Normative Variation Research Articles

On the normative variability of truth and logic

ABSTRACT This paper discusses the normativity of truth and logic. The paper has three objectives. First, I argue that logic is normative for thought in (at least) the sense of underwriting instrumental rationality. Logic is a good instrument for achieving truth, the goal of cognition. In recent work, Filippo Ferrari has argued that the normative nature of truth may vary across domains. My second aim is to extend this idea to logic, against the background of the idea that logic serves to underwrite instrumental rationality. The third objective is to further develop Ferrari’s framework of normative alethic variability. I do so through a discussion of the normative problem of mixed compounds: the challenge of providing a principled account of the normativity of compounds with constituents whose respective normative profiles differ. I argue that the challenge can be met. Besides offering a solution to a major challenge, the response offered sheds new light on the normative variability framework: the truth of a single mixed compound may have different normative profiles across different ‘disagreement-realizers’. This feature of the view is rooted in a key commitment of the normative variability framework – namely, that disagreement and alethic normativity are intimately connected.

Mother-Infant Interaction and Child Brain Morphology: A Multidimensional Approach to Maternal Sensitivity.

Emerging research suggests that normative variation in parenting quality relates to children's brain development. However, although the young brain is presumed to be especially sensitive to environmental influence, to our knowledge only two studies have examined parenting quality with infants as it relates to indicators of brain development, and both were cross-sectional. This longitudinal study investigated whether different components of maternal sensitivity in infancy predicted the volume of two brain structures presumed to be particularly sensitive to early experience, namely the amygdala and the hippocampus. Three dimensions of sensitivity (Cooperation/Attunement, Positivity, Accessibility/Availability) were observed in 33 mother-infant dyads at 1year of age and children underwent structural magnetic resonance imaging at age 10. Higher maternal Accessibility/Availability during mother-infant interactions was found to be predictive of smaller right amygdala volume, while greater maternal positivity was predictive of smaller bilateral hippocampal volumes. These longitudinal findings extend those of previous cross-sectional studies and suggest that a multidimensional approach to maternal behavior could be a fruitful way to further advance research in this area, given that different facets of parenting might be differentially predictive of distinct aspects of neurodevelopment.

ICTs Supportive and Therapeutic Contribution in Psychoemotional Disorders in Childhood and Adolescence

<p>This paper aims at reviewing the supportive and therapeutic contribution of ICTs on the most common psychoemotional disorders of childhood and adolescence. The various approaches to classifying behavioral and emotional dysregulations in children and adolescents have been reviewed and the boundaries between normative variation and clinically significant presentations have been determined. Furthermore, we present the major categories of mental illnesses in children and adolescents investigating the etiology, the diagnostic criteria, the epidemiology and treatments by critically reviewing the outcomes of relevant studies. The findings indicate that significant steps have been made in this field, but it is vital to underline the need for more extended investigation in school aged children and adolescents for this purpose.</p>

Quality of maternal behaviour during infancy predicts functional connectivity between default mode network and salience network 9 years later

Infants’ experiences are considered to determine to a large degree the strength and effectiveness of neural connections and fine tune the development of brain networks. As one of the most pervasive and potent relational experiences of infancy, parent-child relationships appear to be prime candidates to account for experience-driven differences in children’s brain development. Yet, studies linking parenting and functional connectivity are surprisingly scarce, and restricted to the connectivity of limbic structures. Accordingly, this longitudinal study explored whether normative variation in the quality of early maternal behaviour predicts the functional connectivity of large-scale brain networks in late childhood. Maternal mind-mindedness and autonomy support were assessed with 28 children when they were 13 and 15 months old respectively. When children were 10 years of age, children underwent a resting-state functional MRI exam. Functional connectivity was assessed between key regions of the default mode network (DMN), salience network (SN), and frontal-parietal central executive network (CEN). Results revealed that higher mind-mindedness and autonomy support predicted stronger negative connectivity between DMN and SN regions. These findings are the first to provide preliminary evidence suggestive of a long-lasting impact of variation within the normative range of early maternal behaviour on functional connectivity between large-scale brain networks.

Housing affordability and inequality:A consumption-adjusted approach

We introduce a new measure of housing affordability that adjusts for normative variation in housing consumption. The new measure is computed using extensive micro-data from Israel for the 1998–2015 period. Findings suggest sharp declines in Israel quality- and consumption-adjusted affordability. Further, the new consumption-adjusted measure suggests more pronounced affordability burdens among minority and underprivileged groups. The new measure also gives rise to elevated Gini measures of housing affordability inequality. We also find that recent trending up in house prices and income in Israel is associated with more pressing consumption-adjusted affordability challenges among those already in housing distress, particularly in outlying, peripheral areas.

Epigenetic correlates of neonatal contact in humans.

Animal models of early postnatal mother-infant interactions have highlighted the importance of tactile contact for biobehavioral outcomes via the modification of DNA methylation (DNAm). The role of normative variation in contact in early human development has yet to be explored. In an effort to translate the animal work on tactile contact to humans, we applied a naturalistic daily diary strategy to assess the link between maternal contact with infants and epigenetic signatures in children 4-5 years later, with respect to multiple levels of child-level factors, including genetic variation and infant distress. We first investigated DNAm at four candidate genes: the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), μ-opioid receptor M1 (OPRM1) and oxytocin receptor (OXTR; related to the neurobiology of social bonds), and brain-derived neurotrophic factor (BDNF; involved in postnatal plasticity). Although no candidate gene DNAm sites significantly associated with early postnatal contact, when we next examined DNAm across the genome, differentially methylated regions were identified between high and low contact groups. Using a different application of epigenomic information, we also quantified epigenetic age, and report that for infants who received low contact from caregivers, greater infant distress was associated with younger epigenetic age. These results suggested that early postnatal contact has lasting associations with child biology.

The Neurodevelopmental Basis of Early Childhood Disruptive Behavior: Irritable and Callous Phenotypes as Exemplars.

The arrival of the Journal's 175th anniversary occurs at a time of recent advances in research, providing an ideal opportunity to present a neurodevelopmental roadmap for understanding, preventing, and treating psychiatric disorders. Such a roadmap is particularly relevant for early-childhood-onset neurodevelopmental conditions, which emerge when experience-dependent neuroplasticity is at its peak. Employing a novel developmental specification approach, this review places recent neurodevelopmental research on early childhood disruptive behavior within the historical context of the Journal. The authors highlight irritability and callous behavior as two core exemplars of early disruptive behavior. Both phenotypes can be reliably differentiated from normative variation as early as the first years of life. Both link to discrete pathophysiology: irritability with disruptions in prefrontal regulation of emotion, and callous behavior with abnormal fear processing. Each phenotype also possesses clinical and predictive utility. Based on a nomologic net of evidence, the authors conclude that early disruptive behavior is neurodevelopmental in nature and should be reclassified as an early-childhood-onset neurodevelopmental condition in DSM-5. Rapid translation from neurodevelopmental discovery to clinical application has transformative potential for psychiatric approaches of the millennium. [AJP at 175: Remembering Our Past As We Envision Our Future November 1938: Electroencephalographic Analyses of Behavior Problem Children Herbert Jasper and colleagues found that brain abnormalities revealed by EEG are a potential causal factor in childhood behavioral disorders. (Am J Psychiatry 1938; 95:641-658 )].

Housing Affordability and Inequality: A Consumption-Adjusted Approach

We introduce a new measure of housing affordability that adjusts for normative variation in housing consumption. The new measure is computed using extensive micro-data from Israel for the 1998–2015 period. Findings suggest sharp declines in Israel quality- and consumption-adjusted affordability. Further, the new consumption-adjusted measure suggests more pronounced affordability burdens among minority and underprivileged groups. The new measure also gives rise to elevated Gini measures of housing affordability inequality. We also find that recent trending up in house prices and income in Israel is associated with more pressing consumption-adjusted affordability challenges among those already in housing distress, particularly in outlying, peripheral areas.

Attachment network structure as a predictor of romantic attachment formation and insecurity

AbstractWe present a new framework to conceptualize normative variation in attachment network structure and use the framework to predict romantic attachment formation and attachment insecurity. Young adults (N = 2,055) completed the Attachment Network Questionnaire and were classified into one of four network types based on two comparisons: (a) between their primary and secondary figure, and (b) between their secondary and tertiary figure. Each comparison was coded as Similar (S) or Different (D), resulting in the following distribution across four network types: (a) 40% D:D—diversified; (b) 32% D:S—monotropic; (c) 19% S:D—joint principal; and (d) 9% S:S—distributed. Romantic duration predicted a developmental sequence of network structure consistent with infant attachment formation. Findings also indicated that the nonhierarchical network, distributed type, was associated with insecure attachment representations. Results suggest that attachment networks exhibit greater structural diversity than is commonly assumed and that the new framework is useful for understanding developmental and social outcomes.

Frontal, Striatal, and Medial Temporal Sensitivity to Value Distinguishes Risk-Taking from Risk-Aversive Older Adults during Decision Making.

Frontal, striatal, and medial temporal functions implicated in value-based decision processing of rewards and costs undergo substantial age-related changes. However, age effects on brain function and cognition differ across individuals. How this normative variation relates to older-adult value-based decision making is unclear. We found that although the ability make optimal decisions declines with age, there is still much individual variability in how this deterioration occurs. Critically, whereas risk-averters showed increased neural activity to increasingly valuable stakes in frontal, striatal, and medial temporal areas, risk-takers instead increased activity as stakes became more costly. Such distinct functional decision-making processing in these brain regions across normative older adults may reflect individual differences in susceptibility to age-related brain changes associated with incipient cognitive impairment.

Can Gait Signatures Provide Quantitative Measures for Aiding Clinical Decision-Making? A Systematic Meta-Analysis of Gait Variability Behavior in Patients with Parkinson's Disease.

A disturbed, inconsistent walking pattern is a common feature of patients with Parkinson's disease (PwPD). Such extreme variability in both temporal and spatial parameters of gait has been associated with unstable walking and an elevated prevalence of falls. However, despite their ability to discretise healthy from pathological function, normative variability values for key gait parameters are still missing. Furthermore, an understanding of each parameter's response to pathology, as well as the inter-parameter relationships, has received little attention. The aim of this systematic literature review and meta-analysis was therefore to define threshold levels for pathological gait variability as well as to investigate whether all gait parameters are equally perturbed in PwPD. Based on a broader systematic literature search that included 13′195 titles, 34 studies addressed Parkinson's disease, presenting 800 PwPD and 854 healthy subjects. Eight gait parameters were compared, of which six showed increased levels of variability during walking in PwPD. The most commonly reported parameter, coefficient of variation of stride time, revealed an upper threshold of 2.4% to discriminate the two groups. Variability of step width, however, was consistently lower in PwPD compared to healthy subjects, and therefore suggests an explicit sensory motor system control mechanism to prioritize balance during walking. The results provide a clear functional threshold for monitoring treatment efficacy in patients with Parkinson's disease. More importantly, however, quantification of specific functional deficits could well provide a basis for locating the source and extent of the neurological damage, and therefore aid clinical decision-making for individualizing therapies.

Longitudinal Associations Between the Quality of Mother-Infant Interactions and Brain Development Across Infancy.

The aim of this study was to investigate if normative variations in parenting relate to brain development among typically developing children. A sample of 352 mother-infant dyads came to the laboratory when infants were 5, 10, and 24months of age (final N=215). At each visit, child resting electroencephalography (EEG) was recorded. Mother-infant interactions were videotaped at the 5-month visit. The results indicated that higher quality maternal behavior during mother-infant interactions predicted higher frontal resting EEG power at 10 and 24months, as well as increases in power between 5 and 10months, and between 10 and 24months. These findings provide rare support for the hypothesis that normative variation in parenting quality may contribute to brain development among typically developing infants.

25. Strategies to reduce intertrial variability of motor responses to nerve root and transcranial stimulation: A condition for follow-up studies in the individual patient

We investigated the Intertrial Variability and Relative Intertrial Variation (RIV) of latency and area of motor responses to High Voltage Electric Stimulation (HVES) of lumbo-sacral roots and to Transcranial Magnetic Stimulation (TMS) recorded from several sites of lower limbs. The purpose was to obtain normative variability values to detect significant changes in the individual patient in follow up studies. Maximal CMAPs to HVES of lumbo-sacral roots were obtained from 10 proximal and distal muscle districts of lower limbs; MEPs to TMS using the double cone coil were recorded from the same sites. The procedure was repeated twice, 1–2 days apart, in 30 subjects, including healthy volunteers and clinically stable multiple sclerosis patients. The use of stable recording and stimulation sites with maximal root-CMAPs and adequately stabilized MEPs allowed a significant reduction of ITV for all latency and area parameters. Mean RIV values (5th–95th percentile) for Central Motor Conduction Time and Area Ratio (MEP/CMAP) did not exceeded −14.8 and +16.0 ms and −26.0 and +33.7 mV ms, respectively. The combined monitoring of latency and areas indexes allows assessment of both conduction slowing and conduction failure, i.e the variable association of axonal damage and conduction block, which directly correlates with motor impairment.

Neural substrates of child irritability in typically developing and psychiatric populations

Irritability is an aspect of the negative affectivity domain of temperament, but in severe and dysregulated forms is a symptom of a range of psychopathologies. Better understanding of the neural underpinnings of irritability, outside the context of specific disorders, can help to understand normative variation but also characterize its clinical salience in psychopathology diagnosis. This study assessed brain activation during reward and frustration, domains of behavioral deficits in childhood irritability. Children (age 6–9) presenting in mental health clinics for extreme and impairing irritability (n=26) were compared to healthy children (n=28). Using developmentally sensitive methods, neural activation was measured via a negative mood induction paradigm during fMRI scanning. The clinical group displayed more activation of the anterior cingulate and middle frontal gyrus during reward, but less activation during frustration, than healthy comparison children. The opposite pattern was found in the posterior cingulate. Further, in clinical subjects, parent report of irritability was dimensionally related to decreased activation of the anterior cingulate and striatum during frustration. The results of this study indicate neural dysfunction within brain regions related to reward processing, error monitoring, and emotion regulation underlying clinically impairing irritability. Results are discussed in the context of a growing field of neuroimaging research investigating irritable children.

Individual Differences in Theory of Mind From Preschool to Adolescence: Achievements and Directions

AbstractIn this article, we provide a state‐of‐the‐science overview of research on normative individual differences in theory of mind. We begin by examining achievements in research on individual differences in theory of mind in the preschool years and more recent work on middle childhood and adolescence. In doing so, we outline several converging lines of evidence for social influences on individual differences in theory of mind, and assess the claim that individual differences in theory of mind matter for children's social lives. We then evaluate two conceptualizations of individual differences in theory of mind: the developmental lag and genuine differences accounts. By placing the study of individual differences in theory of mind center stage, we aim to highlight fruitful avenues for research on normative variation in theory of mind both within and beyond the preschool years.

Drinking and moral order: Drunken comportment revisited

MacAndrew and Edgerton's seminal Drunken Comportment revealed that normative expectations to drunken behaviour differ greatly across cultures. Such variation also exists within cultures, where different drinking contexts may be associated with great normative variation. However, why social regulation of drunken comportment varies has largely been left unexplored. To examine the basis of such differences, two Norwegian drinking contexts are compared: (i) the high school graduation celebration and (ii) the two introduction weeks at university. Data comprise 71 qualitative interviews and field notes from participant observation. The two practices take place within a time span of only four months and involve many of the same participants. Alcohol plays a key role in both contexts. However, while the first context allows for heavy intoxication, sexual explorations and violating norms that ordinarily regulate behaviour in public, the second context is associated with much more control. We argue that the basis of this difference may be found in the differing value priorities of these practices, with participants' behaviour being guided primarily by hedonism and social integration, respectively. When applied to drinking practices in general this conceptual apparatus might elucidate the basis of context-specific norms and intra-cultural variation in drunken comportment.

Development of a novel observational measure for anxiety in young children: The Anxiety Dimensional Observation Scale.

Identifying anxiety disorders in preschool-age children represents an important clinical challenge. Observation is essential to clinical assessment and can help differentiate normative variation from clinically significant anxiety. Yet, most anxiety assessment methods for young children rely on parent-reports. The goal of this article is to present and preliminarily test the reliability and validity of a novel observational paradigm for assessing a range of fearful and anxious behaviors in young children, the Anxiety Dimensional Observation Schedule (Anx-DOS). A diverse sample of 403 children, aged 3 to 6 years, and their mothers was studied. Reliability and validity in relation to parent reports (Preschool Age Psychiatric Assessment) and known risk factors, including indicators of behavioral inhibition (latency to touch novel objects) and attention bias to threat (in the dot-probe task) were investigated. The Anx-DOS demonstrated good inter-rater reliability and internal consistency. Evidence for convergent validity was demonstrated relative to mother-reported separation anxiety, social anxiety, phobic avoidance, trauma symptoms, and past service use. Finally, fearfulness was associated with observed latency and attention bias toward threat. Findings support the Anx-DOS as a method for capturing early manifestations of fearfulness and anxiety in young children. Multimethod assessments incorporating standardized methods for assessing discrete, observable manifestations of anxiety may be beneficial for early identification and clinical intervention efforts.

Marital Satisfaction and Quality of Father–Child Interactions: The Moderating Role of Child Gender

ABSTRACTThe authors aimed to investigate the prospective links between normative variation in fathers’ marital satisfaction and the observed quality of father–toddler interactions, as well as the moderating role of child gender in these associations. Sixty-three fathers reported on their marital satisfaction when their children were 15 months of age, and were observed interacting with their child at 18 months. The results suggested that marital satisfaction was positively associated with the quality of father–son interactions, while no relations emerged among fathers of girls. These findings reiterate the importance of marital relationships for the quality of fathers’ parenting, while reaffirming previous suggestions that the role of child gender in the marriage-parenting connections requires further investigation.

Why political ontology must be experimentalized: On eco-show homes as devices of participation

This article contributes to debates about the ontological turn and its implications for democracy by proposing an experimental understanding of political ontology. It discusses why the shift from epistemology to ontology in science and technology studies has proved inconclusive for the study of politics and democracy: the politics of non-humans has been assumed to operate on a different level from that of politics and democracy understood as institutional and public forms. I distinguish between three different understandings of political ontology: theoretical, empirical and experimental. Each of these implies a different approach to the problem that non-humans pose for democracy. Theoretical ontology proposes to solve it by conceptual means, while empirical ontology renders it manageable by assuming a problematic analytic separation between constituting and constituted ontologies. This article makes the case for the third approach, experimental ontology, by analysing an empirical site, that of the eco-show home. In this setting, material entities are deliberately invested with moral and political capacities. As such, eco-show homes help to clarify two main features of experimental political ontology: (1) ontological work is here not so much relocated from theory to empirical practice but distributed among relevant actors and registers and (2) normative variability does not just pertain to the enactment of things but can be conceived of as internal to political objects. From these two features of experimental ontology, something follows for democracy as an ontological problem. This problem does not dissolve in empirical settings, but these settings make possible its articulation by experimental means.

Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism

BackgroundAutism spectrum conditions (ASC) are associated with deficits in social interaction and communication, alongside repetitive, restricted, and stereotyped behavior. ASC is highly heritable. The gamma-aminobutyric acid (GABA)-ergic system has been associated consistently with atypicalities in autism, in both genetic association and expression studies. A key component of the GABA-ergic system is encoded by the GABRB3 gene, which has been previously implicated both in ASC and in individual differences in empathy.MethodsIn this study, 45 genotyped single nucleotide polymorphisms (SNPs) within GABRB3 were tested for association with Asperger syndrome (AS), and related quantitative traits measured through the following tests: the Empathy Quotient (EQ), the Autism Spectrum Quotient (AQ), the Systemizing Quotient-Revised (SQ-R), the Embedded Figures Test (EFT), the Reading the Mind in the Eyes Test (RMET), and the Mental Rotation Test (MRT). Two-loci, three-loci, four-loci haplotype analyses, and one seven-loci haplotype analysis were also performed in the AS case–control sample.ResultsThree SNPs (rs7180158, rs7165604, rs12593579) were significantly associated with AS, and two SNPs (rs9806546, rs11636966) were significantly associated with EQ. Two SNP-SNP pairs, rs12438141-rs1035751 and rs12438141-rs7179514, showed significant association with variation in the EFT scores. One SNP-SNP pair, rs7174437-rs1863455, was significantly associated with variation in the MRT scores. Additionally, a few haplotypes, including a 19 kb genomic region that formed a linkage disequilibrium (LD) block in our sample and contained several nominally significant SNPs, were found to be significantly associated with AS.ConclusionThe current study confirms the role of GABRB3 as an important candidate gene in both ASC and normative variation in related endophenotypes.