We define a new generalized inverse (named the gDMP inverse) for a Hilbert space operator using its generalized Drazin inverse and its Moore–Penrose inverse. Thus, we extend the DMP inverse for a square matrix to more general case. Also, we introduce two new classes of operators, $g$-EP and $g$-normal operators which include, respectively, EP operators and normal operators. A new binary relation is associated with the gDMP inverse is presented and studied. The notion of core-EP inverse for matrices is extended to generalized Drazin invertible operators on Hilbert space.