Two-dimensional fully-nonlinear numerical sloshing tank (FN-NST) simulation program is developed based on boundary element method (BEM), potential theory with artificial free-surface damping, and space-fixed (global) coordinate system. The free surface in sloshing tank is updated by the mixed Eulerian-Lagrangian (MEL) method with material node approach (Full Lagrangian approach). The developed potential-based nonlinear model was validated through comparisons with available experimental and CFD (computational fluid dynamics) results and they show good agreements. The nonlinear sloshing model is then further implemented in the fully nonlinear wave and floating-body simulation program to observe the effects of liquid sloshing motion. In the fully nonlinear program, the entire nonlinear fluid pressure is integrated over the instantaneous wetted body surface and position, which is subsequently compared with the corresponding linear theory and results. The second-order effects are also identified from the fully-nonlinear simulation. The floater Response Amplitude Operators (RAOs) for frozen- and liquid-cargo cases are also compared for various wave frequencies and amplitudes to better identify the role of liquid cargo in the stability of rotational motions. The effects of the vertical location of liquid tank and artificial free-surface damping are also investigated.