Abstract
Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, the Third Xiangya Hospital, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China; Department of Stomatology, the Second Xiangya Hospital, Central South University, Changsha 410011, China; Department of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China; Key Laboratory of Information System Engineering, National University of Defense Technology, Changsha 410073, China; Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA
Highlights
Long non-coding RNAs are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1,2,3,4]
Accumulating evidence supports that Long non-coding RNAs (lncRNAs) participate in many physiological processes by modulating gene expression at the epigenetic, transcriptional and posttranscriptional levels
LncRNAs depends on the relative position and sequence features of the lncRNA and the target gene to regulate gene expression
Summary
Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1,2,3,4]. Accumulating evidence supports that lncRNAs participate in many physiological processes by modulating gene expression at the epigenetic, transcriptional and posttranscriptional levels. LncRNAs regulate gene expression at the epigenetic level through DNA methylation or demethyl-
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