Non-syndromic Multiple Supernumerary Teeth Research Articles

Identification of a novel missense mutation in non-syndromic familial multiple supernumerary teeth

ObjectiveThis study intended to evaluate the involvement of genetic factors in the etiology of non-syndromic multiple supernumerary teeth. DesignWe filtered the single nucleotide polymorphisms (SNPs) of the proband and his mother with similar phenotypes through whole-genome sequencing (WGS). By integrating multiple databases related to human genome mutations and disease information for mutation annotation, we excluded the SNPs of people without supernumerary teeth. Subsequently, the bioinformatics analysis tools (Sorting Intolerant From Tolerant (SIFT) < 0.05, Polymorphism Phenotyping (PolyPhen) > 0.90) were used to screen out the most correlated SNPs of the disease, besides, Gene Ontology (GO) analysis (P<0.05, FDR<0.05) and Sanger sequencing was applied to further verify the candidate pathogenic mutation point. ResultsA novel heterozygous variant in fer-1 like family member 6 (FER1L6) gene likely denoted pathogenicity in non-syndromic familial multiple supernumerary teeth. We identified a cohort of 3499 non-synonymous SNPs (nsSNPs), and only 142 nsSNPs with the score of SIFT < 0.05 and PolyPhen > 0.90 were retained. Then we got 54 nsSNPs from 31 candidate genes through GO analysis. Sanger sequencing revealed a missense variant in exon 31 of the FER1L6 gene, causing a transition from guanine to adenine in position 1447 of protein kinase C conserved region 2. ConclusionsWe identified a novel heterozygous chromosome 8q24.13 mutation of FER1L6, which was a new mutation site identified in non-syndromic familial multiple supernumerary teeth through genetic analysis of a Chinese family.

Non-syndromic multiple supernumerary teeth associated with Dens Invaginatus: a case report

&#x0D; &#x0D; &#x0D; &#x0D; &#x0D; Background: Supernumerary teeth are an infrequent developmental alteration causing alteration in normal arch form and occlusion. Multiple supernumerary teeth can be associated with some syndromes. However, it can be present in patients without any systemic pathology. Dens invaginatus is a dental developmental variation resulting from an alteration in the normal growth pattern of the dental papilla of a tooth. Cone Beam Computered Tomography (CBCT) could be used to diagnosis supernumerary tooth and dens invaginatus. Case report: A case of a 10-year-old girl with multiple supernumerary teeth without syndromic association is presented. A rare association with dens invaginatus was present. Supernumerary teeth were located in maxilla and mandible and cause severe tooth displacement and lip incompetence. Discussion: Hyperodontia is a number dental alteration of unknown etiology with a prevalence that varies between 0.1 and 3.8%. Dens in dente is a dental shape alteration of unknown etiology with variable prevalence depending on the population. This alteration puts the integrity and health of the affected tooth at risk. Early diagnosis is important in the long-term prognosis. Radiological tools are the appropriate option for diagnosis and are shown in this article. &#x0D; &#x0D; &#x0D; &#x0D;

A Peculiar Case of Non-Syndromic Multiple Impacted Supernumerary Teeth- A Case Report with a total of 64 Teeth

A Peculiar Case of Non-Syndromic Multiple Impacted Supernumerary Teeth- A Case Report with a total of 64 Teeth

Multiple Unerupted Impacted Supernumerary Teeth: A Rare Case Report of Father and Son

Multiple impacted supernumerary teeth without any associated systemic conditions or syndromes are rare. The prevalence rate of supernumerary teeth in the permanent dentition is between 0.1– 6.9 % as compared to 0.3–0.6% in theprimary dentition. In this article, reporting a rare family history of non-syndromic multiple impacted supernumerary teeth,found incidentally during routine radiographic examination. Though the etiologic factor of multiple impacted supernumerary teeth are still not clearly known especially in cases without any syndrome. However, thorough evaluation is necessary toexclude associated systemic conditions.

A unique case of nonsyndromic concomitant hypodontia and multiple supernumerary teeth with talon cusps

The simultaneous presence of hypodontia and hyperdontia is a rare condition in general population posing a diagnostic dilemma to dental practitioners. Its etiology is still not exactly known. It can result in several clinical problems which may require a multidisciplinary approach and long-term dental care. The growing knowledge about this condition emphasizes that concomitant anomalies should be excluded when hypodontia or hyperdontia is diagnosed. Presented here is an unusual case of bimaxillary concomitant hypodontia and multiple supernumerary teeth with Talon cusps as an associated dental anomaly.

Histological Evaluation and Management of Rare Case of Supernumerary “Ghost” Teeth

Supernumerary teeth are teeth that exceed the normal dental formula. Their prevalence in the permanent dentition is 1–14% and they occur more frequently in maxilla with a sex ratio of 2 : 1 in favor of males. They are often associated with syndromes but there are examples of nonsyndromic multiple supernumerary teeth reported in the literature. CBCT is usually the best exam for radiographic diagnosis and treatment planning, because it provides 3D information about location and morphology of supernumerary teeth. This paper reports a rare case of four supernumerary teeth in a nonsyndromic 9-year-old boy. The peculiarity of this case is that two more exceeding teeth were found during surgical procedure. After extraction, all the teeth underwent a histological undecalcified processing for light microscopical examination. The two “ghost” supernumerary teeth seemed to be primordial dental germs, possibly resulting from an altered odontogenic process. After supernumerary teeth extraction, X-rays and exfoliation monitoring are recommended, since permanent retained teeth often erupt naturally or, at least, improve their condition. Radiographic follow-up is also useful in order to assess the formation of further teeth due to the hyperactivity of the dental lamina.

Non-syndromic multiple unerupted supernumerary teeth : a case report

The exact aetiology of supernumerary teeth is still unknown even though many theories have been proposed to explain their presence. Abnormal reactions to a local traumatic episode, environmental factors or a developmental anomaly, and certain syndromes have been implicated as causative factors. Although a single supernumerary tooth or few teeth have been widely reported in the literature, multiple supernumerary teeth are not a common occurrence. Multiple supernumerary teeth affecting all four quadrants of the jaw is a rare dental anomaly which generally is an accidental finding on routine dental radiography. This article reports the case of non-syndromic multiple supernumerary teeth, affecting all four quadrants in a 23-year-old male, who presented to the Faculty of Dental Sciences, University of Peradeniya for routine dental treatment without any significant medical or dental abnormality. A brief review of the literature on multiple supernumerary teeth is also presented.

Diagnosis and Surgical Management of Nonsyndromic Nine Supernumerary Teeth and Leong's Tubercle.

Nonsyndromic multiple supernumerary teeth (ST) and Leong's tubercle are a condition with a very low prevalence and a multidisciplinary approach is required to restore function and aesthetics. So, this case report aimed at presenting a rare case of nonsyndromic nine supernumerary teeth and Leong's tubercle in a pediatric patient, without any evident familial history, showing its diagnosis and surgical management.

Non-syndromic Multiple Supernumerary Teeth in a Family : Case Reports

Supernumerary teeth (SNTs) refer to extra teeth over normal numbers. SNTs can influence adjacent teeth and structure. Therefore, it is important to find SNTs before they cause problems and to decide when to extract them. Etiology of SNTs has not exactly been found, but it has been proposed that genetic and environmental factors are associated. SNT appears as a single unit in most cases and multiple SNTs usually occur as a part of a syndrome. Non-syndromic multiple SNTs are rarely seen. This report is to document the occurrence of multiple supernumerary premolars in a father and his three sons. Heritage is an important factor in SNT development so familial history is important for early detection of SNT.

Late Developing Supernumeraries in a Case of Nonsyndromic Multiple Supernumerary Teeth

Objective. This case report presents 3-year follow-up of a case of nonsyndromic multiple supernumerary teeth (NSMST) with 11 supernumerary teeth, 2 of which showed subsequent formation. Case Report. A 10-year-old girl was referred to the dental clinic with the chief complaint of delayed eruption. Radiographic examination showed 9 retained supernumerary teeth. The treatment plan consisted of extraction of the supernumerary teeth and associated primary teeth in order to allow the permanent teeth to erupt. After 2 years of follow-up, 2 additional supernumerary teeth were observed. Conclusion. Regular follow-up for late forming supernumeraries is crucial for NSMST cases.

Multiple bilateral impacted distomolars in nonsyndromic condition: A rare case report

The presence of multiple supernumerary teeth in nonsyndromic patients is uncommon. In these patients, the prevalence of extra teeth in the molar regions of both jaws is rare. This study aimed to present a rare case of a 27-year-old woman, with nonsyndromic multiple distomolar supernumerary teeth causing vague and diffuse pain in periauricular, temporomandibular joint, and temporal regions. Impacted third molar and distomolar that were in a close contact with inferior alveolar nerve canal were extracted with minimum bone removal.

A multi-centre evaluation of multiple supernumerary premolar prevalence

Abstract Aim The occurrence of multiple supernumerary teeth is rare and often found in association with syndromes such as cleidocranial dysplasia, Gardner's syndrome or cleft lip and palate. Few examples of non-syndromal multiple supernumerary teeth have been reported. The aim of this multi-centre study was to investigate the prevalence of supernumerary premolar teeth in non-syndromic patients and to investigate the association between the presence of supernumerary premolar teeth and malocclusion type in a Turkish population. Materials and methods The clinical records and panoramic radiographs of 10,700 patients (referred to three different university hospitals) were retrospectively examined for the presence of supernumerary premolars. Age, gender, orthodontic malocclusion type, the number of supernumerary premolars (two or more), the distribution, location, position (vertical, horizontal, inverted, mesio-angular), surgical approach, and related complications (pain, cystic changes, root resorption, or eruption disturbance of adjacent teeth) were recorded. Results Forty-two cases (13 Class I, 17 Class II, 12 Class III) of multiple mandibular supernumerary premolars in patients without an associated syndrome were detected. A total of 97 (27 Class I, 41 Class II, 29 Class III) supernumerary premolar teeth were found, with a prevalence of 0.39%. No statistical difference was found related to gender, malocclusion type and supernumerary premolars (p &gt; 0.05). The majority of the extra premolars were located in the mandible, which was statistically significant (p &lt; 0.05). Conclusion The present study revealed that the prevalence of multiple supernumerary teeth was 0.39%. The most frequently impacted premolars were found in the mandible and more often associated with Class II malocclusions in the examined Turkish population.

Report of a case with 19 supernumerary teeth in a non-syndromic patient

Supernumerary teeth occur frequently in human dentition, but presence of multiple supernumerary teeth in patients without any associated syndrome or systemic disorder is a rare phenomenon. Presence of supernumerary teeth in itself is not a problem and may not require removal in all cases but in certain conditions, they may be associated with several clinical complications and require removal. Here, we present a 14-year-old female who complained of non-emergence of permanent teeth. Orthopantomogram (OPG) initially showed presence of fifteen impacted supernumerary teeth distributed in all quadrants, but later, cone-beam computed tomography (CBCT) further revealed four additional teeth, totaling to nineteen supernumerary teeth. Consultation with concerned specialists ruled out any syndromes or systemic disorders which led us to the diagnosis of “non-syndromic multiple supernumerary teeth” and this probably is the highest number of supernumerary teeth reported in a single non-syndromic patient till date.

Nonsyndromic Multiple Supernumerary Impacted Teeth: Report of Two Unusual Cases

ABSTRACTSupernumerary teeth refer to teeth in excess of the usual number. Most common supernumerary teeth are mesiodense, followed by supernumerary teeth in molar and premolar region. There is a male predilection, and maxilla is involved more frequently. Multiple supernumerary teeth are often found in relation to syndromes. Only a few case reports have reported nonsyndromic multiple supernumerary teeth. Here, we report two unusual nonsyndromic cases with impact supernumerary teeth, the first case has five supernumerary premolars and the second has two unilateral fourth molars.How to cite this articleBagheri F, Taheri JB, Azimi S, Babaei S. Nonsyndromic Multiple Supernumerary Impacted Teeth: Report of Two Unusual Cases. J Contemp Dent 2014;4(2):127-128.

Non-syndromic multiple impacted supernumerary teeth: two case reports

Multiple impacted teeth may be related to syndromes and metabolic disorders. In some cases, however, impaction of multiple teeth is not accompanied by any other disorder or syndrom. Hyperdontia or supernumerary teeth without associated syndromes is a rare phenomenon, as supernumerary teeth are usually associated with cleft lip and palate or other syndromes such as Gardeners syndrome, cleidocranial dysplasia and trichorhinophalangic syndrome. The aim of this paper is to demonstrate that asymptomatic multiple impacted ectopic teeth are not always associated with a syndrome or a disorder. A 15-year old male patient attended our clinic with a chief complaint of irregular teeth and unaesthetic smile. In intraoral examination irregular and amorphous erupted teeth were noticed. On routine radiographical examination, impacted supernumerary teeth were noticed in maxilla and mandible. A 37-year old male patient attended our clinic for routine examination and radiographic examination revealed supernumerary and amorphous teeth in mandible and maxilla. In our cases, medical and family history and extraoral examination were not suggestive of any syndrome or metabolic disorder. A general physician was consulted who confirmed that there was no associated syndrome. The supernumarary teeth were surgically extracted. The 15 year old patient who was suffering from irregular teeth was directed to orthodontics clinic. In conclusion, routine radiographic examination may reveal multiple impactions, even if there is no absence of teeth. The etiologic factor of multiple impacted supernumerary teeth is still not clearly known, especially in cases without any syndrome. However, additional examinations may be necessary to exclude systemic and metabolic conditions.

Non-syndrome patient with bilateral supernumerary teeth: Case report and 9-year follow-up

The presence of supernumerary teeth, also known as hyperdontia, is the condition of having teeth in addition to the regular number of teeth. The occurrence of multiple supernumerary teeth is often found in association with syndromes such as Gardner syndrome, Anderson-Fabry disease, Ellis-van Creveld syndrome, Ehlers-Danlos syndrome, incontinentia pigmenti, and Tricho-rhino-phalangeal syndrome. Only a few examples of nonsyndromic multiple supernumerary teeth have been reported in literature. In this report, we present the unusual case and 9-year follow up of a non-syndrome female patient with bilateral supernumerary teeth that occurred with an interval of several years.

Late Developing Supernumerary Premolars: Reports of Two Cases

This paper presents two cases of late developing supernumerary premolars. Case 1 is a female patient with nonsyndromic multiple supernumerary teeth located in the maxillary right premolar-molar region, maxillary left premolar region, and the mandibular right and left premolar regions. In this patient surgical removal of all supernumerary teeth was carried out to avoid complications during orthodontic treatment. Case 2 is a female aged 19 years in whom formation of a mandibular supernumerary premolar was observed which was not present at age 13. The patient was made aware of the supernumerary tooth presence, and periodic radiographic assessment was planned.

Non-syndromic multiple supernumerary teeth among patients seen in a Nigerian Teaching Hospital

Background : The global prevalence of multiple supernumerary teeth for permanent and primary dentition in various populations is between 0.05- 5.3% and 0.2-0.8%. A previous study in Nigeria reported a very low prevalence of multiple supernumeraries. Aim : To ascertain any variation in the prevalence and presentation of multiple supernumeraries in Ibadan, Nigeria. Methodology : Demographic data was obtained from the patients’ data extraction form. Panoramic radiographs of 100 patients seen in the orthodontic clinic of the University College Hospital were assessed for presence, site, side and clinical characteristics of multiple supernumeraries. Data was analysed using SPSS version 18 and Chi square test was used to determine any significant relationship between the assessed variables. Results : More than half of the study population were females. The age range of the Study population was 5-40 years (mean age 13.58±6.5 years). Seventy-one percent had Angle’s class I molar relationship, 17% had Angle’s class II and 5% had Angle’s class III. The prevalence of supernumerary teeth was 9%. Most presented as a combination of supplemental (premolars) and conical/tuberculate teeth. Most (69.2%) of the supernumerary teeth were unerupted. There was no significant variation in the presence of multiple supernumeraries with respect to sex and molar relationship. Conclusion : This study showed a higher prevalence of multiple supernumeraries than previously reported. There is need for a national survey to present a true population prevalence of multiple supernumeraries. Keywords : Non-syndromic, Multiple, Supernumerary teeth, Nigeria

Multiple bilateral supernumerary mandibular premolars in a non-syndromic patient with associated orthokeratised odontogenic cyst- A case report and review of literature

Multiple supernumerary teeth are very rare, accounting for less than 1% of cases. They are commonly associated with syndromes like Gardner's syndrome and cleidocranial dysostosis and cleft lip and palate. Non-syndromic multiple supernumerary teeth have a predilection to occur in the mandibular premolar region. Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental cyst comprising about 10% of the cases that had been previously implied as odontogenic keratocysts. More than half of the cases of OOC are associated with impacted tooth; but not a single case of OOC associated with supernumerary teeth is reported. Hence, the purpose of this article is to report the first case of multiple supernumerary mandibular premolars associated with OOC in a 35-year-old male and to review the literature associated with multiple bilateral supernumerary mandibular premolars.

Non‐syndromic multiple supernumerary teeth: meta‐analysis

Non-syndromic multiple supernumerary teeth (NSMST) is a condition with a very low prevalence and which is opportunely described in the literature by case reports or group of cases. This represents a problem when it comes to describing and discussing the characteristics of this disorder. A search was conducted in PubMed, Web of Knowledge, Science Direct, and Scopus databases to locate and identify cases and series of cases about articles on multiple supernumerary teeth not associated with syndromes that have been reported so far. The following data were recorded: age, gender, total number of supernumerary teeth, number of teeth in both the maxilla and mandible, respectively, and number of teeth in each dental series (incisor, canine-premolar, and molar). Bilaterality in dental series and its localization in either maxilla or mandible were also determined. A total of 46 cases including patients of both genders with a mean age of 19 years (SD = 6.826) and a ratio of 2.14:1 were identified. A total of 393 supernumeraries were reported; 43.26% (n = 170) were located in the maxilla and 56.74% (n = 223) in the mandible. No significant differences were found between genders with respect to the total number, involvement of the dental series, or distribution of supernumerary teeth in each of the arches. Although NSMST is a condition that has a higher incidence in the male gender, no differences have been found as to their number and localization in both genders. Bilaterality seems to be a common characteristic of this disorder.