The large increase in the number of Internet of Things (IoT) devices have revolutionised the way data is processed, which added to the current trend from cloud to edge computing has resulted in the need for efficient and reliable data processing near the data sources using energy-efficient devices. Two methods based on low-cost edge-IoT architectures are proposed to implement lightweight Machine Learning (ML) models that estimate indoor environmental quality (IEQ) parameters, such as Artificial Neural Networks of Multilayer Perceptron type. Their implementation is based on centralised and distributed parallel IoT architectures, connected via wireless, which share commercial off-the-self modules for data acquisition and sensing, such as sensors for temperature, humidity, illuminance, CO2, and other gases. The centralised method uses a Graphics Processing Unit and the Message Queuing Telemetry Transport protocol, but the distributed method utilises low-performance ARM-based devices and the Message Passing Interface protocol. Although multiple IEQ parameters are measured, the training and testing of ML models is accomplished with experiments focused on small temperature and illuminance datasets to reduce data processing load, obtained from sudden spikes, square profiles and sawteeth test cases. The results show a high estimation performance with F-score and Accuracy values close to 0.95, and an almost theorical Speedup with a reduction in power consumption close to 37% in the distributed parallel approach. In addition, similar or slightly better performance is achieved compared to equivalent IoT architectures from related research, but error reduction of 35–76% is accomplished with an adequate balance between performance and energy efficiency.