This article presents some best proximity point theorems for new classes of non-self mappings, called supreme proximal contractions and supreme proximal cyclic contractions, which are brought forth to generalize the notion of self-contraction. Eventually, these results explore the existence of best proximity points that serve as optimal approximate solutions to the fixed point equations of the form $$Tx=x$$, where T is a supreme proximal contraction or a supreme proximal cyclic contraction. Further, it is interesting to observe that such results generalize the most celebrated and elegant Banach’s contraction to the case of non-self mappings.