AbstractBackgroundIn this study with amnestic mild cognitive impairment impairment (aMCI) subjects, we compared Alzheimer’s disease (AD) converter and non‐converter in findings of F‐18 FDG PET/CT (FDG PET), F‐18 Florbetaben PET/CT (amyloid PET) and other clinical features.MethodPatients with aMCI who underwent both FDG PET and amyloid PET were included. They underwent neuropsychological test, blood test and apoE4 test as well. After follow‐up, AD converter and non‐converter were determined by neurologists. Comparison between AD converter and non‐converter groups were done with FDG PET variables (SUVR), amyloid PET variables (SUVR, RCTU, and conclusion of visual reading), neuropsychological variables (including classification of single domain or multi domain) and other laboratory results. MIM software was used for SUVR. We used P<0.05 as statistical significance.ResultTotal 45 subjects of aMCI (age range from 63 to 89 years, M:F=26:19) were enrolled. After follow up (range from 11.6 to 41.3 months), AD convert group (n=12) and non‐convert group (n=33) were determined. For FDG, there were regions with lower FDG SUVR in AD converter group than non‐converter group (both angular gyrus, both posterior cingulate gyrus, left precuneus, let temporal pole, left inferior temporal gyrus and left inferior medial frontal gyrus).For amyloid, analysis with conclusion by visual analysis (positive vs negative) did not show significant differences. However, quantitative analysis with amyloid SUVR showed that higher amyloid SUVR in AD converter group than non‐converter group (in left angular gyrus, left fusiform gyrus, left inferior temporal gyrus, left lateral temporal lobe and right paracentral lobule). RCTU scores were also higher in AD converter group (in bilateral temporal, frontal, parietal and total sum scores of RCTU). AD converter group also showed worse cognitive function at first evaluation (sum of boxes, RCFT delayed recall and domain memory) AD converter showed higher serum glucose level and triglyceride.There was not significant difference in follow‐up interval, education, age, sex, domain (single domain/multi‐domain), apoE4 carrier/non‐carrier/apoE4 heterogeneity (non‐carrier, homozygotes and heterozygotes). RCTU for left frontal lobe showed significant odd ratio (3.85).ConclusionQuantitative variables of FDG PET and amyloid PET showed different results between AD conveter and nonconverter groups in aMCI.