Next-generation Products Research Articles

Smart Medicine: The Role of Artificial Intelligence and Machine Learning in Next-Generation Healthcare Innovation

The paper focuses on big data and healthcare pharmaceuticals, which pose both great promise and challenge as they can contribute to well-being and deliver innovation and knowledge to next-generation healthcare products. This paper provides an overview of the benefits that machine learning and big data technology contribute to healthcare systems. Realities such as patient and healthcare professional demands, the number of diseases, insufficient drugs, regulations, legal and ethical guideline restrictions, modus operandi, and technology development take place in the healthcare sector. In addition, big data opportunities and challenges for healthcare companies, research, and healthcare infrastructure are discussed. Finally, a vision of health innovation through personalized medicines as well as smart medicine is presented as a step closer to patients through regulatory, legal, and ethical guidelines, applications, and opportunities that need to be regulated and resolved.

Association of Oral Tobacco-Free Nicotine Delivery Product with Acute Renal Tubular Necrosis

Usage of novel non-tobacco oral nicotine delivery products (ONDPs) has been increasing among adolescents in the United States. It is presumed that they are less toxic than their tobacco-containing counterparts, but that has not been examined in controlled studies. Most of the studies have focused on non-renal manifestations of tobacco consumption via different means. The renal manifestations of non-tobacco ONDPs are not very well known, especially in immunocompromised patients. A 19-year-old male transplant recipient presented with flank pain and a few days’ history of intake of ZYNR pouches. Immunosuppression was with tacrolimus, mycophenolate, and steroids. Baseline serum creatinine was 1.1–1.3 mg/dL. Laboratory evaluation showed elevated C-reactive protein, increased serum creatinine and blood urea nitrogen, leukocytosis, neutrophilia, and increased lactate dehydrogenase (LDH). Infectious disease work-up was negative. A kidney transplant biopsy showed severe acute tubular injury/necrosis (ATN) without evidence of rejection. Donor-specific antibodies were negative. Other etiologies of hemolysis were negative. He did not require renal replacement therapy. Kidney function and LDH improved gradually. The most recent follow-up eight months after presentation showed a serum creatinine level of 2.6 mg/dL with stable electrolytes, with eGFR of 35 mL/min/1.73 m2. Here, we describe a 19-year-old adolescent with a kidney transplant who sustained ATN leading to advanced chronic disease apparently following the usage of non-tobacco ONDP. Further larger studies are needed to study ATN as a possible renal manifestation of these next-generation products to raise awareness among the public.

From waste to wonder: Developing engineered nanomaterials for multifaceted applications

The escalating generation of industrial and consumer waste poses a significant environmental challenge, necessitating innovative approaches to waste management and resource utilization. One promising solution lies in the transformation of waste materials into engineered nanomaterials (ENMs), which hold immense potential for a diverse range of applications. This review explores the development of ENMs from waste, highlighting their multifaceted uses in environmental remediation, energy storage, medical applications, and advanced manufacturing. The process of converting waste into ENMs involves sophisticated techniques such as chemical vapour deposition, sol-gel synthesis, and hydrothermal methods, which enable the creation of materials with precise structural and functional properties at the nanoscale. By utilizing waste as a raw material, this approach not only addresses waste disposal issues but also provides a sustainable and cost-effective source of high-value nanomaterials. ENMs derived from waste exhibit unique properties, including high surface area, tunable porosity, and enhanced reactivity, making them suitable for environmental applications such as pollutant adsorption, water purification, and air filtration. In the energy sector, these nanomaterials contribute to the development of advanced batteries, supercapacitors, and fuel cells, enhancing energy storage and conversion efficiency. The biomedical field benefits from waste-derived ENMs through their application in drug delivery systems, diagnostic tools, and tissue engineering. The biocompatibility and functional versatility of these materials enable targeted therapeutic interventions and innovative medical solutions. Furthermore, in advanced manufacturing, ENMs improve the performance and durability of materials used in electronics, coatings, and composites, fostering the development of next-generation products with superior properties. The integration of waste-derived ENMs into various industries represents a paradigm shift towards a circular economy, where waste is not merely a byproduct but a valuable resource. This approach aligns with global sustainability goals, promoting resource efficiency, reducing environmental impact, and driving technological advancements. In conclusion, the development of engineered nanomaterials from waste exemplifies the transformative potential of nanotechnology in addressing critical environmental and industrial challenges. By harnessing waste as a resource, this innovative approach paves the way for multifaceted applications that contribute to environmental sustainability, technological progress, and economic growth. Further research and development in this field will continue to expand the possibilities and impact of waste-derived ENMs in various sectors.

Collaborative interface optimization strategy guided Fe3C/MnO-NC electrocatalysts for rechargeable flexible zinc-air batteries

The flexible zinc-air batteries characterized by heightened flexibility, durability, and high electrochemical performance have been recognized as the most promising candidates for the next-generation wearable electronic products. Herein, a novel Fe3C/MnO heterostructure coupled with nitrogen-doped carbon (Fe3C/MnO-NC) derived from metal-organic frameworks (MOFs) is innovatively designed as a highly active bifunctional electrocatalyst. The Fe3C/MnO heterostructure in Fe3C/MnO-NC can effectively regulate the electronic structure to optimize the free energy of the related intermediates in the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER), consequently improving the catalytic properties of liquid Zn-air battery with impressive power density and outstanding stability. The theoretical calculations reveal that the design of the heterogeneous Fe3C/MnO interface effectively tunes the electron distribution to optimize the adsorption energy of ORR/OER related intermediates and significantly promotes intrinsic ORR/OER activities. Notably, the flexible Zn-air battery was also assembled with the bifunctional Fe3C/MnO-NC electrocatalyst and the prepared polyacrylamide polyacrylic acid-glycerin composite gel polymer electrolyte (PAM-PAA-Gly GPE). The electrochemical results reveal that the constructed flexible Zn-air battery can achieve a remarkable open-circuit voltage of 1.50 V and sustain stable cycling for 48 h (288 cycles). This work not only sheds light on the effective utilization of Fe3C/MnO-NC catalysts but also highlights the potential of hydrogels in achieving high-performance wearable Zn-air batteries.

Low-permittivity BaCuSi4O10-based dielectric Ceramics: An available solution to connect low temperature cofired ceramic technology and millimeter-wave communications

Low temperature cofired ceramic (LTCC) technology can serve for next-generation millimeter-wave electronic products to bring the advantages of integration, miniaturization and excellent high-frequency performance. However, challenges such as the performance of LTCC powders, quality of green tapes and Ag co-firing compatibility still need to be addressed for the application of LTCC technology. In this work, a systematic investigation from powder modification, LTCC process to filter design were carried out based on novel BaCuSi4O10-based dielectric ceramics. Multiple effects in terms of suitable sintering temperature (840 ℃ suit for Ag co-firing), low-permittivity (εr ∼ 5.7) and good thermal stability (temperature coefficient of resonant frequency ∼ − 27 ppm/℃, thermal expansion coefficient ∼3.9 ppm/℃) were achieved by introducing Li-B-Si glass and LiF composite additive. The origin of dielectric response of this LTCC system were discussed using the FIR reflectivity spectrum and THz-TDS. After optimizing the tape casting process for the LTCC powder, green tapes with uniform thickness, smooth surface and no cracking were obtained. Furthermore, the bandpass and lowpass filters exhibited a high level of filtering performance own to excellent dielectric properties and low surface roughness of the LTCC. Consequently, the BaCuSi4O10-based dielectric ceramic is an attractive candidate as LTCC technology expands into millimeter-wave communications.

Novel rapid screening assay to incorporate complexity and increase throughput in early-stage plant biological testing

The search for new biological products with a positive impact on crop performance is typically initiated by laboratory based in vitro assays. However, live plants and their associated microbes are often removed from in vitro testing assays as a way to reduce biological complexity (variation) and facilitate molecular techniques in the pursuit of uncovering mode-of-action (MoA) mechanisms. Nevertheless, when studying biological candidates intended for use in agriculture, it is essential to incorporate this complexity and validate mechanisms under conditions as close to in situ as possible in order to understand the capacities and MoA of the biologicals in the intended application environments. To address this paradox, we have developed a high-capacity early-stage plant assay that incorporates a live non-sterile plant while also enabling molecular MoA investigations, and that can be conducted in laboratories without greenhouse facilities. The high-capacity design features plants grown in 8-chamber transparent boxes to allow for multiplex imaging and increased biological replicates for greater statistical power. The transparent box design allows the visualization of shoots, roots, tagged-microbes, or visible substrates, and further non-destructive access to shoots or roots for sampling. The boxes are held in racks that hold eight plant boxes during growth in a 19 by 17 cm space, further increasing the throughput to >670 plants per m2 and easing the logistical challenges of plant assays. Furthermore, the box can support various levels of microbial complexity with the option to select the plant growth medium that meets experimental objectives, as well as using sterile or non-sterile seeds. A script-based post-imaging quantification was developed to automate image processing and allow for individual plant readings, further enabling increased statistical confidence. As proof of concept, we use the high-capacity plant system to evaluate the biocontrol potential of Pseudomonas protegens and the biostimulation potential of Pseudomonas koreensis, and are in both cases able to show statistically significant differing plant biomass between treatments under these closer-to-nature conditions. We further demonstrate that the high-capacity plant system is suitable for paired molecular investigations by performing metabolomics and qPCR DNA quantification directly from the plant box to explore in situ chemical MoA, as well as confirm the survival of the P. protegens strains to validate their role in the improved plant phenotype. In conclusion, the study presents a modular high-capacity plant assay system that enables increased throughput functional testing of microbial biocontrol and biostimulant candidates in planta. This novel assaying system saves time, reduces human error, provides quantitative and non-destructive in planta data, and can be used in laboratories without greenhouse facilities. We therefore believe it provides a potent early-stage testing option that bridges in vitro and greenhouse testing, and will expedite the discovery of superior next-generation biological products in agriculture.

Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics

Engineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality. A primary challenge in developing these “living drugs” is the complexity of their pharmacology, as the drug product proliferates, differentiates, traffics between tissues, and evolves through interactions with patient immune systems. Using publicly available clinical data from Chimeric Antigen Receptor (CAR) T cells, we demonstrate how mathematical models can be used to quantify the relationships between product characteristics, patient physiology, pharmacokinetics and clinical outcomes. As scientists work to develop next-generation cell therapy products, mathematical models will be integral for contextualizing data and facilitating the translation of product designs to clinical strategy.

Microscale underfill dynamics and void formation of high-density flip-chip packaging: Experiments and simulations

This research focuses on developing high-fidelity experimental and numerical models to analyze microscale underfill dynamics and void formation in high-density flip-chip packaging. Three underfilling scenarios are investigated, namely, point type, I-shaped line type, and L-type line type. The point-type underfilling validates the numerical model against experimental results, while the I-shaped and L-type line-type underfilling explore grid independence, void formation, and critical parameters such as filling position, contact angle, and liquid viscosity. Results indicate that contact angle and viscosity significantly influence filling efficiency and interface evolution. A smaller contact angle accelerates the process, reducing interface jumping motions. Viscous effects are quantified, revealing dimensionless filling time convergence. The use of low-viscosity surrogate fluids enhances numerical simulation efficiency. Sub-bump-sized, bump-sized, and sup-bump-sized voids are observed, identifying three void formation scenarios representing different underfilling flow mechanisms. This study provides insight into microscale flip-chip underfill physics and establishes validated models for next-generation high-density flip-chip products. These models can be further refined and integrated into optimization tools for automated process design, contributing to improved assembly yield and reliability of emerging electronic packages through physics-based understanding and modeling.

Tobacco-Free Nicotine Pouches and Their Potential Contribution to Tobacco Harm Reduction: A Scoping Review.

Tobacco harm reduction (THR) refers to strategies designed to reduce the health risks associated with tobacco smoking but may involve continued use of nicotine and/or tobacco. Next-generation products (NGPs) are a THR alternative as they do not burn tobacco or produce smoke and deliver nicotine and have fewer and substantially lower levels of harmful chemicals compared to cigarettes.Tobacco‑free nicotine pouches (TFNPs) are an emerging category of nicotine‑containing oral products that donot combust or contain tobacco leaf. Similar to Swedish snus, TFNPs are placed between a user's lip and gum, and nicotine is absorbed through the oral mucosa rather than being inhaled.The aim of this scoping review was to systematically collate and evaluate published scientific evidence (cut‑off of 31 May 2023) identified from bibliometric databases investigating the potential of TFNPs to contribute to THR. Overall, studies examining chemical constituents indicated that the use of TFNPs may result in lower exposure to toxicants than other tobacco or nicotine-containing products, both combustible and non‑combustible.This reduction in toxicant exposure has been demonstrated by multiple human biomarker studies andin vitrotoxicological assessments to translate to harm reduction potential in smokers switching to TFNPs. However, further study is warranted.At present, there is some evidence from human behavioral research that TFNPs can support either transitioning away from smoking or reducing cigarette consumption. Furthermore, TFNP use appears very much limited to current users of traditional tobacco products, and youth uptake has been limited.In conclusion, the findings of this review indicate that TFNPs have the potential to support THR effortsand may help inform evidence‑based regulation.

Ultracompact polarization multiplexing meta-combiner for augmented reality display.

Augmented reality (AR) display, as a next-generation innovative technology, is revolutionizing the ways of perceiving and communicating by overlaying virtual images onto real-world scenes. However, the current AR devices are often bulky and cumbersome, posing challenges for long-term wearability. Metasurfaces have flexible capabilities of manipulating light waves at subwavelength scales, making them as ideal candidates for replacing traditional optical elements in AR display devices. In this work, we propose and fabricate what we believe is a novel reflective polarization multiplexing gradient metasurface based on propagation phase principle to replace the optical combiner element in traditional AR display devices. Our designed metasurface exhibits different polarization modulations for reflected and transmitted light, enabling efficient deflection of reflected light while minimizing the impact on transmitted light. This work reveals the significant potential of metasurfaces in next-generation optical display systems and provides a reliable theoretical foundation for future integrated waveguide schemes, driving the development of next-generation optical display products towards lightweight and comfortable.

Novel Arena of Nanocosmetics: Applications and their Remarkable Contribution in the Management of Dermal Disorders, Topical Delivery, Future Trends and Challenges.

Nanocosmetics have attracted a considerable audience towards natural care due to their low cost, target-specific delivery, and reduced toxicity compared to chemical-based cosmetics. Nanofomulations, including nanoemulsions, nanotubes, and polymeric carriers, have become next-generation products explored for the multifaced applications of nanotechnology in skin care. The rise in the cosmetic industry demands innovative and personalized products designed using nanocarriers for better targeting and improving patient compliance. Furthermore, nanocosmetics increase the efficiency of skin permeation active ingredient entrapment, providing better UV protection. Moreover, it offers controlled drug release, targeting active sites and enhancing physical stability. Further, overcoming the drawback of penetration problems makes them sustainable formulations for precision medicine. Skincare nourishment with nanocosmetics using Indian spices helps to maintain, beautify, and rejuvenate human skin. Nanophytopharmaceuticals extracted from plants, including alkaloids, flavonoids, antioxidants, and volatile oils, are essential phyto-products for skin care. Nano herbals and nanocosmetics are a growing market and gift of nature that nourishes and cures skin ailments like acne, pemphigus, anti-aging, albinism, psoriasis, and fungal infections. The emerging concern is highlighted in the investigation of nanoformulation toxicity and safety concerns in skin care. Further, it helps to manifest research, development, and innovation in expanding the scope of herbal industries.

Key Challenges for In Vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for the In Vitro Mouse Lymphoma Assay.

The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to develop recommendations for optimal scientific and technical approaches for conducting in vitro assays to assess potential toxicity within and across traditional tobacco and various tobacco and nicotine next-generation products (NGPs), including Heated Tobacco Products (HTPs) and Electronic Nicotine Delivery Systems (ENDS). This report was developed by a working group composed of attendees of the seventh IIVS workshop, 'Approaches and recommendations for conducting the mouse lymphoma gene mutation assay (MLA) and introduction to in vitro disease models', which was held virtually on 21-23 June 2022. This publication provides a background overview of the MLA, and includes the description of assay conduct and data interpretation, key challenges and recommended best practices for evaluating tobacco and nicotine products, with a focus on the evaluation of NGPs, and a summary of how the assay has been used to evaluate and compare tobacco and nicotine products.

Systemic multiomics evaluation of the therapeutic effect of Bacteroides species on liver cirrhosis in male mice.

The human gut microbiome mediates bidirectional interaction within the gut-liver axis, while liver diseases, including liver cirrhosis, are very closely related to the state of the gut environment. Thus, improving the health of the gut-liver axis by targeting the intestinal microbiota is a potential therapeutic approach in hepatic diseases. This study examines changes in metabolomics and microbiome composition by treating bacteria derived from the human gut in mice with liver cirrhosis. Interorgan-based multiomics profiling coupled with functional examination demonstrated that the treatment of Bacteroides dorei pertained to protective effects on liver cirrhosis by normalizing the functional, metabolic, and metagenomic environment through the gut-liver axis. The study provides the potential value of a multiomics-based and interorgan-targeted evaluation platform for the comprehensive examination and mechanistic understanding of a wide range of biologics, including gut microbes. Furthermore, the current finding also suggests in-depth future research focusing on the discovery and validation of next-generation probiotics and products (postbiotics).

An approach for radical innovative design based on cross-domain technology mining in patents

The key to radical innovation lies in technological breakthroughs, and the key to technical breakthroughs lies in the application of cross-domain knowledge. However, in the conceptual design stage of new product development, the designer’s cognition and knowledge are limited and the retrieval and evaluation of cross-domain technologies is often subjective, making it difficult to generate radical concepts. To address the above issues, this paper proposes a method for cross-domain technology recommendation based on patent analysis. In this method, feature words in various domains of patents are used to generalise the abstract functions of product core subsystems, where designers can obtain more comprehensive cross-domain technologies. This is conducive to breaking the design fixation of designers. Subject–Action–Object structural and functional similarity are combined to quickly extract cross-domain technologies in patents. Then multiple technical indicators are used to objectively evaluate and rank cross-domain technologies. This approach helps designers objectively select cross-domain technologies to change the way next-generation products work, enabling early planning of production conditions and a head start in the market. The method has been verified in a new product development project on peeling equipment, a new product that meets radical indicators is finally obtained.

The Impact of Tobacco Cigarettes, Vaping Products and Tobacco Heating Products on Oxidative Stress.

Cells constantly produce oxidizing species because of their metabolic activity, which is counteracted by the continuous production of antioxidant species to maintain the homeostasis of the redox balance. A deviation from the metabolic steady state leads to a condition of oxidative stress. The source of oxidative species can be endogenous or exogenous. A major exogenous source of these species is tobacco smoking. Oxidative damage can be induced in cells by chemical species contained in smoke through the generation of pro-inflammatory compounds and the modulation of intracellular pro-inflammatory pathways, resulting in a pathological condition. Cessation of smoking reduces the morbidity and mortality associated with cigarette use. Next-generation products (NGPs), as alternatives to combustible cigarettes, such as electronic cigarettes (e-cig) and tobacco heating products (THPs), have been proposed as a harm reduction strategy to reduce the deleterious impacts of cigarette smoking. In this review, we examine the impact of tobacco smoke and MRPs on oxidative stress in different pathologies, including respiratory and cardiovascular diseases and tumors. The impact of tobacco cigarette smoke on oxidative stress signaling in human health is well established, whereas the safety profile of MRPs seems to be higher than tobacco cigarettes, but further, well-conceived, studies are needed to better understand the oxidative effects of these products with long-term exposure.

Sustainable lignin precursors for tailored porous carbon-based supercapacitor electrodes

Sustainable materials are attracting a lot of attention since they will be critical in the creation of the next generation of products and devices. In this study, hydrogels were effectively synthesized utilizing lignin, a non-valorised biopolymer from the paper industry. This study proposes a method based on utilizing lignin to create highly swollen hydrogels using poly(ethylene) glycol diglycidyl ether (PEGDGE) as a crosslinking agent. The influence of different crosslinker ratios on the structural and chemical properties of the resultant hydrogels was investigated. Pore size was observed to be lowered when the amount of crosslinker was increased. The inclusion of additional hydrophilic groups in the hydrogel network decreased the swelling capacity of the hydrogels as the crosslinking density increases. These precursor materials were carbonised and electrochemically tested for application as electrodes for supercapacitors with capacitance characterized as a function of crosslinker ratio.

Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry.

The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to develop recommendations for optimal scientific and technical approaches for conducting in vitro assays to assess potential toxicity within and across tobacco and various next-generation products (NGPs) including heated tobacco products (HTPs) and electronic nicotine delivery systems (ENDSs). This publication was developed by a working group of the workshop members in conjunction with the sixth workshop in that series entitled "Dosimetry for conducting in vitro evaluations" and focuses on aerosol dosimetry for aerosol exposure to combustible cigarettes, HTP, and ENDS aerosolized tobacco products and summarizes the key challenges as well as documenting areas for future research.

Natural killer cells in antitumour adoptive cell immunotherapy.

Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing multiple cytotoxicity mechanisms and the ability to modulate the immune response through cytokine production, NK cells play a pivotal role in anticancer immunity. This role was elucidated nearly two decades ago, when NK cells, used as immunotherapeutic agents, showed safety and efficacy in the treatment of patients with advanced-stage leukaemia. In recent years, following the paradigm-shifting successes of chimeric antigen receptor (CAR)-engineered adoptive T cell therapy and the advancement in technologies that can turn cells into powerful antitumour weapons, the interest in NK cells as a candidate for immunotherapy has grown exponentially. Strategies for the development of NK cell-based therapies focus on enhancing NK cell potency and persistence through co-stimulatory signalling, checkpoint inhibition and cytokine armouring, and aim to redirect NK cell specificity to the tumour through expression of CAR or the use of engager molecules. In the clinic, the first generation of NK cell therapies have delivered promising results, showing encouraging efficacy and remarkable safety, thus driving great enthusiasm for continued innovation. In this Review, we describe the various approaches to augment NK cell cytotoxicity and longevity, evaluate challenges and opportunities, and reflect on how lessons learned from the clinic will guide the design of next-generation NK cell products that will address the unique complexities of each cancer.

A dynamic customer requirement mining method for continuous product improvement

The key to successful product development is better understanding of customer requirements and efficiently identifying the product attributes. In recent years, a growing number of researchers have studied the mining of customer requirements and preferences from online reviews. However, since customer requirements often change dynamically on multi-generation products, most existing studies failed to discover the correlations between customer satisfaction and continuous product improvement. In this work, we propose a novel dynamic customer requirement mining method to analyze the dynamic changes of customer satisfaction of product attributes based on sentiment and attention expressed in online reviews, aiming to better meet customer requirements and provide the direction and content of future product improvement. Specifically, this method is divided into three parts. Firstly, text mining is adopted to collect online review data of multi-generation products and identify product attributes. Secondly, the attention and sentiment scores of product attributes are calculated with a natural language processing tool, and further integrated into the corresponding satisfaction scores. Finally, the improvement direction for next-generation products is determined based on the changing satisfaction scores of multi-generation product attributes. In addition, a case study on multi-generation phone products based on online reviews was conducted to illustrate the effectiveness and practicality of the proposed methodology. Our research completes the field of requirements analysis and provides a new dynamic approach to requirements analysis for continuous improvement of multi-generation products, which can help enterprises to accurately understand customer requirements and improve the effectiveness and efficiency of continuous product improvement.

Abstract 3155: "Super NK cells" - natural killer cells derived from engineered hiPSC with enhanced NK receptor expression demonstrate better anti-tumor effects for solid tumors

Abstract CAR-T cells expressing chimeric antigen receptors (CAR) have shown clinical success for treating hematologic malignancies, but their efficacy in solid tumors has been limited, largely due to tumor heterogeneity and immunosuppressive tumor microenvironment (TME). Natural Killer (NK) cells derived from human induced pluripotent stem cells (hiPSC) hold great potential to become the next-generation cell therapy products because of their established safety profile and their unique biological activities, especially their potential effectiveness for targeting solid tumor. In contrast to T cells, NK cells exert anti-tumor activity without requiring antigen recognition through MHC complex; they are instead activated by calculated signaling through ligation of multiple activating and inhibitory receptors. As various solid tumors highly express activation ligands for NK cells, we reason that enhanced expression of activation receptors on NK cells could improve their killing activity towards solid tumors. Here, we report that “super NK cells” with more than 10 folds higher expression of NK cell receptors such as NKG2D and NCRs derived from engineered hiPSC show improved cytotoxicity against solid tumors compared with non-engineered ones. The “super NK cells” can achieve more than ten rounds of serial killing against both K562 and THP-1 cell lines in vitro. More importantly, the “super NK cells” show improved cytotoxicity to multiple solid tumors in both in vitro system and in vivo xenograft mouse models. In summary, we have engineered hiPSCs which can be differentiated into "super NK cells" as a potential cell therapy product for improved efficacy against solid tumors. Citation Format: Yiyun Wang, Xiangjun He, Linqin Wang, Mi Shao, Yanan Yue, Yangbin Gao, George Church, He Huang, Luhan Yang. "Super NK cells" - natural killer cells derived from engineered hiPSC with enhanced NK receptor expression demonstrate better anti-tumor effects for solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3155.