Congenital syphilis is an infectious disease caused by the spirochete bacterium Treponema pallidum and is among the most frequent perinatal infections in Brazil. The maintenance of its high incidence demonstrates the need for improvement in prenatal care, since the diagnosis is quick and the treatment is carried out with penicillin, an affordable antibiotic. It can lead to serious consequences, such as fetal or perinatal death, prematurity, low birth weight, and neurological sequelae. The epidemiological importance of the disease and the direct and indirect costs it generates justifies the need for investment in better services and professional training. This article proposes to review the main points on the subject, from the current literature. Methodology: A comprehensive bibliographical review of studies contained in the virtual environment was carried out using websites such as (google acadmico), (virtual health library).Objective: To highlight the use of Penicillin Benzatine in the treatment of Syphilis, as well as to bring the mechanism of action, pharmacodynamics and pharmacokinetics of Penicillin Benzatine in the treatment of syphilis .Conclusion: After a review of the literature conducted we concluded the effectiveness of the use of benzatine penicillin in the treatment of syphilis in its different phases.