SESSION TITLE: Diffuse Lung Disease SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/10/2018 01:00 pm - 02:00 pm PURPOSE: To elucidate the phenotypic features of post-tuberculous(TB) bronchiectasis. METHODS: Longitudinal observational study of patients with presenting with acute exacerbation of bronchiectasis to Changi General Hospital, Singapore between Jan 2010-Aug 2017. Patients were categorized according to post-TB bronchiectasis or non post-TB bronchiectasis. Demographics, clinical features, lung function, microbiology and outcomes were compared between the two groups. RESULTS: 148 patients were recruited, mean±standard deviation (SD) age at first admission within the study period was 63±9y, 84 (56.8%) were male and 94 (63.5%) were Chinese ethnicity, mean±SD body mass index (BMI) was 22.1 ± 6. The most common etiology was idiopathic (n=94, 63.5%) followed by post-TB bronchiectasis (n=46, 30.1%). Post-TB bronchiectasis patients had lower body mass index(BMI) (21.3±6.4 vs 23.6±5.7, p=0.049), higher prevalence of non-tuberculous mycobacteria isolation from respiratory specimens (28.3% vs 5.9%, p<0.001), more frequent presentation with hemoptysis (32.6% vs 11.8%, p=0.002), lower FEV1 % predicted (64±27 vs 79±25, p=0.009 ) and higher rate of recurrent admissions for bronchiectasis exacerbation (23.6%/year vs 8.5%/year, Poisson regression rate ratio 2.6, 95% confidence interval 1.01-6.6, p=0.048) compared to non-post-TB bronchiectasis patients. No significant differences were found for C-reactive protein, procalcitonin, Pseudomonas colonization/infection rates or mMRC dyspnea scores. CONCLUSIONS: Post-TB bronchiectasis was associated with a lower FEV1, lower BMI, hemoptysis, non tuberculous mycobacteria colonization and frequent admissions for bronchiectasis exacerbation compared to patients with other etiologies of bronchiectasis. CLINICAL IMPLICATIONS: Bronchiectasis is a heterogeneous disease with distinct clinicopathobiologic subtypes. There is scarce data on post-tuberculous bronchiectasis, especially in Asia where the burden of disease is high. This paper serves to elucidate the phenotypic features of the post-TB bronchectasis patient in an Asian population. DISCLOSURES: No relevant relationships by Isaac Fong, source=Web Response No relevant relationships by Sandra HUI, source=Web Response No relevant relationships by Teck Boon Low, source=Admin input No relevant relationships by Anthony Yii, source=Web Response