Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, the Third Xiangya Hospital, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China; Department of Stomatology, the Second Xiangya Hospital, Central South University, Changsha 410011, China; Department of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China; Key Laboratory of Information System Engineering, National University of Defense Technology, Changsha 410073, China; Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA