The clinical efficacy of transabdominal ultrasonography in the diagnosis of gastroesophageal reflux disease was presented in the article. 250 patients with clinical and endoscopic signs of gastroesophageal reflux disease were examined. The authors examined the distal esophagus, where they determined the length of the abdominal esophagus, the esophageal diameter, lumen width, the thickness and structure of walls. It was revealed that the most common signs of gastroesophageal reflux disease were the expansion of the diameter of the distal part of the esophagus after ingestion of liquids, regurgitation of gastric contents into the esophagus in the form of a symmetrical thickening of the walls of the esophagus.