A typical 8-story RC frame structure model with floor is established by using ABAQUS finite element software. The nonlinear static analysis method and the incremental dynamic analysis method are used to explore the influence of the floor slabs after the demolition on the continuous collapse resistance of the RC frame structure at the same time. Determine the most reasonable amount of reinforcement that meets the requirements for continuous collapse resistance of the frame beams of each layer, and the layer height that is most beneficial to the structure’s continuous collapse resistance.It is concluded that the floor can greatly improve the continuous collapse resistance of the overall structure, and the nonlinear static analysis is conservative; the amount of longitudinal reinforcement in each frame beam should be increased by 1.9% ~ 2.9% to meet the most reasonable requirements for continuous collapse of the frame beam; the floor height is between 4.3 and 4.8 meters, which is the most ideal state for the structure to resist continuous collapse.