Nonverbal Tasks Research Articles

Pupil dilation as a function of pitch discrimination difficulty: A replication of Kahneman and Beatty, 1967.

In the present paper, we carry out a replication of a seminal paper by Kahneman, D. & Beatty, J. (1967). Perception & Psychophysics, 2(3),101-105 for using pupillometry as an implicit measure of auditory processing load, specifically, non-verbal auditory processing. While numerous papers since have supported the notion that pupillometry is a fairly reliable index of processing load in general (Zekveld, A. A., Koelewijn, T., and Kramer, S. E. (2018). Trends in Hearing, 22,1-25; Winn, M. B., Wendt, D., Koelewijn, T., and Kuchinsky, S. E. (2018). Trends in Hearing, 22,1-32), they typically have relied on memory recall, and/or more sophisticated cognitive tasks such as language comprehension or split attention. Kahneman and Beatty's paper, despite that it was published more than 50 years ago, continues to be the primary citation to support the claim that pupillometry is a reliable index of task difficulty for a simple non-verbal pitch discrimination task therefore giving us an implicit measure for listening effort (e.g.,Kramer, S. E., Lorens, A., Coninx, F., Zekveld, A. A., Piotrowska, A., & Skarzynski, H. (2013). Language and Cognitive Processes, 28(4),426-442; Schlemmer, K. B., Kulke, F., Kuchinke, L., & Van Der Meer, E. (2005). Psychophysiology, 42(4),465-472; Lisi, M., Bonato, M., and Zorzi, M. (2015). Biological Psychology, 112,39-45). This type of task takes very little explicit memory, is non-verbal, and relies heavily on more low-level, automatic perceptual processing. Using two different replication studies, one exact, and one modified, we only replicated the main result in the modified replication. The true replication failed to replicate on all nine statistical tests. Overall, our findings suggest that pupil dilation can be used as an implicit measure of task difficulty for a simple, non-semantic, auditory task, however, the robustness of the effect appears relatively weak in comparison with the original study, and the amount of variation across participants much greater.

Scalp and hippocampal sleep correlates of memory function in drug-resistant temporal lobe epilepsy.

Seminal animal studies demonstrated the role of sleep oscillations such as cortical slow waves, thalamocortical spindles, and hippocampal ripples in memory consolidation. In humans, whether ripples are involved in sleep-related memory processes is less clear. Here, we explored the interactions between sleep oscillations (measured as traits) and general episodic memory abilities in 26 adults with drug-resistant temporal lobe epilepsy who performed scalp-intracranial electroencephalographic recordings and neuropsychological testing, including two analogous hippocampal-dependent verbal and nonverbal memory tasks. We explored the relationships between hemispheric scalp (spindles, slow waves) and hippocampal physiological and pathological oscillations (spindles, slow waves, ripples, and epileptic spikes) and material-specific memory function. To differentiate physiological from pathological ripples, we used multiple unbiased data-driven clustering approaches. At the individual level, we found material-specific cerebral lateralization effects (left-verbal memory, right-nonverbal memory) for all scalp spindles (rs > 0.51, ps < 0.01) and fast spindles (rs > 0.61, ps < 0.002). Hippocampal epileptic spikes and short pathological ripples, but not physiological oscillations, were negatively (rs > -0.59, ps < 0.01) associated with verbal learning and retention scores, with left lateralizing and antero-posterior effects. However, data-driven clustering failed to separate the ripple events into defined clusters. Correlation analyses with the resulting clusters revealed no meaningful or significant associations with the memory scores. Our results corroborate the role of scalp spindles in memory processes in patients with drug-resistant temporal lobe epilepsy. Yet, physiological and pathological ripples were not separable when using data-driven clustering, and thus our findings do not provide support for a role of sleep ripples as trait-like characteristics of general memory abilities in epilepsy.

TMS over the pre-SMA enhances semantic cognition via remote network effects on task-based activity and connectivity

BackgroundThe continuous decline of executive abilities with age is mirrored by increased neural activity of domain-general networks during task processing. So far, it remains unclear how much domain-general networks contribute to domain-specific processes such as language when cognitive demands increase. The current neuroimaging study explored the potential of intermittent theta-burst stimulation (iTBS) over a domain-general hub to enhance executive and semantic processing in healthy middle-aged to older adults. MethodsWe implemented a cross-over within-subject study design with three task-based neuroimaging sessions per participant. Using an individualized stimulation approach, each participant received once effective and once sham iTBS over the pre-supplementary motor area (pre-SMA), a region of domain-general control. Subsequently, task-specific stimulation effects were assessed in functional MRI using a semantic and a non-verbal executive task with varying cognitive demand. ResultsEffective stimulation increased activity only during semantic processing in visual and dorsal attention networks. Further, iTBS induced increased seed-based connectivity in task-specific networks for semantic and executive conditions with high cognitive load but overall reduced whole-brain coupling between domain-general networks. Notably, stimulation-induced changes in activity and connectivity related differently to behavior: While stronger activity of the parietal dorsal attention network was linked to poorer semantic performance, its enhanced coupling with the pre-SMA was associated with more efficient semantic processing. ConclusionsiTBS modulates networks in a task-dependent manner and generates effects at regions remote to the stimulation site. These neural changes are linked to more efficient semantic processing, which underlines the general potential of network stimulation approaches in cognitive aging.

Impact of age of onset on bilinguals’ task switching performance in a nonimmigration context

It is not clear whether bilingualism leads to task switching benefits in single-language nonimmigration contexts, as in dual-language and code-switching immigration contexts. Ninety young Persian-speaking monolingual and bilingual adults reported their language proficiency and use, with the early bilinguals indicating a balanced rating for their L1 and L2, and late bilinguals reporting slightly higher ratings for L1, relative to L2. Concerning the onset age of bilingualism, the bilinguals were classified as early and late bilinguals according to whether they initiated active regular use of the two languages before or after the age of eight. A nonverbal alternating-runs task switching paradigm was used to measure global switch cost (GSC) and local switch cost (LSC). The findings revealed a slight nonsignificant GSC but a significantly lower LSC for early bilinguals, compared to monolinguals, suggesting that bilingualism effects on task switching do not transpire uniformly across different contexts.

Handicraft art leisure activities and cognitive reserve

ObjectiveOlder individuals face a higher likelihood of developing dementia. The rate of cognitive decline resulting from dementia is not equivalent for all, as some patients with dementia are able to function independently longer than others, despite having similar disease burden. The cognitive reserve (CR) theory provides one explanation for the differing rate of decline. CR suggests that there are factors—most notably, educational attainment and occupational attainment—that can protect against the cognitive decline. Although the beneficial effects of these notable CR factors are clear, not all are easily modifiable. Participation in leisure activities may represent a more easily modifiable factor. Some research hints at beneficial effects of leisure activities, although specific leisure activities have not been well examined. The present study examined the relations between handicraft art leisure activities (HALAs) and multiple cognitive domains. MethodArchival WAIS-IV and demographic data for 50 California retirement community residents were examined. ResultsHALA participation accounted for statistically significant variance in working memory performance (R 2 = .40, β = .24%) over and above the established CR factors of age, depression, educational attainment, and occupational attainment. In addition, HALA participation was related to a better ability to perform abstract visual information tasks (Block Design subtest, r = .28, p = .05) and non-verbal reasoning tasks (Visual Puzzles subtest, r = .38, p = .008). ConclusionsHALA participation among older adults could contribute to the retention of cognitive function, supporting the role of HALA participation as a CR factor.

We Cannot Ignore the Signs: The Development of Equivalence and Arithmetic for Students from Grades 3 to 4

ABSTRACT Students' understanding of the meaning of the equal sign develops slowly over the primary grades. In addition to updating their representations of equations to recognize that the equal sign represents an equivalence relation rather than signaling an operation, students need to move beyond full computation to efficiently solve equivalence problems. In this study, we examined the longitudinal relation between arithmetic and equivalence for students who were capable of accurately solving arithmetic problems in different formats. Chinese students (N = 612; M age = 9.0 years in Grade 3, 57% boys) completed measures of arithmetic fluency and equivalence fluency in Grade 3 and again in Grade 4. They also completed a non-verbal reasoning task in Grade 3. We tested a cross-lagged structural equation model to examine the reciprocal relations between arithmetic and equivalence fluency. We found reciprocal relations between the development of arithmetic and equivalence fluency from Grades 3 to 4, with a greater influence of arithmetic on the development of equivalence than the reverse. Furthermore, non-verbal reasoning predicted the development of equivalence, but not the development of arithmetic. Based on our findings, we conclude that for Chinese students with prior basic understanding of equivalence, flexible access to arithmetic facts supports their development of equivalence fluency.

Healthy ageing has divergent effects on verbal and non-verbal semantic cognition.

Semantic cognition refers to the storage and appropriate use of knowledge acquired over the lifespan and underpins our everyday verbal and non-verbal behaviours. Successful semantic cognition requires representation of knowledge and control processes which ensure that currently relevant aspects of knowledge are retrieved and selected. Although these abilities have been widely studied in healthy young populations and semantically impaired patients, it is unclear how they change as a function of healthy ageing, especially for non-verbal semantic processing. Here, we addressed this issue by comparing the performance profiles of young and older people on a semantic knowledge task and a semantic control task, across verbal (word) and non-verbal (picture) versions. The results revealed distinct patterns of change during adulthood for semantic knowledge and semantic control. Older people performed better in both verbal and non-verbal knowledge tasks than young people. However, although the older group showed preserved controlled retrieval for verbal semantics, they demonstrated a specific impairment for non-verbal semantic control. These findings indicate that the effects of ageing on semantic cognition are more complex than previously assumed, and that input modality plays an important role in the shifting cognitive architecture of semantics in later life.

Autism and intention attribution test: a non-verbal evaluation with comic strips

BackgroundDespite autism spectrum disorder (ASD) and mentalization being two words often associated in the literature, the assessment of this ability in individuals with ASD in the clinical setting is still limited. Indeed, there are no standardized Theory of Mind (ToM) tests that are adaptable to different cognitive profiles, such as individuals with language poverty, and intellectual or memory impairments. This study proposes a non-verbal test (Intentions Attribution-Comic Strip Test; IA-CST) to evaluate the ability to infer the intentions of others, a basic component of ToM, in the clinical setting.MethodIn Study 1, the test was administered to 261 healthy individuals and we performed structural validation using Exploratory Graph Analysis. In Study 2, the final version of the test was administered to 32 individuals with ASD to assess the known group validity of the measure by comparing their scores with a sample of IQ-matched controls. Moreover, we performed logistic regression and ROC curve to preliminarily assess the diagnostic performance of the IA-CST.ResultsThe IA-CST resulted in a 3-dimension measure with good structural stability. Group comparison indicated that the ASD group shows significantly lower performance in intention attribution but not in inferring causal consequences. The test demonstrated known group validity and that, preliminarily, it is suitable for implementation within the clinical practice.ConclusionsThe results support the IA-CST as a valid non-verbal task for evaluating intentions attribution in the clinical setting. Difficulties in ToM are early and relevant in ASD, so assessing these aspects is valuable for structuring individualized and evidence-based interventions.

Do they know or just do it? Investigating implicit and explicit sequence learning by capuchin monkeys, human adults and children

In humans, it is now established that sequential regularities can be learned implicitly (i.e. without acquiring conscious knowledge) or explicitly (with acquisition of conscious knowledge). Is this dual-processing capability also the case for non-human primates? In this study, we designed a non-verbal task to probe implicit and explicit sequence learning in capuchin monkeys (Sapajus sp., n = 12), human adults (n = 12), and children from 5 to 10 years old (n = 64). After learning spatial sequences on a touchscreen, participants’ conscious access to the sequences was probed with a forced choice sequence completion test. All performed above chance level in this test, without being instructed or trained to do so. However, only human adults who reported the presence of regularities performed at ceiling level. We suggest future directions that could build on our findings to disentangle implicit and explicit learning in monkeys and children.

Features of bioelectric brain activity in people with different level of situational anxiety when performing non-verbal tasks

The purpose of the study: to analyze the parameters of the electroencephalogram in individuals with different levels of anxiety when performing non-verbal tasks.Object and methods. The study was conducted on 20 female students, aged 18 to 22 years. All studies were carried out on a voluntary basis, confirmed in writing, in compliance with bioethical standards governing the conduct of observations on humans. The level of situational anxiety was determined using the Spielberg-Khanin test.The spectral power of the electroencephalogram rhythms was recorded using the NVX 36 digital DC EEG neurovisor using a cap with a set of electrodes that were placed on the head of the subjects according to the international 10–20 system. The EEG recording lasted 1–2 minutes before and during the performance of nonverbal tasks. As non-verbal tasks, the subjects were asked to complete the Portsus maze test and the Cattell intellectual test. The results obtained were statistically processed. Differences were considered statistically significant at p &lt; 0.05. All data obtained are presented as arithmetic means ± standard errors of the mean, as well as changes in average values in %.Research results. It was found that the dynamics of EEG parameters in the performance of nonverbal tasks in students depends on the level of their situational anxiety. In persons with a low level of situational anxiety, when performing nonverbal tasks, an increase in the spectral power of the EEG parameters of beta2 and gamma waves in the frontal, parietal, occipital, and central leads is observed.In subjects with an average level of anxiety in the conditions of performing non-verbal tasks, the EEG parameters of beta2 and gamma waves in the frontal, occipital, and parietal leads noticeably increased. Persons with a high level of anxiety are characterized by an increase in the spectral power of alpha, beta2 and gamma rhythms in the frontal, central, parietal and occipital leads.

Spanish normative studies (NEURONORMA-Plus project): norms for the Delis Kaplan-Design Fluency Test, Color Trails Test, and Dual Task

IntroductionComplex attention and non-verbal fluency tasks are used in neuropsychological assessments with the aim of exploring subdomains of executive function. The purpose of this study is to provide norms and age-, education-, and sex-adjusted data for the Delis Kaplan-Design Fluency Test (DK-DFT), Color Trails Test (CTT), and Dual Task (DT) as part of the NEURONORMA-Plus project. MethodsThe sample included 308 cognitively unimpaired individuals aged between 18 and 92 years. Raw scores were converted to age-adjusted scaled scores. These were further converted into education- and sex-adjusted scaled scores by applying linear regression, with 2 age groups (< 50 and ≥ 50 years). ResultsOverall, age had a negative impact on DK-DFT and CTT performance. We observed a positive effect of education on DK-DFT scores only in the older group (≥ 50 years). Moreover, younger men performed slightly better in the basic condition of this test. Education was positively associated with all CTT scores in both age groups, with the exception of the CTT-1 subtest in the younger group. Age and education did not influence DT performance, whereas sex did, with young women performing slightly better. ConclusionsThese normative data may be useful in the interpretation of neuropsychological assessments in the Spanish population.

Racial differences in the effect of verbal and nonverbal memory on concrete planning for future care needs among older adults: a multi-group structural equation modeling approach

ABSTRACT Concrete planning for future care needs may positively impact older adults’ subsequent mental health and quality of life. However, the cognitive factors that facilitate concrete planning among Black and White older adults are still poorly understood. We investigated whether there are significant differences between Black (n = 159) and White (n = 262) older adults in concrete planning and explored racial differences in the relationship between verbal and nonverbal episodic memory and concrete planning. Results revealed that Blacks showed lower engagement in concrete planning and lower scores than Whites on each verbal and nonverbal memory task. For Blacks, but not Whites, verbal memory and nonverbal memory performance predicted concrete planning with higher nonverbal memory relating to less concrete planning and higher verbal memory associated with more concrete planning. Our findings suggest racial differences exist in how episodic verbal and nonverbal memory affect concrete planning, a crucial factor for older adults’ preparation for future care.

Cerebral Small Vessel Disease Burden: An Independent Biomarker for Anomia Treatment Responsiveness in Chronic Stroke Patients With Aphasia

ObjectiveTo determine whether MRI-based cerebral small vessel disease (cSVD) burden predicts treatment-induced aphasia recovery in chronic stroke patients above and beyond initial aphasia severity and stroke-lesion volume. DesignRetrospective. Four cSVD neuroimaging markers were rated using validated visual scales: white matter hyperintensities, enlarged perivascular spaces, lacunes, and global cortical atrophy. We also calculated a cSVD total score. We employed linear regression models to model treatment response as a function of cSVD burden. We also ran correlation analyses to determine the association among cSVD burden and pre-treatment linguistic and non-linguistic cognition. SettingResearch clinic. ParticipantsThe study includes data from 30 chronic stroke patients with aphasia who received treatment for word finding difficulties and completed additional pre-treatment neuroimaging and behavioral assessments (N=30). Interventions120-minute sessions of anomia treatment 2 times per week for up to 12 weeks. Main Outcome MeasuresChange in accuracy on the treatment probes measured as a percentage (ie, change in accuracy percentage score=post-treatment accuracy percentage minus pre-treatment accuracy percentage). ResultsBaseline cSVD burden predicted response to anomia treatment independently from demographic and stroke-related factors. Patients with lower cSVD burden exhibited enhanced rehabilitation response compared with those with higher cSVD burden (β=-6.816e-02, P=.019). cSVD burden was highly associated with nonverbal executive function at baseline (r=-0.49, P=.005): patients with lower cSVD burden exhibited higher performance on nonverbal executive function tasks compared with participants with higher cSVD burden. No association was observed among cSVD burden and performance on language tasks at the baseline. ConclusionscSVD, a marker of brain reserve and a robust risk factor for post-stroke dementia, may be used as a biomarker for distinguishing patients who are more likely to respond to anomia therapy from those who are less likely to do so and for individualizing treatment parameters (eg, targeting both linguistic and nonlinguistic cognition in severe cSVD).

Impoverished language in early childhood affects the development of complex sentence structure.

The hypothesis that impoverished language experience affects complex sentence structure development around the end of early childhood was tested using a fully randomized, sentence-to-picture matching study in American Sign Language (ASL). The participants were ASL signers who had impoverished or typical access to language in early childhood. Deaf signers whose access to language was highly impoverished in early childhood (N=11) primarily comprehended structures consisting of a single verb and argument (Subject or Object), agreeing verbs, and the spatial relation or path of semantic classifiers. They showed difficulty comprehending more complex sentence structures involving dual lexical arguments or multiple verbs. As predicted, participants with typical language access in early childhood, deaf native signers (N=17) or hearing second-language learners (N=10), comprehended the range of 12 ASL sentence structures, independent of the subjective iconicity or frequency of the stimulus lexical items, or length of ASL experience and performance on non-verbal cognitive tasks. The results show that language experience in early childhood is necessary for the development of complex syntax. RESEARCH HIGHLIGHTS: Previous research with deaf signers suggests an inflection point around the end of early childhood for sentence structure development. Deaf signers who experienced impoverished language until the age of 9 or older comprehend several basic sentence structures but few complex structures. Language experience in early childhood is necessary for the development of complex sentence structure.

Oromotor Nonverbal Performance and Speech Motor Control: Theory and Review of Empirical Evidence.

This position paper offers a perspective on the long-standing debate concerning the role of oromotor, nonverbal gestures in understanding typical and disordered speech motor control secondary to neurological disease. Oromotor nonverbal tasks are employed routinely in clinical and research settings, but a coherent rationale for their use is needed. The use of oromotor nonverbal performance to diagnose disease or dysarthria type, versus specific aspects of speech production deficits that contribute to loss of speech intelligibility, is argued to be an important part of the debate. Framing these issues are two models of speech motor control, the Integrative Model (IM) and Task-Dependent Model (TDM), which yield contrasting predictions of the relationship between oromotor nonverbal performance and speech motor control. Theoretical and empirical literature on task specificity in limb, hand, and eye motor control is reviewed to demonstrate its relevance to speech motor control. The IM rejects task specificity in speech motor control, whereas the TDM is defined by it. The theoretical claim of the IM proponents that the TDM requires a special, dedicated neural mechanism for speech production is rejected. Based on theoretical and empirical information, the utility of oromotor nonverbal tasks as a window into speech motor control is questionable.

Short report: Longitudinal study on emotion understanding in children with and without developmental language disorder

BackgroundChildren with Developmental Language Disorder (DLD) have difficult access to social interactions, which could in turn limit their opportunities to learn about others’ emotions. AimsThis study aimed to investigate the developmental trajectories of emotion understanding in young children with and without DLD. Methods and procedures95 DLD children and 149 non-DLD children were tested twice, with an approximately two-year interval (Mage = 3.58 years at Time 1), on three indices for emotion understanding (discrimination, identification, and attribution in emotion-evoking situations). Outcomes and resultsAt Time 2, DLD children fell behind their non-DLD peers on the non-verbal task for emotion discrimination, while catching up on the verbal tasks for emotion identification and attribution. The two groups developed most of these skills with a similar improvement over time, but DLD children showed a greater increase in positive emotion identification and attribution with age than non-DLD children. Conclusions and implicationsThe findings showed the potential of DLD children to understand others’ emotions in verbal tasks to a similar extent as their non-DLD peers. However, DLD children may still face difficulties understanding more implicit emotional messages in real-life situations, and longitudinal follow-ups are required to reveal these challenges.

Reading fluency and statistical learning across modalities and domains: Online and offline measures.

The vulnerability of statistical learning has been demonstrated in reading difficulties in both the visual and acoustic modalities. We examined segmentation abilities of Hungarian speaking adolescents with different levels of reading fluency in the acoustic verbal and visual nonverbal domains. We applied online target detection tasks, where the extent of learning is reflected in differences between reaction times to predictable versus unpredictable targets. Explicit judgments of well-formedness were also elicited in an offline two-alternative forced choice (2AFC) task. Learning was evident in both the acoustic verbal and visual nonverbal tasks, both in online and offline measures, but learning effects were larger both in online and offline tasks in the verbal acoustic condition. We haven't found evidence for a significant relationship between statistical learning and reading fluency in adolescents in either modality. Together with earlier findings, these results suggest that the relationship between reading and statistical learning is dependent on the domain, modality and nature of the statistical learning task, on the reading task, on the age of participants, and on the specific language. The online target detection task is a promising tool which can be adapted to a wider set of tasks to further explore the contribution of statistical learning to reading acquisition in participants from different populations.

Transdiagnostic overlap in brain correlates of affective and cognitive theory of mind deficits.

Social cognitive symptoms characterize multiple neurological disorders, including brain tumours and neurodegeneration. Recently, Campanella and colleagues1 investigated deficits in cognitive and affective theory of mind (TOM) in 105 tumour patients using a non-verbal task of 18 stimuli that required patients to select one out of three possible endings of a cartoon story, i.e. the Story-based Empathy Task (SET).2 The SET includes three conditions [Causal Inference (CI), Intention Attribution (IA) and Emotion Attribution (EA)], reflecting the type of inference the items tap into: inference of physical properties, intentions, or characters’ emotional state, respectively. The behavioural results of Campanella’s study revealed specific EA deficits in patients with temporal lobe tumours. Furthermore, the authors used parcel-based lesion-symptom mapping (PLSM) and reported an association between a right anterior temporal cluster and EA performance. Right amygdalar lesions showed a stronger association with EA than with IA. The association between EA deficits and amygdalar volume has also been also reported in behavioural variant frontotemporal dementia (bvFTD),3 a neurodegenerative disorder, characterized by deficits in social cognition, including cognitive and affective TOM. Consistent with the findings of Campanella, we also observed an association between performance on the EA condition and grey matter volume of the right temporal lobe and amygdala3 (Fig. 1). As documented by Campanella and colleagues, such common neural correlates of EA performance largely overlap with a ‘reasoning about emotions’ network derived from a recent meta-analysis of functional brain imaging studies in healthy participants.4 These combined findings converge in supporting a critical role of the right amygdala and temporal lobe in emotion attribution.

Activating words without language: beta and theta oscillations reflect lexical access and control processes during verbal and non-verbal object recognition tasks.

The intention to name an object modulates neural responses during object recognition tasks. However, the nature of this modulation is still unclear. We established whether a core operation in language, i.e. lexical access, can be observed even when the task does not require language (size-judgment task), and whether response selection in verbal versus non-verbal semantic tasks relies on similar neuronal processes. We measured and compared neuronal oscillatory activities and behavioral responses to the same set of pictures of meaningful objects, while the type of task participants had to perform (picture-naming versus size-judgment) and the type of stimuli to measure lexical access (cognate versus non-cognate) were manipulated. Despite activation of words was facilitated when the task required explicit word-retrieval (picture-naming task), lexical access occurred even without the intention to name the object (non-verbal size-judgment task). Activation of words and response selection were accompanied by beta (25-35Hz) desynchronization and theta (3-7Hz) synchronization, respectively. These effects were observed in both picture-naming and size-judgment tasks, suggesting that words became activated via similar mechanisms, irrespective of whether the task involves language explicitly. This finding has important implications to understand the link between core linguistic operations and performance in verbal and non-verbal semantic tasks.

The Stroop effect involves an excitatory–inhibitory fronto-cerebellar loop

The Stroop effect is a classical, well-known behavioral phenomenon in humans that refers to robust interference between language and color information. It remains unclear, however, when the interference occurs and how it is resolved in the brain. Here we show that the Stroop effect occurs during perception of color–word stimuli and involves a cross-hemispheric, excitatory–inhibitory loop functionally connecting the lateral prefrontal cortex and cerebellum. Participants performed a Stroop task and a non-verbal control task (which we term the Swimmy task), and made a response vocally or manually. The Stroop effect involved the lateral prefrontal cortex in the left hemisphere and the cerebellum in the right hemisphere, independently of the response type; such lateralization was absent during the Swimmy task, however. Moreover, the prefrontal cortex amplified cerebellar activity, whereas the cerebellum suppressed prefrontal activity. This fronto–cerebellar loop may implement language and cognitive systems that enable goal-directed behavior during perceptual conflicts.