The Progress Granite is one of numerous S‐type granitoid plutons exposed in the Larsemann Hills region, southwest Prydz Bay, east Antarctica. The granite was emplaced into a migmatitised pelitic to felsic paragneiss sequence during a regional high‐grade transpressional event (D2) that pre‐dates high‐grade extension (D3). SHRIMP (II) U‐Pb dating for two occurrences of the Progress Granite from D2 and D3 structural domains gives 206Pb/238U ages of 516.2 ± 6.8 Ma and 514.3 ± 6.7 Ma, respectively. These ages are interpreted as crystallisation ages for the Progress Granite and confirm Early Palaeozoic orogenesis in the Larsemann Hills region. This orogen appears to have evolved during continental convergence and is probably responsible for widespread radiogenic isotopic resetting and the near‐complete exhumation of the adjacent northern Prince Charles Mountains which evolved during a ca 1000 Ma event. The identification of a major Early Palaeozoic orogen in Prydz Bay allows tentative correlation of other domai...