No-go Stimuli Research Articles

Effect of Age in Auditory Go/No-Go Tasks: A Magnetoencephalographic Study.

Response inhibition is frequently examined using visual go/no-go tasks. Recently, the auditory go/no-go paradigm has been also applied to several clinical and aging populations. However, age-related changes in the neural underpinnings of auditory go/no-go tasks are yet to be elucidated. We used magnetoencephalography combined with distributed source imaging methods to examine age-associated changes in neural responses to auditory no-go stimuli. Additionally, we compared the performance of high- and low-performing older adults to explore differences in cortical activation. Behavioral performance in terms of response inhibition was similar in younger and older adult groups. Relative to the younger adults, the older adults exhibited reduced cortical activation in the superior and middle temporal gyrus. However, we did not find any significant differences in cortical activation between the high- and low-performing older adults. Our results therefore support the hypothesis that inhibition is reduced during aging. The variation in cognitive performance among older adults confirms the need for further study on the underlying mechanisms of inhibition.

Trait impulsivity and callous‐unemotional traits as predictors of inhibitory control and risky choices among high‐risk adolescents

Trait impulsivity and callous-unemotional traits are associated with behavioural problems among high-risk adolescents. While both are known to influence behaviour, the nature of their expression in high-risk behaviours, particularly those related to inhibitory control, is not well understood. In the current, preliminary study, we examined whether and how these traits predicted deficits in behaviour driven by bottom-up, automatic versus deliberate, top-down inhibitory processes among high-risk adolescents. Two go/no-go task variants, emotional and non-emotional, were used to assess reactive response inhibition, and the Balloon Analogue Risk Task was used to assess the ability to resist deliberate risky choices. The results showed that the two types of self-reported trait measures were differentially associated with performance on the two types of behavioural inhibition tasks. Trait impulsivity predicted non-emotional inhibitory control whereas callous-unemotional traits predicted risky choices. The results also showed that the emotions task elicited slower reaction times and higher false alarm rates than did the letters task, and that participants had greater difficulty inhibiting responses to negatively than to positively valenced no-go stimuli. While preliminary, the results suggest that the interplay between trait impulsivity and callous-unemotional traits is an important determinant of inhibitory behaviour in this high-risk adolescents.

Accurate response selection and inhibition in healthy aging: An event-related potential study.

Inhibitory control is thought to be critical for appropriate response selection in an ever-changing environment and to decline with age. However, experimental paradigms (e.g., go/no-go) confound stimulus frequency with demands to respond or inhibit responding. The present study eliminated that confound by using a modified go/no-go task controlling for stimulus frequency differences (using frequent-go, infrequent-go, and infrequent no-go types of stimuli) in healthy older and young adults. Event-related potential (ERP) components related to detection of response conflict (N2) and response evaluation (P3) were also examined. Behaviorally, older and young adults were sensitive to stimulus frequencies indicated by significant slowing for the infrequent-go compared with the frequent-go stimuli observed in both groups. Furthermore, older adults were characterized by reduced commission errors and overall slowing, suggesting that they could take advantage of their slower performance. Increase of N2 amplitude was evident for correctly inhibited no-go stimuli in both groups. In contrast, no-go stimulus-related increase in P3 amplitude could be observed only in the young. Stimulus frequency-related ERP amplitude differences were not significant either in the young or in the older adults. These results suggest preserved behavioral control over inappropriate responses in older adults and indicate that efficient response inhibition is related to compensatory mechanisms. The age-related decrease in the P3 amplitude suggests that the evaluation of response inhibition (a) could be independent of the detection of response conflict and (b) supports the notion of strategic differences in performance with age. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Response Activation and Inhibition in Patients With Prolactinomas: An Electrophysiological Study.

Impairment of executive function has been reported in patients with prolactinomas. However, few studies have investigated the electrophysiological mechanisms of response activation and response inhibition in these patients. In this study, we employ an event-related potentials (ERPs) technique to quantitatively assess response activation and inhibition before and after the surgical treatment of prolactinomas. A 64-electrode electroencephalogram (EEG) skullcap was used to record the brain activity in 20 pre-operative patients, 20 follow-up post-operative patients, and 20 healthy controls (HCs) while performing the visual Go/Nogo task. As expected, we identified P300 across all study populations that could reflect response activation and inhibition. Across the three groups, the Nogo stimuli evoked larger frontal-central P300 than the Go stimuli did. In contrast, the Go trials elicited larger parietal P300 than the Nogo trials did. The peak latency of P300 was significantly delayed in both the pre-operative and the post-operative groups compared to the HCs. The amplitude of P300 in both the Go and the Nogo conditions was significantly decreased in the pre-operative patients compared with that of the HCs. At 6 months post-operatively, the prolactinoma patients showed an increase in amplitude of P300 during both the Go and the Nogo tasks. These findings indicate that the prolactinoma patients suffer from deficits in response activation and inhibition, which could be improved by surgical treatment.

Lateral Prefrontal Theta Oscillations Reflect Proactive Cognitive Control Impairment in Males With Attention Deficit Hyperactivity Disorder.

Attention Deficit Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder in which children present prefrontal cortex (PFC) related functions deficit. Proactive cognitive control is a process that anticipates the requirement of cognitive control and crucially depends on the maturity of the PFC. Since this process is important to ADHD symptomatology, we here test the hypothesis that children with ADHD have proactive cognitive control impairments and that these impairments are reflected in the PFC oscillatory activity. We recorded EEG signals from 29 male children with ADHD and 25 typically developing (TD) male children while they performed a Go-Nogo task, where the likelihood of a Nogo stimulus increased while a sequence of consecutive Go stimuli elapsed. TD children showed proactive cognitive control by increasing their reaction time (RT) concerning the number of preceding Go stimuli, whereas children with ADHD did not. This adaptation was related to modulations in both P3a potential and lateral prefrontal theta oscillation for TD children. Children with ADHD as a group did not demonstrate either P3a or theta modulation. But, individual variation in theta activity was correlated with the ADHD symptomatology. The results depict a neurobiological mechanism of proactive cognitive control impairments in children with ADHD.

Disentangling stimulus and response compatibility as potential sources of backward crosstalk

In two experiments (N= 60 each), we investigated the locus of backward crosstalk effects in dual tasking. Specifically, we embedded the typical flanker task within a dual-task paradigm by assigning stimulus-response (S-R) rules to the flankers. In Experiment 1, participants were instructed to first respond to the center letter and only respond to the flanker if the center was a no-go stimulus (i.e., prioritized processing paradigm). Mapping condition was varied between-subjects to be either matched (i.e., same S-R rule for flankers as for center letters), reversed (i.e., opposite S-R rule for flankers), or neutral (i.e., different letters for flankers with separate S-R rules). The results indicated that the backward crosstalk effect was mainly driven by a stimulus-based compatibility, as indicated by a significant S2−R1 compatibility effect in the matched and reversed conditions, with little change in this effect between the matched and reversed conditions. Experiment 2 replicated and extended these findings to a psychological refractory period paradigm. The present findings suggest that in the matched and reversed conditions, there was only one S-R rule active at a time.

Orbitofrontal control of visual cortex gain promotes visual associative learning

The orbitofrontal cortex (OFC) encodes expected outcomes and plays a critical role in flexible, outcome-guided behavior. The OFC projects to primary visual cortex (V1), yet the function of this top-down projection is unclear. We find that optogenetic activation of OFC projection to V1 reduces the amplitude of V1 visual responses via the recruitment of local somatostatin-expressing (SST) interneurons. Using mice performing a Go/No-Go visual task, we show that the OFC projection to V1 mediates the outcome-expectancy modulation of V1 responses to the reward-irrelevant No-Go stimulus. Furthermore, V1-projecting OFC neurons reduce firing during expectation of reward. In addition, chronic optogenetic inactivation of OFC projection to V1 impairs, whereas chronic activation of SST interneurons in V1 improves the learning of Go/No-Go visual task, without affecting the immediate performance. Thus, OFC top-down projection to V1 is crucial to drive visual associative learning by modulating the response gain of V1 neurons to non-relevant stimulus.

A Longitudinal, Prospective Study to Evaluate the Effects of Treatment on the Inhibitory Control Function After Transsphenoidal Surgery for Pituitary Adenomas.

Injured cognitive abilities have been reported in patients with pituitary adenoma. However, to date, few researchers have directly investigated the electrophysiological study of inhibitory control function of pituitary patients both pre- and postsurgery. Thus, this study aimed to identify the factors affecting the inhibitory control function of pituitary patients. Thirty presurgery pituitary patients were recruited and 26 patients of them completed the postsurgery follow-up. Thirty healthy people were recruited for control group. Visual Go/Nogo tasks were carried out by the patients and controls to assess the inhibitory control function before surgery and 6 months after the surgery, respectively. The function of inhibitory control was analyzed with the components of N2 and P3. Across 3 groups, Nogo stimuli evoked larger frontal-central N2nogo and P3nogo than Go stimuli did. Furthermore, N2d of presurgery patients (-1.14 μV) and postsurgery patients(-0.61 μV) were significantly decreased compared with that of control group (-3.09 μV), F(2, 83) = 13.92, P < .01, whereas no difference was detected between pre- and postsurgery groups. There was no remarkable difference in the amplitude of P3d among the 3 groups, F(2, 83) = 0.19, P > .05. With regard to the amplitude of P3 for Go condition, The P3 amplitude of healthy group (4.38 μV) was larger than both pre- and postsurgery (1.00 μV and 3.01 μV). With regard to the amplitude of P3 for Nogo condition, The P3 amplitude of healthy group (5.25 μV) was larger than both pre- and postsurgery groups (2.35 μV and 4.18 μV). These results indicated that presurgery patients showed the dysfunction of inhibition, due to the nerve tissue damage or brain structure alteration caused by the presurgery physical pressure from tumor and abnormal hormone levels. Postsurgery patients showed a tendency toward recovery, but there was no obvious improvement in the inhibitory control function after successful treatments.

Reduced Nogo-P3 in adults with developmental coordination disorder (DCD)

Nogo-N2 is associated with the premotor cognitive process that precedes motor response (e.g., conflict monitoring), whereas Nogo-P3 is related to the inhibition of the actual motor response. We examined the influence of motor clumsiness of developmental coordination disorder (DCD) on components of the event-related potential in a Go/Nogo task. Participants were healthy adults (N = 81) that were classified into control and DCD groups based on the Movement Assessment Battery for Children Second Edition. We manipulated the difficulty in stopping a response by varying the frequency of Nogo stimuli in a response task into rare (20%) and frequent (80%) conditions, and Nogo-N2 and Nogo-P3 were calculated from electroencephalograms (EEGs) during the Go/Nogo tasks. The commission error rate in the rare condition was significantly higher in the DCD group than in the control group, indicating that motor clumsiness decreases task performance. There were no differences in Nogo-N2 between DCD and control groups. However, Nogo-P3 in the rare condition was reduced in the DCD group compared to the control group. These results suggest that the influence of motor clumsiness is limited to the cognitive process after the initiation of the actual motor response.

Differences in effects of task repetition in three modalities Go/No‐go paradigams.

Previous studies suggested that learning, habituation, mental fatigue, or reduced motivation due to task repetition (time‐on‐task) decreased the peak amplitude and/or latency of components of event‐related potentials (ERPs), but the mechanism remains unclear. Also, the effect of the sensory modality on those changes has not been clarified. The difference in modality could modify cerebral blood flow or its distribution in the brain. We hypothesized that the effect of task repetition on ERPs was related to the sensory modality, and the changes in cerebral blood flow contributed to the difference. Subjects performed 6 sessions of Go/No‐go paradigms for 5 minutes with visual, auditory, and somatosensory stimuli on different days, and were allowed to rest for 5 minutes between sessions. In addition to electroencephalography, middle cerebral artery blood mean velocity and finger arterial pressure were continuously measured to evaluate dynamic cerebral autoregulation via transfer function analysis. The amplitude of P300 decreased with the time‐on‐task in all three modalities, and the latency of P300 delayed with the time‐ontask only with somatosensory stimuli. The reductions in amplitude were the greatest with the visual stimuli among the three modalities. The reductions in the amplitude of P300 were greater with No‐go stimuli than Go stimuli across the three modalities. Contrary to our hypothesis, dynamic cerebral autoregulation did not change throughout the trials. These results suggest that the effects of task repetition on ERPs were sensory modality‐dependent, while dynamic cerebral autoregulation during cognitive tasks might not contribute to changes in ERPs.Support or Funding InformationJapan Society for the Promotion of Science 18H03166

Interplay between components of pupil-linked phasic arousal and its role in driving behavioral choice in Go/No-Go perceptual decision-making.

In decision-making tasks, neural circuits involved in different aspects of information processing may activate the central arousal system, likely through their interconnection with brainstem arousal nuclei, collectively contributing to the observed pupil-linked phasic arousal. However, the individual components of the phasic arousal associated with different elements of information processing and their effects on behavior remain little known. In this study, we used machine learning techniques to decompose pupil-linked phasic arousal evoked by different components of information processing in rats performing a Go/No-Go perceptual decision-making task. We found that phasic arousal evoked by stimulus encoding was larger for the Go stimulus than the No-Go stimulus. For each session, the separation between distributions of phasic arousal evoked by the Go and by the No-Go stimulus was predictive of perceptual performance. The separation between distributions of decision-formation-evoked arousal on correct and incorrect trials was correlated with decision criterion but not perceptual performance. When a Go stimulus was presented, the action of go was primarily determined by the phasic arousal evoked by stimulus encoding. On the contrary, when a No-Go stimulus was presented, the action of go was determined by phasic arousal elicited by both stimulus encoding and decision formation. Drift diffusion modeling revealed that the four model parameters were better accounted for when phasic arousal elicited by both stimulus encoding and decision formation was considered. These results suggest that the interplay between phasic arousal evoked by both stimulus encoding and decision formation has important functional consequences on forming behavioral choice in perceptual decision-making.

Dynamics and Hierarchical Encoding of Non-compact Acoustic Categories in Auditory and Frontal Cortex.

Categorical perception is a fundamental cognitive function enabling animals to flexibly assign sounds into behaviorally relevant categories. This study investigates the nature of acoustic category representations, their emergence in an ascending series of ferret auditory and frontal cortical fields, and the dynamics of this representation during passive listening to task-relevant stimuli and during active retrieval from memory while engaging in learned categorization tasks. Ferrets were trained on two auditory Go-NoGo categorization tasks to discriminate two non-compact sound categories (composed of tones or amplitude-modulated noise). Neuronal responses became progressively more categorical in higher cortical fields, especially during task performance. The dynamics of the categorical responses exhibited a cascading top-down modulation pattern that began earliest in the frontal cortex and subsequently flowed downstream to the secondary auditory cortex, followed by the primary auditory cortex. In a subpopulation of neurons, categorical responses persisted even during the passive listening condition, demonstrating memory for task categories and their enhanced categorical boundaries.

The Reaction Switching Produces A Greater Bias to Prepotent Response than Reaction Inhibition.

There is a discussion about common or various mechanisms of response inhibition and response switching. To understand these mechanisms, we used a modified Go/NoGo task with three stimulus categories. The subjects were instructed to press a button in response to frequent Go stimuli, press another button in response to rare Go stimuli and hold any motor response following the presentation of NoGo stimuli. The results showed a decrease in reaction time for frequent Go, following both categories of rare stimuli and the decrease was greater following rare Go. Also, the total number of errors did not differ between Go and NoGo, however, a greater bias of error rate towards frequent Go stimuli was found for rare Go compared to NoGo. Finally, positive correlations were found between the increase in reaction time for rare Go compared to frequent Go and the number of errors for both rare Go and rare NoGo. Together, these results indicate that both rare Go and NoGo stimuli required to inhibit the prepotent response, but rare Go in comparison to NoGo stimuli also evoked a conflict between prepotent and alternative responses, which is expressed in greater response bias toward frequent Go.

Can the Lateralized Readiness Potential Detect Suppressed Manual Responses to Pure Tones?

Willfully not responding to auditory stimuli hampers accurate behavioral measurements. An objective measure of covert manual suppression recorded during response tasks may be useful to assess the veracity of responses to stimuli. To investigate whether the lateralized readiness potential (LRP), an electrophysiological measure of corticomotor response and suppression, may be of use in determining when participants hear but do not respond to pure tones. Within-subject repeated measures with a Go-NoGo paradigm. Five males and five females (mean age = 38.8 years, standard deviation = 8.8) underwent electrophysiology testing. All had normal hearing, except one. Participants were tested in a condition where they consistently responded to tonal stimuli, and in a condition where intensity cued whether they should respond or not. Scalp-recorded cortical potentials and behavioral responses were recorded, along with a question that probed the perceived effort required to suppress responses to the stimuli. Electrophysiology data were processed with independent component analysis and epoch-based artifact rejection. Averaged group and individual LRPs were calculated. Group averaged waveforms show that suppressed responses, cued by NoGo stimuli, diverge positively at approximately 300 msec poststimulus, when compared with performed (Go) responses. LRPs were comparable when Go responses were recorded in a separate condition in which participants responded to all stimuli, and when Go and NoGo trials were included in the same condition. The LRP was not observed in one participant. Subsequent to further investigation, the LRP may prove suitable in assessing the suppression of responses to audiometric stimuli, and, thereby, useful in cases where functional hearing loss is suspected.

Task Co-Representation in Aging: An Event-Related Potential Study

The goal of the present study was to investigate age-related changes in attentional allocation for shared task representations during joint performance; event-related potentials were recorded while participants performed a modified visual three-stimulus oddball task, both alone and together with another participant. Younger adults and older adults (14 each) participated in the study. Participants were required to identify rare target stimuli while ignoring frequent standards, as well as rare non-targets assigned to a partner’s action (i.e., no-go stimuli for one’s own task). ERP component, nogo-P3 and P3b were measured to investigate the inhibition and the attentional allocation to the partner’s stimuli. Results showed that younger adults elicited larger frontal nogo P3 and parietal P3b for non-targets in the joint than in the individual condition. Contrary to expectation, older adults induced frontal no-go P3 in the joint condition not in the individual condition. In the sharing of the task with another, the result suggested that the efficiency of matching of incoming information with the representation of the other’s task declined with age, whereas aging did not affect the suppression of incorrect preparation of motor responses instigated by this representation.

Electrophysiological Correlates of an Alcohol-Cued Go/NoGo Task: A Dual-Process Approach to Binge Drinking in University Students.

Binge drinking is a common pattern of alcohol consumption in adolescence and youth. Neurocognitive dual-process models attribute substance use disorders and risk behaviours during adolescence to an imbalance between an overactivated affective-automatic system (involved in motivational and affective processing) and a reflective system (involved in cognitive inhibitory control). The aim of the present study was to investigate at the electrophysiological level the degree to which the motivational value of alcohol-related stimuli modulates the inhibition of a prepotent response in binge drinkers. First-year university students (n = 151, 54 % females) classified as binge drinkers (n = 71, ≥6 binge drinking episodes, defined as 5/7 standard drinks per occasion in the last 180 days) and controls (n = 80, <6 binge drinking episodes in the last 180 days) performed a beverage Go/NoGo task (pictures of alcoholic and nonalcoholic drinks were presented according to the condition as Go or NoGo stimuli; Go probability = 0.75) during event-related potential recording. In binge drinkers but not controls, the amplitude of the anterior N2-NoGo was larger in response to nonalcohol than in response to alcohol pictures. No behavioural difference in task performance was observed. In terms of dual-process models, binge drinkers may require increased activation to monitor conflict in order to compensate for overactivation of the affective-automatic system caused by alcohol-related bias.

Stimulus Reward Value Interacts with Training-induced Plasticity in Inhibitory Control

Training inhibitory control, the ability to suppress motor or cognitive processes, not only enhances inhibition processes, but also reduces the perceived value and behaviors toward the stimuli associated with the inhibition goals during the practice. While these findings suggest that inhibitory control training interacts with the aversive and reward systems, the underlying spatio-temporal brain mechanisms remain unclear. We used electrical neuroimaging analyses of event-related potentials to examine the plastic brain modulations induced by training healthy participants to inhibit their responses to rewarding (pleasant chocolate) versus aversive food pictures (unpleasant vegetables) with Go/NoGo tasks. Behaviorally, the training resulted in a larger improvement in the aversive than in the rewarding NoGo stimuli condition, suggesting that reward responses impede inhibitory control learning. The electrophysiological results also revealed an interaction between reward responses and inhibitory control plasticity: we observed different effects of practice on the rewarding vs. aversive NoGo stimuli at 200 ms post-stimulus onset, when the conflicts between automatic response tendency and task demands for response inhibition are processed. Electrical source analyses revealed that this effect was driven by an increase in right orbito-cingulate and a decrease in temporo-parietal activity to the rewarding NoGo stimuli and the reverse pattern to the aversive stimuli. Our collective results provide direct neurophysiological evidence for interactions between stimulus reward value and executive control training, and suggest that changes in the assessment of stimuli with repeated motoric inhibition likely follow from associative learning and behavior-stimulus conflicts reduction mechanisms.

Using a Dance Mat to Assess Inhibitory Control of Foot in Young Children.

The development of motor response inhibition is critical during preschool years and has been associated with an improvement in gross motor coordination in this population. However, the assessment of inhibitory abilities in young children is challenging in terms of task selection and subject engagement, especially when investigating foot responses. Thus, the aim of this study was to describe a child-friendly Go/No-go paradigm to assess inhibitory control of foot based on a dance mat protocol. In this method, Go and No-go stimuli are modeled in the context of a fishing game, and behavioral responses are assessed by recording the latency to touch the mat and the accuracy of the touches. In this protocol article, we (1) describe the stages of the experimental set-up, (2) provide an illustrative data collection example in a sample of children aged 3–4 years, and (3) describe how to process the data generated. The utilization of the dance mat provides a feasible tool for researchers interested in studying the development of motor inhibitory control of foot in preschoolers. Potential applications of this protocol may include studies on developmental differences between hand and foot specialization, sports-related performance and neuroimaging.

Associative learning of response inhibition affects perceived duration in a subsequent temporal bisection task

Interval timing, the ability to discern the duration of an event, is integral to appropriately navigating the world, from crossing the road to catching a ball. Several features of an event can affect its perceived duration, for example it has previously been shown that a large stimulus is perceived to last longer than a small stimulus. In the current article, participants performed either a Go/No-Go or variable foreperiod task prior to performing a temporal bisection task. In both the Go/No-Go and variable foreperiod tasks, participants learned an association between a particular response and a particular stimulus. Subsequently, the perceived duration of these stimuli was tested in a temporal bisection task. Our findings indicated that associating a stimulus with response inhibition (i.e. a No-Go stimulus) decreased perceived duration compared to a stimulus associated with a response (a Go stimulus). Associating a stimulus with either a short or long foreperiod, on the other hand, did not affect perceived duration. We relate this finding back to the coding efficiency theory and the processing principle. A No-Go stimulus requires more cognitive processing than a Go stimulus and would thus be predicted to increase, rather than decrease, perceived duration in both these time perception theories. Finally, we suggest how our findings might be used in future investigations of interval timing.

Latent Components of Event-Related Potentials in a Visual Cued Go/NoGo Task

Parallel factor analysis was tested for potential to separate the hidden functionally different components of event-related potentials (ERPs) in a visual cued Go/NoGo task. ERPs were recorded in 351 healthy subjects aged 18–55 years. In the parallel factor analysis model, different components were found to describe a number of well-known ERP waves associated with conflict detection, switching, decision making, and other processes. Based on the waveform analysis of the components, a working hypothesis was proposed to describe the sequence that the processes take to occur in the brain when Go and NoGo stimuli are presented in a Go/NoGo task. Parallel factor analysis thus proved to provide an efficient tool and to allow another viewpoint on brain processes as compared with conventional methods of ERP studies.