Monkey-pox disease is recognized as pathogens, disturbing animals and humans, it is among the family of orthopox virus and the disease causes lymph nodes to swell. In this paper, we developed a deterministic model system for Monkey pox infection by incorporating public awareness parameter and vaccination individual. The study verified the feasible region of the system equations and non-negativity of the solutions is achieved. The disease free and endemic equilibrium states have been obtained. The study computed and analyzed the reproduction number, of the system equations. The study presented and analysed, the global stability of disease free equilibrium and endemic equilibrium state, it has been found that when there is no transmission between human and non-human (), then meaning it is globally asymptotically stable (GAS) at DFE and using nonlinear lyapunov function, the study shows that the endemic equilibrium state is GAS if and unstable if by comparison method of lyapunov functions. Numerical Simulations were done, it was found that the effective reproduction number decreases as vaccination of individual increases, varying the public awareness, the effective reproduction number reduces to zero and becomes stable as public awareness increases. It was discovered that effective reproduction number decreases as public awareness increases.