Two-loop effects on the right-handed neutrino masses can have an impact on the low-energy phenomenology, especially when the right-handed neutrino mass spectrum is very hierarchical at the cut-off scale. In this case, the physical masses of the lighter right-handed neutrinos can be dominated by quantum effects induced by the heavier ones. Further, if the heaviest right-handed neutrino mass is at around the Planck scale, two-loop effects on the right-handed neutrino masses generate, through the seesaw mechanism, an active neutrino mass which is in the ballpark of the experimental values. In this paper we investigate extensions of the Planck-scale lepton number breaking scenario by additional Higgs doublets (inert or not). We find that under reasonable assumptions these models lead simultaneously to an overall neutrino mass scale and to a neutrino mass hierarchy in qualitative agreement with observations.