This article aims to probe postulated phenomena using a paired micropolar and Casson hybrid fluid over a rotating disk. The intension to design a numerical technique (Runge–Kutta fourth-order along with shooting technique) integrated Adaptive Neuro-Fuzzy Inference System (ANFIS) envisioned with a thermal and exponentially space-dependent heat source, nonlinear thermal radiation and entropy production is developed in this phase of work. To ensure that, a nonlinear partial differential equation set of equations has been transformed into an ordinary differential equation by using the proper self-similarity variables. The model's research results, with a few notable outliers, are mostly consistent with those from prior research that was merged into the dataset used to train the ANFIS model. With the impact of active factors, the results are esthetically exhibited for numerous profiles. This displays that with the rise in magnetic field and radiation, the velocity and temperature profiles increase sharply, resulting in a contradiction phenomenon with the decreasing electric field inputs. Also, tilting of vortex viscosity, spin gradient viscosity and microinertia density on the various microrotation components displays inclination. Moreover, ANFIS training was exploited to analyze the approximate solutions for specific scenarios, and the developed ANFIS was evaluated against a testing dataset to emphasize its performance. Due to their longer render, the nanoparticles exploited here are deemed suitable for use in bone implants, iodinated agents for blood imaging and red blood cell stimulation. Thus, the results of this study may be applied to therapeutic anemia therapies.