The structural noise inside the vehicle cabin is mainly low-frequency vibration, which is closely related to the modal characteristics of the vehicle frame. The finite element method was used to simulate and calculate the body frame under free modal conditions, and the first four effective modal shapes were obtained. The calculation error of the natural frequencies was verified through modal experiments. Taking structural stiffness into account, a sound-structure coupled model was established. The suspension connection point was selected as the excitation point, and a one-way dynamic load was applied to obtain the noise and vibration responses of the front and rear rows. Based on the modal analysis results, the top-roof reinforcement scheme was adopted to verify the noise suppression effect of the structure. The results show that the optimized structure can effectively suppress structural noise, which plays an important role in improving the NVH characteristics.