Some norms of the Constitution of the Russian Federation are considered, which together form the basis for the prevention of natural and man-made emergencies, as a legal foundation for the protection of human life and health, and other legally protected values. The mapping of constitutional norms to some provisions of the main federal laws, acts of the President of the Russian Federation and resolutions of the Government of the Russian Federation, their connection with the functional and territorial systems of the unified state system for the prevention and elimination of consequences of emergency situations is carried out. The powers of the highest institutions of state power – the President of the Russian Federation and the Government of the Russian Federation – are considered from the perspective of state discipline. The constitutional principle of harmonization of mutual relations at the federal level and at the level of Russian regions is touched upon. Possession of the constitutional legal apparatus is presented as a condition for preventing cases of discrepancies and conflicts in legislative acts or departmental regulatory legal acts. The directions of development and improvement of regulatory segments that require a new scientific and legal rethinking and revision in the course of further legal work in the field of regulation are presented.