Non-homogeneous Electric Field Research Articles

Analysis of Breakdown Phenomena of SF6-Gas Using Different Electrodes Configuration in High Voltage Application

This research investigates the breakdown voltage of SF6 gas using several electrode configurations, including Sphere-sphere, Rod-rod, Plate-plate, Sphere-plate, and Rod-plate, to guarantee sufficient clearance for an acceptable insulation level. The objective of the various electrode geometries is to produce a homogeneous and non-homogeneous electric field wherein the SF6 gas breakdown could be analyzed. The simulation under the influence of six gaps length be-tween electrodes (0.5cm, 1cm, 2cm, 3cm, 4cm, 5cm) were conducted. The lowest breakdown voltage is found in the Rod-rod electrode arrangement, followed by Plate-plate and Sphere-sphere electrode configuration. Compared with the Sphere-sphere electrode design, the Rod-rod electrode configuration is also asymmetric, with a substantially more inhomogeneous electric field. Based on the results, the Rod-plate and Sphere-plate arrangements appear to be asymmetrical. In the event of discharge and breakdown voltage, different electrode configurations have a significant influence. This study helps to identify the most suitable clearance and electrodes configuration in high voltage SF6 circuit breakers. A few researches were performed to find the breakdown voltage of SF6 gas in medium voltage applications under homogeneous electric stress. Some research paper also studied to find the breakdown voltage of SF6 gas under different temperature and pressure. However, this paper is based on finding out the breakdown voltage of SF6 gas in high voltage application providing homogeneous and non-homogeneous electric stress. This homogeneous and non-homogeneous electric field is designed using different electrodes configuration.

A non-dimensional time-domain lumped model for externally DC biased capacitive microphones with two electrodes

Microphones that utilize externally biased capacitive transduction (condenser microphones) are typically being modeled in lumped parameter networks where the mechanical, acoustical, and electrical elements are all represented as passive electronic circuit components. Those models have been shown to be insufficient to fully describe crucial aspects of this type of transducer, such as the pull-in phenomenon in which, after a certain distance and for a certain bias voltage, the moving electrode, typically a flexible membrane, attaches itself to the stationary. In this paper, we account for several non-linearities present in an extended simplified model of such a transducer in the time domain and identify the different factors related to its nonlinear response. We derive a time-domain non-linear non-dimensional system of equations for the coupled lumped model where we also take into account parasitic capacitances that are usually present and can significantly affect the overall electroacoustic performance as well as the fringing fields due to the nonhomogeneous electric field between the electrodes and nonlinearities related to damping due to the thin-film of air between the electrodes. We present the nondimensionalization method we used that allows for the identification of a novel set of nondimensional parameters that characterize the non-linear behavior of our system in the time-domain. A designer can use these parameters to optimize for linearity in the voltage response of the transducer. We post-process our time-domain solution to calculate the response to the fundamental excitation frequency and discuss the harmonic distortion. It is shown that coupling the electrical nonlinearities to the mechanical can significantly contribute to the nonlinear voltage response of the transducer. Our model agrees well with nonlinear measurements of analog microelectromechanical (MEMS) microphones for a set of physical values of the nondimensional parameters.

Analysis of Red Blood Cell Movement in Whole Blood Exposed to DC and ELF Electric Fields.

To evaluate hematological effects of direct current (DC) and alternating current (AC) extremely low frequency (ELF) electric field exposure, this study investigated red blood cell (RBC) movement in whole blood. Video images of RBCs were recorded under a microscope using specially designed electrode systems. Video analysis software was then used to measure the RBC velocity. The noise level and measurement system stability were confirmed based on results of a no‐field exposure experiment. Using the electrode system to produce a non‐homogeneous electric field, different movements were found to occur in DC and AC field exposure. The RBCs moved in the directions of the electric field and the gradient of field distribution, respectively, in the DC and AC fields. Dependences of the RBC velocity on the field strength were, respectively, linear and quadratic in the DC and AC fields. These results suggest that electrophoretic and dielectrophoretic movements were, respectively, dominant in the DC and AC fields. The magnitude of the electric field necessary to cause these effects was found to be 103–105 times greater than the internationally publicized guideline for human safety. © 2022 Bioelectromagnetics Society.

Purified myelin lipids display a critical mixing point at low surface pressure

Lipids extracted from Purified Myelin Membranes (LPMM) were spread as monomolecular films at the air/aqueous interface. The films were visualized by Brewster Angle Microscopy (BAM) at different lateral pressures (π) and ionic environments. Coexistence of Liquid-Expanded (LE) and cholesterol-enriched (CE) rounded domains persisted up to π ≈ 5 mN/m but the monolayers became homogeneous at higher surface pressures. Before mixing, the domains distorted to non-rounded domains. We experimentally measured the line tension (λ) for the lipid monolayers at the domain borders by a shape relaxation technique using non-homogeneous electric fields. Regardless of the subphase conditions, the obtained line tensions are of the order of pN and tended to decrease as lateral pressure increased toward the mixing point. From the mean square displacement of nested trapped domains, we also calculated the dipole density difference between phases (μ). A non-linear drop was detected in this parameter as the mixing point is approached. Here we quantitively evaluated the π-dependance of both parameters with proper power laws in the vicinity of the critical mixing surface pressure, and the exponents showed to be consistent with a critical phenomenon in the two-dimensional Ising universality class. This idea of bidimensionality was found to be compatible only for simplified lipidic systems, while for whole myelin monolayers, that means including proteins, no critical mixing point was detected.Finally, the line tension values were related with the thickness differences between phases (Δt) near the critical point.

Concentration-Polarization Electroosmosis near Insulating Constrictions within Microfluidic Channels.

Electric fields are commonly used to trap and separate micro- and nanoparticles near channel constrictions in microfluidic devices. The trapping mechanism is attributed to the electrical forces arising from the nonhomogeneous electric field caused by the constrictions, and the phenomenon is known as insulator-based-dielectrophoresis (iDEP). In this paper, we describe stationary electroosmotic flows of electrolytes around insulating constrictions induced by low frequency AC electric fields (below 10 kHz). Experimental characterization of the flows is described for two different channel heights (50 and 10 μm), together with numerical simulations based on an electrokinetic model that considers the modification of the local ionic concentration due to surface conductance on charged insulating walls. We term this phenomenon concentration–polarization electroosmosis (CPEO). The observed flow characteristics are in qualitative agreement with the predictions of this model. However, for shallow channels (10 μm), trapping of the particles on both sides of the constrictions is also observed. This particle and fluid behavior could play a major role in iDEP and could be easily misinterpreted as a dielectrophoretic force.

Dynamical aspects of a bouncing ball in a nonhomogeneous field.

We study some dynamical properties of a charged particle that moves in a nonhomogeneous electric field and collides against an oscillating platform. Depending on the values of parameters, the system presents (i) predominantly regular dynamics or (ii) structures of chaotic behavior in phase space conditioned to the initial conditions. The localization of the fixed points and their stability are carefully discussed. Average properties of the chaotic sea are investigated under a scaling approach. We show that the system belongs to the same universality class as the Fermi-Ulam model.

Computational analysis of gas breakdown modes in direct current micro-plasmas at elevated pressures

Direct current micro-plasmas in the non-homogeneous electric field are analyzed over a wide pressure range using the self-consistent two-dimensional axisymmetric fluid model. We observe that the breakdown voltage is not the unique function of Pd, where P is the gas pressure and d is the interelectrode spacing, but also depends on the aspect ratio d/r, where r is the anode radius. This result agrees with the data reported in the literature. For fixed d, we find two modes of ionization wave propagation on the right branch of the breakdown curve: an axial streamer mode that is obtained at low pressures and a hollow streamer mode obtained at high pressures. By varying the ballast resistance connected to the anode, we analyze the steady-state parameters of the micro-discharge for the cathode–anode gap of 200 μm. We obtain normal and sub-normal glow modes of the micro-discharge operation. The instability of the latter mode is analyzed.

Dipolophoresis and Travelling-Wave Dipolophoresis of Metal Microparticles.

We study theoretically and numerically the electrokinetic behavior of metal microparticles immersed in aqueous electrolytes. We consider small particles subjected to non-homogeneous ac electric fields and we describe their motion as arising from the combination of electrical forces (dielectrophoresis) and the electroosmotic flows on the particle surface (induced-charge electrophoresis). The net particle motion is known as dipolophoresis. We also study the particle motion induced by travelling electric fields. We find analytical expressions for the dielectrophoresis and induced-charge electrophoresis of metal spheres and we compare them with numerical solutions. This validates our numerical method, which we also use to study the dipolophoresis of metal cylinders.

P11.25 Assessing electrical properties of cells as predictive marker for patient-specific TTFields response and optimal frequency

Abstract BACKGROUND Tumor treating fields (TTFields) are currently approved for the treatment of glioblastoma multiforme (GBM, using 200 kHz), and being tested in other tumor types such as non-small cell lung cancer and brain metastases occurring in this indication (LUNAR and METIS trials, using 150 kHz). Response to TTFields in cancer cells was empirically shown to be frequency-dependent specific for cell type; however, there are no markers available predicting optimal frequency or response in different cancer types or individual patients to date. There is evidence indicating electrical properties determine the optimal anti-mitotic frequency. This study analyzed the correlation of electrical properties of cells with their optimal TTFields frequency and sensitivity using the 3DEP reader (LabTech) to determine the electrical properties with the help of Dielectrophoresis (DEP) force. With this technique, cell movements within electric fields of different frequencies can by analyzed based on the physical effect of DEP, exercising a force on polarizable particles inside a non-homogeneous electric field. MATERIAL AND METHODS We used the 3DEP reader to obtain baseline properties (permittivity and conductivity) of 17 different cell lines of several tumor types. The resulting curves were analyzed by a 2-way ANOVA. Additionally, we determined the optimal frequency for maximum cytotoxic effect for each cell line using the inovitroTM system and eventually compared with the detected electrical properties. RESULTS We found cell lines with an optimal TTFields frequency of 150 kHz (corresponding to cells with a membrane capacitance in the lower range of the observed 3DEP curves, n=9) to possess significantly different (p<0.001) electrical properties from cells with an optimal TTFields frequency of 200 kHz (n=8). According to the curve differences in the lower frequency range, the measure of membrane capacitance served as a good predictor for TTFields response. CONCLUSION This study showed a correlation of cell membrane capacitance and optimal TTFields frequency and response. Our results provide a substantial rationale for further studies investigating the predictive potential of electrical properties of tumor cells as a measure for the optimal frequency and sensitivity to TTFields in individual patients.

Abstract 2168: Testing the electrical properties of different cell lines using 3DEP reader and compare to TTFields response

Abstract Background: Tumor Treating Fields (TTFields) are an approved anti-neoplastic treatment modality delivered via application of low intensity, intermediate frequency, alternating electric fields. The electrical properties of cells (such as permittivity and conductivity) determine the optimal frequency of TTFields that incurs the highest reduction in cell counts. Currently, there are no predictive markers for determining TTFields response or the optimal frequency to be applied for individual patient. The goal of this study is to determine the correlation between electrical properties of cells and TTFields’s optimal frequency and sensitivity. The 3DEP reader (LabTech) determines the electrical properties of cells, including permittivity and conductivity, by using Dielectrophoresis (DEP) force. DEP is a physical effect that generates a force on polarizable particles experiencing a non-homogeneous electric field and can therefore be used as a technique to analyse the way cells move within electric fields at different frequencies. Methods: The baseline electrical properties (permittivity and conductivity) of 17 cell lines from different tumor types were determined using the 3DEP reader (LabTech). The curves were analyzed using 2-way ANOVA. The optimal TTFields frequency for each cell line was determined by testing the cytotoxic effect of TTFields at various frequencies using the inovitro system. The electrical properties of cells were compared with the optimal TTFields frequency and sensitivity of each cell line. Results: The results demonstrate significant differences (p<0.001) between the lower frequency range of the 3DEP curves that corresponds to membrane capacitance of cells with TTFields optimal frequency of 150kHz (9 cell lines) and cells with TTFields optimal frequency of 200kHz (8 cell lines). Membrane capacitance was also a good predictor for TTFields sensitivity based on the differences in the curves in the low frequency range. Conclusions: The results presented in this study demonstrate that cell membrane capacitance correlates with TTFields optimal frequency and sensitivity. Based on the above, there is a strong rational to further explore the potential of measuring the electrical properties of cells as a predictive marker to help determine which patient will respond better to TTFields and the optimal TTFields frequency to be applied for each patient. Citation Format: Moshe Giladi, Einav Zeevi, Karnit Gotlib, Cornelia Wenger, Ariel Naveh, Zeev Bomzon, Eilon D. Kirson, Uri Weinberg, Adrian Kinzel, Yoram Palti. Testing the electrical properties of different cell lines using 3DEP reader and compare to TTFields response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2168.

Wettability Manipulation by Interface-Localized Liquid Dielectrophoresis: Fundamentals and Applications.

Electric field-based smart wetting manipulation is one of the extensively used techniques in modern surface science and engineering, especially in microfluidics and optofluidics applications. Liquid dielectrophoresis (LDEP) is a technique involving the manipulation of dielectric liquid motion via the polarization effect using a non-homogeneous electric field. The LDEP technique was mainly dedicated to the actuation of dielectric and aqueous liquids in microfluidics systems. Recently, a new concept called dielectrowetting was demonstrated by which the wettability of a dielectric liquid droplet can be reversibly manipulated via a highly localized LDEP force at the three-phase contact line of the droplet. Although dielectrowetting is principally very different from electrowetting on dielectrics (EWOD), it has the capability to spread a dielectric droplet into a thin liquid film with the application of sufficiently high voltage, overcoming the contact-angle saturation encountered in EWOD. The strength of dielectrowetting depends on the ratio of the penetration depth of the electric field inside the dielectric liquid and the difference between the dielectric constants of the liquid and its ambient medium. Since the introduction of the dielectrowetting technique, significant progress in the field encompassing various real-life applications was demonstrated in recent decades. In this paper, we review and discuss the governing forces and basic principles of LDEP, the mechanism of interface localization of LDEP for dielectrowetting, related phenomenon, and their recent applications, with an outlook on the future research.

Development and simulations of Enhanced Lateral Drift Sensors

We present the concept of a new type of silicon tracking sensor called Enhanced Lateral Drift (ELAD) sensor. In ELAD sensors the spatial resolution of the impact position of ionising particles is improved by a dedicated charge sharing mechanism, which is achieved by a non-homogeneous electric field in the lateral direction in the sensor bulk. The non-homogeneous electric field is created by buried doping implants with a higher concentration with respect to the background concentration of the bulk. The resulting position-dependent charge sharing allows for an improved interpolation of the impact position. TCAD-based electric field simulations for 2D and 3D geometries as well as transient simulations with a traversing particle for the 2D geometry have been carried out. The electric field profiles have further been optimised for position resolution. The simulations show a strong dependence of the charge sharing mechanism on the buried implant concentration. Optimal values for the buried implant concentration allow for nearly linear charge sharing between two readout electrodes as a function of the impact position. Additionally, the foreseen production technique combining silicon epitaxy and ion beam implantation is outlined.

Self-assembly of a two-dimensional molecular layer in a nonhomogeneous electric field: Kinetic Monte Carlo simulations.

Behavior of mobile adsorbed species can be affected by the presence of a strong non-homogeneous electric field. Such a field exists in the proximity of a biased tip of the scanning tunneling microscope. Depending on the electronic properties of the adsorbate and the polarity of the electric field, self-assembly of ordered structures on the surface can be facilitated or prevented. We use a kinetic Monte Carlo model to investigate the effect of the electric field on the assembly of planar molecules on weakly interacting surfaces. Using phthalocyanine molecules as a model system, we study mechanisms behind the results of our previous experimental study of electric-field controlled switching of molecular arrays. The complex interplay between intermolecular and field-molecule interactions is illustrated by detailed phase diagrams at various surface coverages.

Uniform electric field enabled multi-needles electrospinning head based on trapezoid arrangement

The electrospinning electric field is the main factor responsible for the jet stretching force. Previous studies showed that nonhomogeneous electric field would affect the jets formed during the multi-needles electrospinning. Therefore, a multitude of methods were explored to optimize the electric field in multi-needles electrospinning, such as adjusting the supplied voltage on each needle, varying the space of the needles and spatial distribution of the needles. In this paper, three categories of needles distribution were explored for a homogeneous electric field and the design of a higher needles density of electrospinning head. The theoretical and experimental results showed that the homogeneous electric field formed with the trapezoidal head at 15mm distance while the others’ head required over 30mm. Hence, the trapezoidal arrangement is a better multi-needles distribution for electrospinning head, and has much more significance for high yield of electrospinning nanofibers.

Efficient Charge Collection in Coplanar-Grid Radiation Detectors

We have modeled laser-induced transient current waveforms in radiation coplanar grid detectors. Poisson's equation has been solved by finite element method and currents induced by photo-generated charge were obtained using Shockley-Ramo theorem. The spectral response on a radiation flux has been modeled by Monte-Carlo simulations. We show 10$\times$ improved spectral resolution of coplanar grid detector using differential signal sensing. We model the current waveform dependence on doping, depletion width, diffusion and detector shielding and their mutual dependence is discussed in terms of detector optimization. The numerical simulations are successfully compared to experimental data and further model simplifications are proposed. The space charge below electrodes and a non-homogeneous electric field on a coplanar grid anode are found to be the dominant contributions to laser-induced transient current waveforms.

Experimental observation of negative differential characteristic of corona discharge in ultraviolet spectrum

Corona discharge is a self-sustained discharge which appears at electrodes with a small radius curvature in gas insulation. An almost invisible glow occurs just above the inception voltage. Corona phenomenon is mainly used in electro-technological processes to obtain space charge for electrostatic precipitation, separation of different particles, electrostatic liquid or solid coating, neutralization of space charge, etc. All of these processes rely on a strong nonhomogeneous electric field generated by a point – plate electrode system. When the critical value of the applied voltage is reached, the ionization processes near the point electrode start and give rise to the current between two electrodes. If the pointed electrode is positive, it is possible to observe an anomaly of the current – voltage (I-U) characteristic for the point-plate space. It means that while the voltage is raising the current density decreases in a narrow voltage area (2–3 kV). The anomaly was technically named as negative differential conductivity (dI/dU < 0). Unstable current can have a negative influence on electro-technological processes. The anomaly was detected for different shapes and materials of the electrode as well as for various temperatures and distances between electrodes. An oxidation layer, which appears on the metal electrode, also influences the ionization processes near the pointed electrode and causes a decrease of a current. In this paper measuring of the discharge activity in a point – plate electrode system is presented. Ionization of gas atoms and molecules in a high electric field and the following recombination of electrons and positive ions in the corona region can give rise to high-energy photons which produce new electrons in the field of discharge. Corona discharges are detected by DayCor Corona camera which can register UV emission generated by corona in a day light. The experiment was conducted with various shapes of the pointed electrode and distances between the high voltage and the grounded electrode under applied direct voltage with positive and negative polarity.

Microfluidic Biochip for Studying Cellular Response to Non-homogeneous DC Electric Fields

Endogeneous electric fields affect a wide range of cellular functions as migration, wound healing and regeneration. Similar results were observed in the presence of external electric fields. Till date, the phenomenon of electrotaxis was studied only in homogeneous electric field environments. Here, we report on a microfluidic biochip that permits stimulation of cells with stationary, non-homogeneous electric fields, e.g. to simulate the electrical environment during repair processes such wound healing.

Microplasma mode transition and corresponding propagation characteristics controlled by manipulating electric field strength in a microchannel-cavity hybrid structure device

Plasma redistribution in a symmetric microchannel-cavity hybrid structure device has been investigated by modulating the applied electric field strength. The device array has been operated in 200 Torr of argon, driven by a 20 kHz bipolar waveform. With the existence of the intervening microchannel between microcavities, several stable modes of operation of the microplasma have been observed, including cavity mode, hybrid mode and channel mode. Transition between the modes occurs with modulation of the applied voltage from 800 to 1100 V. The characteristics of microplasma propagation in different modes are investigated and the propagation speed along diagonal direction of the device in cavity mode, hybrid and channel mode are calculated to be ~48, ~29 and ~32 km s−1, respectively. Nonhomogeneous electric field strength distribution and plasma interaction have been discussed to explain these experimental results. Emission intensity and propagation speed differences in the cavity mode between the polarities of the applied voltage are interpreted through spatially resolved measurements of the emission profile in a partial channel-cavity array.

Microfluidic measurement of cell motility in response to applied non-homogeneous DC electric fields

Abstract. Endogenous electric fields (EFs) play an important role in many biological processes. In order to gain an insight into these biological phenomena, externally applied electric fields are used to study cellular responses. In this work, we report the construction and fabrication of a direct current (DC)-electrically stimulated microfluidic biochip and its validation with murine photoreceptor-derived 661 W cells. The presented device has the particularity of offering a non-homogeneous EF environment that best resembles the endogenous electric fields in vitro. The fabrication process is relatively easy, namely by photolithography and soft lithography techniques and, furthermore, it enables live-cell imaging under an inverted microscope. First experimental results reveal cathodal directional cell migration upon applied DC EFs. In summary, the microfluidic biochip has proven biocompatibility and suitability for cellular electrotaxis experiments in non-homogeneous DC electric fields.

Point-to-Plane Nonhomogeneous Electric-Field-Induced Simultaneous Formation of Giant Unilamellar Vesicles (GUVs) and Lipid Tubes.

It is well-known that homogeneous electric fields can be used to generate giant unilamellar vesicles (GUVs). Herein we report an interesting phenomenon of formation of GUVs and lipid tubes simultaneously using a nonhomogeneous electric field generated by point-to-plane electrodes. The underlying mechanism was analyzed using finite element analysis. The two forces play main roles, that is, the pulling force (F) to drag GUVs into lipid tubes induced by fluid flow, and the critical force (Fc) to prevent GUVs from deforming into lipid tubes induced by electric fields. In the center area underneath the needle electrode, the GUVs were found because F is less than Fc in that region, whereas in the edge area the lipid tubes were obtained because F is larger than Fc. The diffusion coefficient of lipid in the tubes was found to be 4.45 μm(2) s(-1) using a fluorescence recovery after photobleaching (FRAP) technique. The method demonstrated here is superior to conventional GUV or lipid tube fabrication methods, and has great potential in cell mimic or hollow material fabrication using GUVs and tubes as templates.