In western African cratonic regions, fractured crystalline bedrock, Neoproterozoic sedimentary covers, and regolith deposits constitute the most productive aquifer systems. Structural lineaments derived from remote sensing data and weathered cover thickness from borehole interpretations provide cost-effective methods for evaluating well productivity in regions with limited economic resources and hydrogeological knowledge, such as Houet province in Western Burkina Faso. Structural lineaments were interpreted using 1:200,000 Landsat TM images and 1:50,000 aerial photographs, revealing NE and NW as the most significant directions. An analysis of 101 borehole stratigraphic profiles from rural water supply program reports revealed the weathering depth and cover thickness. Borehole productivity exhibited a strong correlation with increased weathered cover thickness. Negative well results were concentrated in areas with less than 5 meters of cover. In contrast, significant differences in specific yield rates were observed with greater thicknesses, ranging from 2.5 m³/d for 20 meters of saturated thickness to 7.6 m³/d when the regolith reached a depth of 40 meters. These preliminary groundwater exploration tools effectively target successful well sites by accounting for differing lithologies, regional tectonics, and regolith development. This approach is particularly relevant for cratonic regions with limited resources and hydrogeological knowledge, aiding in sustainable groundwater development and land-use planning.