AbstractLittle is known about nutrient fluxes and nutrient‐use efficiencies in urban and peri‐urban agriculture (UPA) of rapidly expanding cities in developing countries. Therefore, horizontal flows of carbon (C), nitrogen (N), phosphorus (P), and potassium (K) as well as leaching losses of mineral N and P were measured over 2 years in three representative agricultural production systems of Kabul. These comprised 21 gardens and 18 fields dedicated to vegetable farming, cereal farming, and table‐grape production (vineyards). Across sites (fields and gardens) biennial inputs averaged 375 kg N ha–1, 155 kg P ha–1, 145 kg K ha–1, and 15 kg C ha–1 while with harvests 305 kg N ha–1, 40 kg P ha–1, 330 kg K ha–1, and 7 kg C ha–1 were removed. In vegetable gardens, biennial net balances were 80 kg N ha–1, 75 kg P ha–1, –205 kg K ha–1, and 4 kg C ha–1, whereas in cereal farming biennial horizontal balances amounted to –155 kg N ha–1, 20 kg P ha–1, –355 kg K ha–1, and 5 kg C ha–1. In vineyards, corresponding values were 295 kg N ha–1, 235 kg P ha–1, 5 kg K ha–1, and 3 kg C ha–1. Annual leaching losses in two selected vegetable gardens varied from 70 to 205 kg N ha–1 and from 5 to 10 kg P ha–1. Night soil and irrigation water were the major sources among the applied nutrient inputs in all studied farming systems, contributing on average 12% and 25% to total N, 22% and 12% to total P, 41% and 53% to total K, and 79% and 10% to total C, respectively. The results suggest that soils in extensive cereal fields are at risk of N and K depletion and in vegetable gardens of K depletion, while vineyards may be oversupplied with nutrients possibly contributing to groundwater contamination. This merits verification.