Body Weight Of Newborns Research Articles

Embryo transfer impact: a comprehensive national cohort analysis comparing maternal and neonatal outcomes across varied embryo stages in fresh and frozen transfers.

The utilization of frozen embryo transfer not only enhances reproductive outcomes by elevating the likelihood of live birth and clinical pregnancy but also improves safety by mitigating the risks associated with ovarian hyperstimulation syndrome (OHSS) and multiple pregnancies. There has been an increasing debate in recent years regarding the advisability of making elective frozen embryo transfer the standard practice. Our study aims to determine the optimal choice between fresh and frozen embryo transfer, as well as whether the transfer should occur at the cleavage or blastocyst stage. In this retrospective cohort study conducted in Taiwan, data from the national assisted reproductive technology (ART) database spanning from January 1st, 2013, to December 31st, 2017, were analyzed. The study included 51,762 eligible female participants who underwent ART and embryo transfer. Pregnancy outcomes, maternal complications, and singleton neonatal outcomes were evaluated using the National Health Insurance Database from January 1st, 2013, to December 31st, 2018. Cases were categorized into groups based on whether they underwent fresh or frozen embryo transfers, with further subdivision into cleavage stage and blastocyst stage transfers. Exposure variables encompassed clinical pregnancy rate, live birth rate, OHSS, pregnancy-induced hypertension, gestational diabetes mellitus (DM), placenta previa, placental abruption, preterm premature rupture of membranes (PPROM), gestational age, newborn body weight, and route of delivery. Frozen blastocyst transfers showed higher rates of clinical pregnancy (CPR) and live births (LBR) compared to fresh blastocyst transfers. Conversely, frozen cleavage stage transfers demonstrated lower rates of clinical pregnancy and live birth compared to fresh cleavage stage transfers. Frozen embryo transfers were associated with reduced risks of OHSS but were linked to a higher risk of pregnancy-induced hypertension compared to fresh embryo transfers. Additionally, frozen embryo transfers were associated with a higher incidence of large for gestational age infants and a lower incidence of small for gestational age infants. The freeze-all strategy may not be suitable for universal application. When embryos can develop to the blastocyst stage, FET is a favorable choice, but embryos can only develop to the cleavage stage, fresh embryo transfer becomes a more reasonable option.

Comparative analysis of pregnancy outcomes in preimplantation genetic testing for aneuploidy and conventional in vitro fertilization and embryo transfer: a stratified examination on the basis of the quantity of oocytes and blastocysts from a multicenter randomized controlled trial

To investigate variations in pregnancy outcomes between preimplantation genetic testing for aneuploidy (PGT-A) and conventional invitro fertilization and embryo transfer (IVF-ET) treatment across distinct groups categorized by oocyte and blastocyst counts. Because the live birth rate (LBR) of assisted reproductive technology treatment is influenced by the number of oocytes and blastocysts retrieved. Our previous study indicated comparable cumulative LBRs (CLBRs) between conventional IVF-ET and PGT-A. A post hoc exploratory secondary analysis of data from a multicenter randomized controlled trial compared the CLBRs between conventional IVF-ET and PGT-A. Academic fertility centers. A total of 1,212 infertile women with a good prognosis for a live birth after PGT-A or conventional IVF-ET were included. Women underwent PGT-A or conventional IVF-ET. Cumulative LBR, cumulative clinical pregnancy loss (CPL) rate, and good birth outcome. In the study, all participants were divided into 4 groups on the basis of quartiles of the number of oocytes retrieved, or blastocysts. There was an interaction between whether to perform PGT-A and the oocyte numbers category on cumulative CPL and biochemical pregnancy loss. Chi-square analysis revealed that the PGT-A group showed a lower cumulative frequency of CPL compared with the IVF-ET group (PGT-A vs. IVF-ET: 5.9% vs. 13.7%; relative risk = 0.430; 95% confidence interval, 0.243-0.763) when the number of oocytes retrieved was <15. Although there was no interaction on CLBR when the retrieved oocyte count ranged from 19-23 (19≤ oocytes <23) the PGT-A group exhibited a lower CLBR than the conventional IVF-ET group (PGT-A vs IVF-ET: 75.6% vs 87.1%; relative risk = 0.868; 95% confidence interval, 0.774-0.973), and the average body weight of newborns from the PGT-A group was approximately 142 g lower than that of the conventional IVF-ET group (PGT-A vs. IVF-ET: 3,334 ± 479 g vs. 3,476 ± 473 g). However, no statistically significant difference in the CLBR was observed between the PGT-A and IVF-ET groups in the other oocyte or blastocyst groups. When the number of retrieved eggs was <15, the PGT-A group exhibited a lower cumulative CPL rate but no higher CLBR than the conventional IVF-ET group. NCT03118141.

Consumo de alimentos ultraprocessados durante a gestação e peso ao nascer do recém-nascido

Abstract Objectives: to assess the association between pregnant women’s consumption of ultra-processed foods and newborn body weight. Methods: prospective study with pregnant women (n=214) selected from all Basic Health Units in the city of Pinhais, Paraná. Socioeconomic, demographic, and health data were collected. Food consumption data were assessed using a 24-hour dietary recall and tabulated with GloboDiet software. Daily relative energy intake of ultra-processed food was estimated and logistic regression analysis was utilized. The infuence of covariates on the association analysis was also explored (e.g., income and education). Results: ultra-processed foods contributed to 26.9% of pregnant women’s total energy intake. About 5.7% of newborns were classifed as small-for-gestational-age and 10.7% as large-for-gestational-age. A borderline statistically signifcant association was observed between large-for-gestational-age newborn weight and maternal consumption of ultra-processed foods (OR= 1.027; p=0.048). Additionally, family income was associated with the consumption of ultra-processed foods (OR= 0.144; p=0.008). With each additional 1% consumption of ultra-processed foods, mothers’ likelihood of having large-for-gestational-age babies increased by about 2.7%. Conclusions: the study reveals a trend of positive association between the weight of large-for-gestational-age newborns and the consumption of ultra-processed foods by pregnant women, but not for small-for-gestational-age children.

Age-Specific Reference Values for Amino Acid Content in Dried Blood Spots in Children in Western Kazakhstan, Measured by Tandem Mass Spectrometry

Measuring the level of amino acids in the blood is one of the stages in the early diagnosis of inborn errors of metabolism (IEM), implying timely initiation of therapeutic measures. Tandem mass spectrometry (MS/MS) is now replacing traditional IEM screening methods. Dried blood spot amino acid reference values developed for the pediatric population are crucial for interpreting test results and diagnosing aminoacidopathies. The study aims to establish reference values for amino acid (AAs) concentrations in samples of dried blood spots from newborns in Western Kazakhstan using LC-MS/MS (liquid chromatography-tandem mass spectrometry) technology. Methods: The cross-sectional study included 250 healthy newborns of Western Kazakhstan aged 1-3 days, born at term and breastfed, 49.2% male and 50.2% female. To establish the age-specific reference values for AAs, newborns were divided into three groups: (1) 1 day, (2) 2 days, and (3) 3 days. Blood samples on Guthrie cards were collected on days 1–3 of life and quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Nonparametric statistical approaches were used to generate the 2.5th–97.5th percentile distributions for newborns. Results: 3 of the 15 DBS amino acid distributions were dependent on gender. There was a statistically significant difference in the mean level of alanine, citrulline, and glutamic acid in males and females. The highest values were determined in the female group. Age-related differences in glutamic acid, leucine, ornithine, tyrosine, and valine concentration levels were observed. No significant correlations were found between the concentrations of 15 amino acids in dried blood spots and the body weight of newborns. Conclusion: The present study established amino acid concentrations that can be utilized as reference standards in Kazakhstan's newborn screening program for inherited metabolic diseases.

Effect of Rye for Transition Sows on the Level of Piglet Serum Immunoglobulin Immunocrit

A sustainable increase in livestock productivity cannot be achieved without the use of sustainable animal feed. Due to the growing awareness of the long-term benefits of sustainability, there is an increasing interest in replacing traditional feed resources with the most sustainable feedstuffs in pig production. Rye production is relatively sustainable compared to wheat. This farm study investigated whether the newborn body weight as well as antibody transfer in piglets (serum immunoglobulin immunocrit) are affected by feeding rye instead of wheat grain to transition sows. A total of 237 sows and their piglets (n = 711) from three farms located in northern Germany participated in this study. During the transition period, the sows were fed either a wheat-based diet used as the control diet (CON) or a 30% rye diet (RYE) for 7 days before the calculated farrowing date. On the day of farrowing, piglet body weights within 24 h post-natal (PN) were recorded, and blood samples were taken from the lightest, medium, and heaviest piglets in each litter to determine the quantification of immunoglobulins in the piglets. Feeding rye-based diets to the sows showed no differences in the body weight of the newborns (within 24 h) compared to the CON group in all body weight categories, except on Farm C in light and medium piglets, where high BW were observed in the CON group. The immunocrit ratio did not show any differences between both feeding groups. A relationship between newborn body weight and immunocrit ratios in the CON and the RYE groups was observed only on farm A. Overall, this study showed that including amounts of rye up to 30% in sows’ diets during the transition period had no negative effects on newborn piglet body weight or on antibody transfer and therefore can be considered an adequate replacement for wheat (up to 30%) in diets for transition sows. However, future research is needed to determine whether a higher proportion of rye may be used.

Colostrum traits and newborn body weight and growth: comparison between single and twin underfed sheep pregnancies.

Maternal nutrition during gestation plays an important role in colostrum production, postnatal growth, and survival of newborn lambs, especially in twin gestations. This research aimed to investigate the effects of chronic natural undernutrition on colostrum traits and early lamb's postnatal growth born from single and twin sheep pregnancies developed in a restrictive prairie, representative of southern Patagonia. Single- and twin-bearing ewes (n = 20 per group) were maintained grazing in a natural pasture. At 140 days of gestation, ewes were placed in individual pens for lambing control. Colostrum was collected immediately after delivery and at 12, 24, and 36 h postpartum, for determination of yield and composition. Maternal blood was obtained at 140 days of gestation and at lambing for plasma glucose, progesterone, 17β-estradiol, and IgG determination. Newborn lamb blood for determining glycaemia and IgG was collected at birth and at 12, 24, 36, and 120 h after birth. Lamb mortality and growth was assessed from birth until 30 days of life. No differences were observed in progesterone and 17β-estradiol. There were no differences in colostrum yields and fat components, however single- had higher values of protein and lactose than twin-bearing ewes (p < 0.05 for both). Singletons had higher glycaemia than twins at 12 h postpartum (102.2 ± 32.8 vs. 73.4 ± 29.9 mg/dL, p < 0.05). Colostrum IgG content was similar at delivery but higher in single ewes at 12 and 24 h, reaching a similar values at 36 h (4.7 ± 9.7 and 5.8 ± 7.7 mg/mL in single and twin pregnancies, respectively). Newborn IgG was higher in singletons compared to twins at least until 48 h of life. Lams body weight was always superior in singleton than twins from birth until 30 days of life. Mortality did not differ during the first week of life, but it increased significantly only in twins until day 30 of life. Undernourishment in pregnant ewes affected colostrum quantity and quality, resulting in a lower postnatal growth and a higher mortality in twins. Alternative managements favoring fetal growth, birth weight and neonatal viability in twin sheep pregnancies are needed, when flocks are breed under harsh environments.

Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine in Pregnancy: Low Coverage and High Prevalence of Plasmodium falciparum dhfr-dhps Quintuple Mutants as Major Challenges in Douala, an Urban Setting in Cameroon.

Intermittent preventive treatment in pregnancy with sulfadoxine and pyrimethamine (IPTp-SP) is a key component in the malaria control strategy implemented in Africa. The aim of this study was to determine IPTp-SP adherence and coverage, and the impact on maternal infection and birth outcomes in the context of widespread SP resistance in the city of Douala, Cameroon. Clinical and demographic information were documented among 888 pregnant women attending 3 health facilities, from the antenatal care visit to delivery. Positive samples were genotyped for P. falciparum gene (dhfr, dhps, and k13) mutations. The overall IPTp-SP coverage (≥three doses) was 17.5%, and 5.1% received no dose. P. falciparum prevalence was 16%, with a predominance of submicroscopic infections (89.3%). Malaria infection was significantly associated with locality and history of malaria, and it was reduced among women using indoor residual spraying. Optimal doses of IPTp-SP were significantly associated with reduced infection among newborns and women (secundiparous and multiparous), but there was no impact of IPTp-SP on the newborn bodyweight. Pfdhfr-Pfdhps quintuple mutants were over-represented (IRNI-FGKAA, IRNI-AGKAA), and sextuple mutants (IRNI-AGKAS, IRNI-FGEAA, IRNI-AGKGS) were also reported. The Pfk13 gene mutations associated with artemisinin resistance were not detected. This study highlights the role of ANC in achieving optimal SP coverage in pregnant women, the mitigated impact of IPTp-SP on malaria outcomes, and the high prevalence of multiple SP-resistant P. falciparum parasites in the city of Douala that could compromise the efficacy of IPTp-SP.

Correction of placental dysfunction in the first trimester of pregnancy as a method of preventing fetal growth retardation

Objective: to study the effectiveness of complex therapy of placental dysfunction (PD) as a method of prevention of fetal growth retardation syndrome in pregnant women with miscarriage in the 1st trimester of pregnancy.Materials and methods. 100 pregnant women with verified PD on the background of miscarriage in the first trimester of pregnancy took part in the study.Verification criteria for PD were: a decrease in the volume of the chorion and its vascularization index by more than 15%, an increase of the resistance index in the uterine and spiral arteries during dopplerometric examination at the end of the first trimester of pregnancy.The patients were divided into groups: group I (main) – 36 pregnant women with PD who received complex treatment, group II (comparative) – 32 pregnant women with PD who were prescribed only hormonal support, III group (control) – 32 patients with the physiological course of the first trimester of pregnancy. Complex therapy in the group I included hormonal agents, venotonic drug Normoven, the drug Magnicum, and the drug Artihol.Clinical data, ultrasound fetometry, dopplerometric study of utero-fetal blood flow were used to assess the effectiveness of treatment.Results. Already in the 22–24th week of gestation there was no significant difference in the resistance index in the spiral and uterine arteries between the main and control groups (p &gt; 0.05). Ultrasound fetometry at 32–34 weeks of gestation showed that in the first group there were 8.3% (3) fetuses small for gestational age, 15.6% (5) in the second group and 3.1% (1) in the control. The average body weight of newborns in the main group and in the comparison group differed significantly and was 2810 ± 267 and 2610 ± 175 g respectively (р &lt; 0.05) and 3295 ± 295 g in the control group.Conclusions. Complex, pathogenetically justified, long-term treatment of PD from the early stages of pregnancy makes it possible to avoid progression of compensated and development of subcompensated stages of placental disorders. Complex therapy of PD, which includes micronized progesterone, Normoven, Artichol and Magnicum, Complex PD therapy, which includes micronized progesterone, Normoven, Artihol and Magnicum, normalizes blood flow in the mother-placenta-fetus system, normal growth and fetus development and is an effective way of preventing fetal growth retardation.

Course of pregnancy and childbirth in women with primary hypothyroidism

Introduction. Primary hypothyroidism is observed in women of reproductive age in 2–3 % of cases. The most common thyroid pathology during pregnancy is subclinical hypothyroidism (SHT), which is caused by newly diagnosed autoimmune thyroiditis (AIT) or severe iodine deficiency. In some regions of the Russian Federation, the population has a mild iodine deficiency, the average concentration of iodine in the urine being found at 78 µg/L (the normal range is 100–200 µg/L). In women with primary hypothyroidism, complications of pregnancy and childbirth include: premature birth, weakness of labor, eclampsia, premature rupture of premature rupture of membranes (PROM), gestational diabetes mellitus (GDM), intrauterine growth retardation syndrome, fetal macrosomia, congenital hypothyroidism in the fetus, etc.Aim: to study the features of pregnancy and childbirth course in women with primary hypothyroidism.Materials and Methods. In a retrospective study, there were analyzed 62 birth histories, of which 37 were for patients with thyroid diseases. Two groups were formed: the main group – 25 patients with primary hypothyroidism, the comparison group – 25 patients without thyroid pathology. During the study, the next parameters were analyzed: age, number of pregnancies, number of births, term of delivery, body mass index, level of thyroid stimulating hormone (TSH), titer of thyroid peroxidase antibodies, newborn body weight, newborn assessment according to Apgar scale.Results. In the main group, the cause of primary hypothyroidism was as follows: newly diagnosed SHT – in 18 (48.6 %), AIT – in 7 (18.9 %) pregnant women. In the first trimester of pregnancy, TSH level in patients with hypothyroidism was 3.06 ± 0.36 mU/L. The following complications of pregnancy and childbirth course were identified: GDM (32.0 %), anemia of the first degree (12.0 %), large fetus (12.0 %), PROM (12.0 %), perineal rupture of the first degree (16.0 %), anomalies of labor activity with ineffective labor stimulation (8.0 %), pelvic-head disproportion (8.0 %).Conclusion. Timely diagnosis and compensation of hypothyroidism with hormone replacement therapy and iodine preparations, prediction of possible complications and correction of identified complications are the main ways to achieve a successful outcome of pregnancy and childbirth for mother and fetus.

БЕРЕМЕННОСТЬ И COVID-19. ПЕРИНАТАЛЬНЫЕ ИСХОДЫ

Abstract. Introduction. The coronavirus infection COVID-19 has become a major medical problem around the world. Despite the fact that the infection is new and research on COVID-19 is ongoing, the main risk factors for severe consequences for pregnant women have already been identified. Aim. The aim of our study – analyze the impact of coronavirus infection and its consequences on the course of pregnancy and perinatal outcomes. Material and methods. The medical records of 4422 pregnant women were studied on the basis of the Kazan city obstetric hospital. The study included two groups: an experimental group – 67 patients who underwent COVID-19 at various times during pregnancy and a control group – 65 patients with a normal pregnancy. The analysis of the collected data was performed in the GraphPad Prism 9 software (GraphPad Software, San Diego, CA, USA). Results and discussion. Most often, pregnant women had infection COVID-19 during the third trimester, n=51 (76%). The main complications during pregnancy in the experimental group were moderate preeclampsia – 6; 9% (in the control group – 2; 3%) and the threatened preterm labor – 14; 17% (in the control group – 2; 3%). The main complications in newborns: respiratory distress syndrome (9; 13%) and intrauterine pneumonia (3; 5%). The calculated odds ratios showed that the chance of getting 7 or more points on the Apgar scale in the control group was 7,2 times higher compared to the experimental group at 1 minute, and 10,1 times higher at the fifth minute. A significant difference (p-value=0,0027) was also shown between the average values of body weight of newborns in the experimental group [(3047±186) g] and control [(3403±243) g]. Conclusion. The number of cases of complicated pregnancy was significantly higher in experimental the group compared to the control group. Children in the control group are more likely to have higher Apgar score and have higher body weight than children born to mothers included in the experimental group. Also, the number of newborns with complications (mainly pathology of the respiratory system) in the early neonatal period was higher in the experimental group compared to the control group.

Features of microbiota in underweight premature infants

The aim . Microbiological monitoring of the digestive tract opportunistic microfl ora in underweight premature newborns to substantiate risk groups and the possibility of a personalized approach to manage such patients. Materials and methods . A case-control observational study included 67 preterm infants (35 boys and 32 girls), divided into three groups according to the underweight degree: low (n = 21), very low (n = 21) and extremely low (n = 25) mass. A comprehensive examination was carried out with clinical- anamnestic, laboratory and clinical- functional diagnostic methods, consultation of a neurologist, ophthalmologist, cardiologist. Microbiological monitoring of opportunistic microfl ora (UPM) of the oral cavity and other biotopes (auricle surface, armpit, fetal part of the placenta) was carried out on the 1st, 3rd and 7 th days of life. Biochemical identifi cation was carried out using test systems “Erba Lachema”. Database creation and statistical processing were carried out using software packages of Microsoft® Offi ce® 2010, IBM® SPSS® Statistics 23.0, WinPEPI© 11.39. Results . The frequency of opportunistic microfl ora isolated from the oral cavity of underweight newborns was signifi cantly higher on the 1st, 3rd days (Fisher’s exact test, p = 0.037) and was characterized by a wider spectrum compared to other studiedbiotopes. The dominant representative of opportunistic microfl ora in most biotopes was S. epidermidis , as well as K. pneumoniae , C. krusei , Burkholderia cepacia complex , and S. maltophilia . There was revealed a correlation link between the qualitative and quantitative parameters of opportunistic microfl ora, as well as the number of opportunistic microfl ora contaminated biotopes with the level of body weight and resistance indicators of underweight premature newborns. Conclusion . Microbiological monitoring of opportunistic microfl ora of the oral cavity and the inner surface of the auricle biotope makes it possible to consider these microecological parameters as a prognostic criterion for the course and outcomes in premature infants with underweight, as well as to scientifi cally substantiate a personalized approach to the management of such patients, the formation of risk groups, the appointment of corrective and preventive measures to form adequate profileof microbial colonization, prevent of infectious pathology and the decrease risk of an unfavorable outcome.

Pathological newborn body weight as predictor of metabolic disorders and reduced exercise tolerance in young female

Background and Aims : Background: Metabolic syndrome (MS) is a claster of metabolic disorders associated with insulin resistance and abdominal obesity, associated with an increased risk of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD). Due to the high prevalence of MS (20-40%), and especially in young people of working age, its early detection has undoubtedly great importance for the timely initiation of prevention of complications (heart attack, stroke, diabetes, etc.). Purpose: assessment of newborn body influence on subsequent metabolic disorders and exercise intolerance in young females during adolescence.Methods: The total number of patients was 92 aged18-21 years. Metabolic syndrome (MS) was diagnosed according to the following "summary" criteria: WHO criteria, 1999 (impaired glucose tolerance), modified WHO criteria (fasting plasma insulin level more than its upper quartile in this population) and IDF criteria (2005, 2009, 2014). Exclusion criteria: active physical activity and/or sports.Results: 48 patients (52.7%) had abnormal body weight at birth: low (<2800 g) - in 23 people (25.3% - group 1); high (>4000 g) - in 25 people (27.5% - group 2). Group 1 showed the highest values of total and LDL cholesterol (p=0.006), group 2 - hypercholesterolemia, hypertriglyceridemia (p=0,05) and hypoalphacholesterolemia (p=0.05). The last had increased basal glycemia (p=0.004), insulin (p=0.05) and C-peptide (p=0.006), while patients of group 1 had an increase in postprandial glucose (p=0.009) and insulin (p=0.05). In patients of group 2 were mentioned cardiac remodeling, reduced exercise tolerance.Conclusions: Abnormal fetal body weight may be a predictor of MS and low exercise tolerance in adolescent females. Background and Aims : Background: Metabolic syndrome (MS) is a claster of metabolic disorders associated with insulin resistance and abdominal obesity, associated with an increased risk of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD). Due to the high prevalence of MS (20-40%), and especially in young people of working age, its early detection has undoubtedly great importance for the timely initiation of prevention of complications (heart attack, stroke, diabetes, etc.). Purpose: assessment of newborn body influence on subsequent metabolic disorders and exercise intolerance in young females during adolescence. Methods: The total number of patients was 92 aged18-21 years. Metabolic syndrome (MS) was diagnosed according to the following "summary" criteria: WHO criteria, 1999 (impaired glucose tolerance), modified WHO criteria (fasting plasma insulin level more than its upper quartile in this population) and IDF criteria (2005, 2009, 2014). Exclusion criteria: active physical activity and/or sports. Results: 48 patients (52.7%) had abnormal body weight at birth: low (<2800 g) - in 23 people (25.3% - group 1); high (>4000 g) - in 25 people (27.5% - group 2). Group 1 showed the highest values of total and LDL cholesterol (p=0.006), group 2 - hypercholesterolemia, hypertriglyceridemia (p=0,05) and hypoalphacholesterolemia (p=0.05). The last had increased basal glycemia (p=0.004), insulin (p=0.05) and C-peptide (p=0.006), while patients of group 1 had an increase in postprandial glucose (p=0.009) and insulin (p=0.05). In patients of group 2 were mentioned cardiac remodeling, reduced exercise tolerance. Conclusions: Abnormal fetal body weight may be a predictor of MS and low exercise tolerance in adolescent females.

Характеристика стану новонароджених від жінок із прееклампсією, фізіологічною масою тіла та ожирінням

The purpose of the study was to characterize the condition of newborns on the Apgar scale and to compare the body weight of newborns from obese women, who used a treatment and prevention complex aimed at preventing preeclampsia, and to compare with the condition of newborns from obese women, who received conventional prevention of preeclampsia and with physiological body weight. Materials and methods. We conducted a clinical and statistical analysis of 255 medical records of newborns, which were divided into 6 groups according to the growth and weight of their mothers, taking into account the presence of preeclampsia and the use of treatment and prevention complex: Group I (control) consisted of newborns (n=33) from women with physiological body weight (body mass index = 18.5-24.9 kg/m2); Group II – newborns from women with physiological body weight and preeclampsia (n=13); Group III – newborns from obese women of I-III degrees (n=90); Group IV – newborns from obese women of I-III degrees, who used treatment and prevention complex (n=65); Group V – newborns from obese women of I-III degrees, and preeclampsia (n=41); Group VI – newborns from obese women of I-III degrees, and preeclampsia who manifested against the background of the use of treatment and prevention complex (n=13). Pregnancy of obese women was carried out according to the order of the Ministry of Health of Ukraine No. 151 dated 24.01.2022, which provides for the appointment of pregnant women at risk (including obesity): acetylsalicylic acid 100 mg/day from 12 weeks to 36 weeks of pregnancy and calcium supplements 1.5 g/day from the 16th week of pregnancy. In addition to the prescribed drugs, obese pregnant women who agreed to take our proposed set of preventive measures aimed at the prevention of preeclampsia, used a combination of drugs L-arginine and semi-synthetic diosmin according to the scheme: from 12 to 16, from 22 to 26, and from 32 to 36 weeks of pregnancy. The dose of diosmin, the release form of which is tableted, was 600 mg per day, the method of oral administration. L-arginine, used as a syrup for oral administration, 5.0 ml 3 times a day. The quantitative indicators obtained in the course of the survey were processed by the methods of mathematical statistics with the help of calculations of the ratio of the chances of the disease in the examined newborns. Results and discussion. The analysis of the state of newborns in the groups we studied shows that the number of premature babies and children who suffered in utero was significantly higher among children born to mothers whose pregnancies were complicated by preeclampsia and mothers who are obese, and as a result further increase in the incidence among these children. We found that the highest percentage of newborns weighing less than 2,500 grams is concentrated in groups with preeclampsia and concomitant obesity, which is due to premature birth and cases of intrauterine fetal growth retardation. Сases of fetal asphyxia were also more common in neonates from women with preeclampsia and concomitant obesity. Cases of fetal macrosomia were significantly more common in infants born to obese women. Conclusion. The use of our proposed treatment and prevention complex for pregnant women with concomitant obesity, having a positive effect on the functioning of the fetoplacental complex, helps to improve the condition of newborns on the Apgar scale and body weight of newborns compared to newborns from obese women who received conventional prophylaxis of preeclampsia

HUBUNGAN ANEMIA DAN KEKURANGAN ENERGI KRONIK PADA IBU HAMIL DENGAN BERAT BADAN BAYI BARU LAHIR

Anemia during pregnancy hurts both mother and baby. The research objective was to analyze the relationship between anemia and chronic energy deficiency in pregnant women with the incidence of new birth weight. This study used a cross-sectional research design. The population in this study were the third-trimester pregnant women in the working area of Ngadiluwih Public Health Center, Kediri Regency. The sample in this study was 52 respondents. The sampling technique used was total sampling. The results of the chi-square test showed the relationship between anemia and weight of newborns had a p-value of 0.001. It shows that there is a correlation between anemia in pregnant women and the incidence of newborn body weight with PR 21.5, which means that mothers who experience anemia during pregnancy have a 21.5 times greater risk of giving birth to babies with low birth weight than mothers who are not anemic. The association of chronic energy deficiency with newborn body weight has a p-value of 0.000. It shows that there is a relationship between chronic energy deficiency and newborn weight with PR 15.6, which means that mothers who experience chronic energy deficiency have a 15.6 times greater risk of giving birth to western babies with low birth weight than mothers who do not experience chronic energy deficiency. During pregnancy, pregnant women consume foods that contain iron and iron supplements.

ВЛИЯНИЕ ГЕСТАЦИОННОГО ВОЗРАСТА НОВОРОЖДЕННЫХ НА ТЕЧЕНИЕ НЕОНАТАЛЬНОГО ПЕРИОДА ПРИ АНОМАЛИЯХ ИНВАЗИИ ПЛАЦЕНТЫ

Objective of the study: to determine the timing of optimal delivery and to identify the features of the course of the neonatal period in children from mothers with placental accreta. Materials and methods of research: the analysis of medical records of 140 children of mothers with placental accreta (main group) and 60 newborns of mothers without placental accreta (comparison group) of various gestational ages (GA), born in the period of 2014–2020, was carried out. The paper presents the results of a single-center retrospective non-randomized continuous comparative study. Results: the effect of GA on the length of the newborn's stay in the neonatal intensive care and intensive care units (ICU) and the hospital as a whole was confirmed. The dependence of the need for respiratory support in newborns on the gestational age was confirmed: with a decrease in GA, the need for respiratory support in newborns increases statistically significantly (p=0.0011), the need for traditional mechanical ventilation in newborns increases statistically significantly (p&lt;0.001). When analyzing the frequency of occurrence of asphyxia, no statistically significant differences were found in the main group and in the comparison group. There were no statistically significant differences (p=0.229) in the body weight of newborns developing during pregnancy complicated by placenta previa compared with newborns born to mothers without a placental invasion anomalies. As a result of our study, there were no statistically significant differences in the length of stay in ICU and hospital for newborns of the same GA of the main group and the comparison group.

Application of International Standards for Assessing Physical Development of Newborns in a Large Agro-Industrial Center by Seasons of the Year on the Example of the City of Barnaul

Introduction: An important health indicator of a newborn available for measurement immediately after birth is the extent of physical development, which reflects individual sex and physique characteristics, various climatic, geographical, and socio-economic living conditions. Objective: To assess physical development of newborns in a large agro-industrial center using international standards that take into account gestational age by months of the year. Materials and methods: We examined archived medical records of women who gave birth in 2014 in the city of Barnaul to analyze anthropometric parameters of 2,019 newborns (788 girls and 1,231 boys), their gestational age, and medical histories of the mothers. All pregnancies were singleton; no congenital malformations were registered in the sample. The analysis of the correspondence of anthropometric parameters of the child at birth to the gestational age and assessment of physical development were carried out using sex-specific INTERGROWTH-21st charts by the seasons of the year. Results: We established some seasonal variations in the body weight of newborns requiring a more detailed monitoring assessment. Conclusion: The use of international standards for assessing physical development of newborns will allow an in-depth consideration of the problem of children’s health maintenance since they take into account gestational age, thus enabling early diagnosis of developmental abnormalities.

HUBUNGAN BERAT PLASENTA DENGAN BERAT BADAN DAN PANJANG BADAN BAYI BARU LAHIR

Abstract. Birth weight is an indicator of newborn health. The size of birth weight depends on how the intrauterine fetus grows during pregnancy. Babies who are born atherem (37 to 42 weeks) have a normal weight of 2,500 - 4,000 grams. Several factors can affect the birth weight of the baby which consists of factors from the mother, fetal factors, and placenta factors. Placental weight is commonly used to summarize the growth and function of the placenta. This study aimed to analyze the relationship between placental weight and body weight and length of the newborn. This type of research is. analytic survey with cross sectional study design. The number of samples in this study were 30 pregnant women who were taken by total sampling analysis.The results showed that there was a relationship between placental weight with body weight and body length for newborns in Kec. Mare, the data was done by using the chi-squar test, with a confidence level of a = 005. Based on the results of this study, the significance value of birth weight p-value = 0.000 p &lt;0.5, the length of birth body value p-0.00 p&gt; 0 , 5. So it can be concluded that there is a relationship between placental weight and body weight and length of newborns. There is a relationship between placental weight and body weight and length in newborns)

Prevention of complications of pregnancy and childbirth of patients with a burdensome gynecological anamnesis

The objective: determination of the effectiveness of prevention and medicinal correction of placental dysfunction in pregnant women with chronic salpingo-oophoritis.Materials and methods. The study included 100 pregnant women (basic group) with chronic salpingo-oophoritis, of these, I group (50 women) included patients who received proposed treatment and prevention approach, II group (50 women) received a common set of treatment and prevention measures. The proposed treatment-and-prophylactic approach included prophylactic administration to pregnant women with chronic salpingo-oophoritis from the 8th to the 10th and from the 16th to the 18th week inclusive of natural micronized progesterone at a dose of 100 mg intravaginally twice a day for two weeks. Venotonik and angioprotector were prescribed prophylactically at dose 600 mg from 18 weeks to 37-38 weeks of pregnancy. For therapeutic purposes (blood flow disorders in the uterine arteries and vessels of the umbilical cord that are determined by Doppler), the drug was prescribed at dose 600 mg twice a day for 3–4 weeks.Results. A lower frequency of obstetric and perinatal complications was found in the women in I group than in the patients in the II group. Thus, the rate of placental dysfunction was 6.0±3.36% vs. 34.0±6.7%, respectively, oligohydramnios – 6.0±3.36% and 12.0±4.59%, polyhydramnios – 10.0±4.24% and 22.0±5.86%, fetal distress during childbirth – 6.0±3.36% and 14.0±4.91%, cesarean section – 12.0±4.6% and 24.0±4.27%. In the group of patients with treatment-and-prophylactic approach, the mean of the body weight of newborns was 3486.7±312.71 g, and in women who received a common set of treatment-and-prophylactic measures – 3099.8±295.69 g. The mean of the assessment of the condition of newborns by the Apgar scale at the 1st minute – 7.92±1.54 and 6.81±1.16 points, respectively.Conclusions. The use of micronized natural progesterone and the drug diosmin 600 mg in pregnant women with a history of chronic salpingo-oophoritis reduces the rate of obstetric and perinatal complications during pregnancy.

Diagnosis, treatment and outcome of adnexal torsion at different gestational weeks during pregnancy

Objective: To investigate the clinical characteristics, diagnosis, treatment and outcome of adnexal torsion at different gestational weeks during pregnancy. Methods: A retrospective analysis was conducted of the clinical data of 24 pregnancy patients with adnexal torsion, aged 21-38 (30.6±4.4) years old, who were admitted and delivered in Peking University Third Hospital from 2015 to 2019. According to the gestational age, all patients were divided into two groups:<28 weeks group (11cases) and ≥28 weeks group (13 cases), to compare the intergroup differences in clinical characteristics, treatment and outcome, and the differences of clinical data and outcome between two groups were compared. Results: The proportion of patients with twin pregnancy and assisted reproductive technology in the<28 weeks group was significantly higher than that in the ≥28 weeks group (5/11 vs 1/13, 8/11 vs 1/13, P<0.05). No significant differences between the two groups were recorded in terms of the size of the adnexal mass, the cycles of torsion and the duration from onset to operation. Compared with the≥28 weeks group, the adnexal removal rate of the<28 weeks group was lower (3/11 vs 6/13), but the difference was not statistically significant. The proportion of blood flow signals of ultrasound before operation, cases undergoing laparoscopic surgery and cases whose pathological findings were physiological cysts in the<28 weeks group were significantly higher than that in the ≥28 weeks group (8/11 vs 4/13, 8/11 vs 0, 8/11vs 4/13; P<0.05). Concerning the pregnancy outcomes, there was no difference in the mode of delivery, the delivery gestational age and the body weight of newborns between the two groups. Conclusions: The patients with adnexal torsion prior to 28 weeks(<28 weeks)of pregnancy were more likely to be conceived by assisted reproductive technologies, and the etiology was more likely to be ovarian physiological cysts. Both laparoscopy and laparotomy were safe and effective in the treatment of adnexal torsion with good outcome for mother and infant in the study.

The Relationship of Anemia in Pregnant Women with Anthropometry and Apgar Score for Newborns in Dr. Tadjuddin Chalid Hospital, Makassar

Introduction: Anemia is one of the problems in pregnant women that can affect anthropometry of newborns that contain weight, body length and head circumference as well as the newborn score. The aim of this study was to determine the relationship between anemia of pregnant women to anthropometry and the apgar score of newborns at Dr. Tadjuddin Chalid Hospital Makassar.&#x0D; Methods: The method used in this research is observational analytic with cross sectional design. Sampling was done by purposive sampling. The total sample of 269 deliveries at Dr. Tadjuddin Chalid Hospital Makassar. The research data were sourced from secondary data such as patient identity, anemia of pregnant women, infant anthropometry which included weight, length, head circumference, and apgar score measured immediately after birth.&#x0D; Results: The results of this study indicate that anemia of pregnant women are significantly related to newborn body weight (p = 0.007), newborn body length (p = 0.011), newborn head circumference (p = 0.039), and anemia of pregnant women does not have a significant relationship with the apgar of newborns score (p = 0.088).&#x0D; Conclusion: The conclusion of this study is that anemia status of pregnant women has a relationship with anthropometry of newborns on the parameters of body weight, body length, head circumference of newborns and anemia status of pregnant women has no relationship with the apgar score of newborns.