This paper proposes a fault-tolerant control scheme for tracking and controlling hypersonic vehicles with unknown dynamics, actuator failures, and unmeasurable states. The approach involves using a radial-based neural network to approximate the unknown dynamics and reconstruct the entire system model. Additionally, a neural network state observer is proposed to estimate the unmeasurable state of the system. To address the impact of actuator faults, a nonlinear observer is designed to estimate and compensate for the approximation error of the neural network system and fault values. Furthermore, a prescribed performance function is introduced to ensure both transient and steady-state performance of the system. The bounded stability of the closed-loop system is demonstrated through Lyapunov stability analysis.