Pathological newborn body weight as predictor of metabolic disorders and reduced exercise tolerance in young female

Abstract

Background and Aims : Background: Metabolic syndrome (MS) is a claster of metabolic disorders associated with insulin resistance and abdominal obesity, associated with an increased risk of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD). Due to the high prevalence of MS (20-40%), and especially in young people of working age, its early detection has undoubtedly great importance for the timely initiation of prevention of complications (heart attack, stroke, diabetes, etc.). Purpose: assessment of newborn body influence on subsequent metabolic disorders and exercise intolerance in young females during adolescence.Methods: The total number of patients was 92 aged18-21 years. Metabolic syndrome (MS) was diagnosed according to the following "summary" criteria: WHO criteria, 1999 (impaired glucose tolerance), modified WHO criteria (fasting plasma insulin level more than its upper quartile in this population) and IDF criteria (2005, 2009, 2014). Exclusion criteria: active physical activity and/or sports.Results: 48 patients (52.7%) had abnormal body weight at birth: low (<2800 g) - in 23 people (25.3% - group 1); high (>4000 g) - in 25 people (27.5% - group 2). Group 1 showed the highest values of total and LDL cholesterol (p=0.006), group 2 - hypercholesterolemia, hypertriglyceridemia (p=0,05) and hypoalphacholesterolemia (p=0.05). The last had increased basal glycemia (p=0.004), insulin (p=0.05) and C-peptide (p=0.006), while patients of group 1 had an increase in postprandial glucose (p=0.009) and insulin (p=0.05). In patients of group 2 were mentioned cardiac remodeling, reduced exercise tolerance.Conclusions: Abnormal fetal body weight may be a predictor of MS and low exercise tolerance in adolescent females. Background and Aims : Background: Metabolic syndrome (MS) is a claster of metabolic disorders associated with insulin resistance and abdominal obesity, associated with an increased risk of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD). Due to the high prevalence of MS (20-40%), and especially in young people of working age, its early detection has undoubtedly great importance for the timely initiation of prevention of complications (heart attack, stroke, diabetes, etc.). Purpose: assessment of newborn body influence on subsequent metabolic disorders and exercise intolerance in young females during adolescence. Methods: The total number of patients was 92 aged18-21 years. Metabolic syndrome (MS) was diagnosed according to the following "summary" criteria: WHO criteria, 1999 (impaired glucose tolerance), modified WHO criteria (fasting plasma insulin level more than its upper quartile in this population) and IDF criteria (2005, 2009, 2014). Exclusion criteria: active physical activity and/or sports. Results: 48 patients (52.7%) had abnormal body weight at birth: low (<2800 g) - in 23 people (25.3% - group 1); high (>4000 g) - in 25 people (27.5% - group 2). Group 1 showed the highest values of total and LDL cholesterol (p=0.006), group 2 - hypercholesterolemia, hypertriglyceridemia (p=0,05) and hypoalphacholesterolemia (p=0.05). The last had increased basal glycemia (p=0.004), insulin (p=0.05) and C-peptide (p=0.006), while patients of group 1 had an increase in postprandial glucose (p=0.009) and insulin (p=0.05). In patients of group 2 were mentioned cardiac remodeling, reduced exercise tolerance. Conclusions: Abnormal fetal body weight may be a predictor of MS and low exercise tolerance in adolescent females.