Normal Sleep Quality Research Articles

Echocardiographic associates of impaired sleep quality in patients with anxiety and depression

Abstract Objective Sleep health, mental health and cardiovascular health are multidimensional constructs that are strongly associated with each other. Anxiety and depression are the most common psychiatric diseases in the community and frequently comorbid in routine clinical practice. This study sought to investigate whether there is an association between sleep quality and echocardiographic parameters in patients with anxiety and/or depression. Methods The clinical and instrumental find­ings of consecutive patients diagnosed with either of anxiety disorders and/or depressive disorders and underwent cardiac examination in our tertiary center on the same day were retrospectively reviewed. The diagnosis was made by a psychiatrist according to the criteria listed in the fifth edition of The Diagnostic and Statistical Manual of Mental Disorders. Afterwards, Hospital Anxiety and Depression Scale (HADS) and Pittsburgh Sleep Quality Index (PSQI) were applied to patients to assess symptom severity and sleep quality, respectively. Subsequent to psychiatric examination, the patients underwent echocardiographic examination that includes two-dimensional conventional echocardiography, tissue doppler imaging (TDI) echocardiography, atrial conduction times, and left atrium (LA) volumes and functions. Results The final study population consisted of 167 patients and divided into two groups according to their PSQI score: PSQI<5 (normal sleep quality) (n=32) and PSQI≥5 (impaired sleep quality) (n=135). Aortic diameter, left ventricular (LV) end-systolic diameter, LV end-diastolic and -systolic volume, LV stroke volume and LV stroke volume index, LV outflow tract velocity–time integral (LVOT-VTI), and LA conduit volume calculations were significantly lower in patients with impaired sleep quality compared to patients with normal sleep quality. The other echocardiographic parameters including LV systolic functions, doppler and TDI echocardiography indices, atrial conduction times, atrial mechanical functions including LA function index (LAFI) were similar among groups. Correlation analysis yielded a negative, weak but statistically significant correlation between LAFI and PSQI score (r=-0.17, p=.030) (Figure 1A). Left intra-AEMD positively and significantly correlated with PSQI score at a weak level (r=0.16, p=.043) (Figure 1B). Aortic diameter, LV stroke volume index, LVOT-VTI and conduit volume were determined as echocardiographic parameters significantly associated with impaired sleep quality in univariate analysis. Among these parameters, only conduit volume remained as significant and independent associate of impaired sleep quality in multivariate logistic regression analysis (Odds ratio:0.91, 95% Confidence interval:0.85-0.98, p=.018) (Table 1). Conclusion There is an independent association between LA conduit volume and impaired sleep quality in patients suffering from anxiety and/or depressive disorders.Figure 1Table 1

Mediating role of inflammatory indicators in the association between sleep status and blood pressure in centenarians: evidence from China Hainan Centenarian Cohort Study.

To conduct a comprehensive analysis in Hainan centenarians on the link between sleep status and their blood pressure status. Furthermore, the study also aims to explore how inflammatory indicators may mediate the relationship. The China Hainan Centenarians Cohort Study (CHCCS) collected baseline data on sleep status, inflammatory indicators, and blood pressure data. The study used a mediation model to investigate how inflammatory indicators mediate the relationship between sleep status and blood pressure status. In this study, a total of 967 centenarians were included. The prevalence of hypertension among the centenarians was 71.4%. The analysis showed that centenarians with poor sleep quality had a 43% higher risk of hypertension compared to those with normal sleep quality (OR = 1.43, 95% CI: 1.03-1.97). Additionally, centenarians with nighttime sleep durations of ≤ 6 h or > 9 h had higher proportions of high pulse pressure (PP), with OR values of 1.76 (95% CI: 1.18-2.63) and 2.07 (95% CI: 1.34-3.19), respectively. Mediation analysis illustrated that complement C3 played a mediating role in the relationship between sleep quality and hypertension, with an effect ratio of 2.4%. Similarly, lymphocyte count, the neutrophil-to-lymphocyte ratio (NLR), and the systemic immune-inflammation index (SII) were identified as mediating factors in the association between nighttime sleep duration and high PP, with effect ratios of 91.22%, 36.93%, and 0.20%, respectively. In centenarians, poor sleep quality raises the risk of hypertension, with complement C3 as a mediator. Additionally, nighttime sleep durations of ≤ 6 h or > 9 h increases the risk of high PP, mediated by lymphocyte count, NLR, and SII.

Sleep disorders among women with post-menopausal osteoporosis

IntroductionOsteoporosis (OP) is characterized by low bone mass and microarchitectural deterioration of bone tissue. Recent studies have suggested that sleep may significantly influence the pathophysiology of OP.Objectives In the present study, we aimed to determine sleep disorders among women with post-menopausal OP.MethodsA cross-sectional study was conducted between January and June 2023. Patients with post-menopausal OP who visited the rheumatology department in a university hospital in Tunisia were interviewed. The Pittsburgh Sleep Quality Index (PSQI). It is a seven-component scale, including: sleep quality (C1), sleep latency (C2), sleep duration (C3), sleep efficiency (C4), sleep disturbances (C5), sleep medication use (C6), and daytime dysfunction (C7).PSQI ≤ 7 indicated normal sleep quality, and PSQI > 7 indicated poor sleep quality.Results Ninety-three women diagnosed with post-menopausal OP were interviewed. the number of complete questionnaires was 72. The valid rate was 77.4%. All were women. The mean age was 72.5 (±1.08). The median duration of menopause was 23 years (IIQ= [10.5-28.5]). Forty-five women were diagnosed with bone fractures (62%). Thirty-three patients (45.8%) were obese (IMC>30). The median PSQI score was 16 (IIQ = [6-18]). Forty-seven participants (65.3%) had poor sleep quality (PSQI > 7). According to the items of PSQI: the median score of sleep duration, sleep Efficiency and sleep disturbances was 1 (IIQ= [1 -2]) for each item. The median score of sleep latency was 3 (IIQ=[2-3]). For daytime dysfunction, the median score was 2 (IIQ=[0-3]). Study analytics revealed a significant association between daytime dysfunction and the presence of bone fractures (p=10-3), the same was with sleep disturbances and bone fractures (p=10-3). Body mass index (BMI) was significantly and inversely associated with sleep quality (r= -0.313; p= 0.007). Sleep latency was significantly associated with physical activity (p<10-3).ConclusionsIn conclusion, our results suggest that sleep quality is associated with physical activity and BMI. This is consistent with the most recent evidence in the literature. These findings support expanding the scope of wellness programs to promote healthy sleep among osteoporotic women.Disclosure of InterestNone Declared

Association of Sleep Status With Cognitive Functions in Centenarians: Evidence From Hainan Centenarian Cohort.

This study aimed to analyze the association between sleep quality, sleep duration, and cognitive functions among centenarians. The baseline data of the China Hainan Centenarians Cohort Study served as the foundation for this study. Logistic regression was utilized to demonstrate the relationship between sleep status and cognitive impairment. Moreover, a canonical correlation analysis was performed to analyze the correlation between these variables. A total of 994 centenarians were included. After adjustment, poor sleep quality centenarians had an odds ratio of 1.77 (95% confidence interval [CI]: 1.00-3.09) for cognitive impairment when compared to centenarians with normal sleep quality. Centenarians who slept for more than 9hr had a stronger association with severe cognitive impairment, indicated by an odds ratio of 1.41 (95% CI: 1.02-1.96), compared to those who slept for 7-9hr. Additionally, the canonical correlation analysis results revealed that the linear combination of sleep quality V1, primarily determined by sleep latency, daytime dysfunction, and subjective sleep quality, was associated with cognitive function; the linear combination of cognitive function W1, mainly determined by orientation, attention and calculation, and memory. There exists a correlation between poor sleep quality and cognitive impairment in centenarians, as well as a correlation between sleep duration >9hr at night and severe cognitive impairment. The primary cognitive domains associated with sleep quality are orientation, calculation, and memory. It is imperative to monitor and safeguard the cognitive functions linked to poor sleep quality in the older individuals, with attention to orientation, calculation, and memory.

Association of sleep status with depressive state in centenarians: Evidence from Hainan centenarian cohort

ObjectiveThe objective of this study is to analyze the association between sleep quality, sleep duration, sleep patterns, and depressive states among centenarians due to the crucial impact of depression on the well-being of elderly individuals, particularly the oldest. Recognizing easily identifiable manifestations and risk factors is essential since the onset of depressive states tends to be insidious. MethodsThe baseline data from the China Hainan Centenarians Cohort Study (CHCCS) served as the basis for this study. Questionnaire surveys were conducted to obtain research indicators, with depressive states evaluated using the GDS-15 scale and sleep quality evaluated using the Pittsburgh Sleep Quality Index (PSQI). Logistic regression was employed to describe the association between sleep status and depressive states. ResultsA total of 994 centenarians, with an age range of 100–116 years and a mean age of 102.77 ± 2.75 years, were included in this study. Among these participants, 815 were female, accounting for 82.0 %. After adjustment, the odds ratio (OR) for the association between poor sleep quality and depressive states was 2.07 (95 % CI: 1.54–2.77) compared to those with normal sleep quality. Additionally, there were associations between depressive states and both nighttime sleep duration and total sleep duration. After adjustment, the strongest association between depressive state and sleep patterns was found for those who had >9 h of nighttime sleep and ≥2 h of daytime sleep (OR = 1.80, 95%CI: 1.02–3.16). Moreover, compared to centenarians with 7–9 h of sleep duration and good sleep quality, the highest odds ratio (OR = 3.44, 95%CI: 2.18–5.43) for the association between depressive states and sleep duration ≤7 h and poor sleep quality was observed. ConclusionThe findings of this study indicate that there is an association between poor sleep quality and depressive states in centenarians. Furthermore, both sleep quality and long/short total sleep duration are associated with depressive states in this population. Therefore, special attention should be given to the psychological state of elderly individuals with short sleep duration and poor sleep quality in order to prevent depression and minimize its negative impact on their overall health.

O045 Sleep Duration is Associated with Young Adult's Heart Rate Variability Response to Stress

Abstract Introduction Young adulthood is a critical developmental period typified by heightened exposure to stress, and a tendency towards insufficient sleep. The relationship between sleep loss and stress may have lifelong health consequences. Currently, our understanding of this relationship in young adults is limited. Heart rate variability (HRV) is an important indicator of balance in the autonomic nervous system. We examined the association between sleep duration and HRV in response to cognitive stressors. Methods Seventy-six young adults (M=20.6±1.9, 72.4% female) who self-identified as short sleepers were recruited. Habitual sleep duration was monitored with actigraphy for two weeks. Participants subsequently underwent an in-lab experiment where their HRV was recorded during baseline, and during a cognitive stress condition involving the completion of computerised cognitive stress tasks. Participants also reported their habitual stress levels and sleep quality. Results Actigraphy assessment revealed that participants slept within the recommended sleep durations (M=7.8±0.7). The participants reported high habitual stress but normal sleep quality. Our moderation analysis indicates that shorter sleep duration was associated with elevated HRV during the cognitively demanding tasks. Conclusions Our findings demonstrate an association between sleep duration and HRV in the context of a cognitive stressor, indicating that sleep and stress are related in young adults. An unexpected negative relationship between sleep duration and HRV during the cognitively demanding tasks suggests complexity in this relationship; however, we should still look to reduce stress and improve sleep where we can in young adults. This association may be better understood via direct manipulation of sleep duration.

Shift Changes' Effects on Sleep Quality and Work Performance among Nurses Working in Bahrain's Intensive Care Units

Objective: To determine the difference in the sleep quality and work performance of nurses between one shift duty, two shifts duty, and three shifts duty in intensive care units at a government hospital in the Kingdom of Bahrain. Methods: This cross-sectional study was conducted at a government hospital of Bahrain from February to April 2021. A total of 200 nurses worked for at least one year in an intensive care units were eligible for the study. A questionnaire was administered online to collect data. The Pittsburgh Sleep Quality Index (PSQI) was used to measure sleep quality while Nurse Work Function Questionnaire (NWFQ) was used to measure work performance.Results: There were 145 (72.5%) females and 55 (27.5%) males with a mean age of 38.2 ± 8.2 years. Most of the nurses were staff nurses 188 (94%), and shift workers 178 (89%). The mean PSQI of nurses who work only one shift reported normal sleep quality of 1.3 ± 1.0 where those who work two shifts had poorer sleep quality measured 9.2 ± 0.8 and nurses who work three shifts had reported even worse sleep quality with a statistically significant difference 15.6 ± 1.8 (p-value <0.0001). Moreover, the more variety of shifts the critical care nurses work, the more impaired their performance was (p-value <0.001). Conclusion: The more shift work schedules the nurse works, the worse is the reported sleep quality and work performance.

Sleep quality index among the elderly population in selected areas of Delhi: a community-based cross-sectional study

Background: Studies have shown that effects of low sleep quality can include cognitive decline, sleepiness during the day, and decreased quality of life. Problems with sleep have also been associated with an increased risk of hospitalization and increased mortality. Therefore, the present study was envisaged to assess the sleep quality index and the factors associated with it among the elderly. Methods: This cross-sectional study was conducted in rural and urban setting of Delhi. We selected 115 participants in each area using systematic random sampling. We used a semi structured questionnaire and validated sleep quality index to collect the data. Results: In the present study, only 41 (17.8%) out of 230 individuals were having normal sleep quality and 189 out of 230 individuals were having poor sleep quality. 105 (55.5%) in the rural area (Fatehpur Beri), and 84 (44.5%) in the urban area (Aliganj) were having poor sleep quality respectively. In the rural area, taking sleeping pills and depression were significantly associated with higher scores of sleep quality index. Conclusions: Poor sleep quality was found in 82.2% of elderly participants which was associated with a rural locality, depression, and not taking sleep pills. There is a need to start a sleep hygiene program for the elderly population, particularly in rural area.

Polikistik Over Sendromu ve Uyku Bozuklukları: Uyku Bileşenleri ile Metabolik ve Androjenik Bozukluklar Arasındaki İlişki

Objective: To investigate the sleep quality in patients with polycystic ovary syndrome (PCOS) and to examine the effects of metabolic parameters on sleep disturbances.
 Material and Methods: The study included 50 patients diagnosed as PCOS and 51 normal healthy volunteers. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality. Index consists of 18 items and seven components and according to the index, the total scores of five or more indicate a poor sleep quality. After the sleep quality scores were determined, serum insulin, triglyceride, cholesterol, fasting glucose and androgen levels were recorded retrospectively and all parameters compared between groups.
 Results: The sleep quality was lower in the patients with polycystic ovary syndrome than in the healthy control group but this was not statistically significant (p>0.05). Serum dehydroepiandrosterone sulfate (DHESO4) and total testosterone level had a significant negative correlation with sleep duration and total
 PSQI scores. In addition, serum total testosterone level also had a significant negative correlation with sleep latency, sleep disturbance and subjective sleep quality. Besides, the patients with the poor sleep quality had significantly lower serum dehydroepiandrosterone sulfate and testosterone levels than those with a normal sleep quality (p

Investigating the Relationship between Sleep Quality and Career Adaptability with Occupational Burnout among Employees

Background and Objective: Disruption of the sleep cycle normal functioning of body system with a significant effect on various dimensions of human lives such as career-related variables. The objective of this study was to investigate the relationship between sleep quality and career adaptability with occupational burnout and to compare them among employees with low and normal sleep quality.
 Materials and Methods: In terms of objective and nature, this study was an applied-descriptive, correlational, and causal-comparative study. The statistical population of the study included a private company in Tehran Province, Iran, where 286 people were selected using simple random sampling as the sample and after completing career adaptability, occupational burnout, and sleep quality scales, the relationship between variables was investigated.
 Results: The findings indicated a significant negative relationship between sleep quality and occupational burnout and its dimensions. Moreover, a significant positive relationship was found between career adaptability of people with normal sleep and low sleep (P < 0.0500) and people with normal sleep quality showed lower occupational burnout and higher career adaptability. In comparing female and male groups regarding career adaptability and occupational burnout, the results showed that a significant difference exists between them in emotional exhaustion; females obtained larger mean values compared to men and no significant difference was observed among the components.
 Conclusion: Given the findings of this study, it can be concluded that sleep, in addition to decreasing occupational burnout, leads to higher career adaptability among employees.

Sleep Quality and Insomnia Are Associated With Quality of Life in Functional Dyspepsia.

BackgroundSleep disturbances are common in patients with functional dyspepsia. Our aim was to assess the relationship between subjective sleep and quality of life and to identify factors associated with impaired sleep in functional dyspepsia.MethodsOne thousand two hundred and twenty patients referred for functional gastrointestinal disorders at a single tertiary care center between end 2017 and June 2019 were studied using a self-administered questionnaire. 355 patients with Rome IV-based functional dyspepsia were identified. Sleep was assessed using both the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI). The severity of dyspeptic symptoms was assessed using the Total Symptom Score (TSS). Quality of life was assessed by the GastroIntestinal Quality of Life Index (GIQLI). Anxiety and depression levels were evaluated using the Hospital Anxiety and Depression (HAD) scale.Key ResultsAmong the 355 patients with functional dyspepsia, 66 (18.6%) patients displayed normal sleep quality whereas 289 (81.4%) patients had altered sleep quality. Functional dyspepsia patients with sleep disturbances were older (48.1 ± 15.4 vs. 41.4 ± 16.0, p = 0.0009), had decreased quality of life (GIQLI: 75.3 ± 18.5 vs. 92.1 ± 15.4, p < 0.0001), greater severity of their symptoms (TSS: 18.9 ± 3.6 vs. 17.2 ± 3.9, p = 0.0007), and higher anxiety and depression scores (HADS: 17.7 ± 7.2 vs. 11.9 ± 5.1, p < 0.0001). A correlation was found between sleep quality and quality of life [r = −0.43 (95% CI: −0.51 to −0.34), p < 0.0001]. Independent factors predicting poor sleep quality were age [OR 1.03 (95% CI = 1.01–1.05), p = 0.006], depression level [OR 1.27 (95% CI = 1.16–1.39); p < 0.0001], and the severity of dyspeptic symptoms [OR 1.13 (95% CI = 1.04–1.22); p = 0.004].Conclusion and InferencesA high prevalence of sleep disturbances was found in patients suffering from functional dyspepsia, with 81% of them having altered sleep quality and 61% having insomnia based on subjective assessment. Altered sleep quality and insomnia were associated with altered quality of life, higher severity of symptoms, and higher anxiety and depression scores in this disorder.

Does smoking impair sleep hygiene?

Sleep architecture and sleep hygiene might be disrupted by several pathogenetic mechanisms, and the effect of smoking has not been evaluated. To investigate the effect of smoking on sleep hygiene behaviors that might be associated with the deterioration of quality-of-life (QoL) parameters. In a prospective cross-sectional study, smokers (n=114) and nonsmokers (n=119) were included. The Pittsburgh Sleep Quality İndex (PSQI), the Epworth Daytime Sleepiness Scale (ESS), the Sleep Hygiene Index (SHI), and the Short Form-36 quality of life scale (SF-36) were applied. We found that none of the components, as well as the PSQI total score were affected in smokers compared with the nonsmoker controls (65.5% of smokers had poor sleep compared to 62.5% of nonsmokers). Although smokers tend to get out of bed at different times from day to day and do important work before bedtime (components of the SHI) more often than non-smokers, no significant differences were detected between groups in any component and SHI total score (27.91±6.72 for smokers and 29.23±8.0 for non-smokers). ESS, depression and anxiety symptoms, and SHI scores in smokers with poor sleep quality were significantly different compared with smokers that had normal sleep quality. Both PSQI and SHI scores were inversely associated with QoL parameters. Our results suggest that smoking by itself is not associated with poor sleep hygiene or sleep quality. It can be concluded that worse SHI and quality of sleep negatively affect QoL, depression, and anxiety in smokers.

Daily evening melatonin prolongs survival among patients with advanced non-small-cell lung cancer

ABSTRACT Cancer patients show the signs and symptoms of a failing circadian organization. Melatonin, secreted only during nightly darkness, promotes nightly sleep and synchronizes daily molecular and physiologic clocks. Using a placebo-controlled randomized double-blind clinical trial, we determined whether the hypothesized proper physiologic daily timing, the evening, is essential for cancer patients to benefit from melatonin. Eighty-four advanced non-small cell lung cancer (NSCLC) patients from two centers (42 each) receiving standard etoposide/cisplatin therapy, were randomly assigned to one of three arms (I, 8AM & 8PM placebo; II, 8AM 20 mg melatonin and 8PM placebo; III, 8AM placebo and 8PM 20 mg melatonin. Each patient was followed until death. After adjusting for covariates, the Cox proportional hazards regression analysis found that the overall survival was enhanced only among those patients randomized to receive evening melatonin (p = 0.031 HR = 0.39). Survival benefit in the PM melatonin arm was optimized in patients who reported normal sleep quality. After adjusting for significant covariates at baseline, we found an overall survival advantage for PM melatonin when compared against placebo. Moreover, PM melatonin’s therapeutic effect was optimal in patients who self-reported normal sleep quality.

Efficacy and safety of acupuncture for senile insomnia: A protocol for systematic review and meta-analysis.

Background:Senile insomnia seriously affects the quality of life of the elderly. With the increase of the proportion of insomnia in the elderly, compared with the elderly with normal sleep quality, the elderly with long-term insomnia are more likely to have dizziness, fatigue, and decreased immunity. Acupuncture has shown good effects in the treatment of insomnia. At present, there is a lack of systematic review on acupuncture in the treatment of senile insomnia. We conduct this study to evaluate the efficacy and safety of acupuncture in the treatment of senile insomnia.Methods:We will search Chinese and English databases: China National Knowledge Infrastructure, Chinese Scientific and Journal Database, Wan Fang database (Wanfang), Chinese Biomedical Literature Database, PubMed, EMBASE, Cochrane library to identify articles of randomized clinical trials of acupuncture for senile insomnia. All above electronic databases will be searched from inception to September 1, 2021. RevMan 5.3 software will be used to conduct this systematic review.Results:The study will prove the efficacy and safety of acupuncture for senile insomnia.Conclusion:We plan to submit this systematic review to a peer-reviewed journal.INPLASY registration number:INPLASY202160106.

Association between sleep duration and augmentation index in post-menopausal women: A moderating role of depressive symptoms

Objectives: Physiological and psychological changes, including sleep disturbance and mood changes, frequently occur in post-menopausal women. We explored associations between sleep duration/quality and arterial stiffness, as well as the moderating role of depressive symptoms, in post-menopausal women. Study design: This cross-sectional study utilized data obtained from 1687 post-menopausal women in the Cardiovascular and Metabolic Diseases Etiology Research Center cohort study. Main outcome measures: Self-reported sleep was classified into short (<6 h/day), normal, and long (≥ 8 h/day) sleep durations. Poor sleep quality was operationally defined using the fatigue-related Berlin questionnaire. Depressive symptoms were assessed using the Beck Depression Index-II (BDI-II). Arterial stiffness was evaluated using the augmentation index (AI) and the HEM-9000AI system. The associations between sleep and AI were examined using generalized linear models, followed by a path model to investigate whether depressive symptoms act as an effect modifier. Results: AI (%) values for participants with poor sleep quality were higher than those for participants with normal sleep quality (β=1.53, standard error [SE]=0.59, p = 0.009). Although overall sleep duration was not associated with AI values, the severity of depressive symptoms altered the association (p-for interaction=0.021). The magnitude of the positive association between sleep duration and AI was amplified in participants with higher BDI-II scores. In participants with severe depressive symptoms (BDI-II ≥20), a long sleep duration was significantly associated with elevated AI values (β=4.80, SE=1.56, p = 0.003) compared with those with a normal sleep duration. Conclusion: In post-menopausal women, poor sleep quality appears to result in an increase in arterial stiffness, and depressive symptoms seem to modify the association between sleep duration and AI. This modifying role for mental health should be considered in the association between sleep and cardiovascular health in post-menopausal women.

Screen time and Sleep Quality among College and University Students of Karachi

Objectives: To assess the relationship between screen times and sleep quality of the age group 17-24. Methodology: This is a cross-sectional study. The study was conducted on students of Colleges and universities in Gulshan-e-Iqbal Town Karachi. A total of 600 undergraduate students were approached in colleges and universities of Gulshan Town, Karachi. The sampling technique was Multi Staged sampling. The research instrument comprised of 3 parts i) Demographic profile, ii) Sleep quality measures and iii) Screen time usage measures. Results: The mean total hour of sleep was 6.7 ± 1.5. The Mean Cumulative score of the components of the questionnaire was 7.47 ± 3.56, while 174 (29%) have Normal Sleep quality and 426 (71%) have poor sleep according to the questionnaire. The odds ratio suggests there were 4.23 times higher chances of poor sleep quality in students whose screen time was more than 2 hours on weekdays as compared to other students. (OR: 4.23, 95% CI: 2.66-6.72). The odds ratio suggests there were 24.15 times higher chances of poor sleep quality in students whose screen time was more than 2 hours on weekends as compared to other students (OR: 24.15, 95% CI: 11.192-52.11). Conclusion: As, negative impacts were determined within sleep quality, and increased screen watching of multiple versions of the devices (screen time), influencing the commended level of screen watching among university and college students (age 17-24) is an affair of public health.

Morning sympathetic activity after evening binge alcohol consumption.

Binge alcohol consumption elicits acute and robust increases of muscle sympathetic nerve activity (MSNA), yet the impact of evening binge drinking on morning-after MSNA is unknown. The present study examined the effects of evening binge alcohol consumption on polysomnographic sleep and morning-after MSNA. We hypothesized that evening binge drinking (i.e. 4-5 drink equivalent in <2 h) would reduce sleep quality and increase morning-after blood pressure (BP) and MSNA. Following a familiarization night within the sleep laboratory, 22 participants (12 men, 10 women; 25 ± 1 yr) were examined after simulated binge drinking or fluid control (randomized, crossover design). Morning MSNA was successfully recorded across both conditions in 16 participants (8 men, 8 women) during a 10-min baseline and three Valsalva's maneuvers (VM). Binge drinking reduced rapid eye movement (REM) sleep (15 ± 1 vs. 20 ± 1%, P = 0.003), increased stage II sleep (54 ± 1 vs. 51 ± 1%, P = 0.002), and increased total urine output (2.9 ± 0.2 vs. 2.1 ± 0.1 liters, P < 0.001) but did not alter morning-after urine specific gravity. Binge drinking increased morning-after heart rate [65 (54-72) vs. 58 (51-67) beats/min, P = 0.013] but not resting BP or MSNA. Binge drinking elicited greater sympathoexcitation during VM (38 ± 3 vs. 43 ± 3 bursts/min, P = 0.036). Binge drinking augmented heart rate (P = 0.002), systolic BP (P = 0.022), and diastolic BP (P = 0.037) reactivity to VM phase IV and blunted cardiovagal baroreflex sensitivity during VM phases II (P = 0.028) and IV (P = 0.043). In conclusion, evening binge alcohol consumption disrupted REM sleep and morning-after autonomic function. These findings provide new mechanistic insight into the potential role of binge drinking on cardiovascular risk.NEW & NOTEWORTHY Chronic binge alcohol consumption is associated with future cardiovascular disease (CVD) risk in both men and women. In addition, binge alcohol consumption is known to disrupt normal sleep quality during the early morning hours, coinciding with the morning sympathetic surge. In the present study, an evening of binge alcohol consumption increased baseline morning heart rate and cardiovascular reactivity during the Valsalva maneuver (VM) strain. Specifically, muscle sympathetic nerve activity and phase IV hemodynamic responses increased during VM the morning after binge alcohol consumption. The autonomic dysfunction and increased cardiovascular reactivity during VM suggests a contributing mechanism to CVD risk present in individuals who binge drink.

Sleep Quality and Psychosocial Factors in Liver Transplant Recipients at an Outpatient Follow-Up Clinic in China.

BackgroundSleep disturbance is a common problem in liver transplant recipients, but few studies have confirmed the psychosocial factors associated with sleep quality in patients after liver transplantation. This study aimed to identify the psychosocial factors related to sleep quality among liver transplant patients during outpatient follow-up.Material/MethodsA retrospective cross-sectional study was performed in 124 liver transplant patients during outpatient follow-up. All participants completed a general demographic questionnaire, the Pittsburgh Sleep Quality Index (PSQI), the Generalized Anxiety Disorder-7 scale (GAD-7), the Patient Health Questionnaire-9 (PHQ-9), and the perceived social support scale (PSSS).ResultsThe mean global PSQI score was 6.57 (SD, 4.28), which was significantly higher than the mean score for people with normal sleep quality; 50 (40.3%) recipients were classified as having poor sleep quality (PSQI >7). Among the self-reported sleep problems, 62 (50.0%) participants reported that they had to go to the bathroom at night, 58 (43.5%) woke up in the middle of the night or early morning, 84 (67.7%) reported depression symptoms, and 116 (93.5%) had low-level social support. The global PSQI score was positively correlated with anxiety and depression scores, while the global PSSS score was negatively correlated with anxiety and depression scores (p<0.01). Multiple linear regression analysis showed that the length of the post-liver transplant period, the type of residence, BMI, depressive symptoms, and anxiety symptoms were important factors affecting sleep quality among liver transplant patients (p<0.05).ConclusionsOur findings showed high prevalence and incidence of poor sleep quality in liver transplant recipients in outpatient follow-up, with significant correlations with anxiety, depression, and social support, and it was affected by multiple factors. This indicates a need for further research on the follow-up results of sleep and the benefits of comprehensive interventions involving psychosocial factors in liver transplant recipients in China.

The correlation between post-traumatic growth and sleep quality among parents of children with epilepsy

Objective To explore the correlation between post-traumatic growth (PTG) and sleep quality among parents of children with epilepsy. Methods In this cross-sectional study, 191 parents of children with epilepsy were selected from Shangdong Province Third Hospital by convenience sampling method, the questionnaire included socio-demographic questionnaire, the Post-Traumatic Growth Inventory (PTGI) and Pittsburgh Sleep Quality Index (PSQI). Results The score of PTGI and PSQI of parents of children with epilepsy were (28.63±10.85) and (5.97±3.72), respectively. The score of PTGI and PSQI in parents' health status with health, general, worse was (29.44±10.66), (25.28±11.26), (19.00±7.81) and (5.57±3.51), (7.23±3.53), (15.00±1.73), the difference was significant (F=3.07, 12.69, P<0.05 or 0.01). The score of PSQI in parents with or without major negative events was (8.50±4.16), (5.67±3.57), the difference was significant (t=-3.12, P<0.01). There was a negative correlation between PTGI and PSQI among parents of children with epilepsy (r=-0.159, P<0.05). Hierarchical regression analysis showed that there was a significant positive correlation between the dimension of PTG appreciation life and the sleep quality of parents (B=0.455, P<0.01). Conclusions Parents with epilepsy have normal sleep quality, but at the same time have a certain level of PTG, and the level of PTG appreciated by parents is related to their sleep quality. Therefore, by promoting parents with epilepsy to actively appreciate life, it helps to alleviate their sleep problems. Key words: Children with epilepsy; Parents; Post-traumatic growth; Sleep quality; Related factors

The Role of Sleep Quality in the Psychological Well-Being of Final Year UndergraduateStudents in China.

There are increasing numbers of university students in China suffering from poor sleep and psychological well-being problems. In particular, the issues are more severe among the final year undergraduate students, because they are experiencing a transitory period from university life to the workplace. However, extant research has rarely explored sleep quality and psychological well-being of final year university students. To better understand the role of sleep quality in psychological well-being, we examined the association between different sleep quality and mental health. Based on a cross-sectional survey of 2495 full-time final year university students in China, we employed multivariable logistic regression to assess association between sleep quality and psychological well-being by controlling for sociodemographic factors such as age, gender, education, marital or relationship status, household conditions, place of birth, study subjects and etc. According to the research results, we can find strong association between sleep quality and psychological well-being. Having normal sleep quality is associated with lower level of psychological well-being problems. By contrast, poor sleep quality is associated with high level of negative psychological well-being. Poor sleep quality has higher potency than normal sleep quality due to negative bias. Among covariates, age, gender and education have significant effects on psychological well-being.