1. (1) Studies were carried out upon a series of 600 unselected patients between the age-limits of 11–99 who died in the first State University Hospital in Warsaw. 2. (2) In 31.3% of cases there were no atheromatous changes in the larger cerebral arteries; in the remaining 68.7% of the subjects examined there were degenerative vascular changes which were classified as mild atheroma in 29.8%, in 11.5% as moderate, and in 27.3% as severe. 3. (3) Atheromatous changes were first found in cases in the third decade of life. After that age the number of cases with brain atheroma was found to increase gradually according to the patient's age. At the same time there was a definite shift within the spectrum of atheroma from changes classified as mild to those of severe degree. 4. (4) The internal carotid arteries, the anterior and posterior portions of the basilar artery, and the middle cerebral arteries were the ones most severely involved. The degenerative atheromatous changes occurred in these situations most often and most early. In cases with mild atheroma there was clear-cut selectivity as to localization of atheromatous changes for the above-mentioned arteries; as the intensity of atheroma increased, the degenerative changes were also seen to occur in other regions of the cerebral arterial tree. 5. (5) There was no great difference in the frequency and intensity of atheromatous changes in the brain arteries, with regard to sex. 6. (6) A comparison was made with the results obtained and the data presented by Baker et al. in their American and Norwegian series.
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