristics influencing the knowledge and practice of proper use of facemasks. The study included a total of 198 participants. The results were derived through binomial logistic regression analysis to determine the relationship between the demographic characteristics and responses. The key findings of the study which are crucial in developing targeted intervention strategies to enhance the responsible use and disposal of facemasks are gender, income and employment. A significant difference was found between male and female participants regarding a positive approach to using facemasks, such as washing their hands (P=0.042). In addition, homemakers differed significantly from students, regarding the correct usage of facemasks (P = 0.026). The study participants were aware that hand hygiene is essential when putting on and removing facemasks. Despite wearing facemasks properly, adult participants possessed less knowledge about the hazards of reusing facemasks and appropriate disposal (OR = 0.202, 95% CI [0.032-1.298]). The present research identified gender, income, and employment as the primary attributes that play a pivotal role in the formulation of focused intervention tactics aimed at improving the cautious use and appropriate disposal of facemasks. It is essential to implement nationwide awareness activities, such as information campaigns, to enhance knowledge. Health authorities should establish a functional infrastructure for the collection and disposal of used facemasks by the general public, starting with the dissemination of knowledge. Moreover, the results of the present study have significant implications for health preventive programs aimed at preparing for future pandemics, since they highlight the specific demographic groups that should be prioritized in the development of such policies. Furthermore, it is advisable to integrate these interventional initiatives with national health polices to promote preparedness for handling future pandemics.

Abstract 105: Sex Difference in Brain Energy Metabolism After Electronic Cigarette Vape Exposure May Contribute to Worsened Stroke Injury in Rats

Introduction: Electronic cigarettes (EC) are battery-powered nicotine delivery devices that have gained popularity as alternatives to tobacco cigarettes for young smokers and smokers trying to cease. Because of its relative novelty, our understanding about the effects of EC vaping on stroke outcome is limited. Here we aim to investigate the effects of EC on energy metabolism in the brain and on stroke outcome in animals of both sexes. Methods: Female and male Sprague-Dawley rats (2-3 months old; n=8) were randomly assigned to either air or EC vapor (5% nicotine Juul pods) exposure for 16 nights using the EcigAero-TM Aerosol Exposure Apparatus. After the exposure period, the rats were divided into two cohorts. The brains were collected from the first cohort of rats for unbiased metabolomic (Metabolon Inc.) or Western blot analysis. The second cohort underwent transient middle cerebral artery occlusion (tMCAO; 90 min) or sham surgery and was survived for 21 days. During the post-tMCAO/sham survival, cognition was assessed using the Morris water maze followed by brain collection for histopathological analysis. Results: Metabolomic analysis showed substantial changes in glycolytic metabolites in EC-exposed female rats in relation to air controls, implying altered brain energetics. In EC-exposed female animals, a significant increase (p<0.05) in glucose, glucose 6-phosphate, fructose-6-phosphate, and fructose 1-6 diphosphate was noted compared to air controls. However, such changes were not seen in EC-exposed male rats. Quantification of infarct volume demonstrated that, compared to air rats, EC-exposed rats displayed a significantly increased infarct volume in female rats while showing a trend of increase in male rats. In female rats, infarct volumes were 86 ± 19 mm 3 and 151 ± 25 mm 3 for air and EC groups, respectively, a significant difference (p<0.05). In the male rat air group, tMCAO resulted in an infarct volume of 80 ± 37 mm 3 , while EC yielded 130 ± 38 mm 3 . Behavioral testing showed worsened post-stroke cognitive outcome in EC groups compared to air groups in rats of both sexes. Conclusion: EC vape exposure, even for as short as two weeks, impacts glucose metabolism and worsens post-stroke cognitive deficits in female more than male rats.