PurposeThis study aims to improve the muscle model control performance of a tendon-driven musculoskeletal system (TDMS) to overcome disadvantages such as multisegmentation and strong coupling. An adaptive network controller (ANC) with a disturbance observer is established to reduce the modeling error of the musculoskeletal model and improve its antidisturbance ability.Design/methodology/approachIn contrast to other control technologies adopted for musculoskeletal humanoids, which use geometric relationships and antagonist inhibition control, this study develops a method comprising of three parts. (1) First, a simplified musculoskeletal model is constructed based on the Taylor expansion, mean value theorem and Lagrange–d’Alembert principle to complete the decoupling of the muscle model. (2) Next, for this simplified musculoskeletal model, an adaptive neuromuscular controller is designed to acquire the muscle-activation signal and realize stable tracking of the endpoint of the muscle-driven robot relative to the desired trajectory in the TDMS. For the ANC, an adaptive neural network controller with a disturbance observer is used to approximate dynamical uncertainties. (3) Using the Lyapunov method, uniform boundedness of the signals in the closed-loop system is proved. In addition, a tracking experiment is performed to validate the effectiveness of the adaptive neuromuscular controller.FindingsThe experimental results reveal that compared with other control technologies, the proposed design techniques can effectively improve control accuracy. Moreover, the proposed controller does not require extensive considerations of the geometric and antagonistic inhibition relationships, and it demonstrates anti-interference ability.Originality/valueMusculoskeletal robots with humanoid structures have attracted considerable attention from numerous researchers owing to their potential to avoid danger for humans and the environment. The controller based on bio-muscle models has shown great performance in coordinating the redundant internal forces of TDMS. Therefore, adaptive controllers with disturbance observers are designed to improve the immunity of the system and thus directly regulate the internal forces between the bio-muscle models.