New Perspectives Research Articles

Cancer stem cells: A new target for cancer therapy.

The introduction of the theory of cancer stem cells (CSCs) has provided a new direction and perspective for our understanding of the nature and origin of tumors. Cancer stem cells are believed to be responsible for the treatment failure, drug tolerance, metastasis, and recurrence of tumors. However, it remains a challenge to identify or isolate tumor stem cells and determine their regulatory mechanisms. Therefore, further understanding of the biological characteristics and functions of CSCs is of great practical significance and value to develop new methods of tumor diagnosis and treatment, and may bring new hope patients with cancer.

New perspective to control of tenacibaculosis in sea bassDicentrarchus labraxL

New perspective to control of tenacibaculosis in sea bass<i>Dicentrarchus labrax</i>L

Feng Youlan’s Research into the History of Philosophy and Philosophical Creation

With regard to the study of the general history of Chinese philosophy and the creation of a philosophical system, Feng Youlan (Fung Yu-lan) has still not been surpassed in the circle of contemporary Chinese philosophy. His text A History of Chinese Philosophy (in two volumes) has particular value not only because of its description of the history of Chinese philosophy, but also because of its historical linking of antiquity and modernity, and of China and the West, a feat realized through philosophy. His philosophical system, set forth in the Six Books of Zhenyuan 貞元六書 (six philosophical monographs) and widely known as the New Learning of Principle system, has ontologically established the primacy of Principle, and, culturally, has instantiated the process of modernization, all of which retains its significance even today. Feng’s thought on realms in his philosophy of life is centered around understanding-based self-enlightenment and has opened a new perspective for reflective thought about, and understanding of, Chinese philosophy. However, it falls short in its failure to acknowledge that “understanding-based self-enlightenment should also be a dynamic process of practice.” Feng showed his academic orientation, distinguished by syncretizing the Learning of Principle and the Learning of Mind, by integrating philosophical creation into the research on the history of philosophy in his late years; however, this syncretism can be pushed further with regard to the issue of unity between subject and object—continuity between the investigation of things before complete understanding and complete enlightenment of the mind after the complete understanding of things. Feng thinks in A Short History of Chinese Philosophy that the most significant contribution that Chinese philosophy has made to the world is in its philosophy of life, and, subsequent to this assertion, one can point out that Chinese philosophy can also make contributions in terms of methodology. In Chinese philosophy, benevolence has an ontological meaning, and is the ontological basis for man and all the other beings to exist in the oneness, as well as the ontological basis for man and the world to be united. Chinese philosophy contains valuable insights in overcoming the opposition between subject and object, establishing a new view of subjects, a new view of objects, and, consequently, creating a new type of subject-object relationship and realizing a second enlightenment of the world.

Smart Cities and Historical Heritage

The theme of smart grids will connote in the immediate future the production and distribution of electricity, integrating effectively and in a sustainable way energy deriving from large power stations with that distributed and supplied by renewable sources. In programmes of urban redevelopment, however, the historical city has not yet been subject to significant experimentation, also due to the specific safeguard on this kind of Heritage. This reflection opens up interesting new perspectives of research and operations, which could significantly contribute to the pursuit of the aims of the Smart City. This is the main goal of the research here presented and focused on the binomial renovation of a historical complex/enhancement and upgrading of its energy efficiency.

Review of New perspectives on translanguaging and education

Review of New perspectives on translanguaging and education

A new perspective on Kuhn—in Spanish

A new perspective on Kuhn—in Spanish

A new perspective on the attitude-behavior relation: The essential function of goals

A new perspective on the attitude-behavior relation: The essential function of goals

Reading Paul with the Reformers: Reconciling Old and New Perspectives. By Stephen J.

Book review: Reading Paul with the Reformers: Reconciling Old and New Perspectives. By Stephen J. Chester. Grand Rapids, MI: Eerdmans, 2017, xxi + 478 рр.; ISBN: 978-0802848369 (hbk.); 60 USD.

Fibroblast growth factor signaling as a bypass mechanism of the androgen receptor pathway: new perspectives for castrationresistant prostate cancer

Till now, prostate cancer (PC) appears among the most critical public health concerns in men in developed as well as developing countries. Androgens operating through androgen receptor (AR) nourish the development and function of normal prostate and may pathologically contribute to PC in case of any deformation or deregulation (1). Based on this, inhibiting the production of androgens by castration or their effects by using anti- AR agents is employed as a treatment of advanced PC disease. However, in most instances, upon therapy, cancer will develop in a form called castrate-resistant prostate cancer (CRPC).

ЭНЕРГЕТИЧЕСКАЯ ТРАНСФОРМАЦИЯ В ГЕРМАНИИ: ИТОГИ И НОВОЕ ВИДЕНИЕ ПЕРСПЕКТИВ

ЭНЕРГЕТИЧЕСКАЯ ТРАНСФОРМАЦИЯ В ГЕРМАНИИ: ИТОГИ И НОВОЕ ВИДЕНИЕ ПЕРСПЕКТИВ

Riflessioni comparative: la Sibilla come frontiera letteraria dell’identità dei popoli

Sibyl is a mythological figure that provides an opportunity to reflect on the conscious comparativism in the past. Through the ananlysis of four texts (Paus., Per., I, 2,2; Or. Sib., III, vv. 813-823; Erma, Vis., I e II; Mundus Origo, vv. 1-6), in which the Sibyl is described as a prototype of the classical, jewish and christian prophetic imaginary, we discuss among the possibility of a comparative attitude of authors from the Classical Age to the Late Antiquity. The tipology of Sibyl's descriptions can explain the role of this seer in order to define an . This approach demonstrates how different and distant populations elaborated a mythological boundary, a frontier where an evolutive, historical and genetic contact was possible, according to the method founded by A. Gnisci and M. Detienne, in collaboration with the psycological-mythological parameter. As a metamorphic clone, the Sibyl provides a consideration on the usefulness of contents offered by a silent comparativism of the past. It gives a new perspective to the modern-contemporaneus comparativism, evaluating the necessity of a dialogue between literatures and cultures in a synchronic and diachronic sense.

The effectiveness of cognitive behavioral therapy for mental disorder

Large numbers of studies have proved that cognitive behavior therapy (CBT) made great effects on the treatment of psychiatic disorders.Based on evidence of effects on various psychiatry disorders, especially on major depressive disorder, anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder, bipolar disorder, schizophrenia, somatoform disorder, substance abuse, eating disorders and personality disorders treated by CBT, this article aims to provide a new perspective of future research. Key words: Cognitive behavior therapy; Psychiatry disorders; Effects

New perspective of the international geriatric medicine: Acute care for the elderly

Older patients often experience a loss of physical, cognitive and social functioning during an acute illness-caused hospitalization.The loss of function could be due to a traditional model of hospital care, which focuses only on diagnosis and treatment of acute disease.Restoration of elderly patients’ lost functions is important for better prognosis of hospitalized elderly patients and would reduce the cost of additional medical treatment.Acute care for the elderly (ACE) is a new model of care aiming at function restoration by practicing a geriatric assessment in the special ACE unit of hospital.The ACE intervention includes interdisciplinary team rounds, discharge planning of hospital, medical care review, a prepared environment, and patient-centered care.Multiple randomized control trials have demonstrated that ACE unit can improve the functional status and prognosis of old patients, reduce the cost of hospitalization, and improve patients’ satisfaction.Currently, ACE care model is poorly known by Chinese hospitals and doctors.This article introduces the concepts of ACE unit, technical elements and the clinical evidence of its effectiveness. Key words: Interdisciplinary cooperation; Recovery of function

The role of microRNA-137 gene in schizophrenia

Schizophrenia is a chronic devastating psychiatric disorder, which severely damages public mental health. The pathophysiological mechanism of schizophrenia is complex and the etiology of schizophrenia is still unclear. Epidemiological study, twins study and family study show that genetic factors play a substantial part in the process of schizophrenia. Previous research indicates that there is a close association between microRNA-137 and schizophrenia, and that the ablation of microRNA-137 significantly affects clinical symptoms and prognosis of patients with schizophrenia. So it highlights the relationship between microRNA-137 and schizophrenia, which reveals its special role in the etiological mechanism of schizophrenia, and may provides new perspective about the treatment of patients in schizophrenia. Key words: microRNA-137; Schizophrenia; Single nucleotide Polymorphism

The Long-Term Effects of the Youth Crime Prevention Program "New Perspectives" on Delinquency and Recidivism.

New Perspectives (NP) aims to prevent persistent criminal behavior. We examined the long-term effectiveness of NP and whether the effects were moderated by demographic and delinquency factors. At-risk youth aged 12 to 19 years were randomly assigned to the intervention group (NP, n = 47) or care as usual (CAU, n = 54). Official and self-report data were collected to assess recidivism. NP was not more effective in reducing delinquency levels and recidivism than CAU. Also, no moderator effects were found. The overall null effects are discussed, including further research and policy implications.

Exploring Health Information Technology Events from FDA MAUDE Database.

To facilitate preventing patient safety events, researchers have been using the Federal Drug Administration (FDA) Manufacturer and User Device Experience (MAUDE) database as a publicly accessible data source for retrieving reports of medical devices including Health Information Technology (HIT) devices. A combined search strategy built with keywords in several fields such as Generic Name, Brand Name and Manufacturer is commonly used to extract reports of specific classifications of devices in the MAUDE. However, another structured field, Classification Product Code, is rarely visited. To improve the secondary usage of the MAUDE database in retrieval of HIT events, we extracted HIT reports from a nine-year MAUDE dataset by combining keywords filter and expert review, and explored Classification Product Codes. The distributions and relationships between Product Codes and keywords in Generic Name/Manufacturer in HIT reports were visualized to provide a view of the landscape. This study presents a new perspective for improving the search strategy of HIT events in MAUDEwhich would facilitate the understanding of HIT events for improving patient safety.

Remapping Black Germany: New Perspectives on Afro-German History, Politics, and Culture ed. by Sara Lennox

Remapping Black Germany: New Perspectives on Afro-German History, Politics, and Culture ed. by Sara Lennox

From this SEED:New Perspectives on Cognition and in the Arts

From this SEED:New Perspectives on Cognition and in the Arts

Community without Consent: New Perspectives on the Stamp Act ed. by Zachary McLeod Hutchins

Community without Consent: New Perspectives on the Stamp Act ed. by Zachary McLeod Hutchins

A New Perspective on Antisthenes: Logos, Predicate and Ethics in His Philosophy by P. A. Meijer

A New Perspective on Antisthenes: Logos, Predicate and Ethics in His Philosophy by P. A. Meijer