Objective To understand the effect of percutaneous coronary intervention on quality of life,status of anxiety and depression,status of medical coping modes of patients with acute myocardial infarction (AMI).Methods A total of 200 patients with AMI,were recruited and divided into PCI group(n =100) and non-PCI group (n =100) according to them whether received the PCI.The common status questionnaire,the myocardial infarction dimensional assessment scale (MIDAS),the hospital anxiety and depression scale (HADS),the medical coping modes questionnaire(MCMQ) were performed among all the participants in 3-4 days before they were discharged from the hospital.Results The life quality score of PCI group was significantly lower than that of non-PCI group [(34.80 ± 19.89) vs (45.54 ± 22.33) ; t =3.591,P < 0.01].While the scores of anxiety and depression of the non-PCI group were respectively higher than that of PCI group [(6.20 ± 3.29) vs (5.03 ± 3.14),(6.02 ± 3.44) vs (4.83 ± 3.28)],and the difference was statistically significant (t =2.572,2.506,respectively; P < 0.05).Significant difference was found in the surrender score of medical coping style between two groups (P < 0.05),and they were had higher score of coping style.No significant difference was found in the score of confront between PCI group and normal group(P > 0.05),but the score of surrender was significantly lower than that of normal group (t =5.148,P < 0.01).No significant difference was found in the scores of surrender,avoid,confront between non-PCI group and norm group (P > 0.05).Conclusions PCI therapy can improve the life quality and reduce anxiety of patients with AMI during hospitalization,and patients with AMI can face with the disease positively,while patients of PCI group using less acceptance coping style than that the non-PCI group ones. Key words: Myocardial infarction; Percutaneous coronaryIntervention; Quality of life; Coping style