Cell lysis is a crucial process for the detection of intracellular secrets, which is important in various areas, such as biochemical detection, biomechanical analysis and biophysics. Typically, the acoustic method induced cell lysis relies on acoustic cavitation, which requires high acoustic power and may damage the important cell contents, such as DNA, RNA, and mRNA. We introduce herein an efficient microfluidic cell lysis approach based on nanowires collision induced by acoustic streaming using surface acoustic wave in a gentle and controllable manner. The magnetic Ag-nanowires were introduced to the cell suspension, and rotational acoustic streaming induced strong drag and the shear stress result in the collision between the cells and nanowires, leading to the cell lysis. The maximum velocity of the streaming could reach 3 mm/s Cell-lysis was obtained between 10 s, and more than 97 % lysis efficiency was achieved at just 1 W power. The experimental results show that this method has the advantage of high efficiency, very low consumption of power, ultrafast, reusability and tiny sample consumption, also Ni coated Ag-Nanowires provide reusability and highly applicable in point of care diagnostics.