Taking a residential district in Foshan along the city road as an example, the impact of urban road traffic noise on it is studied. Firstly, the data is monitored in the noise field, then three-dimensional simulation models of residential buildings and road distribution are established in Cadna/A software, and noise simulation prediction is carried out according to the actual situation and relevant norms and standards. The predicted noise values of the exterior surface of residential buildings are obtained, which has exceeded the permissible interior noise level for residential buildings. By comparing the application effects of noise reduction measures in buildings, the noise reduction design scheme of new residential buildings along urban roads is finally proposed: the sound insulation doors and windows that meet the requirements are adopted. After the completion of the house, the indoor background noise and the sound insulation performance of the doors and windows are measured. The measured results show that the selection of sound insulation doors and windows is suitable and the indoor noise environment meets the design requirements of noise reduction. The results are helpful to provide technical reference for the noise reduction design and renovation of other residential buildings along urban roads.