Network Connectivity Research Articles

A Latent Space Model for Weighted Keyword Co-occurrence Networks with Applications in Knowledge Discovery in Statistics

Keywords are widely recognized as pivotal in conveying the central idea of academic articles. In this article, we construct a weighted and dynamic keyword co-occurrence network and propose a latent space model for analyzing it. Our model has two special characteristics. First, it is applicable to weighted networks however, most previous models were primarily designed for unweighted networks. Simply replacing the frequency of keyword co-occurrence with binary values would result in a significant loss of information. Second, our model can handle the situation where network nodes evolve over time, and assess the effect of new nodes on network connectivity. We utilize the projected gradient descent algorithm to estimate the latent positions and establish the theoretical properties of the estimators. In the real data application, we study the keyword co-occurrence network within the field of statistics. We identify popular keywords over the whole period as well as within each time period. For keyword pairs, our model provides a new way to assess the association between them. Finally, we observe that the interest of statisticians in emerging research areas has gradually grown in recent years. Supplementary materials for this article are available online

Digital Infrastructure as a New Organizational Digital Climate Dimension

This study investigates the influence of digital infrastructure on creating an organizational climate conducive to digital transformation. It highlights the critical role of data lakes, network connectivity, and a shared digital language in cultivating an environment that aligns managerial objectives with employee engagement in digital initiatives. Through grounded theory methodology, the research uncovers how robust digital infrastructure can bridge the gap between leadership’s digital aspirations and employees’ practical use of digital tools, promoting data-driven decision-making and improving organizational performance. The findings suggest that a well-developed digital infrastructure is essential for fostering a digital climate that supports strategic business goals and enhances competitive advantage.

The multiple dimensions of resilience in agricultural trade networks

Abstract The global food and agricultural trade network is crucial for food security. Shocks such as those posed by extreme weather events, conflicts, pandemics, and economic crises can test the resilience of the trade network to the sudden interruption of trade flows. Depending on the level of connectivity in the trade network and its structure, such shocks have the potential to propagate through the entire network and can affect countries’ food availability and variety. The paper contributes to the literature on food and agricultural trade networks in two main ways: (1) understanding the global trade network as a complex system that can be affected by and responds to shocks, we define and operationalize its resilience as a multidimensional concept which is shaped by the interdependencies in the network and their structure; (2) applying techniques from network analysis to examine the evolution of three dimensions of resilience within the global food and agricultural trade network between 1995 and 2019. The main findings show that, between 1995 and 2007, trade connectivity among countries increased. Overall, this bolstered countries’ and the network's resilience to trade shocks. However, vulnerabilities persisted in terms of ensuring sufficient product variety and quantity. Adding to these vulnerabilities, trade integration stalled in the second half of the series, pointing to a slight tendency towards trade disintegration and potentially lower resilience of countries to trade shocks already in 2019.

Magazine Identification on SS1-V1 Assault Rifle using Web-based HX711 Load Cell Sensor

The SS1-V1 is an assault rifle model equipped with a magazine as one of its main components. The magazine plays a crucial role in storing and loading ammunition. However, magazines must be stored separately from the weapon as their integrated storage can pose a risk to a country’s security. Therefore, this research proposes a web-based system capable of identifying the presence of magazines in weapons in real-time. This system is supported by various hardware components, including a load cell sensor, HX711 sensor module, Arduino UNO R3, and an Ethernet shield for network connectivity. In addition, API is used for data management, which is then stored in the database. The results of this research indicate that the average response time for each rack within a cabinet is between 2.7s to 3.3s, while for racks serving as slaves, it ranges from 14.16s to 15.01s. Based on the results of the weight-based weapon identification testing, there is a weight difference of 0.1kg to 0.2kg. These results state that all tests were successfully identified by the web system according to the conditions of the weapons on the rack.

Localization and Network Connectivity of Lesions Causing Limb Ataxia in Patients With Stroke.

Ataxia is primarily considered to originate from the cerebellum. However, it can manifest without obvious cerebellar damage, such as in anterior circulation stroke, leaving the mechanisms of ataxia unclear. The aim of this study was to investigate whether stroke lesions causing limb ataxia localize to a common brain network. In this prospective cohort study, adult patients with new-onset stroke with visible lesions on CT or MRI from Turku University Hospital, Finland, were clinically examined (1) after their stroke while still admitted to the hospital (baseline) and (2) 4 months later (follow-up) to assess limb ataxia. Lesion locations and their functional connectivity, computed using openly available data from 1,000 healthy volunteers from the Brain Genome Superstruct Project, were compared voxel-by-voxel across the whole brain between patients with and without ataxia, using voxel-based lesion-symptom mapping and lesion network mapping. The findings were confirmed in an independent stroke patient cohort with identical clinical assessments. One hundred ninety-seven patients (mean age 67.2 years, 39%female) were included in this study. At baseline, 35 patients (68.3 years, 34%female) had and 162 (67.0 years, 40%female) did not have new-onset acute limb ataxia. At follow-up, additional 4 patients had developed late-onset limb ataxia, totalling to 39 patients (68.6 years, 36%female) with limb ataxia at any point. One hundred eighteen patients (66.2 years, 40%female) did not have ataxia at any point (n = 40 with missing follow-up data). Lesions in 54% of the patients with acute limb ataxia were located outside the cerebellum and cerebellar peduncles, and we did not find an association between specific lesion locations and ataxia. Lesions causing acute limb ataxia, however, were connected to a common network centered on the intermediate zone cerebellum and cerebellar peduncles (lesion connectivity in patients with vs without acute limb ataxia, pFWE < 0.05). The results were similar when comparing patients with and without ataxia at any point, and when excluding lesions in the cerebellum and cerebellar peduncles (pFWE < 0.05). The findings were confirmed in the independent stroke dataset (n = 96), demonstrating an OR of 2.27 (95% CI 1.32-3.91) for limb ataxia per standard deviation increase in limb ataxia network damage score. Lesions causing limb ataxia occur in heterogeneous locations but localize to a common brain network.

Characterization of the α-relaxation and gel-like dynamics in mixed network forming (GeO2)x(NaPO3)100-x glass melts by photon correlation spectroscopy

Dynamic light scattering investigations of the α-relaxation in network-forming (GeO2)x(NaPO3)100-x glass melts is reported for x = 0 to 40 mol% GeO2. Addition of GeO2 results in an increased density of bridging oxygen bonds. This monotonically increases the glass transition temperature but generates complex changes to the glass forming fragility which initially decreases with increasing GeO2 but increases again at higher GeO2 contents. A resolution to this odd fragility behavior is obtained by applying a coarse-graining procedure used previously in sodium germanate melts to arrive at a topological network connectivity for which fragility exhibits a universal dependence. Also observed in the light scattering measurements is a secondary relaxation, several orders of magnitude slower than that of the α-relaxation, which we tentatively attribute to gel-like anomalous diffusion of Ge crosslinks formed between phosphate chains.

In-Depth Analysis of Molecular Network Based on Liquid Chromatography Coupled with Tandem Mass Spectrometry in Natural Products: Importance of Redundant Nodes Discovery.

The identification of molecules within complex mixtures is a major bottleneck in natural products (NPs) research. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has emerged as the main tool for the high-throughput characterization of NPs. The large amount of data sets by LC-MS/MS presents a challenge for data processing and interpretation, and the LC-MS/MS molecular network (MN) is one of the most prominent tools for analyzing large MS/MS data sets, widely used for rapid classification, identification, and structural speculation of unknown compounds. However, the existence of a large number of redundant nodes leads to false-positive results. To solve this problem, we proposed the in-depth analysis of MN. In this study, in-depth analysis of MN of five NPs representing the common structures of saponin, steroid, flavonoid, alkaloid, and phenolic acid revealed the presence of redundant nodes (including other adducts, isotope, and in-source fragmentation) in addition to the normal nodes, which can lead to false-positive identification results. Additionally, the reasons for different redundant nodes are discussed and experimentally verified, and it was found that the impact of redundant nodes can be mitigated by optimizing the experimental conditions and employing Feature-Based Molecular Networking. Furthermore, Ion Identity Molecular Networking can rapidly discover and screen redundant nodes, simplifying the in-depth analysis of MN and improving the network connectivity of structurally related molecules. Finally, a combination formulation of 7 NPs is used as an example to provide a guide for in-depth analysis of MN for comprehensive characterization of complex systems. This study highlights the importance of an in-depth analysis of MN for better understanding and utilization of MS/MS data in complex systems to reduce the false-positive rate of identification by screening and filtering redundant nodes.

Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system.

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a prevalent, dose-limiting, tough-to-treat toxicity involving numbness, tingling, and pain in the extremities with enigmatic pathophysiology. This randomized controlled pilot study explored the feasibility and preliminary efficacy of exercise during chemotherapy on CIPN and the role of the interoceptive brain system, which processes bodily sensations. Nineteen patients (65 ± 11 years old, 52% women; cancer type: breast, gastrointestinal, multiple myeloma) starting neurotoxic chemotherapy were randomized to 12 weeks of exercise (home-based, individually tailored, moderate intensity, progressive walking, and resistance training) or active control (nutrition education). At pre-, mid-, and post-intervention, we assessed CIPN symptoms (primary clinical outcome: CIPN-20), CIPN signs (tactile sensitivity using monofilaments), and physical function (leg strength). At pre- and post-intervention, we used task-free ("resting") fMRI to assess functional connectivity in the interoceptive brain system, involving the salience and default mode networks. The study was feasible (74-89% complete data across measures) and acceptable (95% retention). We observed moderate/large beneficial effects of exercise on CIPN symptoms (CIPN-20, 0-100 scale: - 7.9 ± 5.7, effect size [ES] = - 0.9 at mid-intervention; - 4.8 ± 7.3, ES = - 0.5 at post-intervention), CIPN signs (ES = - 1.0 and - 0.1), and physical function (ES = 0.4 and 0.3). Patients with worse CIPN after neurotoxic chemotherapy had lower functional connectivity within the default mode network (R2 = 40-60%) and higher functional connectivity within the salience network (R2 = 20-40%). Exercise tended to increase hypoconnectivity and decrease hyperconnectivity seen in CIPN (R2 = 12%). Exercise during neurotoxic chemotherapy is feasible and may attenuate CIPN symptoms and signs, perhaps via changes in interoceptive brain circuitry. Future work should test for replication with larger samples. Registered Jan 2017 on ClinicalTrials.gov as NCT03021174.

Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders.

The chromosome 15q11.2 locus is deleted in 1.5% of patients with genetic epilepsy and confers a risk for intellectual disability and schizophrenia. Individuals with this deletion demonstrate increased cortical thickness, decreased cortical surface area and white matter abnormalities. Human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPC) from 15q11.2 deletion individuals exhibit early adhesion junction and migration abnormalities, but later neuronal development and function have not been fully assessed. Imaging studies indicating altered structure and network connectivity in the anterior brain regions and the cingulum suggest that in addition to alterations in progenitor dynamics, there may also be structural and functional changes within discrete networks of mature neurons. To explore this, we generated human forebrain cortical neurons from iPSCs derived from individuals with or without 15q11.2 deletion and used longitudinal imaging and multielectrode array analysis to evaluate neuronal development over time. 15q11.2 deleted neurons exhibited fewer connections and an increase in inhibitory neurons. Individual neurons had decreased neurite complexity and overall decreased neurite length. These structural changes were associated with a reduction in multiunit action potential generation, bursting and synchronization. The 15q11.2 deleted neurons also demonstrated specific functional deficits in glutamate and GABA mediated network activity and synchronization with a delay in the maturation of the inhibitory response to GABA. These data indicate that deletion of the 15q11.2 region is sufficient to impair the structural and functional maturation of cortical neuron networks which likely underlies the pathologic changes in humans with the 15q11.2 deletion.

Adaptive neural network based quadrotor UAV formation control under external disturbances

The formation control of a team comprised of multiple quadrotor Unmanned Aerial Vehicles (UAVs) may severely be affected by the unknown external disturbances. The external disturbances are caused by wind forces to create aero-dynamical disturbances. This article addresses the robust formation control problem of multiple UAVs system despite the effect of external disturbances that allow sustaining a stable network connection among the UAVs and maintaining different formations assigned to them. First, a Radial Basis Function Neural Network (RBFNN) based model is developed to reciprocate the external disturbances along the positional and the attitude subsystems. Then incorporating the estimated disturbance values a distributed adaptive formation controller is devised using the Lyapunov theory. It consists of a positional and an attitude controller associated with the translational and the rotational movements of the UAVs. The stability is validated by satisfying the criteria of the Lyapunov stability function. The UAVs are connected through variable adjacency matrix based directed network topology and the network connectivity is established through the properties of the Laplacian Matrix. The robustness of the designed controller is justified via rigorous simulation studies for different sets of desired formations such as triangular, squared, tetrahedron, octahedron and cube shaped. The reference trajectories are considered as spiral, straight line and circular shaped. The time varying external disturbances are considered of sinusoidal waveform of different magnitudes. The simulation results signifies that the proposed RBFNN based formation controller reciprocate different sinusoidal waveforms to achieve the desired formations successfully. Extensive comparative studies demonstrate the efficacy of the proposed adaptive formation controller over the existing controllers presented in the literature for different shapes of trajectories and desired formations.

Training for Making Wordwall Learning Media for Teachers in SMK PGRI Kuwu, Grobogan Regency

It doesn't feel like the Covid-19 pandemic that has lasted for 2 years has changed the learning model that we have known so far, namely face-to-face, although the blended learning model that combines conventional models with online learning has been introduced as an evolutionary model, but with the pandemic forcing it to happen. for teachers to immediately adapt and implement it in the schools where they teach as a need that must be met considering the demands of the community who want educators and educational institutions to be able to provide quality education in the midst of this crisis. As an affected educational institution, SMK PGRI Kuwu strives to continue to provide quality learning by applying the blended learning model (Purnomo et al., 2016). After communicating with the service team from PGRI Semarang University, consensus was obtained that the problems faced by partners could more or less be solved by implementing information technology in learning, one of which was the introduction of interactive learning media Wordwall with additional Gamification learning models (Putri, 2020). The application and learning model itself uses a Cloud system or Cloud Computing where between teachers and beneficiaries of learning or students can use information technology devices that vary depending on availability, and do not require device specifications with special and updated technology, the most important thing is the availability of internet network connectivity. Sari Yarza, 2021). Wordwall specifically can be used to create learning media such as quizzes, matchmaking, pairing, anagrams, word randomization, word search, word grouping, and several other additional features such as questions and answer results that can be printed on paper making it easier for teachers and students to document results. work as a task (Hasram, 2021). Through this introduction activity or PKM (Community Partnership Program), it is hoped that teachers and lecturers at SMK PGRI Kuwu can implement it in their learning classes, and are expected to be able to overcome the learning gap that has occurred as a result of the Covid-19 pandemic. The results of the ongoing activities in the form of mentoring and evaluation training, carried out for 3 days which were carried out in a blended manner (offline and online) with the results and responses of the activity participants showing positive indications as indicated by the reapitulation of the questionnaire results of participants' responses to this training activity which showed an average result of 3, 85 on a scale of 4 which indicates a good response or a positive response to the implementation of the training activities.

F-Bypass: a low-power network-on-chip design utilizing bypass to improve network connectivity

With the development of transistor feature size to nanometer level, static power consumption has gradually become the main factor affecting the overall power consumption of network on chip (NoC). Power gating is an effective technology to reduce static power consumption, but it also brings new challenges, such as BET violation, wake-up latency and network connectivity. Therefore, a power gating method is needed to improve NoC performance and reduce static power consumption. This paper proposes a low-power bypass method, namely Forwarding bypass (F-Bypass). First, F-Bypass adds bypass paths between all input and output ports and the network interface (NI), and connects the pop-up port and injection port in NI through the bypass path. When the router is powered off, F-Bypass performs wake-up-free packet transmission, which reduces the break-even time (BET) violation and cumulative wake-up latency while ensuring network connectivity. Secondly, This paper add the modified VC state table to NI, so that the power-off router can perform normal traffic control. Finally, a new wake-up criterion is proposed, which can effectively avoid the frequent wake-up of power-off routers, and the detailed hardware implementation of F-Bypass is provided.The simulation results under integrated traffic load show that compared with the traditional scheme, the delay of F-Bypass is reduced by 2.2%, the throughput is increased by 13.1%, and the total static power consumption is reduced by 75.2%. Key performance indicators are superior to other solutions, and the increased area cost is moderate.

Divergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients.

Schizophrenia (SZ) and bipolar disorder (BD) share common clinical features, symptoms, and neurocognitive deficits, which results in common misdiagnosis. Recently, it has been suggested that alterations within brain networks associated with perceptual organization yield potential to distinguish SZ and BD individuals. The aim of our study was to evaluate whether functional connectivity (FC) of the dorsal attention network (DAN) may differentiate both conditions. The study involved 90 participants: 30 remitted SZ patients, 30 euthymic BD patients, and 30 healthy controls (HC). Resting state functional magnetic resonance imaging was used to compare the groups in terms of the FC within the core nodes of the DAN involving frontal eye fields (FEF) and intraparietal sulcus (IPS). BD patients presented weaker inter-hemispheric FC between right and left FEF than HC. While SZ did not differ from HC in terms of inter-FEF connectivity, they presented increased inter- and intra-hemispheric FC between FEF and IPS. When compared with BD, SZ patients showed increased FC between right FEF and other nodes of the network (bilateral IPS and left FEF). We have shown that altered resting state FC within DAN differentiates BD, SZ, and HC groups. Divergent pattern of FC within DAN, consisting of hypoconnectivity in BD and hyperconnectivity in SZ, might yield a candidate biomarker for differential diagnosis between both conditions. More highly powered studies are needed to confirm these possibilities.

Alterations of perfusion and functional connectivity of the cingulate motor area are associated with psychomotor retardation in major depressive disorder

AbstractPsychomotor retardation, characterized by slowing of speech, thoughts, and a decrease of movements, is frequent in patients with major depressive disorder (MDD). However, its neurobiological correlates are still poorly understood. This study aimed to explore if cerebral blood flow (CBF) and resting state functional connectivity (rs-FC) of the motor network are altered in patients with MDD and if these changes are associated with psychomotor retardation. Thirty-six right-handed patients with depression and 19 right-handed healthy controls (HC) that did not differ regarding age and sex underwent arterial spin labelling (ASL) and resting-state functional MRI (rs-fMRI) scans. Psychomotor retardation was assessed with the motoric items of the core assessment of psychomotor change (CORE) questionnaire. Patients with MDD had more pronounced psychomotor retardation scores than HC. Patients with MDD had reduced CBF in bilateral cingulate motor area (CMA) and increased resting-state functional connectivity (rs-FC) between the cluster in the CMA and a cluster localized in bilateral supplementary motor areas (SMA). Furthermore, increased rs-FC between the CMA and the left SMA was associated with more pronounced psychomotor retardation. Our results suggest that reduced perfusion of the CMA and increased rs-FC between the CMA and the SMA are associated with psychomotor retardation in patients with depression.

Altered functional connectivity of resting-state networks and the correlation with clinical characteristics in intermittent exotropia adult patients: a resting-state magnetic resonance imaging study

BackgroundThe pathogenesis of intermittent exotropia (IXT) remains unclear. The study aims to investigate alterations of resting-state networks (RSNs) in IXT adult patients using resting-state functional magnetic resonance imaging (rs-fMRI) data to explore the potential neural mechanisms.MethodsTwenty-six IXT adult patients and 22 age-, sex-, handedness-, and education-matched healthy controls (HCs) underwent fMRI scanning and ophthalmological examinations. Brain areas with significant functional connectivity (FC) differences between the IXT and HC groups were selected as regions of interest (ROI) and mean z-scores were calculated to control for individual differences.ResultsCompared with HCs, IXT patients exhibited altered FC in various brain regions within RSNs involved in binocular fusion, stereopsis, ocular movement, emotional processes and social cognition, including the default mode network (DMN), the dorsal attention network (DAN), the visual network (VN), the sensorimotor network (SMN), the executive control network (ECN), the frontoparietal network (FPN) and the auditory network (AN). The degree of exodeviation was positively correlated with FC value of left middle occipital gyrus (MOG) within the VN. Correspondingly, we found a negative correlation between the degree of exodeviation and the FC value of left angular gyrus (AG) within FPN (P < 0.05). The FNC analysis between different RSNs also provides evidence on visual-motor cortical plasticity.ConclusionsIXT patients showed widespread changes of brain activity within RSNs related to binocular fusion, stereopsis, oculomotor control, emotional processes, and social cognition. These findings extend our current understanding of the neuropathological mechanisms of IXT.Trial registrationBeginning date of the trial: 2021-09-01. Date of registration:2021-07-18. Trial registration number: ChiCTR 2,100,048,852. Trial registration site: http://www.chictr.org.cn/index.aspx.

Optimizing underwater connectivity through multi-attribute decision-making for underwater IoT deployments using remote sensing technologies

The underwater Internet of Things (UIoT) and remote sensing are significant for biodiversity preservation, environmental protection, national security, disaster assistance, and technological innovation. Assigning tasks to autonomous underwater vehicles (AUVs) is a fundamental challenge in underwater technology and exploration. Remote sensing and AUVs are vital for pollution detection, disaster prevention, marine observation, and ocean monitoring. This work presents an optimized network connectivity using a multi-attribute decision-making approach for underwater IoT deployment. A feature engineering approach highlights the significant characteristics of underwater things, incorporating remote sensing data, and a multi-objective optimization method is used to select optimal UIoT for effective task allocation in deep-sea environments. A balance between data transmission, energy economy, and operational performance is necessary for efficient task distribution. Effective communication algorithms and protocols are needed to maintain environmental sustainability, protect marine ecosystems, and improve underwater monitoring enhanced by remote sensing technologies. Multi-criteria decision-making (MCDM) is beneficial for addressing various challenges in underwater technology, considering factors such as mission objectives, energy efficiency, environmental conditions, vehicle performance, safety, and much more. The proposed criteria importance through intercriteria correlation (CRITIC) methodology will assess technical competencies like communication, resilience, navigation, and safety in an underwater environment, leveraging remote sensing and aiding decision-makers in selecting appropriate undersea devices and vehicles for enhancing communication and transportation. This method prioritizes characteristics and aligns them with specific objectives, improving decision-making quality in the marine environment.

Resting-state alterations in emotion salience and default-mode network connectivity in atypical trajectories of psychotic-like experiences.

Social cognition is commonly altered in people with psychosis. Two main brain networks have been implicated: the default-mode network (DMN), which is associated with socio-cognitive processing, and the salience network (SN) associated with socio-affective processing. Disturbances to the resting-state functional connectivity of these networks have been identified in schizophrenia and high-risk individuals, but there have been no studies in adolescents displaying distinct trajectories of subclinical psychotic-like experiences (PLEs). To address this, the present study measured SN and DMN resting-state connectivity in a unique longitudinally followed sample of youth (n = 92) presenting with typical and atypical 4-year PLE trajectories. Compared to the typically developing low PLE control group, the atypical increasing PLE trajectory displayed reduced connectivity between the SN and DMN, increased connectivity between left and right insula, and widespread dysconnectivity from the insula and amygdala. These alterations are similar to those reported in schizophrenia and clinical high-risk samples, suggesting that early detection may be useful for mapping the developmental trajectories of psychotic disorders.

Business model structuration in Industry 4.0: an analysis of the value-based strategies of smart service providers in Brazil

PurposeThis study examines the use of a dynamic value-based approach to analyze the business model structuration of smart service providers in Brazil, mapping their value creation, configuration and appropriation strategies, and determining how well-defined their current business models are.Design/methodology/approachThis is a qualitative study based on semi-structured interviews with entrepreneurs (or CEOs and directors of technology) of seven business ventures in three different phases of business model structuration: (1) academic: companies or innovation and research centers linked to universities; (2) startups: technology-based companies originating from the technological needs of clients, be they new branches of the traditional business of incumbents or new entrants and (3) autonomous service providers whose offerings are related to master’s or doctoral projects.FindingsWe propose a typology of business model structuration with four stages. At first (individual or initial business model), albeit with high skilling of owners, only manual or adaptation services are offered. In the second stage (platform business model), although services offered are oriented toward the entire process automatization of the client (Factory integrated), technologies are restricted to the client company (or even one department) and these clients' needs are mainly data processing and connectivity. In the third stage (scaling digital business model), although the services offered are oriented toward greater digitalization through an entire array of field devices connected to the internet (IoT) and organized in a more formalized structure, the business model is still being constructed, companies in this stage are mainly startups. In the fourth stage (innovation ecosystem business model), the entire manufacturing process is digitized, with integration and network connectivity, both between service providers and the extended supply chain of their clients, and new technologies are customized and developed through the interaction of a whole innovation ecosystem.Research limitations/implicationsMapping value-based strategies aids in understanding business model structuration in Industry 4.0. Future research should focus on parameterizing the dimensions founded of each value strategy.Originality/valueThis study advances the comprehension of the business model in |Industry 4.0 by providing a value-based strategy perspective of business model structuration. Practically, by focusing on smart service providers, it contributes to a greater understanding of smart service providers in Brazil and their strategic challenges.

From gut to brain: unveiling probiotic effects through a neuroimaging perspective-A systematic review of randomized controlled trials.

The gut-brain axis, a bidirectional communication network between the gastrointestinal system and the brain, significantly influences mental health and behavior. Probiotics, live microorganisms conferring health benefits, have garnered attention for their potential to modulate this axis. However, their effects on brain function through gut microbiota modulation remain controversial. This systematic review examines the effects of probiotics on brain activity and functioning, focusing on randomized controlled trials using both resting-state and task-based functional magnetic resonance imaging (fMRI) methodologies. Studies investigating probiotic effects on brain activity in healthy individuals and clinical populations (i.e., major depressive disorder and irritable bowel syndrome) were identified. In healthy individuals, task-based fMRI studies indicated that probiotics modulate brain activity related to emotional regulation and cognitive processing, particularly in high-order areas such as the amygdala, precuneus, and orbitofrontal cortex. Resting-state fMRI studies revealed changes in connectivity patterns, such as increased activation in the Salience Network and reduced activity in the Default Mode Network. In clinical populations, task-based fMRI studies showed that probiotics could normalize brain function in patients with major depressive disorder and irritable bowel syndrome. Resting-state fMRI studies further suggested improved connectivity in mood-regulating networks, specifically in the subcallosal cortex, amygdala and hippocampus. Despite promising findings, methodological variability and limited sample sizes emphasize the need for rigorous, longitudinal research to clarify the beneficial effects of probiotics on the gut-brain axis and mental health.

A user-centric model of connectivity in street networks

Modelling street network connectivity is a fundamental research problem in transportation science. Here, we argue that the connectivity of a street network cannot be defined independently from the users of that street network. That is, different users will experience different levels of connectivity depending on their corresponding travel behaviour. In this work, we propose a model of connectivity that is defined with respect to a user’s travel behaviour within a given street network. We demonstrate that many real-world problems can be posed as instances of an optimisation problem defined with respect to this model. This includes optimising a user’s home location with respect to their connectivity and optimising the location of a facility with respect to the connectivity of its users. We prove the above optimisation problem is NP-hard and present an integer programming solution that scales to large problem instances.