Stable liquid jets are crucial for successful serial crystallography experiments. They are produced from gas dynamic virtual nozzles (GDVNs), where the liquid from an inner capillary is focused by a co-flowing gas from an outer converging capillary. Our previously investigated non-Newtonian jets with incompressible and compressible focusing gas under atmospheric conditions were extended towards compressible chocked gas under vacuum conditions. An axisymmetric GDVN was considered with a fixed gas flow rate of 15 mg/min and liquid flow rate of 40 µl/min. A mixture formulation of the laminar compressible multiphase problem was solved within finite volume method and volume of fluid framework. The jet lengths, diameters, velocities, and temperatures were analysed as a function of the power-law non-Newtonian modification of reference water. It is observed that the jets under vacuum conditions are thinner for Newtonian and shear-thickening fluids than those in the atmosphere. The jet length increases from shear-thinning to shear-thickening rheology but is not affected by the pressure. The shear produced at the nozzle outlet is similar for both pressure conditions but increases in downstream directions for vacuum conditions. Gas expanding into vacuum cools by ~100-150 K while the temperature of the liquid jet drops only by a few K.