The recent experimental observation of Light-by-Light (LbL) scattering at the Large Hadron Collider has revived interest in this fundamental process, and especially of the accurate prediction of its cross-section, which we present here for the first time at Next-to-Leading Order (NLO) in both QCD and QED. We compare two radically different computational approaches, both exact in the fermion mass dependence, thus offering a strong cross-check of our results. The first approach is a fully analytic method to calculate compact and well-organized two-loop helicity amplitudes. The second one is entirely numerical and leverages the Local Unitarity construction. Our two calculations agree with each other and conclude that including the exact fermion mass contribution typically increases the size of the NLO corrections. Moreover, we find that the exact result converges slowly to the massless limit of the high-energy regime, thus emphasizing the importance of including the full mass dependence at NLO. We also compare our results with the ATLAS measurement of LbL in ultra-peripheral lead-lead collisions, and find that the inclusion of exact NLO corrections reduces, but does not eliminate, the existing tension with theoretical predictions.
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