The labyrinth control valve has been widely used in the secondary circuit flow regulation system of nuclear power field for good pressure reduction and cavitation suppression characteristics. The design of the labyrinth channel is a key to realizing pressure regulation and cavitation suppression for the labyrinth control valve. However, an unreasonable labyrinth flow channel design will be challenging to meet the requirements and aggravate the noise problem under severe operating conditions. This paper proposes a hybrid labyrinth flow channel structure (HLS) that combines the traditional labyrinth flow channel (TLS) and orifice plate structure. The cavitation volume and maximum flow velocity are used as evaluation parameters of the labyrinth flow channel noise. The flow characteristics analysis show that compared with the TLS, the HLS can reduce flow velocity, decrease cavitation volume, improve transmission loss, and lower sound power levels. In addition, the influence between the HLS structural parameters and the noise evaluation parameters is clarified by correlation coefficient analysis. A low noise HLS based on the adaptive NSGA-II algorithm is established. The experimental results indicate that the optimized HLS reduces air noise by 4.21 dB(A) compared to the TLS. The optimized HLS can effectively reduce noise, and help the design of low noise labyrinth flow channels for nuclear power field.