North European Research Articles

Optimizing active chilled beam systems in the South Korean Climate: Comparative analysis of cooling energy and thermal comfort by set-point temperature

In this study, the feasibility of implementing the active chilled beam system (ACBS) in South Korea has been analyzed, and an appropriate control strategy has been proposed. While ACBS is increasingly adopted in North America and Europe, its spread in South Korea has been slow due to different climatic characteristics and a lack of diverse understanding and analysis. Furthermore, research discussing the effects of key system parameters on ACBS is notably scarce. Therefore, this study aims to assess the impact of air handling unit discharge air temperature (AHU DAT) and ACBS entering chilled water temperature (ACBS ECWT) on ACBS and propose a control strategy suitable for the South Korean climate. The applicability of ACBS, compared with existing HVAC systems using this control strategy, has been evaluated. The study incorporates two methodologies: firstly, the impact of control variables has been assessed, and a suitable control strategy has been proposed through a sensitivity analysis of these variables. Secondly, the feasibility of applying ACBS, in comparison with conventional HVAC systems, has been evaluated from the perspectives of energy and thermal comfort. It has been found that system parameters, tailored for the South Korean climate, can maintain a level of thermal comfort like existing HVAC systems while achieving up to 18% in energy savings. Overall, this research not only demonstrates the potential applicability of ACBS in hot and humid climates like South Korea but also emphasizes the need for controlling key system parameters

Accuracy assessment of recent global ocean tide models in coastal waters of the European North West Shelf

The accuracy of global ocean tide models is assessed in coastal waters of the European North West Shelf to ascertain where higher resolution local (forecast) models are most needed for geophysical and navigational applications, and which global models are most suitable for providing boundary conditions for regional and local tide models. Five recent global ocean tide models (FES2014b, EOT20, TPXO9-atlas-v5, GOT4.10c, and DTU16) are considered, with the models first compared by interpolating them onto common grids and computing the mean absolute deviation at each grid point. Coastline tide gauge and offshore bottom pressure sensor data were collated from several sources to give a total of 279 observation sites for evaluating model accuracy, including observational values from 137 locations that have not previously been released and have therefore not been assimilated into any of the global models tested. The residual errors between each model’s predicted phasor and the corresponding observed phasor were calculated at each observation location, and quantified using the root mean square (RMS) and median absolute residual (MAR) for the eight tidal constituents M2, S2, N2, O1, K1, K2, P1, and Q1. To avoid RMS values being biased by observation point density, a Voronoi-weighted RMS based on the water area of the Voronoi polygon about each observation location was also developed and used. Four zones were defined based on ocean depth to gauge model performance, and model inaccuracy is again demonstrated in near-shore regions. Seven further zones were defined based on geographical areas, which reveals inhomogeneity among the global models. The smallest overall root sum square (RSS) RMS error across all eight constituents arises with FES2014b, although TPXO9-atlas-v5 has the best performance when using the MAR and Voronoi-weighted RMS metrics. Using only the 137 observation sites that have not been assimilated by any model and therefore provide an independent accuracy assessment, FES2014b exhibits the smallest errors at the coastline, with an RSS RMS of 24.46 cm. All models exhibit larger errors with the 137 independent observation sites than with all 279 observation sites, with an average overall increase in RSS RMS error of 12%, and an increase of 30% for coastline tide gauges, highlighting the need for local model development in these areas.

Motivations, perceptions and impacts of direct-to-consumer genetic testing among users in Brazil.

Numerous studies have focused on direct-to-consumer genetic testing (DTC-GT), but little is known about consumers outside North America and Europe. Therefore, this study assesses the sociodemographic profile, motivations, and impacts of DTC-GT among Brazilian consumers. DTC-GT customers were invited to complete a 30-question online survey anonymously. Descriptive statistics and Chi-Square tests were used to analyze the data, with significant findings analyzed using post-hoc and correspondence analysis. This study comprised 1513 Brazilian DTC-GT consumers with a mean age of 42 years old and mostly female (60.8%). Participants' primary motivation for purchasing the test was to learn about their genetic predispositions to diseases (87.2%) followed by biogeographical ancestry (86.2%). Fewer than 20% of respondents reported consulting a healthcare professional due to the test results (18.4%), and most consumers felt confident in independently understanding the test results (66.9%), which was significantly associated with Health/Biological Sciences professional field (p < 0.001). Additionally, many customers felt glad (63.3%), and few felt worried after receiving their results (13.4%), particularly concerning health outcomes. Lifestyle changes included dietary adjustments (38.7%), regular health check-ups (24.2%) and increased physical activity (16.5%). Overall, 64.0% of respondents reported altering habits following test results. These findings contribute to understanding the motivations and impacts of DTC-GT among Brazilian consumers, indicating positive lifestyle changes and limited negative psychological impacts.

Further Evidence That Female Anoplophora glabripennis (Coleoptera: Cerambycidae) Utilizes Photo-Degradation to Produce Volatiles That Are Attractive to Adult Males

The Asian longhorned beetle, Anoplophora glabripennis (Coleoptera: Cerambycidae: Lamiinae), is a serious pest of over 43 species of hardwood trees in North America, China and Europe. The development of an effective lure and trap for monitoring A. glabripennis has been hindered by the fact that mate finding involves a rather complex series of behaviors and responses to several chemical (and visual), cues. Adults (female-biased) locate a tree via host kairomones. Research has demonstrated that female contact pheromone components are precursors that undergo abiotic oxidation to yield attractive volatile components. Males also produce a pheromone to attract other adults nearby before the final step of recognition by males to the female-produced trail and contact pheromones. Our research aimed to identify new female-produced components from ozone and UV-treated A. glabripennis body washes and test them for behavioral activity using laboratory and field assays. The ozone and UV treatment of virgin female extract yielded sixteen aldehydes, nine of which were found in trace amounts. All sixteen aldehydes elicited antennal responses (GC-EAD) in both males and females, although responses were clearer and more distinct with standards of hexanal, heptanal, octanal, nonanal, decanal, undecanal and dodecanal. Olfactometer assays showed that males were highly attracted to a blend of these seven aldehydes. Females did not show any attraction to the blend in olfactometer assays. Despite low population levels during field tests in 2018 in China, traps containing the aldehyde blend detected A. glabripennis on a weekly basis over 6 weeks and caught significantly more adults (mainly males) than control ‘flight intercept panel’ traps. Field tests in China in 2019 that used the aldehyde blend along with a three-component host blend lure also caught significantly more males (nearly 5×) than blank control traps.

Optimal Coordination of Directional Overcurrent Relays in Microgrids Considering European and North American Curves

Protecting AC microgrids (MGs) is a challenging task due to their dual operating modes—grid-connected and islanded—which cause sudden variations in fault currents. Traditional protection methods may no longer ensure network security. This paper presents a novel approach to protection coordination in AC MGs using non-standard features of directional over-current relays (DOCRs). Three key optimization variables are considered: Time Multiplier Setting (TMS), the plug setting multiplier’s (PSM) maximum limit, and the standard characteristic curve (SCC). The proposed model is formulated as a mixed-integer nonlinear programming problem and solved using four metaheuristic techniques: the genetic algorithm (GA), Imperialist Competitive Algorithm (ICA), Harmonic Search (HS), and Firefly Algorithm (FA). Tests on a benchmark IEC MG with distributed generation and various operating modes demonstrate that this approach reduces coordination times compared to existing methods. This paper’s main contributions are threefold: (1) introducing a methodology for assessing the optimal performance of different standard curves in MG protection; (2) utilizing non-standard characteristics for optimal coordination of DOCRs; and (3) enabling the selection of curves from both North American and European standards. This approach improves trip time performance across multiple operating modes and topologies, enhancing the reliability and efficiency of MG protection systems.

Outcomes of Adjunct Emergent Stenting Versus Mechanical Thrombectomy Alone: The RESCUE-ICAS Registry.

Underlying intracranial stenosis is the most common cause of failed mechanical thrombectomy in acute ischemic stroke patients with large vessel occlusion. Adjunct emergent stenting is sometimes performed to improve or maintain reperfusion, despite limited data regarding its safety or efficacy. We conducted a prospective multicenter observational international cohort study. Patients were enrolled between January 2022 and December 2023 at 25 thrombectomy capable centers in North America, Europe, and Asia. Consecutive patients treated with mechanical thrombectomy were included if they were identified as having underlying intracranial stenosis, defined as 50-99% residual stenosis of the target vessel or intra-procedural re-occlusion. The primary outcome was functional independence, defined as modified Rankin Scale of 0-2 at 90 days. After applying inverse probability of treatment weighting (IPTW) based on propensity scores, we compared outcomes among patients who underwent adjunct emergent intracranial stenting (stenting) versus those who received mechanical thrombectomy alone. A total of 417 patients were included; 218 patients treated with mechanical thrombectomy alone (168 anterior circulation) and 199 with mechanical thrombectomy plus stenting (144 anterior circulation). Patients in the stenting group were less likely to be non-Hispanic White (51.8% vs 62.4%, p=0.03), and less likely to have diabetes (33.2% vs 43.1%, p=0.037) or hyperlipidemia (43.2% vs 56%, p= 0.009). In addition, there was a lower rate of IV thrombolysis use in the stenting group (18.6% vs 27.5%, p=0.03). There was a higher rate of successful reperfusion (modified Treatment In Cerebral Infarction score ≥ 2B) in the stenting versus mechanical thrombectomy alone group (90.9% vs 77.9%, p<0.001) and a higher rate of a 24-hour infarct volume of <30 mL (n=260, 67.9% vs 50.3%, p=0.005). The overall complication rate was higher in the stenting group (12.6% vs 5%, p=0.006), but there was not a significant difference in the rate of symptomatic hemorrhage (9% vs 5.5%, p=0.162). Functional independence at 90 days was significantly higher in the stenting group (42.2% vs. 28.4%, adjusted odds ratio 2.67; 95% CI, 1.66-4.32). In patients with underlying stenosis who achieved reperfusion with mechanical thrombectomy, adjunct emergent stenting was associated with better functional outcome without a significantly increased risk of symptomatic hemorrhage. https://clinicaltrials.gov/study/NCT05403593.

The Effectiveness of International Knowledge Spillover Channels in Korea

This study constructs an extensive dataset at the level of the Korean manufacturing industry for the period from 2006 to 2019 to assess the relative effectiveness of knowledge spillover channels on domestic productivity. Unlike previous studies, we consider both embodied and disembodied knowledge channels by analyzing both the aggregated and disaggregated manufacturing sectors. Utilizing a first-difference model, we demonstrate that knowledge spillovers from the inward FDI channel have a strongly positive impact on the productivity growth of domestic manufacturing at both the 1-digit and 2-digit levels. In contrast, while disembodied channels, such as technology imports, do enhance domestic productivity growth, their effect is less pronounced than that of the inward FDI channel. Furthermore, we find that the positive effects of inward FDI vary according to international partners (North America, Asia, and Europe) and the technological intensity of the industry. Specifically, FDI from Europe and inflows into high-technology industries significantly contribute to the diffusion of knowledge spillover effects. These empirical findings provide important policy implications for the Korean government, suggesting the need to encourage and support domestic R&D activities and inward FDI, particularly from Europe and in high-tech industries.

A review of non-microbial biological control strategies against the Asian longhorned beetle (Coleoptera: Cerambycidae).

The Asian longhorned beetle (ALB), Anoplophora glabripennis (Motschulsky), is a polyphagous woodboring beetle that infests and damages hardwood host trees in Asia, Europe, and North America. Native to China and the Korean peninsula, ALB is invasive in both North America and Europe. Due to the large environmental and economic impacts associated with ALB, much effort has been placed on its management and eradication from invaded areas. Eradication programs consist of visual surveys, regulatory quarantines, host removal, public outreach and education, and in some cases, insecticides. Host removal is effective but is laborious and costly, and while insecticides have been useful as a component of some eradication programs, they can be expensive, ineffective, and environmentally detrimental. Thus, several arthropod biological control agents (BCAs) have been evaluated which could support a more environmentally friendly management strategy to supplement traditional ALB management tactics. Here, we review the biological control strategy for ALB, including the exploration within the native and invaded ranges of the pest, to find potential arthropod BCAs. We discuss the ecological premise behind the method as well as the potential for its success, and we identify knowledge gaps and future considerations for the enactment of this method. While biological control shows promise, care will be needed in utilizing this method, and further research must explore the success of BCAs in field settings.

The Performance of GPM IMERG Product Validated on Hourly Observations over Land Areas of Northern Hemisphere from Global Meteorological Stations

The integrated multi-satellite retrievals for the global precipitation measurement (IMERG) data, which is the latest generation of multi-satellite fusion inversion precipitation product provided by the Global Precipitation Measurement (GPM) mission, has been widely applied in hydrological research and applications. However, the quality of IMERG data needs to be validated, as this technology is essentially an indirect way to obtain precipitation information. This study evaluated the performance of IMERG final run (version 6.0) products from 2001 to 2020, using three sets of gauge-derived precipitation data obtained from the Integrated Surface Database, China Meteorological Administration, and U.S. Climate Reference Network. The results showed a basic consistency in the spatial pattern of annual precipitation total between IMERG data and gauge observations. The highest and lowest correlations between IMERG data and gauge observations were obtained in North Asia (0.373, p &lt; 0.05) and Europe (0.308, p &lt; 0.05), respectively. IMERG data could capture the bimodal structure of diurnal precipitation in South Asia but overestimates a small variation in North Asia. The disparity was attributed to the frequency overestimation but intensity underestimation in satellite inversion, since small raindrops may evaporate before arriving at the ground but can be identified by remote sensors. IMERG data also showed similar patterns of interannual precipitation variability to gauge observation, while overestimating the proportion of annual precipitation hours by 2.5% in North America, and 2.0% in North Asia. These findings deepen our understanding of the capabilities of the IMERG product to estimate precipitation at the hourly scale, and can be further applied to improve satellite precipitation retrieval.

A first look at diversity gaps in psychotherapy research publications and representation

Objective There is a pervasive underrepresentation of researchers and clinicians from diverse backgrounds in psychology. This is the first study to focus on diversity gaps in Psychotherapy Research. We examine a gap in the representation of research from low-income countries and summarize barriers and solutions to increase diversity in the field. Method We examined trends in submission, acceptance, and rejection rates of all submissions (n = 7183) from 75 countries, representing eight geographical regions to Psychotherapy Research, between 28 April 2005 and 22 June 2023. Results Most submissions were from Europe and North America, with the fewest from Africa and Asia/Northeast Asia. High-income countries had significantly more submissions than low-income countries, with gaps increasing over time. North America and Europe had the highest acceptance rates and Africa and Asia/Southeast Asia had the lowest rates. Conclusion Psychotherapy Research is one of the most internationally representative journals in the field. Yet, we found underrepresentation of non-western countries. There is a need to increase the representation of research participants and researchers from non-western countries through direct initiatives and investments in research and researchers from underrepresented backgrounds.

Origins of Extreme CAPE Around the World

AbstractSevere convection, responsible for hazards such as tornadoes, flash floods, and hail, is usually preceded by abundant convective available potential energy (CAPE). In this work, we use a Lagrangian approach to study the buildup of anomalously large values of CAPE from 2012 to 2013 in various regions. Nearly all extreme values of CAPE arise from surface fluxes underneath a layer of convective inhibition (the CIN layer) over several diurnal cycles, but the origin of the CIN layer and the diurnal cycle of surface fluxes differ around the world. In some regions, such as North America and Europe, the air above the boundary layer must be much warmer than usual to form this CIN layer, whereas in other regions, especially the Middle East and central Africa, a CIN layer is common. Additionally, high CAPE occurrences that are over land (those in the Americas, Europe, Africa, and Southeast Asia) tend to lose their CIN layers before the time of maximum CAPE due to large diurnal cycles of sensible heating, whereas those that occur over coastal waters (in the Middle East, Northern Australia, South Asia, and the Mediterranean) usually retain substantial convective inhibition. Uniquely, CAPE in Southeast Australia often builds up due to cooling aloft rather than to boundary layer warming. These results show that one hoping to understand or predict CAPE patterns must understand a variety of mechanisms acting in different regions.

Quantifying the association between PM2.5 air pollution and IQ loss in children: a systematic review and meta-analysis

BackgroundA growing body of epidemiologic and toxicologic literature indicates that fine airborne particulate matter (PM2.5) pollution is neurotoxic and threatens children’s neurobehavioral development, resulting in reduced cognitive function. Understanding the magnitude of this effect is critical for establishing public health policies that will protect children’s health, preserve human capital, and support societal progress.ObjectiveTo quantify the association between ambient PM2.5 air pollution and loss of cognitive function in children, as measured by Intelligence Quotient (IQ) scores, through a systematic literature review and meta-analysis.MethodsFollowing PRISMA guidelines, we conducted a systematic literature search across seven databases: Agricultural and Environmental Science, BIOSIS Citation Index, Embase, GreenFILE, PubMed, Scopus, and Web of Science to identify original scientific studies that investigated the impact of PM2.5 exposure during pre-and postnatal periods on IQ loss during childhood. Using data from studies included for final review, we conducted a meta-analysis, using a random effects model to compute a beta coefficient that quantifies the overall effect of PM2.5 exposure on Full-Scale IQ (FSIQ), Performance IQ (PIQ), and Verbal IQ (VIQ).FindingsOf the 1,107 unique publications identified, six studies met the inclusion criteria for final review, representing 4,860 children across three continents (North America, Europe, and Asia). The mean PM2.5 concentration across all studies was 30.4 ± 24.4 µg/m3. Exposure timing ranged from the prenatal period to mid-childhood. Children were an average of 8.9 years old at the time of cognitive testing. We found that each 1 µg/m3 increase in PM2.5 concentration is associated with a -0.27 point change in FSIQ (p < 0.001), 0.39 point change in PIQ (p = 0.003), and -0.24 point change in VIQ (p = 0.021).ConclusionThrough a systematic review and meta-analysis, we identified a statistically significant relationship between increased exposure to PM2.5 air pollution and reduced cognitive function in children, with the most pronounced impact on PIQ. This analysis will enable estimation of the burden of adverse neurobehavioral development attributable to PM2.5 in pediatric populations and will inform local and global strategies for exposure prevention.

Anthracological analysis of wooden shaft remains from the Roman‐period sacrificial lake of Nidajno, Czaszkowo 1 site, north‐eastern Poland

AbstractHere, we report on an archaeobotanical study of charred wood remains from eight iron spearhead sockets from a sacrificial aquatic site at Nidajno/Czaszkowo 1, Mazurian Lakeland, NE Poland (c. second–fifth c. CE), in search of botanical evidence for the selection of wood for manufacture of wooden shafts used with iron spearheads. The samples were analysed using a Nicon Eclipse ME600 metallographic microscope. The results show significant botanical data for Fraxinus excelsior L. and Tillia sp.The results of this research illustrate the material standard of the finds from a unique sacrificial site of the Scandinavian ‘sacrificial bog’ type, such as the sacrificial site at Nidajno/Czaszkowo 1—one of the most scientifically prospective in the entire zone of the North European Barbaricum. They also reveal a clear preference in the way spears and javelins were made, linked to the use of ash wood for this purpose. This choice is rational, justified by the technological and operational properties of this type of wood, but it also has connotations from the world of symbolic religious imagery.

Projected epidemiological trends and burden of liver cancer by 2040 based on GBD, CI5plus, and WHO data

Incidence of liver cancer as one of the most common cancers worldwide and become the significant contributor for the mortality among cancer patients. The disease burden, risk factors, and trends in incidence and mortality of liver cancer globally was described subsequently estimated the projections of liver cancer incidence or mortality by 2040. Data regarding age-standardized incidence and mortality rates for liver cancer was obtained from multiple databases, including GLOBOCAN 2020, CI5 volumes I–XI, WHO mortality database, and Global Burden of Disease (GBD)-2019. Concentrating on worldwide variations, this thorough analysis offers insights into patterns of incidence and mortality based on gender and age. Our findings encompass significant indicators, including age-standardized rates (ASRs), average annual percentage change (AAPC), and future projections extending up to the year 2040. Liver cancer holds the sixth position in terms of most frequently diagnosed cancers and stands as the sixth leading cause of cancer-related deaths worldwide in 2020, accounting for 905,677 new cases and 782,000 fatalities. Additionally, liver cancer contributed to 12,528,421 age-standardized disability-adjusted life years (DALYs), with an age-standardized DALYs rate of 161.92 in 2019 worldwide. The age-specific incidence rates exhibited significant variations across different regions, showing a fivefold difference in males and females. A significant increase in incidence was observed in North Europe and Asia, while North African countries reported a higher mortality burden (ASR, 10 per 100,000) compared to developed countries. Since last few years, the incidence and mortality rates have increased and attained Annual Average Percentage Change (AAPC) incidence rate of 7.7 (95% CI 3.9–11.6) for men and the highest AAPC mortality rate of 12.2 (95% CI 9.5–15.0) for women. In 2019, Western Europe emerged as the high-risk region for DALYs related to smoking and alcohol consumption, while high-income North America carried a high risk for DALYs associated with a high body-mass index. The projected trend indicates a surge in new liver cancer incident cases, expected to rise from around 905,347 to an estimated 1,392,474 by 2040. This study described the evidence pertinent to higher incidence trends in liver cancer, particularly among both young and older adults, encompassing males and females, as well as those who are HIV-infected and HBsAg positive. A significant rise in the young population poses a significant public health concern that warrants attention from healthcare professionals to prioritize the promotion of health awareness and the development of effective cancer prevention strategies, particularly in many developing countries.

The Summer North Atlantic Oscillation, Arctic sea ice, and Arctic jet Rossby wave forcing.

We use Coupled Model Intercomparison Project Phase 6 (CMIP6) coupled and Atmospheric Model Intercomparison Project (AMIP) climate models, dynamical analyses, and observations to investigate interactions between summer Arctic sea ice concentration (SIC) variations and the Summer North Atlantic Oscillation (SNAO). Observations suggest that SIC-SNAO relationships mainly come from the East Siberian to Arctic Canada (ESAC) region where a weak atmospheric jet stream exists in summer. Twelve CMIP6 models with the most realistic atmospheric climatologies over the North Atlantic and Europe agree well with reanalyses on relationships between SIC and Northern Hemisphere atmospheric circulation. CMIP6 model data indicate that ESAC SIC influences the SNAO with a lead time of several weeks. However, AMIP simulations do not reproduce the observed atmospheric circulation when observed sea ice is prescribed. Rossby wave analyses do though support observed ESAC SIC influences on the SNAO. We conclude that ESAC Arctic SIC modestly influences the SNAO, and such investigations require the use of coupled models.

The key role of forest disturbance in reconciling estimates of the northern carbon sink

Northern forests are an important carbon sink, but our understanding of the driving factors is limited due to discrepancies between dynamic global vegetation models (DGVMs) and atmospheric inversions. We show that DGVMs simulate a 50% lower sink (1.1 ± 0.5 PgC yr−1 over 2001–2021) across North America, Europe, Russia, and China compared to atmospheric inversions (2.2 ± 0.6 PgC yr−1). We explain why DGVMs underestimate the carbon sink by considering how they represent disturbance processes, specifically the overestimation of fire emissions, and the lack of robust forest demography resulting in lower forest regrowth rates than observed. We reconcile net sink estimates by using alternative disturbance-related fluxes. We estimate carbon uptake through forest regrowth by combining satellite-derived forest age and biomass maps. We calculate a regrowth flux of 1.1 ± 0.1 PgC yr−1, and combine this with satellite-derived estimates of fire emissions (0.4 ± 0.1 PgC yr−1), land-use change emissions from bookkeeping models (0.9 ± 0.2 PgC yr−1), and the DGVM-estimated sink from CO2 fertilisation, nitrogen deposition, and climate change (2.2 ± 0.9 PgC yr−1). The resulting ‘bottom-up’ net flux of 2.1 ± 0.9 PgC yr−1 agrees with atmospheric inversions. The reconciliation holds at regional scales, increasing confidence in our results.

Analysis of the Effects of Organic and Synthetic Mulching Films on the Weed, Root Yield, Essential Oil Yield, and Chemical Composition of Angelica archangelica L.

Angelica archangelica L. (Garden angelica) is a medicinal and aromatic plant from the Apiaceae family, originating from North Europe (Iceland, Greenland, and Scandinavian countries). A. archangelica is commonly used in traditional medicine to treat anxiety, insomnia, stomach and intestinal disorders, skin conditions, respiratory problems, and arthritis. This plant is generally cultivated for its root and seed where the essential oil (EO) is concentrated the most. Angelica archangelica cultivation has a lot of challenges but the main one is weed control; so, the aim of this study was to investigate the influence of four different mulch types as non-chemical weed control measures on weediness, fresh root yield, and EO chemical composition and yield from A. archangelica roots. A field trial was conducted with the following six treatments: two organic mulches, two synthetic mulches, and two controls (regular hand-weeded and weeded). The results show that the most present weeds were Ambrosia artemisiifolia, Chenopodium album, Polygonum aviculare, and Polygonum lapathyfolium, but synthetic mulch foils achieved the best weed suppression (100%). These fields also achieved the highest fresh root yield in both of the experimental seasons. The highest EO yield was detected with agrotextile mulch foil at season I (0.41%, v/w) and with the weeded control (0.51%, v/w) at season II, but dominant components at both seasons were α-pinene and β-phellandrene. The results suggest that the agrotextile black and silver–brown mulch foils achieved complete weed suppression, but the agrotextile black mulch foil had a better effect on fresh root yield, EO yield, and its chemical composition.

Indirect Treatment Comparisons in Healthcare Decision Making: A Targeted Review of Regulatory Approval, Reimbursement, and Pricing Recommendations Globally for Oncology Drugs in 2021-2023.

Indirect treatment comparisons (ITCs) evaluate novel treatments compared to appropriate comparators when direct evidence is unavailable or infeasible. The objective of this study was to highlight the prevalence of different ITC methods in oncology drug submissions and to provide insights into how ITCs have been used in recent regulatory approval, reimbursement recommendations, or pricing decisions across various regions and diverse assessment frameworks. A targeted literature review was conducted to identify assessment documents for oncology drug submissions that included ITCs. This included hand searches of the websites of four regulatory bodies and four health technology assessment (HTA) agencies with varying assessment frameworks across North America, Europe, and Asia-Pacific. A total of 185 documents were included for synthesis. Documents were retrieved from all four HTA agencies and the European Medicines Agency (EMA), the only regulatory body with eligible records. Within these, 188 unique submissions included a total of 306 supporting ITCs of various methods. Authorities more frequently favored anchored or population-adjusted ITC techniques for their effectiveness in data adjustment and bias mitigation. Furthermore, ITCs in orphan drug submissions more frequently led to positive decisions compared to non-orphan submissions. This review highlights the crucial role and widespread use of ITCs in global healthcare decision-making, particularly when direct evidence is lacking, and in the discernment of market-specific clinical benefits. This work contributes to bolstering the credibility and recognition of ITCs across regulatory and HTA agencies of diverse regions and assessment frameworks.

Real-world use of androgen-deprivation therapy intensification for metastatic hormone-sensitive prostate cancer: a systematic review.

To conduct a systematic literature review of real-world data (RWD) studies to summarise treatment patterns among men with metastatic hormone-sensitive prostate cancer (mHSPC).While androgen-deprivation therapy (ADT) is a primary treatment strategy for mHSPC, ADT intensification with androgen receptor pathway inhibitors (ARPIs) and/or chemotherapy is recommended by current guidelines and has improved clinical outcomes in the last decade. We searched electronic databases (PubMed; Excerpta Medica dataBASE [EMBASE]) for eligible studies (retrospective or prospective observational RWD studies examining mHSPC treatment patterns) between database inception and July 2023, and manually screened the past 2 years of relevant conference proceedings. Of 2336 retrieved citations, 29 studies met the inclusion criteria, covering North America (United States, n = 21; Canada, n = 2), Europe (n = 8), and Asia (n = 6). Most studies utilised retrospective cohorts (n = 26) and included men with a median age of ≥70 years (n = 20). ADT monotherapy was predominantly used across geographies, followed by ADT + ARPI and ADT + docetaxel in the United States and Europe but not in Asia, where use of each combination remained low. Studies with recent electronic medical record data from cancer centres/registries showed >40% use of ADT + ARPI in the United States and Europe. Abiraterone was the most frequently used ARPI, followed by enzalutamide. Quantitative factors associated with ADT intensification were high disease burden, younger age, Eastern Cooperative Oncology Group performance status score of 0 to 1, fewer comorbidities, and oncologist physician specialty; qualitative factors were patient preference, unsatisfactory response to ADT, ability to tolerate adverse events, and absence of cost barriers. While there was an increasing trend in ADT intensification for mHSPC over the study period across geographies, use remained suboptimal considering the high proportion of patients who were still receiving ADT monotherapy only. These findings highlight the need for interventions to further optimise current mHSPC therapies with high guideline concordance.

A single immunization of Borreliella burgdorferi-infected mice with Vanguard crLyme elicits robust antibody responses to diverse strains and variants of outer surface protein C.

Lyme disease, caused by Borreliella burgdorferi and related species, is a growing health threat to companion animals across North America and Europe. Vaccination is an important preventive tool used widely in dogs living in, or near, endemic regions. In this report, we assessed anti-outer surface protein (Osp) A and anti-OspC antibody responses in B. burgdorferi-infected and -naïve mice (C3H/HeN) after immunization with a murine-optimized single dose of the Lyme disease subunit vaccine, Vanguard crLyme. crLyme is comprised of OspA and an OspC chimeritope-based immunogen designated as CH14. Mice that were infected and immunized developed higher levels of anti-OspC antibodies (Abs) than those infected only or that received one vaccine dose. The anti-OspC Abs that developed in the infected/immunized mice bound to all OspC variants tested (n = 22), whereas OspC Abs in serum from infected mice bound predominantly to the OspC variant (type A) produced by the infecting B. burgdorferi strain. Consistent with the absence of OspA expression in infected mammals, none of the infected mice developed Abs to OspA and did not develop anti-OspA Abs after single dose immunization. Lastly, serum from infected/immunized mice displayed significantly higher and broader killing activity than serum from non-immunized infected mice. The results of this study demonstrate that a single vaccination of actively infected mice results in strong anti-OspC Ab responses. This study contributes to our understanding of Ab responses to vaccination in actively infected mammals.