To investigate the effect of mesoporous media as electrodes for the observation of a noncatalytic Faradaic current of redox proteins adsorbed on an electrode (i.e., redox peaks in adsorption voltammetry), we propose a simulation model with randomly oriented redox proteins to obtain adsorption voltammograms. Furthermore, we compare the simulated currents of redox proteins adsorbed on planar and mesoporous electrodes. In this model, a redox protein is postulated as a sphere with the active site located at a certain distance from the center of the protein. For a mesoporous electrode, a spherical pore with a radius of Rp is assumed. When Rp is close to the radius of the protein, a redox peak is obtained even when the active site is located at a great distance from the protein surface; however, the peak is not observed for a planar electrode. This is ascribed to an increase in the number of proteins with orientations suitable for electron transfer because of the curvature effect of the pore. This work indicate...