Normal University Research Articles

Genetic analysis of a Chinese pedigree affected with Cowden syndrome due to variant of PTEN gene

To explore the clinical features and genetic etiology of a Chinese pedigree affected with Cowden syndrome (CS). A CS pedigree diagnosed in November 2022 at the Ningde Municipal Hospital Affiliated to Ningde Normal University was selected as the study subject. Clinical data were collected, and genetic testing was carried out for available members. Pathogenicity analysis was carried out for the candidate variant. The proband, a 7-year-old male, was found to have autism and intellectual disability. Whole exome sequencing revealed that he has harbored a c.462_463del (p.F154Lfs25) variant of the PTEN gene. The proband's 35-year-old mother, who was diagnosed with pulmonary hamartomas at our hospital, has manifested with lipomas, nodular goiter, and adenomas. Sanger sequencing confirmed that she was also heterozygous for the c.462_463del (p.F154Lfs25) variant of the PTEN gene. No other family members has carried the same variant. Based on the guidelines from the American College of Medical Genetics and Genomics (ACMG), the variant was classified as pathogenic (PVS1+PM2_Supporting+PM6). The newly discovered c.462_463del (p.F154Lfs*25) variant of the PTEN gene probably underlay the CS in this pedigree. CS patients have higher risk for developing malignant tumors. Clinicians should be aware of this condition and emphasize follow-up of the patients.

Research on the Development Strategy of Panxi Sunshine Health and Wellness Homestays and Hotels Based on Traditional Chinese Medicine Health Preservation

This study is the first phase of research results from the student innovation project “Yunqiao Sunshine Health and Wellness Homestay” group at Chengdu Normal University. By analyzing the current state of the Sunshine Health and Wellness Tourism Area economy in the Panxi region of Sichuan, local policies, and the current state of Sunshine Health and Wellness homestays and hotels, this paper proposes the possibility of developing Sunshine Health and Wellness homestays and hotels through traditional Chinese medicine (TCM) health preservation methods. It also proposes development strategies for such hotels through a market survey SWOT analysis.

THE HISTORY OF SINO-RUSSIAN COMMUNICATIONS ON ANTHROPOLOGY: WITH THE EXAMPLE OF DONG TICHEN, THE FIRST CHINESE ANTHROPOLOGIST WHO STUDIED IN THE SOVIET UNION

Introduction. The centennial development of physical anthropology in China can be divided into three periods: 1) the initial period fr om the end of the 19th century to the founding of New China in 1949, when anthropology was imported from the West and gradually localized; 2) the unstable development period from 1949 to 1976, which was faced with a major restructuring of the discipline, the epoch of Sino-Soviet friendship, and a ten-year period of turbulence of the Cultural Revolution; 3) the period of rapid development after the reform and opening up of the country at the end of the 1970s. Materials and methods. The author presents the history of anthropological exchanges between China and Russia over the past hundred years through the study of literature and photographic sources. Results. Before the founding of New China, communications of anthropology between China and Russia was represented by S.M. Shirokogorov; after the founding of New China, it was represented by N.N. Cheboksarov; during the period of Sino-Soviet friendship, China adopted the suggestions of Soviet scientists and launched journals, translated and published monographs, and dispatched international students, Dong Tichen and Cui Chengyao, to study in the Soviet Union. Conclusion. In this article, for the first time, a large number of old photographs from private collections have been released to show the life story of Dong Tichen, the first anthropologist who went to the Soviet Union to study and returned to China. After graduating from Beijing Normal University, Dong Tichen went to Moscow University to study anthropology and obtained his Ph.D. in biology in 1961. He became a lecturer in the Department of Anthropology at Fudan University, wh ere he was one of the earliest teachers of anthropology in New China. His research was pioneering and prospective, for example, his proposed taxonomic position of the Gigantopithecus was very forward-looking; he created a precedent in the study of dermatoglyphics in China and contributed to the foundations of anthropometrics. His return solidified the discipline of anthropology at Fudan University, and during his short life he trained several students who would become the mainstay of anthropology in the new China in the future. Unfortunately, he died in 1966, as a result of social unrest and change.

One new genus and species of the tribe Meconematini (Orthoptera: Tettigoniidae: Meconematinae) from Yunnan, China

One new genus with one new species is proposed in this paper according to the newly obtained specimen from Yunnan deposited in Guangxi Normal University. To better distinguish the new genus, the morphological illustrations of twelve known belonging to five allied genera were provided.

Research on the Integration Path of Postgraduate Professional Courses into the Construction of Curriculum Ideology and Politics

The curriculum ideology and politics play an important role in cultivating students’ correct worldview, outlook on life, and values. In recent years, universities and colleges have begun to pay attention to the cultivation of postgraduates’ moral education and the construction of postgraduates’ curriculum ideology and politics. This paper takes the course “Theory of Software Engineering” of Anqing Normal University as an example, discusses the paths of integrating postgraduate professional courses into the construction of curriculum ideology and politics, and puts forward the paths of feeding back from scientific research, connecting with practice and summarizing and condensing, which are aimed at improving postgraduates’ comprehensive quality and innovation ability, and have positive significance for cultivating high-level applied scientific and technological talents who are both moral and talented.

Research on the Reform of Training Applied Talents in Vietnamese Major in Border Universities -- Guangxi Minzu Normal University

Vietnamese language talents are the bridge and foundation for the sustained and healthy development of good-neighborly friendship and comprehensive strategic partnership between China and Vietnam. With the continuous deepening of China-ASEAN cooperation and the implementation of relevant strategies, today s society has put forward new and higher requirements for Vietnamese language talents. Currently, colleges and universities on the China-Vietnam border are facing problems such as lagging teaching material construction, lack of targeted talent output in cultivating Vietnamese language applied talents. Taking Guangxi Minzu Normal University as an example, combined with the current background and the characteristics of school, the article explores the methods and concepts for cultivating applied talents in the Vietnamese language major in border universities from the aspects of improve teaching mode, strengthening textbook constructio. To cultivate high-standard, high-level, all-round and compound talents who serve local economic and social development and ASEAN cooperation.

Two new species of Aphlugiolopsis (Orthoptera: Tettigoniidae: Meconematinae) from Yunnan, China

This paper proposed two new species from Yunnan Province, China. All the descriptions and morphological illustrations of two new species were provided based on the specimens deposited in Guangxi Normal University.

Factors influencing pre-service special education teachers’ intention toward AI in education: Digital literacy, teacher self-efficacy, perceived ease of use, and perceived usefulness

The use of artificial intelligence in education (AIEd) has become increasingly significant globally. In China, there is a lack of research examining the behavioral intention toward AIEd among pre-service special education (SPED) teachers in terms of digital literacy and teacher self-efficacy. Building on the technology acceptance model, our study evaluated the aspects influencing pre-service special education teachers’ intention toward AI in education. Data was gathered from 274 pre-service SPED teachers studying at a Chinese public normal university of special education and analyzed using structural equation modeling (SEM). The results show that digital literacy is associated with the perceived usefulness and ease of use of AIEd, which influences SPED teachers' intention to use AIEd. Additionally, digital literacy significantly impacts the self-efficacy of SPED teachers. Given these results, AI designers in special education should comprehend the effectiveness and usability of AIEd for fostering behavioral intention formation. Simultaneously, special educational programs that identify key content and activities for digital literacy training should be developed, and educators should attempt to execute the relevant pre-service training to enhance the intention of pre-service SPED teachers toward AIEd.

First Report of Powdery Mildew on Sophora flavescens Caused by Erysiphe diffusa in China.

Sophora flavescens (Fabaceae) is a deciduous subshrub which has been used in Chinese popular medicine for a long history (He et al. 2015). In June 2023, severe powdery mildew symptoms were observed on wild S. flavescens plants on Longwen hill of Guizhou Normal University, Guiyang, China. The incidence was approximately 80% among 100 S. flavescens plants observed. Almost all leaves were infected. Mycelia occurred on both adaxial and abaxial leaf surfaces, petioles, and stems, forming small-to-large patches. Hyphae were hyaline, 5 to 7 μm wide. Hyphal appressoria were solitary. Conidiophores were erect, straight to somewhat flexuous, and 45 to 120 µm long (n = 50). Foot cells were subcylindrical to slightly curved, followed by 2 to 3 shorter cells. Conidia formed singly, were ovoid to cylindrical, 26 to 42 × 12 to18 µm (n = 50). Based on these morphological characteristics, the powdery mildew fungus was tentatively identified as Erysiphe diffusa (Braun and Cook 2012). To confirm the identification, the ribosomal DNA internal transcribed spacer (ITS) and the ribosomal large subunit (LSU) region were amplified and sequenced using primer pairs ITS1/ITS4 (White et al. 1990) and NL1/NL4 (Ziemiecki et al. 1990), respectively. The obtained 647-bp ITS sequence (GenBank accession no. PP130131) displayed 100% identity with the ITS sequences of E. diffusa. The obtained 618-bp LSU sequence (GenBank accession no. PP693303) displayed 100% identity with the ITS sequences of E. diffusa (MT325922 and MT628019) and E. manihoticola (MT106658 and MT106660). Using a phylogenetic tree based on the combined ITS-LSU data, the isolate was grouped in a clade with the E. diffusa strain (GenBank accession no. LC777871). To fulfill Koch's postulates, leaves of three healthy potted S. flavescens plants were inoculated by gently pressing with diseased leaves. Non-inoculated plants were used as controls. All plants were incubated in a greenhouse at 25 ± 2°C, 80% relative humidity. After 15 days, typical powdery mildew symptoms were observed on the inoculated plants, whereas no symptoms were found on the control plants. The reisolated fungus from the inoculated S. flavescens was morphologically identical to that on naturally diseased plants, and the ITS sequence of the reisolated fungus showed 100% identity with PP130131. As the causal fungus of soybean powdery mildew, E. diffusa is known to infect papaya and other legumes, including Lens culinaris and Mimosa caesalpiniifolia (Attanayake et al. 2009; Luz et al. 2019). Particularly, E. diffusa has been previously reported to infect S. flavescens in the United Kingdom (Jones and Baker 2007; Bradshaw et al. 2023), but this is the first report of S. flavescens powdery mildew caused by E. diffusa in China. This work further expands the geographical range of E. diffusa-infected S. flavescens plants.

COSMOLOGICAL CONCEPT OF TIME IN “THE CHANGE OF ZHOU” (“THE BOOL OF CHANGE”)

This paper represents one chapter from my PhD dissertation, written and successfully defended at Beijing Normal University in 2012. The whole content is translated from my doctoral dissertation that was originally written in Chinese language. According to the existing references, the earliest Chinese philosopher who mentioned in his essays the word “cosmos – yuzhou” was Shi Jiao (390-330 BC). He said: “four directions of Heaven and Earth are called ′yu′, time since ancient times till today is called ′zhou′”. In other words, yu represents space, while zhou symbolizes time, and that is why Chinese ancient cosmology may be even called “concept of space and time”. Inscriptions on the oracle bones and tortoiseshells with the symbols called “ganzhi”, originating from the Yin dynasty, were used to record hours, days, months and years i.e. time, but at the same time, Chinese people used these symbols to mark the directions of space, too. All of the cosmological diagrams used by “The Change of Zhou” and yijingologists, like Fuxi’s transcendental bagua diagram, king Wen’s empirical bagua diagram, river map and Luo book simultaneously depict time and space. In the eyes of the Chinese people, since ancient times, time and space are one whole and inseparable unity. However, being a foreigner, the writer of these lines will separately analyze the meaning of time in “The Book of Change”. As a foreigner, I find that the greatest charm of Chinese characters is that every character holds the whole history and etymology of one word or term in it. In other words, the most prominent feature of Chinese characters is symbolism. Therefore, if we want to explore “the time” concept, we must start from the character 时- shi meaning “time”. Character shi is formed of one radical meaning “sun”, and another meaning “measure”. This shows that the meaning of character shi is “measuring the sun”, i.e. measuring the length of sun shadow. The shorter the sun shadow is, the weather is being warmer and the Yang energy gets more abundant. It explains that character shi depicts increasing and decreasing of Yin and Yang energy in the cosmos and on the Earth. This paper analyzes time concept in “The Change of Zhou” from the Chinese and Western point of view. It explains meanings of Heavenly dao, Heavenly time, chance and synchronicity. The paper uses time theories (like simplicity of time, presentism, etc.) of German scientist Leibniz（1646 – 1716）, and famous Swiss psychologist Carl Jung’s（1875 - 1961） concepts (like cosmical archetypes and synchronicities), and compare them with ideas of “the cognition of subtle”, “progress through change” and “capability to grasp the chance” in “The Change of Zhou”. Finally, it combines and summarises the concept of time from “The Change of Zhou” and Western point of view.

BIBLIOMETRIC ANALYSIS OF INNOVATION AND ENTREPRENEURSHIP EDUCATION IN CHINA: BASED ON CNKI DATABASE (2014-2023)

Innovation and entrepreneurship education is the engine and driving force to promote social and economic development and advancement. China's innovation and entrepreneurship education has been researched and developed for more than 20 years. In order to grasp the current situation, hotspots, trends and future of innovation and entrepreneurship education research in China, 1330 sample literatures in CNKI database are used as the research object, and bibliometric methods are adopted to visualise, analyse and compare the big data of the literature in terms of the annual volume of published papers, research topics, disciplinary distributions, authors of the published papers, journals of published papers, institutions of the published papers, high citations, downloads, and categories of sources, etc. The results are as follows. The results found that: China's innovation and entrepreneurship education research disciplines are mainly divided into higher education and vocational education; journals such as Education and Career, Science and Technology in Chinese Colleges and Universities, and Secondary School Politics Teaching Reference are the main dissemination carriers; Peking University Core is the main journal source; Northeast Normal University, Xiamen University, and Wenzhou Medical University are the main publishing institutions; and the National Educational Science Programming Project, and the National Social Science Foundation are the main funding funds.

RESEARCH STATUS OF INNOVATION AND ENTREPRENEURSHIP EDUCATION ECOSYSTEM: DATA ANALYSIS FROM CNKI IN CHINA

Innovation and entrepreneurship education ecosystem is a hot and difficult issue in the field of innovation and entrepreneurship education research in recent years. The research on innovation and entrepreneurship education ecosystem in China has gone through 10 years of research and development. In order to grasp the current status, hotspots, trends and future of innovation and entrepreneurship education ecosystem research in China, 158 sample documents from the CNKI database were taken as the research object, and the bibliometric method was used to visualise and analyse the big data of the literature in terms of the amount of papers published annually, the research topics, the distribution of disciplines, the high-yield authors, the journals of the published papers, the institutions of the published papers, the high citations, the number of downloads, and the categories of the sources. Comparison. The results found that: China's innovation and entrepreneurship education ecosystem research is mainly divided into the disciplines of higher education and vocational education; journals such as Innovation and Entrepreneurship Theory, Research and Practice, Journal of Heilongjiang Institute of Education and Modernisation of Education are the main dissemination carriers; PKUC is the main source of journals for high-quality theses; Huangshan College, Wenzhou University, Northeast Normal University and Henan University of Technology are the main publication institutions ; Jiangsu Provincial Fund Project and Ministry of Education Fund Project are the main funding funds.

Expression and diagnostic value of serum free light chain in lung cancer.

The expression of serum free light chain (FLC) is abnormal in various diseases, but its role in lung cancer remains unclear. This study aims to investigate the expression and diagnostic value of serum FLC in lung cancer. A total of 80 lung cancer patients treated at Xiangdong Hospital, Hunan Normal University from January to December 2021 were selected as the lung cancer group. Another 80 healthy individuals undergoing routine physical examinations during the same period were chosen as the control group. General information and serum κFLC and λFLC levels were collected for all subjects. Clinical indicators such as serum carcinoembryonic antigen (CEA), cytokeratin fragment antigen 21-1 (CYFRA21-1) levels, tumor diameter, histological type, TNM stage, and lymph node metastasis status were recorded for lung cancer patients. The expression levels of serum FLC [κFLC, λFLC, and FLC (κ+λ)] were compared between the lung cancer group and the control group. Lung cancer patients were grouped based on gender, age, smoking history, tumor diameter, TNM stage, histological type, and lymph node metastasis to compare differences in serum κFLC and λFLC levels. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic value of serum FLC alone and in combination with other indicators in lung cancer. The expression levels of serum FLC (κ+λ) and κFLC were significantly higher in the lung cancer group than those in the control group (both P<0.001), while there was no significant difference in serum λFLC levels between the 2 groups (P>0.05). There were no significant differences in serum κFLC levels among lung cancer patients with different tumor diameters, histological types, or TNM stages (all P>0.05); however, serum κFLC levels were higher in lung cancer patients with lymph node metastasis than in those without, with statistical significance (P=0.033). There were no significant differences in serum λFLC levels based on tumor diameter or histological type (both P>0.05), but serum λFLC levels were higher in stage III+IV and lymph node metastatic lung cancer patients compared to stage I+II and non-metastatic patients, with statistical significance (P=0.033 and P=0.019, respectively). The area under the curve (AUC) for κFLC and CEA in diagnosing lung cancer showed no significant difference (P=0.333). The combination of κFLC+CYFRA21-1 had the highest diagnostic efficacy (AUC=0.875) and sensitivity (71.3%). The AUC for the combined diagnosis of κFLC+λFLC+CEA+CYFRA21-1 was 0.915 (95% CI 0.860 to 0.953, P<0.001). Serum FLC is highly expressed in lung cancer and is associated with its invasion and metastasis. Serum FLC, particularly κFLC, has diagnostic value for lung cancer, and the combined detection of FLC, CEA, and CYFRA21-1 offers the best diagnostic efficacy.

Teaching Skills Cultivation of Information Technology Normal University Students from the Perspective of Group Intelligence: Research on the Training and Application Optimization of GPT Dialogue Model

With the wide application of information technology in education, the cultivation of teaching skills for information technology normal university students is particularly important. However, the traditional teaching model faces challenges, and new methods are needed to improve the teaching ability of normal university students. The purpose of this study is to explore the teaching skills training mode of information technology normal students based on the perspective of group intelligence, and to use GPT dialogue model for training and application optimization, so as to improve the teaching effect and the professional level of normal students. Through the teaching mode from the perspective of group wisdom, normal university students can have more in-depth interaction and cooperation with classmates, teachers and teaching resources, and promote the innovation and improvement of information technology teaching. Using GPT dialogue model for training and application optimization can realize personalized and intelligent teaching assistance, and provide teaching content and methods more close to the needs of students. The results show that the teaching mode based on the perspective of group intelligence and the GPT dialogue model can effectively improve the teaching skills of information technology normal university students, and provide new ideas and methods for the innovation and development in the field of education.

Optimizing BOPPPS Teaching Strategy in Influencing College Students after Class Sports Activities

Lifelong sports aim to deeply embed the concept into people's daily lives. This study extends physical education beyond the classroom with innovative teaching models to boost students' extracurricular sports participation and develop lifelong physical education skills. It aimed to optimize college students' sports participation and explore effective teaching models and strategies. The study involved 364 students from basketball, volleyball, and aerobics majors at Xinyang Normal University, using a descriptivecomparative-correlational research design and a self- constructed questionnaire. The study employed statistical tools such as ranking, standard deviation, weighted mean computation, frequency count and percentage, T-test, and Spearman's rho Correlation Coefficient for a methodical presentation, analysis, and interpretation of data. It concluded that all components of the BOPPPS model-Bridge in, Objective, Preassessment, Cognitive Participation, Participant Learning and Behavioral Participation, Post-assessment and learning outcomes, and Emotional Participation-are effective in engaging students in PE classes. The analysis showed insignificant differences based on respondents' sex, age, and elective choices, thus accepting the null hypothesis. However, the study found a significant relationship between the four elements of BOPPPS (Bridge in, Objectives, Pre-assessment and cognitive engagement, Participation Learning and Behavioral Participation, Post-assessment and effect Participation, and Emotional Participation) and respondents' participation in after class sports activities, including interests and motivation, habits and plans, and attitude and behavior, necessitating the rejection of the null hypothesis. It is recommended to continue promoting inclusivity and diversity in sports participation to ensure equitable access and opportunities for all individuals, regardless of demographic characteristics. Emphasizing and integrating the BOPPPS framework into sports education programs can enhance participants' interest, motivation, habits, plans, attitudes, behaviors, and overall engagement in after class sports activities, leading to more effective outcomes.

One new genus and species of the tribe Meconematini (Orthoptera: Tettigoniidae: Meconematinae) from Hainan, China

In this paper, we propose one new genus with one new species from Hainan Province, namely, Neophlugiolopsis gen. nov. and N. longiprocera sp. nov. The differences between the new genus and allied genera in morphology are discussed, which can be distinguished by the shape of the posterior process of the tenth abdominal tergite and cerci in males. All specimens were deposited in Guangxi Normal University.

Three new species and one new synonymy in the genus Phlugiolopsis (Orthoptera: Tettigoniidae: Meconematinae)

In this paper, we describe three new species from Yunnan Province and propose one new synonym in the genus. To better understand the new species, we provided morphological illustrations of allied species. All specimens were deposited in Guangxi Normal University.

Physical Activities and Psychological Needs of Physical Education Students

The study examined the levels of physical activity and psychological needs of students enrolled in physical education at Tangshan Normal University. The respondent profile indicated that the sample consisted mainly of female, first-year students aged 17-18, with the majority having a healthy BMI. In terms of physical activity, the pupils exhibited proficient fundamental movement abilities and independence in structuring their fitness regimens. Nevertheless, certain areas that may be enhanced were identified, including the decision to opt for stairs. The analysis revealed no statistically significant differences in the levels of physicalactivity among the students based on their sex, age, BMI, or year level. Regarding psychological needs, the students expressed a robust sense of autonomy, experiencing a sense of freedom to independently make important life choices. Nevertheless, their perceptions of opportunities for self-determination in daily life were somewhat diminished. Regarding competence, pupils experienced acknowledgment from others for their abilities.

Team Cohesion and Student Athlete Well-Being in A Normal University in Jiangxi Province

This study aims to gain a deeper understanding of the relationship between team cohesion and WELL-BEING among college athletes. This study adopts a quantitative research design, with a sample of 627 college athletes from a regular university in Jiangxi Province, China. A survey was conducted on the basic information of student respondents in terms of gender, age, grade, and years of experience, as well as their self-evaluation of athlete well-being, including physical health, mental health, emotions, balance, socialization, achievement, recovery and rest, and support systems. The relationship between team cohesion and self-evaluation of well-being was studied by analyzing the differences in personal characteristics and self-evaluation of well-being. This study also evaluated the positive effects of team cohesion, coach behavior, and athlete well-being on physical, psychological, emotional, and social health, and recommended promoting open and transparent communication within the team, strengthening leadership, establishing conflict resolution mechanisms, cultivating common values and goals, focusing on mental health, balancing lifestyles, and promoting internal respect and team spirit through team building and support networks to increase athlete well-being and team cohesion.

The Effectiveness of Historical and Cultural Heritage in Relation to Technological Innovation

This study investigates the effectiveness and technological innovation in historical and cultural heritage education across several Chinese universities, focusing on Yulin College, Shaanxi Normal University, Yan’an University, Weinan Normal University, and Shenmu Vocational and Technical Education Center. Utilizing a purposive sampling technique, the research involves 250 students who have taken history classes in these institutions. Data collection is conducted through a self-made questionnaire informed by extensive literature reviews. Employing a non-experimental quantitative design, this descriptive comparative correlational research examines the relationship between educational effectiveness and technological innovation. The study aims to provide a detailed depiction of the association between these variables within their natural educational settings. The findings reveal a diverse student demographic, with 56.1% females and 88.5% aged 16-20 years. Students rated the curriculum's comprehensiveness, engagement, pedagogical techniques, resource accessibility, and cultural value positively. While perceptions of educational effectiveness were consistent across genders, age-related differences highlighted varied experiences and expectations. Technological innovation, including digital resources, interactive platforms, and multimedia integration, received favorable evaluations from students, indicating a positive impact on their learning experience. The study found a strong positive correlation between curriculum comprehensiveness and technological innovation, suggesting that integrating technology enhances educational effectiveness. The study concludes that historical and cultural heritage education in the surveyed universities is effective, with students responding positively to curriculum and technological integration. Recommendations include developing age-inclusive strategies, expanding technological integration, enhancing digital skills, ensuring gender-inclusive education, evolving curricula, improving feedback tools, providing professional development for educators, and conducting ongoing research and evaluation.