Neural Representations Of Self Research Articles

The Role of the Medial Prefrontal Cortex in Moderating Neural Representations of Self and Other in Primates.

As a frontal node in the primate social brain, the medial prefrontal cortex (MPFC) plays a critical role in coordinating one's own behavior with respect to that of others. Current literature demonstrates that single neurons in the MPFC encode behavior-related variables such as intentions, actions, and rewards, specifically for self and other, and that the MPFC comes into play when reflecting upon oneself and others. The social moderator account of MPFC function can explain maladaptive social cognition in people with autism spectrum disorder, which tips the balance in favor of self-centered perspectives rather than taking into consideration the perspective of others. Several strands of evidence suggest a hypothesis that the MPFC represents different other mental models, depending on the context at hand, to better predict others' emotions and behaviors. This hypothesis also accounts for aberrant MPFC activity in autistic individuals while they are mentalizing others.

Dispositional Self-Construal Modulates Neural Representation of Self: An ERP Study.

This study aimed to investigate the influence of dispositional self-construal on self-related processing. Event-related potentials (ERPs) were recorded for a participant’s own and a famous person’s name in a three-stimulus oddball task. The results showed greater P2 and P3 amplitudes induced by one’s own than by a famous person’s name in both independent and interdependent self-construal groups. However, no N2 amplitude differences were found between the partcipant’s own name and a famous person’s name in either group. Moreover, the strength of the P2 effect (own vs. famous person’s name) was stronger in the independent than in the interdependent self-construal group, whereas the P3 effect was similar between these two groups. Thus, these findings might reflect fast modulation of self-related processing by dispositional self-construal.

Changes in the Effective Connectivity of the Social Brain When Making Inferences About Close Others vs. the Self.

Previous research showed that the ability to make inferences about our own and other’s mental states rely on common brain pathways; particularly in the case of close relationships (e.g., romantic relationships). Despite the evidence for shared neural representations of self and others, less is known about the distributed processing within these common neural networks, particularly whether there are specific patterns of internode communication when focusing on other vs. self. This study aimed to characterize context-sensitive coupling among social brain regions involved in self and other understanding. Participants underwent an fMRI while watching emotional video vignettes of their romantic partner and elaborated on their partner’s (other-condition) or on their own experience (self-condition). We used dynamic causal modeling (DCM) to quantify the associated changes in effective connectivity (EC) in a network of brain regions involved in social cognition including the temporoparietal junction (TPJ), the posterior cingulate (PCC)/precuneus and middle temporal gyrus (MTG). DCM revealed that: the PCC plays a central coordination role within this network, the bilateral MTG receives driving inputs from other nodes suggesting that social information is first processed in language comprehension regions; the right TPJ evidenced a selective increase in its sensitivity when focusing on the other’s experience, relative to focusing on oneself.

The neural representation of self is recapitulated in the brains of friends: A round-robin fMRI study.

Humans continually form and update impressions of each other's identities based on the disclosure of thoughts, feelings, and beliefs. At the same time, individuals also have specific beliefs and knowledge about their own self-concept. Over a decade of social neuroscience research has shown that retrieving information about the self and about other persons recruits similar areas of the medial prefrontal cortex (MPFC), however it remains unclear if an individual's neural representation of self is reflected in the brains of well-known others or if instead the two representations share no common relationship. Here we examined this question in a tight-knit network of friends as they engaged in a round-robin trait evaluation task in which each participant was both perceiver and target for every other participant and in addition also evaluated their self. Using functional MRI and a multilevel modeling approach, we show that multivoxel brain activity patterns in the MPFC during a person's self-referential thought are correlated with those of friends when thinking of that same person. Moreover, the similarity of neural self-other patterns was itself positively associated with the similarity of self-other trait judgments ratings as measured behaviorally in a separate session. These findings suggest that accuracy in person perception may be predicated on the degree to which the brain activity pattern associated with an individual thinking about their own self-concept is similarly reflected in the brains of others. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Decoding the neural representation of self and person knowledge with multivariate pattern analysis and data-driven approaches.

Multivariate pattern analysis and data-driven approaches to understand how the human brain encodes sensory information and higher level conceptual knowledge have become increasingly dominant in visual and cognitive neuroscience; however, it is only in recent years that these methods have been applied to the domain of social information processing. This review examines recent research in the field of social cognitive neuroscience focusing on how multivariate pattern analysis (e.g., pattern classification, representational similarity analysis) and data-driven methods (e.g., reverse correlation, intersubject correlation) have been used to decode and characterize high-level information about the self, other persons, and social groups. We begin with a review of what is known about how self-referential processing and person perception are represented in the medial prefrontal cortex based on conventional activation-based neuroimaging approaches. This is followed by a nontechnical overview of current multivariate pattern-based and data-driven neuroimaging methods designed to characterize and/or decode neural representations. The remainder of the review focuses on examining how these methods have been applied to the topic of self, person perception, and the perception of social groups. In this review, we highlight recent trends (e.g., analysis of social networks, decoding race and social groups, and the use of naturalistic stimuli) and discuss several theoretical challenges that arise from the application of these new methods to the question of how the brain represents knowledge about the self and others. This article is categorized under: Neuroscience > Cognition.

Neural representations of the multidimensional self in the cortical midline structures

Self-concept consists of self-identity that distinguishes self from other people and knowledge that describes one's own attributes in different dimensions. Because self-concept plays a fundamental role in individuals' social functioning and mental health, behavioral studies have examined cognitive processes of self-identity and self-knowledge extensively. Nevertheless, how different dimensions of the self-concept are organized in multi-voxel neural patterns remains elusive. Here, we address this issue by employing representational similarity analyses of behavioral/theoretical models of multidimensional self-representation and blood oxygen level dependent responses, recorded using functional MRI, to judgments of personality traits, physical attributes and social roles of oneself, a close (one's mother) other, and a distant (celebrity) other. The multivoxel patterns of neural activities in the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC) distinguished representations of the self from both close and distant others, suggesting a specific neural representation of the self-identity; and distinguished different dimensions of person knowledge of oneself, indicating dimension-sensitive neural representation of the self. Moreover, the pattern of PCC activity is more strongly coupled with dimensions of self-knowledge than self-identity. Our findings suggest that multivoxel neural patterns of the cortical midline structures distinguish not only self from others but also discriminate different dimensions of the self.

Neurofeedback and the Neural Representation of Self: Lessons From Awake State and Sleep.

Neurofeedback has been around for half a century, but despite some promising results it is not yet widely appreciated. Recently, some of the concerns about neurofeedback have been addressed with functional magnetic resonance imaging and magnetoencephalography adding their contributions to the long history of neurofeedback with electroencephalography. Attempts to address other concerns related to methodological issues with new experiments and meta-analysis of earlier studies, have opened up new questions about its efficacy. A key concern about neurofeedback is the missing framework to explain how improvements in very different and apparently unrelated conditions are achieved. Recent advances in neuroscience begin to address this concern. A particularly promising approach is the analysis of resting state of fMRI data, which has revealed robust covariations in brain networks that maintain their integrity in sleep and even anesthesia. Aberrant activity in three brain wide networks (i.e., the default mode, central executive and salience networks) has been associated with a number of psychiatric disorders. Recent publications have also suggested that neurofeedback guides the restoration of “normal” activity in these three networks. Using very recent results from our analysis of whole night MEG sleep data together with key concepts from developmental psychology, cloaked in modern neuroscience terms, a theoretical framework is proposed for a neural representation of the self, located at the core of a double onion-like structure of the default mode network. This framework fits a number of old and recent neuroscientific findings, and unites the way attention and memory operate in awake state and during sleep. In the process, safeguards are uncovered, put in place by evolution, before any interference with the core representation of self can proceed. Within this framework, neurofeedback is seen as set of methods for restoration of aberrant activity in large scale networks. The framework also admits quantitative measures of improvements to be made by personalized neurofeedback protocols. Finally, viewed through the framework developed, neurofeedback’s safe nature is revealed while raising some concerns for interventions that attempt to alter the neural self-representation bypassing the safeguards evolution has put in place.

Reminders of mortality weaken P2 amplitude underlying both self-reflection and mother-reflection

Recent research has repeatedly shown that people usually escape self-related thoughts to behaviorally buffer the anxiety elicited by death, and that reminders of mortality influence the brain activations related to self-related thoughts. Meanwhile, neuroimaging studies have suggested an overlapped neural representation of self and intimate others (e.g., mother) in Chinese individuals. However, whether mortality salience (MS) influences the neural processing of both self and mother in Chinese individuals has not been examined. Therefore, the current study recorded the event-related potentials in response to self-reflection and mother-reflection after MS priming. Our results showed that relative to neutral priming, MS priming significantly decreased the peak of P2 in response to both self-related and mother-related traits. Our work suggested a similar neural mechanism of the avoidance of both self-focus and mother-focus after being reminded of mortality.

Shared neural representations of self and conjugal family members in Chinese brain

Human adults share ample experiences with their spouse and offspring. Do these experiences produce shared neural correlates of reflection on oneself and family members? We addressed this issue by scanning 14 Chinese middle-aged married couples, using functional MRI, during personality trait judgments of the self, one’s spouse, one’s child, and a celebrity. We found common activations in the medial prefrontal cortex (MPFC) during trait judgments of the self, spouse, and child compared to a celebrity. Self- and spouse-judgments also elicited overlapping activations in the ventral thalamus and caudate. Female and male participants showed comparable MPFC activity during child-judgments but females exhibited stronger MPFC activity during spouse-judgments compared to males. Our neuroimaging findings suggest that life experiences with conjugal family members during adulthood shape the functional organization of the brain and result in shared neural representations of oneself and conjugal family members during reflection on personality traits.

Protecting the Self: The Effect of Social-evaluative Threat on Neural Representations of Self

One of the most robust ways that people protect themselves from social-evaluative threat is by emphasizing the desirability of their personal characteristics, yet the neural underpinnings of this fundamental process are unknown. The current fMRI study addresses this question by examining self-evaluations of desirability (in comparison with other people) as a response to threat. Participants judged how much personality traits described themselves in comparison with their average peer. These judgments were preceded by threatening or nonthreatening social-evaluative feedback. Self-evaluations made in response to threat significantly increased activation in a number of regions including the OFC, medial pFC, lateral pFC, amygdala, and insula. Individual differences in the extent to which threat increased desirability were significantly correlated with medial OFC activity. This is the first study to examine the neural associations of a fundamental self-protection strategy: responding to threat by emphasizing the self's desirability. Although neural research has separately examined self-evaluation processes from the regulation of social-evaluative threat, little is known about the interplay between the two. The findings build on this previous research by showing that regions, often associated with self-evaluation, are modulated by the degree to which people respond to threat by emphasizing their own desirability.

Pourquoi les autres me regardent ainsi ? À propos de la sensibilité au regard des patients insulino-dépendants

The neural representation of self is a fundamental question for brain research. Employing activation likelihood estimation (ALE) meta-analyses, we assessed the commonalities and distinctions between different components of the self by focusing on the ‘physical’ self and the ‘psychological’ self – assessed respectively through face processing and self-referential tasks. We first conducted ALE meta-analyses by computing the convergence of findings on brain activation in self-face recognition and self-referential studies respectively. Contrast and conjunction analyses of these two meta-analytic results were then applied to extract the distinctions and commonalities in self-face and self-reference tasks. Facial self processing was particularly associated with lateral brain regions with a right hemispheric dominance, while processing psychological self predominantly activated cortical midline structures, more specifically the anterior cingulate cortex/superior frontal cortex. In contrast, the conjunction analyses showed that the two aspects of self-processing recruit the dorsal anterior cingulate cortex and the left inferior frontal gyrus extending to the insula. A framework including both distinct and common neural representation of selfs is discussed.

Familiarity promotes the blurring of self and other in the neural representation of threat

Neurobiological investigations of empathy often support an embodied simulation account. Using functional magnetic resonance imaging (fMRI), we monitored statistical associations between brain activations indicating self-focused threat to those indicating threats to a familiar friend or an unfamiliar stranger. Results in regions such as the anterior insula, putamen and supramarginal gyrus indicate that self-focused threat activations are robustly correlated with friend-focused threat activations but not stranger-focused threat activations. These results suggest that one of the defining features of human social bonding may be increasing levels of overlap between neural representations of self and other. This article presents a novel and important methodological approach to fMRI empathy studies, which informs how differences in brain activation can be detected in such studies and how covariate approaches can provide novel and important information regarding the brain and empathy.

Medial PFC Damage Abolishes the Self-reference Effect

Functional neuroimaging studies suggest that the medial PFC (mPFC) is a key component of a large-scale neural system supporting a variety of self-related processes. However, it remains unknown whether the mPFC is critical for such processes. In this study, we used a human lesion approach to examine this question. We administered a standard trait judgment paradigm [Kelley, W. M., Macrae, C. N., Wyland, C. L., Caglar, S., Inati, S., & Heatherton, T. F. Finding the self? An event-related fMRI study. Journal of Cognitive Neuroscience, 14, 785-794, 2002] to patients with focal brain damage to the mPFC. The self-reference effect (SRE), a memory advantage conferred by self-related processing, served as a measure of intact self-processing ability. We found that damage to the mPFC abolished the SRE. The results demonstrate that the mPFC is necessary for the SRE and suggest that this structure is important for self-referential processing and the neural representation of self.

Shared Neural Circuits for Mentalizing about the Self and Others

Although many examples exist for shared neural representations of self and other, it is unknown how such shared representations interact with the rest of the brain. Furthermore, do high-level inference-based shared mentalizing representations interact with lower level embodied/simulation-based shared representations? We used functional neuroimaging (fMRI) and a functional connectivity approach to assess these questions during high-level inference-based mentalizing. Shared mentalizing representations in ventromedial prefrontal cortex, posterior cingulate/precuneus, and temporo-parietal junction (TPJ) all exhibited identical functional connectivity patterns during mentalizing of both self and other. Connectivity patterns were distributed across low-level embodied neural systems such as the frontal operculum/ventral premotor cortex, the anterior insula, the primary sensorimotor cortex, and the presupplementary motor area. These results demonstrate that identical neural circuits are implementing processes involved in mentalizing of both self and other and that the nature of such processes may be the integration of low-level embodied processes within higher level inference-based mentalizing.

Dynamic bicultural brains: fMRI study of their flexible neural representation of self and significant others in response to culture primes

Where in the brain are the self and significant others (e.g. mother) represented? Neuroscientists have traced self‐representation to the ventral medial prefrontal cortex for both Westerners and East Asians. However, significant others were represented alongside the self in the same brain area for East Asians but not for Westerners. In this experiment, Westernized bicultural Chinese were scanned using functional magnetic resonance imaging while performing trait judgments that referenced the self, mother, or a non‐identified person (NIP) after Western or Chinese culture priming. Consistent with Western independent self‐construals and Chinese interdependent self‐construals, Western priming increased, whereas Chinese priming decreased the neural differentiation of mother and NIP from self.

Interdependent self-construal and neural representations of self and mother

Representations of self are thought to be dynamically influenced by one's surroundings, including the culture one lives in. However, neuroimaging studies of self-representations have either ignored cultural influences or operationalized culture as country of origin. The present study used functional magnetic resonance imaging to examine the neural correlates of individual differences in interdependent self-construal. Participants rated whether trait adjectives applied to themselves or their mothers, or judged their valence or font. Findings indicated that individual differences in interdependent self-construal correlated positively with increased activation in the medial prefrontal cortex and posterior cingulated cortex when making judgments about one-self vs making judgments about one's mother. This suggests that those with greater interdependent self-construals may rely more upon episodic memory, reflected appraisals, or theory of mind to incorporate social information to make judgments about themselves.

Neural basis of individualistic and collectivistic views of self

Individualism and collectivism refer to cultural values that influence how people construe themselves and their relation to the world. Individualists perceive themselves as stable entities, autonomous from other people and their environment, while collectivists view themselves as dynamic entities, continually defined by their social context and relationships. Despite rich understanding of how individualism and collectivism influence social cognition at a behavioral level, little is known about how these cultural values modulate neural representations underlying social cognition. Using cross-cultural functional magnetic resonance imaging (fMRI), we examined whether the cultural values of individualism and collectivism modulate neural activity within medial prefrontal cortex (MPFC) during processing of general and contextual self judgments. Here, we show that neural activity within the anterior rostral portion of the MPFC during processing of general and contextual self judgments positively predicts how individualistic or collectivistic a person is across cultures. These results reveal two kinds of neural representations of self (eg, a general self and a contextual self) within MPFC and demonstrate how cultural values of individualism and collectivism shape these neural representations.

Neural Representations of Self versus Other: Visual-Spatial Perspective Taking and Agency in a Virtual Ball-tossing Game

Human self-consciousness relies on the ability to distinguish between oneself and others. We sought to explore the neural correlates involved in self-other representations by investigating two critical processes: perspective taking and agency. Although recent research has shed light on the neural processes underlying these phenomena, little is known about how they overlap or interact at the neural level. In a two-factorial functional magnetic resonance imaging (fMRI) experiment, participants played a ball-tossing game with two virtual characters ("avatars"). During an active/agency (ACT) task, subjects threw a ball to one of the avatars by pressing a button. During a passive/nonagency (PAS) task, they indicated which of the other avatars threw the ball. Both tasks were performed from a first-person perspective (1PP), in which subjects interacted from their own perspective, and a third-person perspective (3PP), in which subjects interacted from the perspective of an avatar with another location in space. fMRI analyses revealed overlapping activity in medial prefrontal regions associated with representations of one's own perspective and actions (1PP and ACT), and overlapping activity in temporal-occipital, premotor, and inferior frontal, as well as posterior parietal regions associated with representation of others' perspectives and actions (3PP and PAS). These findings provide evidence for distinct neural substrates underlying representations of the self and others and provide support for the idea that the medial prefrontal cortex crucially contributes to a neural basis of the self. The lack of a statistically significant interaction suggests that perspective taking and agency represent independent constituents of self-consciousness.