Neurological Origin Research Articles

Charcot’s interest in faith healing

ABSTRACT Jean-Martin Charcot believed that “miraculous” cures followed the rules of nature and that the resolution of physical stigmata after pilgrimages to shrines followed the laws of physiology. He acknowledged that some of the patients he had failed to improve at La Salpêtrière had subsequently been cured by the “faith cure” at Lourdes, but he believed their recovery had occurred through “autosuggestion.” Although this term is more commonly associated with his collaborator Pierre Janet, it is clearly expressed in Charcot’s final pronouncements. Charcot’s recognition of the neurological origin of hysteria is central to contemporary ideas about the cause of functional neurological disorders, and even some components of his once derided treatment approach—including mental training, graded exercise, and medical hypnotism—are in vogue.

Guidelines underscore the benefits of functional electric stimulation

Foot drop arises from weakness of the dorsiflexor muscles in the leg and foot. Treatments for foot drop include physiotherapy, orthosis, medicines and surgery. This feature introduces functional electric stimulation (FES), which the National Institute for Health and Care Excellence recommends for drop foot with a central neurological origin. In 2022, the Association for Chartered Physiotherapists in Neurology published evidence-based guidelines for using FES to improve mobility in adults with lower limb impairment, including foot drop, due to upper motor neurone lesions. The guidelines cover: referral; potential benefits; considerations and precautions; access to FES services; service provision; initial assessment and treatment; monitoring and ongoing support; and minimum training standards. This feature aims to inspire readers to consult the full document.

A REVIEW ARTICLE ON NEELAA AND MANYA MARMA WITH RESPECT TO INTERNAL CAROTID ARTERIAL DEFICITS

Introduction: Mookata (Complete loss of voice), Swaravaikrita (Defective voice) and Arasagrahita (Loss of taste sensation) are Abhighata Lakshanas (symptoms of injury) of Neelaa Manya marma. They are mentioned as Vaikalyakara Marmas (deformity) of the head & neck region. They are also included as avedya sira (vessels to be avoided during surgical procedure), as injury will lead to either deformities or death. In a comprehensive study done on Shiromarma Abhinaya Lakshanas in 100 patients with intracranial neurological disorders at SDMACH, Udupi, Karnataka (2014-2017), eight individuals were observed with the incidence of Mookata, Swaravaikrita and Arasagrahita having notable pathological changes in the calibre and patency in the Doppler study of the carotid arteries1,2. Aims and objectives: To understand Neelaa Manya Marma Abhinaya Lakshanas and to localise the structures involved in the lesions of neurological origin from the CT, MRI scan of the brain & Doppler imaging study of the carotid artery in the marma region. Materials and methods: Concerned Literary works, books, journals, and CT MRI scans and Doppler imaging studies collected from patients suffering from intracranial diseases were reviewed, and related information was collected and analyzed scientifically. Results and Discussion: In the pathogenic sequel of injury to any Marma sthana, aggravated vayu diffuses into the surrounding areas and spreads throughout the body via siras (vessels). Both Neela and many are included among the Vaikalyakara Marmas as well as they come under the category of Madhya siras (vessels supplying to trunk area). Here the vitiation of Dhamanis (vessels) such as Vatavaha (vessel carrying life force), Rasanagrahana (vessels responsible for taste sensation), Bhashya (vessel accountable for speech), Gosh (vessel responsible for voice artriculation) located in the neck region near the Marma Sthana, may be one of the reasons for the symptoms such as Mookata, Swaravaikrita and Arasagrahita. The branches of the internal carotid artery supply to the cortical, sub-cortical, as well as the thalamic & sub-thalamic areas of the brain. Any occlusion of these vessels will undoubtedly result in the ischemia or infarct of the areas of its supply, causing functional deficits such as Aphasia, dysphonia, dysphagia, etc. Conclusion: This was a review article based on the observational study representing the fact that it was possible to clinically assess the Neelaa Manya marma abhinaya lakshanas on patients diagnosed with intracranial lesions with internal carotid arterial deficit, especially notable pathological changes in the calibre and patency in the Doppler study of the carotid arteries.

More than just dermatitis: The multifaceted nature of chronic itch through the historical perspective of Napoleon Bonaparte

Derived from the survival advantage needed to eradicate harmful irritants from the skin's surface, itch, also known as pruritus, is an intriguing phenomenon and a key feature of many dermatologic diseases. The pathologic form, chronic itch, is a condition that precedes itself by its complex pathophysiology, numerous etiologies, and interplay of mechanisms that often make it difficult to diagnose and treat. One particular sufferer of this condition, the 18th-century French emperor Napoleon Bonaparte, makes for a compelling case study of the complexity of chronic itch. We delve into the many etiologies and mechanisms of chronic itch, using Napoleon's lifelong struggle with this condition as our model, identifying potential environmental, neurologic, psychiatric, and immunologic origins of his condition.

Epidemiological predictors of quality of life and the role of early markers in children with cerebral palsy: A multi-centric cross-sectional study

BackgroundMore than 100 million children in the world have at least one type of disability. Among disabled children, approximately 25% of chronic disabilities are of neurological origin. Cerebral Palsy is the leading cause of chronic disability in children, making them not only physically and mentally handicapped but also socially aloof. MethodsThis study was conducted among 200 eligible participants from three centers with Child Guidance or Cerebral Palsy clinics in the outpatient department. All the participants were included in the analysis of the epidemiological profile and the role of early markers. Of these, 70 participants were assessed for quality of life according to the age criteria of a pre-tested Cerebral Palsy Quality of Life questionnaire (CP-QOL). ResultsMean ± S.D. age in years was 3.7 ± 2.8. Birth history included 182 (39%) neonatal etiopathology, followed by 173 (38%) perinatal, and 106 (23%) antenatal causes. Mean ± S.D. birth weight was 2.3 ± 1.2 kg. The positive predictors of various domains of Quality of Life were an absence of any associated sensory, neurological, communication, or psychological disorder or disability. While, the negative predictors were decreasing functional capacity, involvement of number of limbs in increasing order, high therapeutic requirements, and dependency. ConclusionThe association between early diagnosis of cerebral palsy and improved functional capacity, involvement of a lesser number of limbs, better quality of life, and absence of associated disabilities is established from the findings of our study.

139 Role of Hemodialysis in Cases of Uncertain Altered Mental Status: Navigating Between Neurologic and Toxicologic Origin

139 Role of Hemodialysis in Cases of Uncertain Altered Mental Status: Navigating Between Neurologic and Toxicologic Origin

Epidemiological, Clinical and Etiological Aspects of Urinary Sphincter Disorders of Neurological Origin at Conakry University Hospital

Introduction: Most neurological disorders in our context have a high frequency of urinary sphincter disorders, which makes it necessary to investigate the etiologies and analyze the epidemio-clinical features.

Forecasting Epileptic Seizures Using XGBoost Methodology and EEG Signals

INTRODUCTION: Epilepsy denotes a disorder of neurological origin marked by repetitive and spontaneous seizures without any apparent trigger. Seizures occur due to abrupt and heightened electricity flowing through the brain, which can lead to physical and mental symptoms. There are several types of epileptic seizures, and epilepsy itself can be caused by various underlying conditions. EEG (Electroencephalogram) is one of the most important and widely used tools for epileptic seizure prediction and diagnosis. EEG uses skull sensors to record electrical signals from the brain., and it can provide valuable insights into brain activity patterns associated with seizures.
 OBJECTIVES: Brain-computer interface technology pathway for analyzing the EEG signals for seizure prediction to eliminate the class imbalance issue from our dataset in this case, a SMOTE approach is applied. It is observable that there are more classes of one variable than there are of the others in the output variable. This will be problematic when employing different Artificial intelligence techniques since these algorithms are more likely to be biased towards a certain variable because of its high prevalence
 METHODS: SMOTE approaches will be used to address this bias and balance the number of variables in the response variable. To develop an XGBoost (Extreme Gradient Boosting) model using SMOTE techniques to increase classification accuracy.
 RESULTS: The results show that the XGBoost method achieves a 98.7% accuracy rate.
 CONCLUSION: EEG-based model for seizure type using the XGBoost model for predicting the disease early. The Suggested method could significantly reduce the amount of time needed to accomplish seizure prediction.

Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice

Transmembrane prolyl 4-hydroxylase (P4H-TM) is an enigmatic enzyme whose cellular function and primary substrate remain to be identified. Its loss-of-function mutations cause a severe neurological HIDEA syndrome with hypotonia, intellectual disability, dysautonomia and hypoventilation. Previously, P4H-TM deficiency in mice was associated with reduced atherogenesis and lower serum triglyceride levels. Here, we characterized the glucose and lipid metabolism of P4h-tm−/− mice in physiological and tissue analyses. P4h-tm−/− mice showed variations in 24-h oscillations of energy expenditure, VO2 and VCO2 and locomotor activity compared to wild-type (WT) mice. Their rearing activity was reduced, and they showed significant muscle weakness and compromised coordination. Sedated P4h-tm−/− mice had better glucose tolerance, lower fasting insulin levels, higher fasting lactate levels and lower fasting free fatty acid levels compared to WT. These alterations were not present in conscious P4h-tm−/− mice. Fasted P4h-tm−/− mice presented with faster hepatic glycogenolysis. The respiratory rate of conscious P4h-tm−/− mice was significantly lower compared to the WT, the decrease being further exacerbated by sedation and associated with acidosis and a reduced ventilatory response to both hypoxia and hypercapnia. P4H-TM deficiency in mice is associated with alterations in whole-body energy metabolism, day-night rhythm of activity, glucose homeostasis and neuromuscular and respiratory functions. Although the underlying mechanism(s) are not yet fully understood, the phenotype appears to have neurological origins, controlled by brain and central nervous system circuits. The phenotype of P4h-tm−/− mice recapitulates some of the symptoms of HIDEA patients, making this mouse model a valuable tool to study and develop tailored therapies.

Equine desmitis, pelvic disease Desmitis of the wide portion of the sacroiliac ligament in horses

Two adult horses, a male (6 years old, castrated) half-blooded Quarter Horse and a Mangalarga mare (7 years old) each showed decreased step amplitude and lameness of one of their hind limbs (right and left respectively) after working in handling cattle (both with Grade I, scale from 0 to 5). In addition, the male presented slight atrophy in the musculature of the right superficial gluteus. After clinical examination and screening with thermography (done before the animal worked, at the pen and not exposed to any heat source or solar irradiation or any product on the skin surface) no "hot spot" was found in in the right or left limb of either horse, thus raising suspicion of a "high" lesion, without neurological origin, opting for transrectal pelvic evaluation by ultrasound (6.5 MHz linear rectal transducer) in those animals. Differences were found between the left and right sides in the ligaments, in the images produced by the examination of the wide portions of the sacroiliac ligament, associated with pain on the side corresponding to the change in the image obtained. We can thus conclude, after thermography and clinical and neurological examination which excluded any injuries to the hind limbs, that the cause of lameness in these clinical cases is unilateral desmitis of the wide portions of the sacroiliac ligament, showing the importance of transrectal ultrasound evaluation in cases of pain in the limbs or even high claudication.

Facial Blanching As An Unusual Complication After The Injection of Local Anesthesia: A Clinical Report

Facial blanching is a complication related to local anesthesia in dentistry. Anatomical variation, intravascular injection, rapid local anesthetic injection, decreased blood flow with the vasopressor effect of epinephrine, ortho-retrograde movement of the solution, incorrect positioning of the needle, and neurological origin may cause this phenomenon, the etiology of which is not fully known. Most of the blanching cases reported in the literature are related to injection of the inferior alveolar nerve block. Also, intra-extraoral clinical photography is limited. Supraperiosteal infiltration anesthesia is a safe and easy technique that is frequently used in daily practice in dental clinics. This unique case report describes partial blanching of the face and gingiva after supraperiosteal infiltration of vasoconstrictor containing local anesthetic into the maxilla. In addition, the clinical-anatomical relationship of facial-mucosal blanching with the injection site, literature information, and clinical management with this complication are explained.

Emergencies in occupational medicine: the experience of an on-site medical office

Abstract Objective : Medical emergencies (ME) in the occupational medicine (OM) office represent an increasingly frequent challenge, because they may require treatment or an ambulance, involving monitoring the patient, halting scheduled activity. The objective of this retrospective observational study was to study ME in the on-site medical office of a local pharmaceutical company, with an emphasis on the differences between major and minor emergencies, and on the factors associated with a longer duration of consultations, in order to optimize management. Methods : ME in the on-site office of a local company, January - June 2023 (109 working days), were recorded. The presentations were divided into 2 groups (G): G1 - ME that required ambulance/hospitalization/immediate treatment (etiological and/or symptomatic) and G2 - ME without immediate intervention. Results : During the 109 working days analyzed, 173 consultations involved ME (12.5% of the total presentations), with a mean of 1.6 presentations/day, On the 62 days with ME, the average was 2.7 presentations/day. The presentations, with a mean age of 40.8 years and a female predominance (69.4%), were divided into 2 groups: G1 included 95 (54.9%) presentations with immediate intervention, G2 - 78 (45.1%). In G1, 8 (8.4%) presentations required ambulance to hospital, 39 (41.1%) received etiological treatment, and 76 (81.1%) symptomatic treatment. Presentations for infectious diseases in a pandemic context ranked first This emphasizes the role of the OM physician in assessing Covid-19 contacts/patients. An ME consultation lasted on average 16.2 minutes, with a maximum of 19.4 minutes (excluding Covid-19 rapid testing). The most frequent ME complaints/humors were of cardiovascular, neurological, digestive and musculoskeletal origin. The maximum duration was in cardiovascular disease, associated with each type of intervention (p<0.0001 in the 3 cases: ambulatory/symptomatic/etiological treatment). Conclusion : ME in the OM doctor’ activity are frequent, more so in middle-aged women, especially between 12:01-16:00. They add approximately 2-3 consultations daily, in addition to the scheduled ones (30-45 additional minutes). Most ME require medical intervention: treatment in the office/ambulance. Apart from the COVID-19 context, most ME were cardiovascular (most time-consuming), digestive, neurological, and musculoskeletal. The duration of emergency consultations, additional to appointments, could require dedicated intervals, in order not to overload the physician. A systematized analysis of ME, paralleled by a good feedback towards the employer, could favor an individualized approach and an optimized endowment of the office, allowing identification of undiagnosed chronic disease, which would enhance productivity.

Sexual Violence and Alcohol Intake: A Population-Based Explorative Study in a Northwestern Italian Area.

Background and Objectives: Sexual violence (SV) is a major global public health concern. While socioeconomic factors and familial relationships have been widely reported to contribute to SV, the role of alcohol consumption should not be ignored. Indeed, alcohol can impair cognition, distort reality, increase aggression, and ease drug-facilitated sexual assault. This retrospective study aims to explore the relationship between alcohol consumption and SV by examining the prevalence, characteristics, and consequences of violence episodes. Materials and Methods: A total of 1481 women accessed the Rape Centre "Centro Soccorso Violenza Sessuale" in Turin, Italy between 2008 and 2019, with 223 reporting alcohol consumption before the assault. Results: The alcohol group had a younger age profile, predominantly within the 18-25-year-old category. SV incidents involving alcohol consumers were more likely to occur in public places or in someone else's home, while the non-alcohol-consuming group experienced more violence in their own homes. Acquaintances and unknown individuals were primarily responsible, whereas partners were the most common perpetrators of violence against non-alcohol-consuming women. Alcohol consumers sought medical attention sooner after the assault and exhibited more symptoms and injuries, particularly of neurological origin. Concurrent use of recreational drugs was higher among alcohol consumers. The logistic regression analysis revealed higher odds of injury for Italian women and those in the 18-35 age groups after consuming alcohol. Conclusions: This study contributes to the understanding of the relationship between alcohol consumption and SV. The prevalence of alcohol-related sexual aggression is lower compared to that shown in previous studies. Nationality, age, and assailant identity influence SV dynamics. These findings can guide well-targeted interventions and prevention strategies to address SV and inform communities facing similar challenges.

Pharmacological Management for Pediatric Irritable Bowel Syndrome: A Review.

Irritable bowel syndrome is a multifactorial disease with chronic symptoms that interfere with the quality of life of patients. It represents one of the most common causes of functional abdominal pain in the pediatric population. Various theses with little evidence tried to explain the pathophysiology of the disease. Neurological origin was one of the theories explaining the disease, either by the disturbance of neurotransmitters like dopamine, noradrenaline, and serotonin, which have some evidence of their relation to GI tract functions. Other factors like bio-psycho-social factors that affect the pediatric population are represented in bullying, unrealistic academic expectations from the parents, continuous educational stress, and difficult relationships with peers. Other factors may be genetic abnormalities of the receptors or visceral hypersensitivity. Treatment strategies for the disease varied from physical activity like yoga to a diet like a low-FODMAP diet. Pharmacological treatment of the disease targets the presenting symptoms, represented by antispasmodic drugs treating abdominal pain/discomfort, antipsychotics that regulate the disturbance in the brain-gut axis, and other drugs targeting diarrhea or constipation that present with the patient according to the type of IBS and the condition of the patient.

Hiccups of Neurological Origin: A Case Report

Hiccups are most often benign and short-lived, but they can also be persistent (> 48h) or even refractory (> 1 month). In these cases, it impairs qualitý of life and can have serious health consequences. We report the case of a patient who consulted for chronic hiccups with absences and in whom the neurological origin was confirmed on brain MRI.

Neurologic orphan diseases: Emerging innovations and role for genetic treatments.

Orphan diseases are rare diseases that affect less than 200000 individuals within the United States. Most orphan diseases are of neurologic and genetic origin. With the current advances in technology, more funding has been devoted to developing therapeutic agents for patients with these conditions. In our review, we highlight emerging options for patients with neurologic orphan diseases, specifically including diseases resulting in muscular deterioration, epilepsy, seizures, neurodegenerative movement disorders, inhibited cognitive development, neuron deterioration, and tumors. After extensive literature review, gene therapy offers a promising route for the treatment of neurologic orphan diseases. The use of clustered regularly interspaced palindromic repeats/Cas9 has demonstrated positive results in experiments investigating its role in several diseases. Additionally, the use of adeno-associated viral vectors has shown improvement in survival, motor function, and developmental milestones, while also demonstrating reversal of sensory ataxia and cardiomyopathy in Friedreich ataxia patients. Antisense oligonucleotides have also been used in some neurologic orphan diseases with positive outcomes. Mammalian target of rapamycin inhibitors are currently being investigated and have reduced abnormal cell growth, proliferation, and angiogenesis. Emerging innovations and the role of genetic treatments open a new window of opportunity for the treatment of neurologic orphan diseases.

Admission and discharge profiles of people with MS accessing in-patient rehabilitation in Canada

BackgroundRehabilitation is the mainstay of management for people with disabilities of neurological origin to maximize function and reduce disability. Access to in-patient rehabilitation is usually reserved for people after crises or those who are discharged from acute care such as in stroke or trauma. Access to people with Multiple Sclerosis (MS) differs across countries and unknown for Canada. With the progression of MS, quality of life (QOL) becomes more closely coupled with independence and hence timely access to rehabilitation is important. The objectives of this paper are (i) to characterize the disability profiles of people with MS admitted to in-patient rehabilitation in Canada; and (ii) to estimate the extent to which disability profiles differ from admission to discharge. MethodsA longitudinal study of a rehabilitation admission-to-discharge cohort of 3500 people with MS was conducting using latent class analysis on the five Functional Independence Measure (FIM) subscales for Self-care, Transfers, Locomotion, Bladder/Bowel, and Cognition. The extent to which age, sex, and calendar time was associated with latent class membership, at both admission and discharge, was estimated using ordinal logistic regression, and proportional odds model was calculated for each age and sex. ResultsAt admission five classes were identified. The two most prevalent classes included people with total or moderate dependency in all FIM subscales except cognition (n = 1205 and n = 1099). The third most common was dependent in ambulation only (n = 523), followed by dependence in ambulation with varying degree of limitation in self-care and transfers (n = 465, and n = 208). At discharge four classes were identified with the largest class comprising of people dependent in ambulation and to a lesser degree in transfers (n = 1010). The second most prevalent class was no dependency (n = 946), followed by two classes with varying dependency in all subscales but cognition (n = 678 and n = 771). ConclusionOverall 62.3% of admissions transitioned to a more functional class by discharge. By discharge 28% of the population was characterized by no dependencies; however, 23% remained with dependencies in all areas. Those in the most dependent classes showed the greatest probability of transitioning to a better class at discharge highlighting the importance of reserving scarce rehabilitation services to those with more disability.

Melatonin in the regulation of human life and its role in development pathology

The aim of our study was to research the literature data available for analysis of the melatonin role in the neurological and mental disorders origin. Materials and methods: to compile a literature review by keywords, articles there were selected and analyzed in the MEDLINE / PubMed and e-library databases from 1993 to 2021. For a detailed analysis, 42 literature sources were selected for the melatonin role in the development of neurological and mental disorders. Results: Melatonin is a hormone with unique adaptive capabilities. Violation of its production, both quantitatively and its rhythm, is the starting point, leading at the initial stages to desynchronizes, followed by the emergence of organic pathology. Consequently, the very fact of a violation of melatonin production can be the cause of various diseases. It was found that the volume of the pineal gland can change with the development of various types of neurological and psychiatric diseases, which is associated with a violation of the synthesis of melatonin and serotonin. Melatonin has been found to have important protective properties in Alzheimer's disease - the ability to inhibit the formation of beta-amyloid peptide in the brain, which is the morphological basis of this disease. The same correlation was found in patients with autism, psychosis and obsessive-compulsive disorder compared with healthy volunteers. Regarding the neuroprotective properties of melatonin, it should be noted its effectiveness in age-related diseases (Alzheimer's, Parkinson's, vascular diseases) Conclusion: Melatonin can be considered as a unique bioregulator, adaptogen and stabilizer of the whole organism and, in particular, the functions of the central nervous system. It has been proven that disruption of melatonin metabolism leads to various neurological and mental disorders.

A COMPREHENSIVE STUDY OF CLINICAL PROFILE, RISK FACTORS AND TREATMENT OUT COME OF PERIPHERAL ARTERIAL DISEASES OF LOWER EXTREMITIES

Objectives: To study the pattern of clinical presentation, aetiology, various investigations for diagnosis and management of Peripheral arterial occlusive disease. This is a cross-sectional s Materials And Methods: tudy including 50 patients who presented to OPD at Government General Hospital, Anantapur, with Peripheral arterial occlusive disease. patients above the age of 18 years with symptoms of rest pain, claudication pain, ulceration and gangrene with evidence of lower limb arterial occlusive disease on doppler are included in this study. Patients less than 18 years of age and PAD of upper extremities, patients with history of trauma of lower extremities and pain due to musculoskeletal or neurological origin are excluded. The results of the Statistical Analysis: study are expressed in terms of proportion. In this study the most common etiological factor contributing for Peripheral arterial o Results: cclusive disease is atherosclerosis (76%) followed by thromboangiitis obliterans (24%). This disease has male preponderance and the most common age group affected is 41 years and above. The most common mode of presentation is rest pain and 50% of patients presented with gangrene affecting foot and lower 1/3rd of leg. The most common co-morbid condition associated with Peripheral arterial occlusive disease in this study is diabetes mellitus. Tobacco smoking is the most common addiction associated with Peripheral arterial occlusive disease. 45% patients with atherosclerosis showed involvement of infra-popliteal site. Almost all patients required surgical intervention due to the late presentation at tertiary care center. 66% of patients in this study required amputation. None of the patient died following amputation in this study.The cardiac evaluation showed abnormality in almost 20% of the study group. This emphasises the need for cardiac evaluation in all cases of peripheral arterial disease and this condition is called atherosclerosis. peripheral arterial disease is due Conclusion: to atherosclerosis in most of cases with male preponderance after 41 years and above with gangrene as the most common clinical presentation. Prompt surgical intervention in the form of amputation, reduced mortality rate.

In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain

There is growing evidence that Alzheimer's disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey, a good source of antioxidants and bioactive molecules, has been tied to many health benefits, including those from neurological origin. Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are still unknown. The aim of this study is to further its characterization, focusing on the phenolic profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo. Finally, a deep analysis on the pathophysiological features of AD such as oxidative stress, amyloid-β aggregation, and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans. AH exerted a high antioxidant capacity in vitro and in vivo. No toxicity was found in C. elegans at the dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally, AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although the real contribution of AH remains unclear. The mechanisms under the observed effects might be attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results increase the interest to study the biomedical applications of AH; however, more research is needed to deepen the mechanisms under the observed effects.