Water is a vital resource for life on earth; hence its maintenance is very important. Different regions especially in arid and semi-arid areas are facing population growth and subsequent increase in the domestic, industrial and agricultural activities. Planning of water systems in order to be ready for future development conditions needs further studies on the estimation of the sustainable levels of demands based on the sustainable levels of supplies. In this study a threefold approach for estimating sustainability level of supply and demand in Ahachay river basin in northwestern part of Iran as a case study is taken. In the first method, the internal flows and the origins and final uses of the total resources for each subsystem are estimated and planning for sustainability use index is determined by calculating the available water. Second method introduced a simulation model which is utilized to estimate reliability, resiliency, vulnerability and maximum deficit for a river basin to determine a group sustainability index. In the third method, for evaluating the movement toward sustainability, an index is developed. This index includes parameters that are the difference between supply and demand, percentage of the satisfied demand, productivity of water resources and an indicator for evaluating the reduction of aquifer storage. Finally these methods are compared and a hybrid index combining the indices is developed. An uncertainty analysis is also performed to investigate the random nature of variables in estimating water balance and quantifying the water sustainability. This hybrid index can be used for evaluating the planning scenarios and for maintaining and improving the sustainable state of supply-demand for the region.