When imaging maneuvering targets with inverse synthetic aperture ladar (ISAL), dispersion and Doppler frequency time-variation exist in the range and cross-range echo signal, respectively. To solve this problem, an ISAL imaging algorithm based on integral cubic phase function-fractional Fourier transform (ICPF-FRFT) is proposed in this paper. The accurate ISAL echo signal model is established for a space maneuvering target that quickly approximates the uniform acceleration motion. On this basis, the chirp rate of the echo signal is quickly estimated by using the ICPF algorithm, which uses the non-uniform fast Fourier transform (NUFFT) method for fast calculations. At the best rotation angle, the range compression is realized by FRFT and the range dispersion is eliminated. After motion compensation, separation imaging of strong and weak scattering points is realized by using ICPF-FRFT and CLEAN technique and the azimuth defocusing problem is solved. The effectiveness of the proposed method is verified by a simulation experiment of an aircraft scattering point model and real data.