Introduction: academic burnout and self-esteem are critical factors that impact both academic performance and the overall well-being of students. This study focuses on analyzing self-perception, fatigue, and other related variables among students from three different nursing faculties. Objective: to estimate the relationship between academic burnout and self-perception among nursing students in northwestern Mexico through a multicenter study. Method: a multicenter study with a descriptive, relational, and cross-sectional design was conducted, involving 702 students from the nursing faculties in Culiacán, Mazatlán, and Los Mochis, Sinaloa. A stratified probabilistic sampling method was used. Data were collected through a personal information form, the Maslach Burnout Inventory Student Survey, and the Rosenberg Self-Esteem Scale. Descriptive and inferential statistics were employed for data analysis. Results: culiacán exhibited the highest proportion of students with high self-esteem, with statistically significant differences compared to Mazatlán and Los Mochis (X²= 9.81, p=0.04). Students from Mazatlán showed the lowest proportions of burnout (52.9%), while Los Mochis had the highest proportion of severe burnout (71.4%) (X²=37.92, p=0.001). Emotional exhaustion was higher in Mazatlán (53.3%). Conclusions: significant differences in self-esteem and burnout exist among the academic units, influenced by marital status, scholarship availability, and employment status, with the latter impacting students' emotional exhaustion
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