Coastal regions face climate-induced threats that have likely increased over the past four decades. In this work, we quantify the future climate impacts on hydroclimatic extremes in the risk-prone, 15-m-above-sea-level Eastern Shore of Virginia (ESVA) region, utilizing the Sixth International Coupled Model Intercomparison Project (CMIP6) Assessment Report 6 (AR6) and General Circulation Models (GCMs). We incorporate historical data on demographics and disasters, land use land cover (LULC), Landsat imagery, and sea level rise (SLR) to better understand and highlight the correlation between hydroclimatic extremes and societal components in this region. The hydrological model Soil and Water Assessment Tool (SWAT), Standardized Precipitation Index (SPI), Normalized Difference Water Index (NDWI), and Interquartile Range (IQR) method have been used to evaluate the intensity and frequency of projected climate extremes, in which SLR projections under different greenhouse gas emission pathways are temporally and spatially quantified. Our findings include (1) a trend towards wetter conditions is found with an increase in the number of flood events and up to an 8.9 % rise in the severity of flood peaks compared to the 2003–2020 period; (2) current coastal high-risk regions, identified using historical data of natural disasters, demographics, and LULC, are projected to be more susceptible to future climate impacts; and (3) low-lying coastal towns and regions are identified as currently vulnerable to coastal and SLR-induced flooding and are projected to become even more susceptible by 2100. This is the first effort that provides a valuable scientific basis for anticipated shifts in future climate patterns, essential for natural hazard prevention in ESVA. It highlights the need for authorities and decision-makers to plan and implement adaptive strategies and sustainable policies for the ESVA region and other coastal areas across the United States.